Caffeinum

Alkaloid obtained from Coffea Arabica. Formula, CJLJSTXX

reparation, Indurations.

Authorities. 1, Dr. C. G. Lehman, effects on students of doses of 2 to 10 grains, from Brill's monograph on C. ; 2, Dr. Frerichs took 25 grains, from the same; 3, Dr. J. Lehman (see No. 12, under Coffea tosta), effects of 4 to 6 grain doses ; 4, Eustratiades, These de Paris, 1870, conclusions from series of examinations of urine. (See also sphygmographic tracing, Plate II, Fig. 11 to 22, from 5 Marvaud, Aliments d'Epargne.)

Mind

Emotional. Great excitement, so that he was unable to fix the mind

Very excited fantasies

Peculiar intoxicated condition

Delirium

Visions

Intellectual. Confusion of ideas

Obscuration of mind

Head

Slight vertigo

Pulsation of the arteries on the head and temples very marked

Head heavy and confused

Headache

Eyes

Vision of sparks

Eat

Roaring in the ears

Stomach

Vomiting, with relief of all the symptoms (after one hour)

Urinary Organs

Urethra. Constant urging to urinate, but only very scanty discharge

Micturition. Amount of urine increased 140 c.c. ; urea diminished 2.9 grammes; phosphoric acid diminished 0.2 grammes ; sodium chloride diminished 0.9 grammes

Amount of urine increased 4.84 c.c. ; urea diminished 3.1 grammes ; phosphoric acid diminished 0.37 grammes; sodium chloride increased 0.1 grammes

Urine. Increase of urea during first twenty-four hours

First, Caffeine lessens the quantity of urea excreted, to a remarkable degree ; diminution of 14.100 grammes the first week, from 15 centigrammes Caffeine ; of 28.100 grammes, the second week, from 30 centigrammes. This diminution begins from the first day of taking Coffeine. On the subsequent days it is greater than at first, but is not afterwards increased (no cumulative action in the system, as in the case of Digitalin)

Sexual Organs

Erections

Chest

Oppression of the chest

Heart and Pulse

Palpitation

Pulse very rapid

Extremely frequent, irregular, and often intermitting pulse

Pulse full and hard, rising from 70 to 80, in fifteen minutes

On considering the changes in the pulse under the action of Caffeine, they are seen to be very similar to those observed after drinking a decoction of raw coffee ; only they are, as might be expected, more strongly marked

Generalities

Great excitement of the nervous and vascular systems

Trembling

Great uneasiness

Sleep

At last very sound sleep

Loss of sleep

Conditions

Amelioration.

( Vomiting) All symptoms.