Chininum Sulfuricum

Sulphate of quinine or chinin. Formula, 2C20H24N,O2,SH,O4+7H2O (Regnault).

Preparation for use, Triturations.

Authorities. ' 1, Boiler (Inaug. Diss., Leipsic, 1828, De Chin. Sulph.), 24 years old, effects of i to 2 grains, repeated doses in the morning, fasting, from Journ. f. Arzneim., 2, 154; 2, N. N. took 10 grains, from ibid.; 3, N. N., 26 years of age, took 6 grains, ibid.; 4, "a physician," 33 years old, took 2 grains twice with an interval of three hours, ibid.; 5, Dr. Otto Piper, 21 years old, provings with repeated doses of | grain to 12 grains, and a second proving (days noted) as follows: (first day), \ grain, (third day), h grain, (fourth day), 1 grain, (seventh day), 1 grain, (thirteenth day), 2 grains, (seventeenth day), 3 grains, Journ. f. Arznm., 2, from Piper's MSS. of his Inaug. Diss., with the author's additions; 6, Leonard, medical student, 23 years old, provings with (first day), 1 grain, (fourth day), 1 grain, (fifth day), 1 grain, (ninth day), 3 grams, (seventeenth day), 4 grains, Noack'a provings, Journ. f. Arznm., 2; 7, Laurent Fritz, provings with £ grain to 6 grains, ibid.; 8, Johanna Bader, 17^ years old, not yet menstruated, but suffered lately from "menstrual leucorrhcea," usually excoriating, took (first day), 1 grain, (fifth day), 2 grains, (ninth day), 3 grains, (thirteenth day), 3 grains, (nineteenth day), 11 grains, 'twenty-seventh day), 12 grains, (thirty-first day), 20 grains,' ibid. ; 9, Friedrike Rithe, 27 years old, took 2 grains, and after some time 6 grains (had not menstruated lately, in consequence of a "nervous fever"), ibid. ; (10 to 46, selected authorities) ; 10, Baldwin, effects of 8 grains in two doses (with an interval of three hours) on a child 6 years old, N. A. J. of Horn., 8, 76 (from Southern Med. and Surg. J.); 11, ibid., effects of 68 grains in twenty-four hours, ibid.; 12, Benz, general effects of doses over 15 grains, or of smaller doses frequently repeated, Deutsche Klinik, 1871 (Am. J. M. S., n. s., 64) ; 13, Benz, provings on two sound men of 0.1 to 0.5 gramme, with special reference to urine, Virchow's Archiv, 46, p. 166 ; 14, Blade, Journ. f. Arznm., 2, effects of 24 grains in twenty-four hours ; 15, Dictionnaire de Med., 18, 132, effects of 5 to 6 grains on a man, Journ. f. Arznm., 2; 16, Dr. Elon, experiments with 2 to 20 grains, effect on pulse, Am. J. M. S., n. s., 52, 97 ; 17, Favier, took 18 grammes in ten days, Inaug. Thesis, Montpellier, 1848 (from Wenz, Monograph on Chinin, p. 126) ; 18, Caraway, effects of large doses on a woman aged 40, Br. Med. J., 1869; 19, Giaconini, a nurse, in a fit of melancholia, took 3 drachms at once, Omod. Ann. di Med., 1841 (S. J., 33, 24) ; 20, ibid., a man took 12 to 15 grammes by mistake, ibid. ; 21, Giaconini, Traite Experimental de Mat. Med., took 3 to 4 grammes every evening (Wenz's Monograph ) ; 22, Caraway, toxic action of 1 grain, Br. Med. J., 1870 ; 23, v. Graefe, in Canton on Quinine, St. Thos. Hosp. Rep., 1870, effects of half-drachm doses continued for some time (in all, 6 drachms); 24, Harsher, effects of 1 grain every two hours, Journ. f. Arznm., 2; 25, Kenning, effects of about 1 grain on a convalescing patient, Br. Med. Journ., 1869; 26, Prof. Ith, effects of several doses of 3 to 4 grains, Journ. f. Arznm., 2; 27, Kremers, effects of 20 grains on a young man aged 25, Journ. f. Arznm., 2; 28, Kremers himself took 20 grains, ibid.; 29, Lambert, Essay sur la Methode Endermique, p. 97 ; 30, Lieber, effects in inunction (by means of a blister), Journ. f. Arznm., 2; 31, Kreuser, effects on workers in Chinin factory (from Wenz's Monograph) ; 32, Meniere’s, general statement, from Trousseau and Pidoux, Traite de Therap. ; 33, Mutter, general statement, Journ. f. Arznm., 2; 34, Perrine, experiments on pulse with doses of 8 grains a day for several days (Journ. f. Arz., 2, "from Phil. Journ., No. 7, 1828") ; 35, Viol and Mossop, effects of 5 and of 10 grains, as observed by ophthalmoscope, B. and F. Med.-Chir. Rev., 1872; 36, Ranke, provings, on self and two others (10 and 20 grain doses), Med. Times and Gaz., 1857 ; 37, Ringer and Gell, influence on temperature of body in health, a boy took 10 grains on three occasions, girl took five doses in six days (8 to 20 grains), Lancet, Oct. 1868; 38, M. Scott, effect of 2 grains three times a day, increasing a grain each day to 20 grains a day, Lond. Med. and Phys. J., 1833; 39, Sistach, effects on uterus, Gaz. de Paris, 1874 ; 40, Skinner, effects of \ of a grain on a delicate young woman, Br. Med. J., 1870; 41, Whittmann, effects of 6 grains on a man aged 24, Journ. f Arznm., 2 ; 42, ibid., effects of 4 grains on a man of 18, ibid. ; 43, ibid., effects of 6 grains, repeated to 24 grains in twenty-four hours, on a man of 20, ibid.; 44, tox. by med. dose, Phil. Med. Times, 1, 446, 1871 ; 45, Chevalier, general effects on workers in Chinin factories, N. Am. J. Horn., 5, 265; 46, Dr. W. H. Burt, provings, (first day), 2 grains, (second day), 4 grains, (third day), 10 grains, Monograph on Cinchona; 47, J. C. P., one dose, 5 grains, ibid. ; 48, Berridge, proving with 200th dil., one dose, N. Y. Journ. of Horn., 2, 461 ; 49, J. C. Morgan, provings, 3d dec. trit., as follows: first day, morning and evening; second day, morning and evening; third day, evening; fourth day, evening; sixth day, 3 a.m. ' and evening ; seventh day, evening ; ninth day, evening ; tenth day, noon and evening; twelfth day, evening; thirteenth day, morning; fourteenth day, morning. Took crude drug as follows: fourteenth day, ^ grain, noon and night ; fifteenth day, i grain, morning and evening ; sixteenth day, \ grain, morning and evening; seventeenth day, 1 grain, morning; nineteenth day, 2j; grains ; twentieth day, 4 grains, at noon and 6 p.m. Took 200th dil. as follows : twenty-fourth day four doses, twenty-fifth day four doses, twenty-sixth day, one dose, Am. J. of Horn. Mat. Med., 8, 325 ; 50, Dr. Adhere, hematuria caused by Quinine administered in intermittent fever, New Orleans Journ. of Med., Oct. 1869 ;f 51, Jerusalimsky (of Moscow), Monograph on Chinin, 1875, a woman, aged 20, took 10 grains, and afterward 6 grains, to observe effect on pulse, etc.; 52, ibid., a woman, aged 27, perfectly well, made three experiments with 5, 10, and 10 grains; 53, ibid., another woman, aged 26, made three experiments with same doses; 54, Bohn, effects of 0.25 gramme, three times a day for twenty days, N. Z. f. H. K., 1870. .

Mind p. 216

Emotional. Excited

Sensation as though he were intoxicated, though his mental powers were perfect

An intoxicated sensation, changing to a heaviness of the head (fifth day)

Uncommonly lively mood (ninth day)

An extremely lively mood and an activity returned about 9 p.m., only after a walk in the open air (eighth day),ti.

Buoyant feeling in the evening (twelfth day)

Rather more vim and buoyancy than usual, during the evening especially (second day)

Feeling of considerable mental resolution, with shrinking from taking much trouble about matters, evening (twenty-sixth day)

Found my will positive in insisting on professional orders, but self-restrained and deliberate, in the forenoon (seventeenth day)

Awoke at midnight with long-continued cries ; he knew that he was crying, but could not help it ; he was obliged to get out of bed ; he wrapped himself in the clothes, and remained sitting; after a few minutes he came to himself again, and soon fell asleep (sixth day )

Great depression of spirits (fourteenth day)

Great depression of spirits and fretfulness (eleventh day)

* Despondency?.

During much of the proving the morale has been one of Will, with little courage, or hope, or contentment, which, however, I am not prepared to attribute to the drug with confidence (twenty-seventh day i

Anxiety (after two hours)

Great anxiety, amounting to an apprehension, as if some evil would happen (fifth day)

Attacks of anxiety ( third day)

Feeling of anxiety, which at times obliges him to leave the bed (third and fourth nights)

Anxious and sleepless during the night,'-

The day being clear and windy, and a holiday to many, few people being on the street produced a sort of street-quietness ; felt'a gloom come over me, *as if some evil were impending ; relieved by a specific trust in the Almighty ; this from 3 to 4.15 p.m. (first day)

Recurrence of feeling of impending evil, in the afternoon (sixth day)

Ill-humored and fretful (ninth day-

After sleep, readily angered, even by a cold draft on my legs (fortieth day)

Intcllcettial. The morale, from the first, has resembled the physical symptoms, dull feelings in both coexisting; in both simultaneously sharpness, the former in the beginning, the latter at present (twentieth day)

Thought difficult, while writing (fifth day)

Great disinclination to mental labor (eighth day)

Averse to difficult study or other work (twelfth day)

At 12 p.m., some repugnance to the prospective burden of to-morrow's business (having partaken of vegetable soup, an orange taken after that) ; then at 12.25 took another powder; then, leaning over my table, tasted the food (second day)

4.30 p.m., whilst writing, was interrupted ; decided feeling to cut it short (first day)

Wrote "right instead of "left by mistake (twenty-eighth day)

Wrote the word "left instead of "right afternoon (twenty-sixth day)

Wrote the word "left instead of "right;" have made a number of similar mistakes in talking during the past few days, in the evening (fourteenth day)

Again I mistakenly wrote at first "left instead of "right (I remember a report I published some time ago of contusion of the spine cured by Hypericum, in which the same error occurs; I do not remember whether I had then taken any medicine; possibly I had taken China or some other), (fifteenth day)

Memory "all muddled

Lost the power of naming substantives; was obliged for a long while to consider what different familiar things were called; and as to casting up a line of six or eight figures correctly, it was utterly impossible; he could never make the amount twice alike; his perceptions of quantity were greatly impaired, so that in prescriptions he wrote ounces instead of drachms, ordered drachms instead of grains, directed draughts to be put in gallipots, and prescribed fluids to be made into pills (14 to 16 grains daily)

Head p. 217

Confusion and Vertigo. Confusion of the head (fifth and twentieth days;,5.

Vertigo,19 20; (after one hour and a quarter)

Vertigo, on stooping (twenty-first day)

Vertigo and whirling in the head (twenty-ninth day)

Vertigo and palpitation (after four hours)

Whirling in the head, like a "millwheel (thirty -first day)

General Head. In morning, whole head swollen, and the face so altered that she could with great difficulty open her mouth for food

Rush of blood to the head

Rush of blood to the head, towards evening

Chronic disturbance of brain

Head stupefied, and especially painful in the left temple (twenty-sixth day)

Head empty, in the morning

Light, hollow feeling in head

Heaviness in the head (seventh day

Heaviness and confusion of the head continue until going to sleep in the evening (seventh day)

Heavy feeling in head, especially the top, in the evening (twenty- seventh day)

Heavy feeling in th head is notable; sitting after stool with protrusion ; the room being somewhat warm, the day stormy. It is not unlike the inertia of the muscles of the legs in walking before mentioned; it is also attended by a sense of vascular tension and fulness and dry heat, fingers and feet cold; the head feels much better by application of my cold hand on the top, in the forenoon (twenty-eighth day)

Pain in the head (after one hour)

Very violent pain in the head, on rising in the morning, especially noticed on stooping or moving (twentyninth day)

Such fulness in the head that he was unable to walk

■ Sudden fulness of head (head leaning to left), especially the left side and top, after writing, in the forenoon (twentieth day)

Head feels full while sitting writing, in forenoon (twenty-eighth day)

A moderate excitement caused a marked feeling of dull tension (not a rare symptom) about the head, especially at the sides; settling on the top as a pressure, extending later to the perceptive region of the forehead, at last completing the circuit to occiput like a rim, in the morning (twenty-third day)

Headache,15; (tenth day)

Headache (boy, after twenty-five minutes, lasted five minutes); (girl, from 8 grains, began in one hundred and seventy minutes ; from 10 grains, in one hundred and seventy-five minutes; from 12 grains, in ninety-five minutes; from 20 grains, in thirty minutes; from 20 grains, in fifteen minutes)

Headache, extending to the temples, in the afternoon, and was somewhat relieved towards evening (eighteenth day)

Headache after walking a longtime in the sun, in the afternoon (seventh day)

Headache at 3 a.m., with violent pressive pains in the occiput, which only disappear on rising (second day)

Headache at 7 p.m., commencing in the forehead, and at last extending to the occiput, lasting an hour (thirteenth day)

Headache, with vertigo and loss of consciousness

Very severe headache, worse towards evening, with violent palpitation of the arteries of the head, as if the head would be torn asunder, with glowing heat of the face, vertigo, at times ringing and roaring in the ears

Violent headache, which disappeared after eight to twelve days

Violent headache in the forenoon, more especially in the left side, with frequent pulsation of the temporal arteries, with excitement through the whole body (twelfth day)

Dull headache (fourteenth day)

The headache and fever were relieved on walking in the open air, with appearance of slight sweat (thirty-first day)

I rose and bent over my table; then throbbing in the head and shoulders; forgot it on going out (first day)

Forehead. About 4 p.m., the frontal arteries began to pulsate, the heat of the face increased to redness, and continued; especially was it the most intense about the eyes (seventh day)

Pain in the forehead,9; (twenty-second day)

Pain in the forehead after dinner (seventh day)

Pain in the forehead between 5 and 6 p.m. (third and fourth days)

Pain in the forehead and temples appeared towards evening, and gradually increased in intensity, with visible pulsation of the temporal arteries, heat of the head, and ringing in the ears (fourth day)

Some pain in the forehead in the afternoon (fifth day)

Some pain in the forehead about 4 p.m. (second day)

Much pain in the forehead and temples (eighth day)

Violent pain in the forehead, lasting twentyfour hours (after four hours)

Violent pain in the forehead two hours alter 2 grains; it disappeared in the course of the afternoon (fifth day)

Extremely violent pain in the left side of the forehead, with vertigo, ringing in the ears, and weakness as from long illness, at 9 a.m. (eighteenth day)

Frontal headache from 1 to 4 p.m. (thirty -first day)

Slight frontal headache, lasting all day, and becoming worse towards evening

Violent frontal headache on waking (twenty-third day)

Violent frontal headache in the evening (fifth day)

Severe frontal headache, worse on the left side, on rising iu the morning, becoming somewhat less during the forenoon, but succeeded by confusion of the head the whole day; it was again worse at 5 p.m., without any general excitement (nineteenth day)

Dull frontal headache (twenty-fourth day)

Headache in the forehead and left temple (thirteenth day)

Dull headache, extending from the temples to the middle of the forehead, in the afternoon (eighth day)

D rawing headache, extending from the temples to the middle of the forehead ( twenty-seventh day)

Pressive pain in the forehead and orbits, aggravated by moving the eyes or turning the head

Sudden boringsticking in left centre of forehead; spot like the end of the little finger, in the evening (twenty-fifth day)

Tearing and drawing in the forehead and left temple (twenty-third day)

Temples. Temporal arteries and veins of hands seem quite full, evening (twenty-sixth day)

Repeated twitching of fibres of temporal muscles above left zygoma, in the afternoon (twenty-fourth day)

Violent pains in the left temple; the pain extends to the eyebrow, and obliges him to lie down, with which he seeks a cool place on the sofa in order to relieve the pain (first day )

Violent headache in the temples, towards evening (twenty-ninth day)

Dull pressing pain in the temples (twenty-seventh day)

Sitting at table, leaned to right, neuralgic sensation shot up the anterior left temple (forty-second day I

Vertex. Reading, bent forward, steady neuralgic pain from the right supra-orbital foramen, straight up to vertex, in a narrow line, ceased after sitting up straight, in the night (twentieth day)

Pftrietftls. Dull neuralgia, left parietal region, then right vertex, in the evening (twenty-fourth day)

On raising the eyebrows, neuralgic pain from outer right brow up that side of the head; then a slight twinge in outer end of left eyebrow, early in morning (nineteenth day),49-

Left side of head and throat feel as if they would ache (not rare), in the afternoon (third day)

Whilst writing, with head inclined to left, dull headache on the right side (after five minutes); I have the like sometimes from constipation or from mechanical tension of the right cervical muscles (twelfth day)

Whilst writing, dull ache, right side, extending as a sharp neuralgic sensation to right outer brow, and dull, later, to right mastoid process, returning slightly to brow, and up temporal ridge, same side; again in ear, right side, then back to brow; later, a catch iu middle of right sterno-mastoid muscle, when turning head that way, after midnight (seventeenth day)

Whilst writing, with head inclined to left side, dull headache on left side (similar to early symptoms), extends to left side of neck and throat, and right mastoid process, then to vertex, then to occiput; shifting, then to brows (varying with position of head), now pressing in both temples, extending over coronal suture, in the morning (twenty-first day)

Slight dull headache, right side (old symptom since an attack of fever, with misapplied water-cure, in 1860, in Illinois), in the afternoon (fourteenth day;,49.

Whilst standing holding my head down, a little dull stitch iu upper left parietal, felt also to root of nose, left side (soon), (fifteenth day)

On suddenly rising to a standing posture, a quick stitch in left upper parietal region (soon), (fourteenth day)

Walking in open air, neuralgic twinge, right side of head, lingering some time in upper right temple, in the evening (eighteenth day)

Sitting, sudden neuralgic twinge in right side of head, from brow to lambdoidal suture, in the evening (eighteenth day)

When about to dine, and whilst standing, return of the twinge from outer right brow to lambdoidal suture, i. e., above temporal ridge (nineteenth day)

On going out with head down, sharp neuralgic twinge in and behind left parietal protuberance, in the afternoon (twentieth day)

Occiput. Threatening of dull headache, left occiput, in the evening (nineteenth day)

Dull twinges, left occipital protuberance, becoming a steady ache for a short time, in the afternoon (twentyfourth day)

On holding up head suddenly to right, a little shock across lower occiput, in the evening (fifteenth day)

External Head. Dandruff in large amount also falls when scratching the scalp, attended by relief; also similar conditions in the beard on the chin, especially left side, in the evening (twenty-fourth day)

Prickling in the forehead, with confusion of the same (seventh day)

Recurrence of itching of scalp here and there, coming and going, in the evening (twenty-fourth day)

Whilst writing, itching above edge of frontal hair, right and left sides, then below right zygoma, then right side of top of head, then left vertex, right chin, left post-mastoid surface, inner left eyebrow, etc. (twentyfirst day)

Itching in vertex and occiput, left side (twenty-first day)

Eyes p. 220

Objective. Lustreless eyes

Gray rings about the eyes (twenty-sixth day)

With. some, the eyes become red and there is swelling of the lids, with the appearance of pimples

Eyes restless (twelfth day )

Subjective. Peculiar dryness of the eyes

All day, eyes feel as if they had been in a glare, or as if the atmosphere were too dry, as if parched (twentieth day)

Walking in the wind I observed the cessation of the parched feeling in the eyes, and in the right lachrymation in the evening (twentieth day)

Eyes and frontal region feel heavy, in the afternoon (third day)

While sitting, sleepy feeling in the eyes, in the afternoon (sixteenth day)

Brow and Orbit. (From the beginning of proving, have had an habitual symptom considerably increased, i. e., disposition to contract eyebrows)

Slight neuralgic sensation, right inner brow, when bending forward in the morning (twentieth day)

Dull neuralgic grip, in outer right brow, deepseated ; then, a somewhat similar pain in (outer) left biceps tendon, whilst holding the forearm flexed and pronated, hand on edge of table, at noon (twenty-fourth day)

Recurrence of neuralgic ache, outer half of right brow, after midnight (twenty-fourth day)

Whilst writing, stitch at inner left eyebrow, in the evening (fourteenth day)

Twinges about right outer brow, and various other places, in the afternoon (nineteenth day)

Neuralgic twinge in outer right brow, at 11.30 p.m. (eighteenth day)

Neuralgic twinge, inner right eyebrow (eighteenth day)

Neuralgic twinges, alternating in both brows; rather dull in character, in the night (twenty-first day)

While sitting, hard aching in outer half of orbit, above it, below it, and in the eyeball (I think this was on the right side), in the evening (twenty-third day)

Pain in left infra-orbital nerve (slight ache), in the night at 1.30 a.m. (twenty-sixth day)

Pain in left infra-orbital, malar, and superior maxillary nerves ; aching and boring, worse in cold air, but nearly constant, even involving the eye at times, with tumefaction adjacent to upper molars (fortieth day)

Slight pain recurring in right outer supra-orbital region, in the early morning (twenty-sixth day)

Neuralgic pain in right supraorbital nerve, then in left (whilst sitting in street car), in the evening (twenty-fifth day)

Whilst writing, neuralgic pain in left supra-orbital nerve, slight, near foramen, in the evening (eighteenth day)

Neuralgic twinge in left supra-orbital nerve, in the forenoon (nineteenth day)

Sunn- in church, felt a neuralgic twinge in right supra-orbital nerve,'near foramen (nineteenth day)

Flashing in branches of infra-orbital nerve, left side, in the afternoon (twentieth day)

Ziids, Eyes closed from weakness, while writing (fifth day)

Twitching of left eyelid (recurrence), several previous occasions not noted (twenty-third day)

Twitching of left eyelids; outer canthus, as most commonly (thirtieth day)

Twitching of left eyelids, in the evening (twenty-fifth day)

Whilst writing, renewed twitching in left eyelids, evening (twenty-sixth day)

Decided twitching of left eyelid, in the afternoon (twenty-fifth day)

Repeated twitchings in left eyelids, especially the lower, afternoon (twenty-sixth day)

Lachrymal Apparatus. Lachrymation in the open air ( twenty-ninth day)

On going out (air not very cold, but sunshiny), lachrymation from both eyes, obscuring sight. (Not rare in right eye; but now, worse in left) (fifth day)

Lachrymation of the eyes in the full light, at 5 p.m. (seventh day)

Conjunctiva. Dirty color to the white of the eye

Ball. Disk on both sides, now decidedly paler (10 gr. doses), (after two and a half hours)

* Disk and retina both very anaemic. Disk looks dry, with the vessels smaller than usual running over it (10 gr. doses), (after one and a half hours)

Vessels on the disk appear smaller, and the disk itself of a papery whiteness (10-gr. doses), (after one and a half hours)

With five-grain doses, the effects on one observer were similar to those already mentioned, though not so marked ; with the other observer, on one occasion, when the quinine created considerable disturbance of the stomach, a diminution of the vascularity was observed only to a slight extent, and about an hour and a half after exhibition of the dose; otherwise, the fundus remained, as it had been at the first, rather congested

Pupil Dilatation of the pupils™.

Pupils dilated,5-.

Pupils much dilated,19; (after eight hours)

Mydriasis

Vision, Dim vision

Dimness of vision, as from a net before the eyes, and once, as from a dark fog

Dimness of sight (girl, 5, from 10 grs.) of left eye only, began in 177 min., lasting 40 min. ; from 8 grs., first of left eye, then of right, in the latter continuing after it had disappeared from the former ; from 20 grs., appeared in 20 min., first in right, then in left eye, lasted 160 min. ; from 20 grs., appeared in 25 min., in right eye only, lasted 105 min.,37.

Amaurosis (two cases).23

More or less complete, or even incurable amaurosis of one or both eyes

Sight and hearing nearly lost

Sight lost (after eight hours)

Blindness.10.

* Great sensitiveness of the eye to the light, xvith lachrymation in the full glare of light (thirteenth day)

Sitting at a lecture, the glare of light felt disagreeable, although it is a dull day ; drowsy, had to shut my eyes and press the inner canthi, in the afternoon (twenty-seventh-day)

Sparks before eyes when sunlight is strong, for one week (after four weeks)

* Bright lights and sparks before the eyes

* Black sjiot, size of pin's head, about eighteen inches from right eye, and moving with eye for some weeks (after eighteen days)

Blackness before the eyes, with pain in the forehead, so violent that the head seemed as though it would burst (thirty-first day)

Ears p. 222

External. From entrance of cool wind, left ear and neck instantly felt rheumatic, i. e., neck extending towards ear (twenty-ninth day)

Aching above right mastoid process and ear, in the evening (twenty-fifth day)

Parotid tension and flow (twenty-ninth day)

Sitting, tension in parotids recurs, with flow of saliva, in the afternoon (twenty-fourth day)

After supper, walking, after a little jar, sudden tension in right parotid region, with flow of saliva (twenty-eighth day)

At 11.30 p.m., tension set in, and flow of saliva from right parotid gland, also right submaxillary ; afterwards the left glands likewise. Continued up to time of taking second powder, and falling asleep, 12 p.m. (first day)

Internal. Pain in right ear, then below left zygoma, between 1 and 2 a.m. (twenty-sixth day)

Sudden aching in left ear, while walking out of doors, in the afternoon (fourteenth clay)

Sticking in right ear, at noon (twentieth day)

Sticking, right ear, in the evening (thirtieth day)

Sticking in left ear, involving the throat, then drawing in the chin (twenty-third day)

Left side, sticking, slow and dull in the ear, in the forenoon (twenty-fourth day)

After going downstairs, sticking in left meatus auditorium, very slight, but recurrent, in the afternoon (fifteenth day)

Hearing. Difficult hearing, on the second or third day

Hearing lost (after eight hours)

Deafness of both ears, on account of loud ringing in them (thirty-first day)

Transient deafness in the left ear (twenty-sixth day)

The child became completely deaf for several years and never quite recovered

Morning, in bed, the not heavy tread of another person in the -room is intolerable; it seems to go through my head (forty-seventh day)

Intolerant of the noise of boys behind me in the street whilst walking home; crossed the street to be rid of them ; but the church music had been very enjoyable, evening (twenty-sixth day)

Slight and transient resonance in right ear, in the morning (twentieth day)

The characteristic tingling in the ears, was felt with the ten-grain doses

Ringing iu the ears (after four hours)

* Ringing in the ears, especially noticed in the left, seldom in the right (twenty-sixth day)

Ringing in the ears, with frequent interruptions (nineteenth and twentieth days)

Ringing in ears, with sensation as if they were filled or plugged up

Frequent transient ringing in the ears

Constant ringing in the ears (first day)

Constant ringing, hissing sound in ears

Noises in the ears, buzzing sounds, as if bells were ringing (boy, after thirty-five minutes, lasting about five minutes) ; (girl, from 8 grains, began in one hundred and ten minutes, and lasted sixty minutes; from 10 grains, began in one hundred and twenty minutes, lasted eighty minutes; from 12 grains, began in forty minutes, lasted one hundred and eighty-five minutes; from 20 grains, began in fifteen minutes; from 20 grains, began iu forty minutes)

Walked out; whilst doing so, sudden transient sounding in right ear, like the tone of a bell in E (eighteenth day)

Roaring in the ears,3-7.

Roaring in the ears and head,515-53.

Roaring in the ears, so that the patient was almost completely deaf,-7.

Roaring in the ears, with transient deafness

Constant roaring in the ears

Constant roaring in the ears, for several years

Great roaring in the ears (after forty-five minutes)

Nose p. 222

Objective. Twitching of the nose, in the afternoon (thirtyfirst day)

Previous to retiring, feeling a draft on the bare feet, sneezing; again, morning, while dressing, discharged old and new mucus from nose (seventh day)

On coming into the room from out of doors, sneezing, in the afternoon (twenty-fourth day)

After going out to the yard, in slippers, and returning to the warm room, sneezing. (Sneezing has occurred a number of times during the proving; which, although not very common, seemed trivial, and thence is not noted. But the most common provocation is getting the feet cold; last night, from resting the back against the cool Avail ), (twenty-ninth day )

Sitting in shirt-sleeves, sneezing, in the evening (twenty-third day)

Sitting in shirt-sleeves (room not cold), sneezing ; had the same at 2 p.m., standing in a cool, shady alley ; afterwards, blew out a little inspissated mucus, from right side, along with some which was transparent and fresh (twenty-first day)

After repeated titillation in upper right nasal passage, sneezing, followed by snuffling and slight flow of water, in the afternoon (fifteenth day)

Whilst out at practice, had sneezing (twenty-ninth day)

Whilst waiting on doorstep, sneezing, at noon (twentieth day)

Whilst walking out of doors, sneezing (twenty-third day)

Moisture in nose, especially right side, in excess, in the evening (eighth day)

Slight fluent coryza through the day, right side (ninth day)

Riding in wind, then in a greenhouse, nose stopped slightly (ninth day)

Subjective. Sensation of coryza in the nose, with sneezing (after quarter of an hour)

Sensation of coryza in the nose, sneezing (third day)

(Head held obliquely down in writing); neuralgic sensation at end of left nasal bone; feels like that sometimes caused by spectacles, evening (twenty-sixth day)

After supper, going from one room to another, tingling in left side of nose; sneezing, and flow from the right side (fifteenth day)

While sitting, tingling within both sides anterior part of nose, slight, in the evening (fifteenth day)

Face p. 223

Objective. Expression sickly during the whole proving

Expression sickly and hollow-eyed (twentieth day)

Slight puffiness of the face

The face becomes swelled aud bloated to an extent rendering the person unrecognizable

Suddenly seized with oedema of the face and limbs, accompanied by an unusual erythematous rash. Greatly disfigured, aud arms felt ready to burst

* Face pale,19; (after forty-five minutes)

* Face pale and suffering (twentieth day)

Paleness of the face (thirteenth day)

Paleness of the face continued a long time after the proving

The paleness of the face lasted several weeks after the proving

Paleness- of the face, with excessive thirst and nausea (twelfth day)

Great paleness of the face (tenth day)

Earthy color of the face

Earthy color of the face (towel 1th clay)

Dark redness efface

Subjective. Face and hands feel dry and heated, whilst writing, at 1.30 a.m. (twenty-sixth day)

Late, evening, in cold air, recurrence of left-sided facial pains (forty-fourth day)

Cheek. Slight twitching in the left zygomatic muscles (twenty-sixth day)

Cool air blowing on right side of face, felt rheumatic (or neuralgic) dull pain in zygoma, malar and nasal bones, extending to side of head, with slight tingling in nose, as before sneezing, in the afternoon (fifteenth day)

* Aching about left malar bone in the evening (twenty-fifth day)

* While writing, sudden ache above left zygoma (whilst inclining head to that side), also at temporal ridge (after twenty-five minutes, fourth day)

Riding in street-car, with head inclined, reading, pains varying from left supra-zygomatic region, to ear, throat, and upper molars, sharp, but slight, relieved by holding head up, in the evening (ninth day)

Dull twinge above root of right zygoma, in the afternoon (twenty-third day)

Lips. Mouth very pale

Great paleness of the mouth (fifth day)

Lips and fingers livid (after eight hours)

Lips and extremities livid and cool

Jaws. Cracking in the joints of the jaw every time the mouth is opened (eighteenth and subsequent days)

The cracking at the maxillary joint continues very marked (twenty-sixth day)

Continuous pain in left lower jaw, like pressure of a dull knife-blade, downward and forward, from first molar, in the afternoon (twentieth day),49.-

Recurrence of dull cutting in left lower jaw, in the night (twenty-first day)

Cutting, sharp, left lower jaw, from amalgam-filled molar, downward and forward (twenty-ninth day)

Sharp neuralgic twinge (sitting), down right ramus of lower jaw, in the morning (twenty-third day)

Neuralgic twinges in left lower jaw from molars; less, in upper jaw and ear, in the afternoon (twenty-fifth day)

The neuralgia of left lower jaw is quite persistent; room cool (warmth relieves all the pains of a neuralgic sort), (twenty-fifth day)

Mouth p. 224

Teeth. Tartar on teeth much increased (twenty-fourth day)

Thick accumulation of soft tartar on anterior upper teeth ; feels rough, disagreeable to upper lip ; removal with thumb-nail left gums feeling sore to touch of lip, in the evening (sixteenth day)

Find my teeth clenched, unawares, after midnight (twenty-fourth day)

Teeth feel rough, in the morning (twenty-third day)

Returning home in steamcars, from left molars (filled with amalgam) to both upper and lower maxillary bones, had somewhat persistent neuralgic pains (twenty-second day)

A sudden ache in upper left molars, containing amalgam filling; transient, like neuralgia. Soon after felt in both upper and lower (central) molars, in the afternoon (fourth day)

Pains affecting the left upper and lower jaws, near amalgam-filled molars, between these, and constituting a hard toothache ; worse when cold air strikes the face; better by applying a warm hand (thirty-eighth day)

Sticking in anterior teeth, especially left side, in the afternoon (fifteenth day)

Sticking in left upper second and third molars, in the evening (eighteenth day)

Neuralgic twinge from last left upper molars to zygoma, in the afternoon (nineteenth day)

Renewed sensitiveness of right lower bicuspid (I often have this also after a glass of ale), in the afternoon (fifteenth day)

Defective tooth in the right lower jaw (bicuspid), somewhat sensitive, or rather its socket; subject to it in other, i. e., cold damp weather; weather to-day mild and pleasant (fifteenth day)

The secretion about the upper molars seems to putresce and irritate (fortieth day)

The teeth-sockets are sore; gum inflamed (thirty-ninth day)

Totif/ite. Twitching of middle of right lingualis muscle, in the afternoon (twenty-fourth day)

- Twitching of terminus of left lingualis muscle while writing, in the afternoon (fifteenth day)

Tongue flabby and slightly whitish, in the morning (twenty-third day)

White tongue

Tongue white in the centre, pale on the margins

Tongue coated with white mucus (eighth day)

The whole tongue, even to the tip, was covered with a thick yellowish white fur (twenty-first day)

Tongue pale, covered with a thick tenacious mucus (after eight hours)

Tongue covered with thick yellow fur, which cannot be scraped off, lasting four days

Tongue covered with thick yellow fur, except the tip, which is red (twenty-sixth day)

Tongue coated yellow (twentieth day)

Tongue coated with slimy yellowish froth (fifth day)

Yellow coat at the root of the tongue (eighteenth day)

Yellow coating at the root of the tongue (second morning)

Tongue dry, coated yellow

Saliva. Greatly increased secretion of saliva, which in some cases lasted several days

Sitting, moderately free flow of saliva noticed (fourteenth day)

Mouth full of mucus, with great hunger, compelling him to eat (twenty-fifth night)

Dryness of the mouth,1; (first day)

Dryness of mouth and fauces (14 to 16 grs. daily)

Taste. . Rose with bad taste and breath (twenty-third day)

Mouth tastes as if its secretions were unhealthy, all day, and previous days (twentyfourth day)

Taste of abnormal secretion, when the tongue is not moved, dissipated on moving it ; hence the flavor is not describable (has frequently recurred), in the evening (twenty-fifth day)

I observed carefully the abnormal taste, and found that it had a slightly acrid quality (twentysixth day)

Increasing stale and disagreeable flavor of mouth, as has been pretty constantly the case for a week or more past; odor somewhat affected likewise, in the evening (eighteenth day)

Pasty taste (twentieth day

Taste pasty and flat (twenty-first day)

Flat and bad taste (twenty-seventh day)

Very bitter taste, with a very clean tongue (twelve to twenty-four hours)

After breakfast, say at 10 a.m., while writing, slight brassy taste, transient (second day)

Since supper, I taste it now and then, and when sitting doubled up, eructations, and a sense of fulness and uneasiness in stomach (twenty-first day)

At 10.45 p.m. took five broken granules, i. e., grs. ijss., pulse being moderate ; caused and left a good deal of bitter taste in back of mouth (nineteenth day)

Bread tastes bitter (thirty-first day)

Speech. Speech difficult

* My articulation seems somewhat impaired, as I have a number of times had to repeat my words to make myself understood (forty-second day)

Disturbance of the organ of speech, occasionally entire loss of speech, for a longer or shorter period

Throat p. 225

Objective. Tough mucus in the throat

Collection of much tough mucus in the throat, waking him from sleep, and obliging him to cough it up (fourteenth night)

Subjective, Pain in the throat, reaching a very great height, gradually diminishing through the day, and disappearing in the evening (twenty-first day)

Pain in the throat, at the place where the irritation to cough had been earlier in the proving, so that swallowing was difficult (twenty-sixth day)

Pain in the throat, with roughness of the voice, lasting through the night (seventeenth day)

Throat feels a little full ; clogging of upper pharynx by mucus ; slowly detached by repeated swallowing, in the afternoon (fifteenth day)

Constant scraping in throat, with irritation to cough, and slimy expectoration difficult to loosen, in afternoon (seventeenth day)

The cough began to loosen to-day, without relief of the scraping in throat, which causes the cough (twentieth day)

Irritation to cough in throat, without special pain, and without increased secretion of mucus (second day)

Tickling in the throat and larynx

JJvilla. Itching of right side of velum palate, in the afternoon (twenty-fourth day)

Pharynx (did CEsoj/Jt((f/as. Catarrhal clogging of upper pharynx, in the morning (twenty-sixth day)

Catarrhal secretion descended the pharynx in considerable amount; again some hawked up the windpipe; and all afternoon there remained a tenacious coating of the same on the back of the palate, causing efforts to swallow7 it (twenty-fourth day)

Phlegm from upper pharynx came down, also swallowed, in afternoon (twelfth day)

At 10.30 a.m. took two granules (gr. j); for some time felt as if they had lodged half way down (seventeenth day)

Before supper (after a powder), recurrence of sensation of something lodged (twenty-sixth day)

Stomach p. 225

Appetite. Appetite good, in the evening very great (fifth day)

Appetite and thirst increased (ninth day)

Great desire for food and drinks continued many days

Hunger at 9 a.m., after eating considerable bread and butter, the hunger was greater than before (eighth day)

Hunger after supper, then nausea (fourteenth day)

Hunger, with eructations, at 2 p.m. (twenty-fifth day)

Ravenous hunger, at night (once)

Ravenous hunger after a hearty meal, becoming a qualmishness and nausea when continuing a long time (fourteenth day)

Hungry this afternoon (fourteenth day)

2 p.m., hungry and drowsy whilst riding in street-car (fifteenth day)

Diminished appetite

Appetite much diminished

Loss of appetite (twenty-seventh day),6; (thirteenth day)

Anorexia

Aversion to food

OChivst. Thirst (seventh day),0; (twenty -seventh day),6; (first day)

Thirst was especially great in the morning, although he had drunk two pitchers of water before 9.30 a.m., during which time he had passed no urine (twenty-sixth day)

Thirsty in the evening (sixteenth day)

Thirst, with unusual appetite and sensation of fasting

Thirst, eructations, and nausea, with great appetite (eighteenth day)

Considerable thirst in the afternoon (sixth day)

Much thirst in the afternoon (twenty-sixth day)

Thirst great

Very marked thirst (twentieth day)

Thirst, with increased appetite was very marked to-day, continued especially through the night, on which account the prover was obliged to rise several times to drink (eleventh day)

Constant thirst during the day, which frequently compels him to drink water (first day)

Constant thirst, with decided distension of the abdomen (fourteenth day)

Eructation and Hiccough/h. Eructations (after half an hour)

Eructations tasting of breakfast (twelfth day)

On retiring to bed, in crouching attitude, eructations tasting of the supper, with flatus and yawning, at 1.30 a.m. (eleventh day)

Eructation tasting of tea taken at supper (twelfth day)

Eructation, like a light hiccough, on starting to go out of the room, with stitch in right lumbar region, at 1 a.m. (twenty-fourth day)

While sitting, eructation of half-digested matters quite frequently, causes me to loosen my clothing; slight pyrosis, 1 a.m. (twenty-second day)

Eructations while sitting, tasting of supper, at midnight (twenty-fourth day)

Eructations and heartburn (eighth and ninth days)

Slight eructation, empty (soon), (fifteenth day)

Repeated slight eructations, tasting of supper mainly; then rising of ingesta whilst sitting bent, in the evening (nineteenth day)

Frequent eructations

Bitter eructations, lasting three hours

Hiccough and retching

Heartburn. Heartburn

Ate a piece of dry bread ; just after, standing bent over my table, heartburn, at midnight (twenty-sixth day)

Pyrosis in the evening (thirtieth day)

Nfinsca and Vomiting. Nausea,5; (thirteenth day),8 19 20.

Nausea, continuing the whole day (soon)

Nausea, with frequent eructations (fifth day)

Nausea and eructations, sometimes empty and sometimes bitter, without being followed by vomiting

Nausea and vomiting (thirty-first day)

Nausea and vomiting during a meal

Nausea, weakness, and shivering (eighteenth day)

Slight nausea, relieved by eructation, in the early morning (twenty-sixth day)

A little nausea sometimes

Sudden nausea, obliging her to go to bed (thirty-first day after 20 grains)

Walking after eating, threatening of nausea, better by loosing waistbands (twentyninth day)

Inclination to vomit

Inclination to vomit, without being followed by vomiting

Vomiting on two occasions (evening after taking)

Frequent vomiting of an insipid taste, in the afternoon

Stomach. Two apples eaten caused indigestion, late at night (twenty-ninth day )

Feeling of hollowness of stomach and desire for sugar (often taken for a like symptom at night, with effect, after early supper ; but this time only a little over three hours from a late supper); sugar relieved in the night (eleventh day)

Intensely acid stomach for four days, with distress in epigastrium

Sensation of warmth in the stomach

Slight warmth in the region of the stomach and duodenum, followed by copious eructations

Intense sensation of heat in the stomach, starting from the cardiac orifice, and extending to the abdomen, sometimes up to the chest

After eating ice creamit seemed to cause a continuing coldness in stomach and slight uneasiness, less when clothes were loosened ; later eructation, tasting of ice cream, in the evening (fifteenth day)

Pain in the stomach (after one hour)

Cardialgia,19 20 26.

Fulness in the stomach (seventh day i

Sense of fulness in the epigastrium after half an hour

Full feeling in stomach, in the afternoon (twentieth day)

A feeling as if the stomach were too full, and something had failed to go down, and lodged in the chest ; better by eructation, but fulness still felt (twenty-fourth day)

The head symptoms merged whilst walking out into a goneness and empty feeling in the stomach, with drowsiness; better by drinking cold water, also eating a bun; the shattered feeling subsiding more slowly (twenty-third day)

Sensation of constriction of the stomach, with swelling of the abdomen

10.30 p.m., having not yet supped, felt whilst going upstairs a sudden gnawing in stomach, then crampy gastralgia, quite severe, better by standing up straight; then the final, repeated shuddering of the head before mentioned, and eructations, which conclude the pain (twentyfifth day)

Pressure in the stomach

* After eating, pressure in the stomach, followed by cutting in the upper and middle abdominal region (fifth day)

* Even the slightest food causes pressure in the stomach and a return of the usual symptoms*.-

Sitting down, oppression of stomach ; had to loosen my waistbands ; better thereby, but only relieved by repeated eructations, in the evening (twenty-eighth day)

Near morning, awoke, with painful oppression at epigastrium ; turned over in bed and fell asleep again (third day)

Oppressive sensation in the epigastric region and in the hypochondrium, especially in the left side, with occasional passage of very offensive flatus twenty-second day)

Fasting; visiting a patient, sitting on a low chair, preparing medicine on my knee, sudden oppressive sensation in stomach, with salivation, and tension in the salivary (parotid) glands ; better after leaving the house, but previously constant flow and swallowing. (I have occasionally had the like, with shuddering of the head at the end of the spell added to the above, in the evening), (tenth day)

Sudden cutting and twisting in the epigastric and umbilical regions, transversely across the abdomen (eighteenth day)

Twitching sensation in the stomach and oesophagus

Trembling in the stomach

Abdomen p. 227

Hypochondria. *Pain in the region of the liver, shortly before going to bed

* Dull painful sensation in the region of the spleen, disappearing on pressure; this frequently reappeared during the succeeding days (second day)

Pressure in the region of the liver, lasting a quarter of an hour, disappearing on pressure of the hand, in the morning (sixth day)

Pressive pain in the region of the spleen (thirteenth day)

Stitch moving at a slow rate forward, from region of gallbladder to right rectus muscle (forty-first day)

* Stitches in the left side, below the short ribs (fourteenth day)

Subcutaneous cutting stitch in left hypochondrium, in the afternoon (fifteenth day)

A sensation of suppuration in the region of the liver, disappeared with the pain in the right side of the chest (thirty-second day)

Umbilical. While sitting in a room, colicky pain to the left of and above umbilicus ; propagated to sigmoid flexure and rectum, immediately (not severe), in the afternoon (tenth day)

A rasping pain in the abdomen, from the umbilicus up to the chest, with dragging downwards towards the genitals (thirtyseventh day) ; this violent griping and rasping, with dragging towards the genitals, lasted two days, when at last traces of menstruation appeared in the night of the forty-first day, when it reached its height, and was quite copious ; on the forty-third day the whole evolution was completed ; after this the girl continued to menstruate regularly but scantily

General Abdomen. Abdomen distended (tenth day)

Abdomen distended, with passage of much flatus, upwards and downwards (thirty-first day)

Distended abdomen,3 ; (seventh day)

Greatly distended abdomen, in the afternoon/.

Much distension of the abdomen, followed by diarrhoea (twentieth day)

Great distension of the abdomen, without passage of flatus

Commotion in the abdomen, which is sensitive to pressure, with passage of much flatus (fourteenth day)

Commotion in the abdomen, as if diarrhoea would follow ; followed by passage of flatus only (thirteenth day)

Commotion in the abdomen, as from diarrhoea, with passage of much flatus

Commotion in the abdomen, with passage of much flatus, followed by soft stool (had been constipated the previous day)

Commotion in the bowels began soon after rising in the morning, as if diarrhoea would follow ; stool, however, was normal (eighteenth day)

Some commotion in left colon, including the left lumbar region, in the evening (twelfth day)

Rumbling in the abdomen,1 15:i0.

Grumbling in small bowels (within boundaries of colon), (twenty-ninth day)

Sitting, after motion, colicky grumbling in left colon, at noon (fourteenth day)

Some flatulence (second day)

Passage of flatus (after two or three hours)

Passage of flatus by the mouth and anus

Passage of much offensive flatus (tenth day)

Profuse passage of flatus (fifth day)

Copious passage of flatus, upward and downward

Emission of non-fetid flatus ; subsequently some fetid wind, in the evening (sixteenth day)

Whilst moving about, another emission of still more fetid flatus, after midnight (seventeenth day)

Sonorous evacuation of decidedly fetid flatus, after urinating (twelfth day)

When leaning back in chair, flatus goes down into rectum with a shock, then presses on anus ; escapes, with subsequent similar movements in left colon, and twinges of colic, coming and going; flatus not notably fetid; colic better by passing wind (twelfth day)

On rising, breaking wind ; after it, irritable around anus, with slight indication of protrusion (twenty-fifth day)

The pain in the upper abdomen aggravated by pressure of the hand, returns and continues some days; it began in the epigastric region, and extended towards the umbilicus (ten and eleven days, etc.)

An unpleasant sensation in the upper abdomen, which increased to a tension and distension of the abdomen towards evening, with dull pain on pressure, and some oppression of the chest, after 2 p.m.,5.

Pinching in transverse and left colon, whilst going about house, continuing whilst in street-car, in the afternoon (thirteenth day)

While standing, notable cramp in left colic region, causing me to give down somewhat, in the morning (seventeenth day)

Dull crampy pain at left border of left upper rectus abdominis, whilst going about, recurring more sharply when sitting, at 1 a.m. (twenty -second day)

Crampy ache in left border of upper left rectus abdominis, in the evening (twenty-fifth day)

Cutting in the upper abdomen

Tearing pain in the abdomen (after two hours)

Colic, transverse and left colon (twentysecond day)

Colic and diarrhoea

Colic, immediately after rising, followed by stool, at first mushy, like diarrhoea, with cadaverous odor, with gradual relief of the colic (twenty-third day)

Colic in transverse and left colon to rectum, afternoon (twenty-seventh day)

Colic in transverse colon persists while sitting (twelfth day)

Colic aggravated on standing up suddenly; then emission of fetid flatus; some amelioration, not complete relief, at noon (fourteenth day)

The colic, with cutting pains in the upper abdomen, continues for several days, aggravated by pressure with the hand (fifth day)

Some colic during the day (first day)

Sudden colic, with passage of much flatus, at 2 p.m. (twentieth day)

Sitting, inclining to left side, slight, left-sided colic, in the evening (sixteenth day)

Walking about, colic in transverse and sigmoid colon, quite sharp ; relieved by emissions of flatus, evening (twenty-sixth day)

Violent colic, lasting the whole day, with distension of the abdomen (thirteenth day)

Writing, colicky feeling in right superior angle of the colon, evening (twenty-seventh day)

Colicky pain in transverse colon, slight, going to rectum as if for stool, in the afternoon (twelfth day)

Colicky sticking in transverse colon, in the evening (eighteenth day)

Irritation of the intestinal canal from the arrest of the ordinary movements by the action of the quinia

Hypogastrium and Iliac Hegiotl. Painful sensation in the lower abdomen, like a dragging towards the genitals (first day)

Wandering pains and cutting in the ileum, followed by diarrhoea (twenty-second to twenty-fifth day)

Little cutting stitch, outer left groin ; subcutaneous, whilst sitting, in the afternoon (fifteenth day)

Rectum and Anus p. 229

Hectum. Stool, with usual protrusion (nineteenth day)

Stool at 10 a.m., with protrusion, rectal activity deficient (twenty-third day)

After stool, mucous protrusion, requiring the usual means of correction, in the morning (twenty-sixth day)

After stool, with protrusion ; sitting, felt the mucous fold spontaneously retracted, and on touching the anus, afterwards found very little of it. This is very notable (twenty-first day)

Slight tenesmus

Commotion in rectum, pressure of flatus, in the evening (eighteenth day)

Pressure of flatus, and commotion in rectum, sitting, in the evening (eighteenth day)

Itching in the rectum

Anus. Increased hemorrhoidal trouble

Discharge of bright blood from the anus, without previous pain in the back

After breakfast, stool soft, but impeded by painful contraction of inner sphincter, which feels like a firm rim ; comparable with rigid os. (This is a marked and repeated symptom, which I do not remember to have had before this proving.) Protrusions, requiring to be reduced (twenty-seventh day)

Twice, when standing, sudden crampy or cutting stitch at inner sphincter ani (forty-fourth day)

Whilst walking, in the evening, sticking to right of anus, like a straw; itchy and irritable ; at the same spot, afterwards (twenty-third day)

After stool, considerable soreness in front of anus ; better by oiling, and sitting quietly with a bunch of clothing under perineum, on a cushion, in the forenoon (old symptom), (twenty-fourth day)

Sticking in left side of inner sphincter ani, afternoon (twenty-sixth day)

Urging. Urging to stool, without subsequent evacuation (fourteenth day)

Urging to stool, without subsequent stool, in the forenoon (fifth day)

Urging to stool, in the evening, with passage of very difficult small soft stool (fourteenth day)

Urging to stool, with slight griping in the abdomen, followed by a natural stool at 2 p.m. (fifteenth day)

Stool Diarrhcea. Diarrhoea (eighteenth day)

Diarrhoea, with violent colic-like pains across the abdomen (thirty-first day)

Diarrhoealike stool, with drawing and cutting in the intestines, at 6.45 a.m. (twentyfourth day)

Stool at first mushy, then like diarrhoea, preceded by excessively offensive flatus, at 9 a.m. (twentieth day)

Some thin stools

Repeated stools, thinner and lighter color than usual

Four stools, first normal, the others liquid (first day)

Stool (after exertion of the body) postponed by circumstances ; soft, except the very first ; came away suddenly, partially arrested by a cramplike contraction of the sphincter, concluding as this gradually subsided ; followed by painless prolapse of mucous membrane, etc., like piles, on right side (same as for some time past, but more pronounced), requiring replacement, and sitting on it to retain, for awhile (eighth day)

After breakfast, good stool, yellow, soft, with yellow-tinted clear mucus ; protrusion of right rectal fold considerable, requiring reduction with sweet oil, followed by pressure of cushion, to retain it (fourteenth day)

Stool at first solid, then liquid, at 11 a.m. (twenty-seventh day)

Stool, with yellow mucus, after breakfast (forty-second day)

Constipation. Stool hard, crumbly (second day)

Stool harder than usual

Stool very hard (sixth day)

Stool at first hard, afterwards thin (fifteenth day)

Postponing stool, it proved scanty, with the habitual protrusion (fifteenth day)

Stool with exertion and pain to-day (eleventh day)

Stool difficult, faeces of ordinary consistence

Stool not very hard, but difficult to pass, always with the peculiar sensation extending from the right hand to the shoulder, as before noticed

Defecation this morning, a little sluggish, and rather incomplete in amount (twelfth day)

Defecation attempted at a later hour than usual is very incomplete and difficult; the peristaltic action deficient, and the sphincter contraction too great (usual in like circumstances), (seventh day)

After breakfast, imperfect defecation; painful spasmodic resistance of the inner sphincter ; afterwards marked protrusion, with difficulty of manual reduction, and irritability; better by applying cold water, then oil, and sitting on cushion as before. Stool contained some yellow mucus (twenty-fifth day)

Constipation

Constipation, for one day

Obstinate costiveness (14 to 16 grains daily)

No stool, with distension of the abdomen (fourth day)

Urinary Organs p. 230

Bladder. Catarrhal inflammation of the urinary bladder

Urethra. Constrictive biting pain in the orifice of the urethra after urinating, at 9 p.m. (seventeenth day)

When going about the room, desire to urinate, with colic in transverse colon ; urination normal, in the afternoon (fourteenth day)

As in several other instances, had to rise early in the morning to urinate (at ordinary times more during the night), (twenty-fourth-day )

Urging to urinate, with passage of 16^ ounces of watery, straw-colored urine, which does not redden litmus-paper (after one hour and a quarter)

Micturition. Urine increased to double the usual amount, although he did not eat (twenty-sixth day)

Urine copious, high-colored, turbid (second day)

Urine scanty and turbid

Secretion of urine increased ; urine deposited a large quantity of orange-colored crystals, shown under the microscope to be right-angled prisms, with rhomboidal fragments,7.-

|_540.] Increased secretion of cloudy urine for several days

Increased secretion of urine, preceded by distension of the upper and lower abdomen, and oppressed respiration

Passage of much urine, with much thirst and drinking, without deposit of crystals (fourth day)

14 and 8^ ounces of urine passed at 5 and 10 a.m. respectively; it was of a strong urinous odor, and turbid ; 63^ ounces was the aggregate amount of seven passages (second day))5

25 ounces of urine m four passages, and containing many crystals (tenth day)

29^- ounces of urine in four passages, depositing If grains of crystals (ninth day)

46? ounces of urine in six passages (fourteenth day)

50i ounces of urine in four passages, high-colored, and very acid, without sediment (fifteenth day I

- Urine, 51 ounces in five passages, depositing a loose, yellowish sediment, and a large number of orange-colored crystals,5. f

60^ ounces of urine in seven passages, pale yellow ; the sediment was small, like brown granules, and seemed to be conglomerated crystals, but much smaller than on the previous day, and did not show the concentric layers (sixteenth day)

6H ounces of urine in seven passages, high-colored, with a deposit of yellowish-red crystals (twentieth day)

66 ounces of urine in eight passages; a crystallized deposit the next morning like a conglomerate of candied sugar, in which regular forms could not be distinguished, consisting of urate and purpurate of ammonia, with phosphates (seventeenth day i

701 ounces was the aggregate amount of seven passages of urine (first day)

Urine, 99i ounces in eight passages (thirteenth day)

Flow of urinary residue after replacement of clothing after urinating, occurred once (thirty-ninth day).49.

Urine. Urine, clear, pale, increased in quantity, even if nothing had been drunk

Urine high-colored, 40^ ounces in five passages (eighth day)

Urine high-colored, having a strong urinous odor and acid reaction, 80| ounces in nine passages (seventh day)

Urine high-colored ; on cooling it deposited a thin, powdery, yellowish-white sediment (third day)

Decided dark color to urine after thirty-five minutes, becoming darker, and even a dark orange color, with decided sediment after four hours ; tests demonstrated Chinin in the urine

Urine very frothy

Urine turbid (second day)

Decided turbidity of urine after fifteen minutes; a thick, chocolate-colored sediment, with great turbidity (Chinin found in urine)

Hemorrhage of the urinary passages (on one occasion profuse), (in a boy and a girl whenever the drug was administered)

Urine as clear as water, containing, the next morning after the chill, a number of clear transparent crystals, shown under the microscope to be four-sided prisms, with four-sided pointed ends (about one- fourth of a grain of these crystals in 10 ounces of urine); the crystals were enveloped by tough mucus, as with a spider's web (fifth day),5.|

Formation of crystals in the urine (character not mentioned)

Urine deposited crystals of prisms of three-sided pointed pyramids (fourteenth day)

Urine deposited crystals as before (twenty-third night)

Deposit of crystals in the urine continued daily

Urine deposits a red sediment (fourth, fifth, sixth, and succeeding days)

Urine deposited a rose-red sediment, which under the glass showed rhomboidal flat crystals, with here and there double pyramids,6.§

Brickdust sediment in the urine

Urine deposited a thick brickdust sediment

A brickdust sediment in the urine of the previous day, consisting of adhering brown grains of the size of poppyseeds, having the external appearance of gravel ; they were round, oval, and kidney-shaped ; one of the larger showed under the glass several concentric layers of a bright color; under a magnifying power of three hundred they seemed of the size of a bramble (Rufus calsius) berry, and the surface had the appearance of a collection of beautiful crystals (fifteenth day),5.f

* From the nineteenth to twenty-third day, the urine deposited a strain-yellow, granular sediment, mingled with transparent, glittering, perfectly colorless crystals

Urine deposits a yellowish-white sediment, adhering to the vessel and of a strong odor (fourth day)

On the vessel is a light-colored, mealy deposit, containing two grains of glittering crystals, showing facets on all sides, consisting of urate of ammonia, phosphates, and sulphate of chinin (seventeenth day)

The solids in general, and the urea, I found not materially affected under the influence of quina, but the phosphoric acid appeared to be augmented

In the first experiment I took 20 grains of disulphate of quina in the course of the day, and during the next fortyeight hours the excretion of uric acid amounted in all to 0.542 grammes, less than half my normal quantity

The quantity of uric acid excreted during forty-eight hours, after 15 grains of quina had been taken, was equal to 0.790; on the third day, after quina had been taken, I excreted again about my normal average, namely, 0.621 grammes ; and on the two following days 0.543 and 0.656 grammes respectively. I now took quina for a third time, and the quantity of uric acid again fell to 0.438 grammes on the first, and to 0.192 grammes on the second day,36. . . .

Dr. S. excreted during the two days previously to his taking quina 0.544 and 0.543 grammes of uric acid. On the third day he took 20 grains of disulphate of quina, in two 10-grain doses, and on that day he excreted 0.376 grammes of uric acid. The next morning he again took 5 grains of quina, and the quantity of uric acid subsequently fell to 0.317 grammes. During the three following days he excreted 0.483, 0.460, and 0.654 grammes respectively

Dr. M. excreted, during four days prior to his taking quina, 0.662, 0.774, 0.585, and again 0.585 grammes of uric acid. Then he took 10 grains of quina, and on that day excreted 0.358, and on the next 0.387 grammes of uric acid. On the third day after he had taken quina the uric acid rose again to 0.670 grammes, and remained there stationary, amounting to 0.671 and 0.668 grammes on the two following days

After taking 6 grammes of Chinin., over 4 grammes were found in the urine within forty-eight hours. (Binz.)

Sexual Organs p. 232

Male. Decided depression of the sexual sphere during the proving

Disappearance of the sexual function through the proving

Sexual function completely lost during the proving

Relaxation and aching of right testis, in the evening (thirtieth day)

Slight aching in right spermatic cord, with relaxed scrotum (this side has usually tenderness of the globus major), in the afternoon (twenty-fifth day)

Have had, since taking Chininum sulph., several times renewal of an old symptom, i. e., relaxed spermatic cord, right side, with dragging aching, requiring support; to-day (after sitting with some compression of it by the pants, and with suppressed sexual feeling), 10.30 A.M., aching constriction, worse when taking certain positions; better by the little jar of going down stairs; extends to epididymis, but worse at external inguinal ring; better by careful friction ; testes full and firm (seventh day)

An emission during the night, without waking (seventh day)

Normal seminal discharge, without sensation, in the morning (twenty-fifth day)

Female. The leucorrhoea reappeared after 2 grains ;f on the first day it was mixed with blood ; examination showed heat and turgescence of the inner labia (fifth and sixth days)

Uterine epistaxis, coming on generally a few hours after the first dose, and lasting continuously, though moderately, for about sixteen hours (1 gramme daily)

Moderate uterine epistaxis, lasting two days (8 decigramme daily for two days)

After the last dose, menstruation reappeared in a moderate degree, and afterwards returned regularly at the usual time

Respiratory Organs p. 233

Larynx, Trachea, and Bronchi. A contractive feeling, hardly a pain, in a weak spot the left side of hyolaryngeal space, in the early morning (twenty-sixth day)

On rising this morning, scraping soreness of larynx and trachea when swallowing, with raising and coughing of considerable mucus, accumulated during the night, relieving the laryngeal scraping by degrees, but causing rawness in bronchus and lung of left side; later in the day, the cough affected rather the fauces, with rending sensation (eleventh day)

Tickling in larynx, cough, and raising of mucus (as usual), in the evening (twenty-fifth day)

Decided laryngeal tickling, after midnight (seventeenth day)

Considerable tickling at bifurcation of trachea (behind upper end of sternum), cough, and raising and swallowing of phlegm, in the evening (nineteenth day)

Tickling in left bronchus and trachea (site of my usual irritation); cough scarcely detaches anything, but is painful to the palate and fauces; phlegm seems as usual to come from the lower lobe, in front of the heart, detached and swallowed after awhile, in morning (twelfth day)

Voice. Hoarseness at 4 p.m., with a deep tone to the voice (twentieth day)

The daily hoarseness reappeared about 4 p.m., and reached such a degree that the voice was like a bass voice, and the throat seemed constricted (twenty-fourth and subsequent days)

The attack of hoarseness, without anginose symptoms, recurred every afternoon for a long time

All day, rough hoarse tone of voice, diminishing with the expectoration ; this always swallowed (eleventh day)

Voice lost (after eight hours)

Cough and Expectoration. The cough became worse towards morning, and was accompanied by the previous anginose condition (twenty-seventh night)

While dressing, cough, with stitch in upper left lung (?), and simultaneous slight rheumatic pain in left trapezius, near posterior edge of scapula, in the evening (ninth day)

Sitting in street-car, cough, with cramp to left and above umbilicus; standing in street (wearing no overcoat, being averse to it), coughing, with crampy lumbago, left side, better by external support and adjusting position (cough aggravated when without overcoat to-day in open air, constantly, also after every powder), (after one hour and a half, tenth day)

Cough and tickling in windpipe at 12.30 a.m., less at 1 A.M. (eleventh day)

Frequent cough towards morning; the cough is caused by a small painful spot in throat (seventeenth night)

Loose cough (twentieth day)

Cough continued during the whole of six days, loose, but very severe, and whilst yesterday the mucus seemed to come from the throat, to-day it seemed as though he was obliged to cough deeply in order to raise the mucus from the lowest portion of the bronchi; expectoration was of a gelatinous nature (twenty-third day)

Cough and raising of phlegm, in the forenoon (twenty-eighth day)

Cough, raising and swallowing mucus, after midnight (seventeenth day)

Standing in open air, cough, with raising, and threatened irritability in left bronchi, in the evening (twenty-fifth day)

Cough, which must be continued until expectoration is raised from very low down (twenty-fourth day)

Frequent cough and need to raise in the night, so that he was obliged to sit up in bed to get his breath (twenty-sixth and other nights)

Frequent cough, with raising of mucus; once this struck the roof of my mouth (several times, also before in the morning), (twenty-fourth day)

Short cough, with expectoration, swallowed, in the afternoon (fourteenth day

Walking in the open air, noticed that the raising of mucus by cough was renewed, and that I kept my teeth involuntarily pressed together, as has been the case frequently during the proving, but having had the same formerly at times, overlooked it, in the afternoon (fifteenth day)

I noticed this morning that the phlegm came up the right side of the glottis, afterwards, the posterior (twenty-fourth day )

The expectorated mucus, when examined, consisted of a basis of an opaque, white, globose little mass, say one-eighth of an inch in size; another, smaller, as of slower formation, with exfoliated epithelium; these, surrounded by about three times their quantity of fresh transparent secretion, stretching out between the fingers to more than an inch, in the forenoon (twenty-fourth day)

JEtespiratiotl Expired air cool

Breath offensive (after eight hours)

Repeated loud expirations from time to time, like interrupted sighing (thirty-ninth day)

Superficial and irregular respiration

Repeatedly, whilst eating, took a long inspiration wearily, followed by loud sighing, heaving, groaning expiration, in the evening (seventeenth day)

* Respiration increased, 4 (after one hour)

Respiration rose from 18 to 20 (after four hours); was 20 next morning; 24 next evening; 18 third morning (first proving); rose from 18 to 20 (second day), (second proving).52.

Respiration rose from 16 to 20 (after one hour); 20 (after four hours); 20, next morning; 22 (second evening); 18 (third morning)

Respiration increased from 16 to 24 (after four hours); 22 the next morning; 20, next evening; 20, third morning; 16 (normal), third evening

Respiration rose from 22 to 26 (after one hour and fortyfive minutes) ; was 24 (after two hours and forty-five minutes ) ; 24 (next morning), (first proving); respiration 24 before taking; 22 (after one hour); 22 (after four hours) ; 26 (second morning) ; 25 (second evening) ; 20 (third morning), (second proving); respiration 20 before taking; 22 (after one hour); 24 (second morning); 22 (third morning), (third proving)

Respiration slow and easy (after eight hours)

Slow and irregular breathing (68 grains)

Respiration slow, interrupted by sighs

Dyspnoea

Respiration oppressed, as from a pain about the chest (tenth day)

This warm weather, averse to close air in street-cars; it is oppressive (sixteenth day)

In a close steam-car, felt oppressed ; had to open the window (twenty-second day)

Rising suddenly from my seat, on attempting to swallow at the same moment, arrest of breath by a contraction of the throat, in the evening (twenty-eighth day)

Chest p. 234

Haemorrhage from lungs (probably) and eruptions on skin

Chest seemed completely dry; all provocation to cough had disappeared; he could breathe freely from the bottom of the lung; towards evening, however, the cough returned (twenty-seventh day)

Some pain transversely through the chest, as it seemed, in consequence of the racking night-cough (twenty-sixth day)

Pressive pain in the chest, on rising (twenty-first day)

* Oppression of the chest (twentieth day),5; (third day)

Front. Pain in the sternum, almost sticking, especially noticed on deep breathing or a sudden movement (twenty-first day)

In a few minutes a feeling behind mid-sternum (oesophagus?) as if food had failed to go down (first day)

Feeling as if something indigestible had been eaten, behind lower sternum; better, temporarily, from slight eructations, in the evening (nineteenth day)

Slight sensation in breast, left of sternum, as if spasmodic state of oesophagus from indigestion, in the morning (fifteenth day)

Craved and chewed some fresh orange-peel, then ate some white sugar, and drank some cold water after it ; immediately, as repeatedly heretofore has happened, dull but smart pressure in subensiform space, preceded by salivary tension and flow; afterwards, repeated shuddering of the head; no chilliness; this attack differs from others in being more instantaneous; relief after a few minutes by eructations, in the evening- (seventeenth day)

Sides. Pain in the right side of the chest, on rising in the morning, lasting till noon, when it disappeared (thirty-second day)

Pains in the left clavicle (thirtieth day)

In street-car, crampy feeling in right side of chest, four inches outside of and below nipple (twenty-first day)

Crampy feeling at ends of right false ribs, when bending forward to urinate, in the morning (twenty-third day)

Slight crampy feeling at angles of last true ribs, right side, in the afternoon (nineteenth day)

Pressive pain in the left half of the chest, which was very sensitive to deep inspiration, most sensitive when the left arm was thrown forcibly backward; it seemed to extend through the middle of the chest to the back, and was relieved by leaning upon the left forearm, with the body bent forward (position as when writing), at 7 p.m. (seventeenth day i

Sticking in right thorax ;f also round lower angle of right scapula (twenty-ninth day)

Sticking in the right half of the chest, extending up to the shoulder, during the afternoon, impeding respiration; relieved by bending the body forward (tenth day)

Stitches in the left half of the chest (thirteenth day)

Stitches in the left side of the chest, preventing deep breathing, continuing uninterruptedly until the next day, and very gradually disappearing (nineteenth day)

On entering my house, felt decided stitch, slow, moving from edge of liver upward, terminating outside and below the right nipple, in the evening (twenty-fifth day)

Tickling in left chest persistent, in the evening (twelfth day)

Phlegm (of chronic formation) in left chest, working up fast, tickles, with frequent coughing and raising, but swallowing, as usual, what is raised; irritability of left bronchi afterwards, in the evening (eighth day)

Heart and Pulse p. 235

Prweordinm. Extreme precordial anxiety

Slight uneasiness in the praecordia

Considerable uneasiness in the praecordia

Tension in the precordial region, especially on the left side, below the short ribs, becoming so severe that the bands of the clothing must be loosened (thirteenth day)

Pressure in the precordial region, with passage of flatus

Sticking in the region of the apex of the heart, disappearing after a few minutes, (immediately after taking)

Heart's action subjectively perceptible, this whilst sitting partially doubled up, in the forenoon (nineteenth day)

Sitting, heart's action subjectively felt, extending to head ; having just had an incomplete stool, with protrusion of mucous membrane, especially right side, after postponement, in the forenoon (twentieth day)

Heart's Action. Pulsations of heart, conscious, slightly accelerated, in the forenoon (twenty-eighth day)

While at stool, pulsation of the heart increased, after straining, so as to be felt throughout left side of the body (abdomen and chest), in the forenoon (twenty-fourth day)

This evening, at 6 oclock, a nap, with hands joined over top of head ; lying on back. Was awakened at 6.45, the heartbeat with abnormal impulse, felt through much of the chest ; and too frequently, better by lying still awhile, then stirring about moderately (fourteenth day)

At 10 A.m., strong heart-beat, after excitement (third day)

Pulsation of heart felt in left chest after going upstairs, in the afternoon (twenty-fifth day)

Conscious pulsation from heart to left chest, arm, and abdomen (not very rare), in the forenoon (third day)

Palpitation (third day)

Palpitation of the heart

Slight palpitation, in the afternoon (fifteenth day)

Woke on right side; palpitation; relieved by lying in abdominal position (fourth day)

Roused suddenly, "palpitation, had to lie on it with hand supporting heart (twenty-third day)

After breakfast, sitting at stool, elbows on knees, palpitation, felt through chest, down back to sacrum, and through abdomen (twenty-sixth day)

Owing to indignation, in the morning, palpitation of the heart; better by lying on it, alternating with changes of position, stretching, etc. (as usual), (twentieth day)

Woke in the morning, lying on left side, with slight, yet notable palpitation of the heart, ceasing on lying fairly upon it (third day)

Pulse. Pulse rapid, full

Pulse rapid, neither hard nor full

Pulse more rapid, but not fuller than usual

Pulse accelerated by nine beats, small and irritable (after two hours)

Pulse, morning and afternoon 45; towards noon 60 (seventh day)/

Pulse 72, sitting, in the early morning (twenty-sixth day)

Pulse in the morning 65, in the afternoon 66, in the evening 75 (fourteenth day)

Pulse 88, at 8£ p.m. (twenty-second day)

Pulse varied from 75 to 94 (the last one hour after eating), (second day)

Pulse (in temporal artery) beat very strongly under finger, bounding, counted 98 to 100 per minute; no other sign of fever, in the forenoon (nineteenth day)

Pulse 100,27.

Pulse 100, at 3 p.m. (fifth day)

Rise of pulse began in 95 minutes ; greatest frequency reached in 120 minutes (girl), (12 grains)

Rise of pulse began immediately ; greatest frequency in 65 minutes; fell again in 195 minutes (girl), (20 grains)

Rise of pulse began in 15 minutes ; greatest frequency reached in 15 minutes ; fell again in 120 minutes (girl), (10 grains)

Pulse rose from 64 and 68 to 92, in 55 minutes (girl), (8 grains, after thirty-five minutes)

Pulse rose from 72 to 80 (after one hour) ; 80 (after four hours) ; 84 (next morning) ; 88 (next evening) ; 74 (third morning)

Pulse rose from 72 to 84 (after one hour)

Pulse rose from 72 to 86 (after four hours) ; 82 the next morning ; 80 in the evening ; 84 third morning ; 72 normal, in the evening

Pulse 88 before taking ; 90 (after one hour and three-quarters); 90 (after two hours and three-quarters) ; 90 (after four hours) ; 96 (second morning) ; (first proving). (She then took a second dose of 10 grains), 108 (after one hour) ; 106 (after four hours) ; 100 (next morning) ; 88 (next evening), (second proving). Pulse 84, before taking ; 98 (after one hour); 98 (after four hours); 108 (next morning); 100 (next evening); 88 (third morning), (third proving)

Pulse rose from 72 to 78 (after two hours) ; 74 (after four hours), (first proving). Rose from 76 to 100 (after one hour); 92 (after four hours); 84 (second day); 84 (third morning); 72 (third evening), (second proving). Rose from 72 to 86 (after one hour) ; 82 (second hour) ; 84 (second morning) ; 86 (second evening) ; 72 (third morning), (third proving)

Daily Means, calculated from the Detailed Observations.

x, r , -vt u Mean pulse of

Day of observ. Noofobserv. each day% observ.

]STo med., 1 6 70£

5 grains Quinia pr. | hr. till 8 doses, . 2 5 704

5 grains Quinia pr. £ hr. till 8 doses, . 3 8

5 grains Quinia pr. £ hr. till 3 doses, . 4 3 69£

10 grains Quinia pr. £ hr. till 10 doses, . 5 10 69|

20 grains Quinia pr. £ hr. till 10 doses, . 6 10 73|16 Slowness of the pulse

Action on the circulation was constant; it usuallyoccurred half an hour after taking, and proportionate to the size of the dose, producing slowness of the pulse

Pulse regular, slow, scarcely perceptible

Pulse diminished four beats to a minute, within two hours

The pulse fell in a few days to 57, and then to 50 (from daily doses of 8 decigramme)

Pulse on taking the drug, 80 ; after dinner it sank to 64 (whilst it was usually 73 to 75, at that time) ; in the evening, the pulse was normal, 75 (first day)

Pulse, on taking the drug in the morning, 60 ; after an hour, 62 ; taken at various times through the rest of the day 45 (fifth day)

Pulse became small, almost imperceptible, and tell to 40, 45 (from 32 decigramme a day)

Pulse 83, in the morning of the third day before taking half a grain ; one hour after taking, it was 75,5.

Whilst eating in the evening, pulse 76; 72 after writing; full, forcible (seventeenth day)

Pulse diminished in frequency for about 30 minutes ; began to rise in 50 minutes ; greatest frequency in 100 minutes (girl), (20 grains)

For fifty minutes afterwards the pulse fell a little in frequency and gained in strength. The fall was from 108 and 112 to 104 and 96. " After this it beat 120 in the minute, and at the same time lost in strength (boy)

Pulse at 9 a.m. 75, irregular, weak, and small (twentysixthday)

On those two occasions, when the temperature was decidedly depressed, the pulse beat the fastest when the temperature began to fall, and became less frequent again when the depression in the temperature was attained. On every occasion of the increase in the rapidity of the pulse there occurred also a loss of strength. On two occasions, when the pulse was at its quickest, the pulse became for a short time irregular and intermittent. On two other occasions the pulse, at first after the administration of the Quinia beat a little slower, and also grew in strength ; but this temporary loss in frequency and gain in strength, was soon followed by the opposite circumstances (girl)

Pulse full, firm, in the forenoon (twenty-eighth day),49.- Strength of the pulse fell (boy), (two doses in one day)

Pulse regular and very weak, scarcely perceptible (alter eight hours),20. , , „ . .

Neck and Back p. 237

Neck. The neck began to swell, at 4 p.m., so that respiration was impeded thereby and the voice became hoarse (twentysecond day)

Swelling perceptible externally along the right sternocleido-mastoid muscle, which is not painful, even to pressure (twentieth day)7

Pain in the neck, especially on moving it and on swallowing (nineteenth day) 7.

Pains in both sides of the neck, sensitive to pressure, afterwards extending into the larynx, then disappearing towards evening (eighteenth day)

Slight crampy feeling in left sterno-mastoid muscle; then in left levator anguli scapulas (apparently), in the early morning (twenty-sixth day)

On suddenly turning head to right, sprained feeling in upper right sterno-mastoid muscle, lasted a good while, with sticking aching in right ear (this on Sunday afternoon in street-car), (forty-first day)

* Sensitiveness of the last cervical and first dorsal vertebrae to pressure (twentieth day)

Hack. Pains in the back (twentieth day)

Dorsal. Rheumatic feelings in left scapular muscles, upper and inner, after sitting in a draft, in the afternoon (twenty-seventh day)

Rheumatic feelings several times at inner border of left scapula (twenty-second day)

Midnight, writing, rheumatic ache at inner left scapular border ; better when the arm is supported (twenty-second day)

Twinges in lower half of right scapula ; immediately after, in right lower jaw, then in upper, in malar region ; these sensations succeed each other rapidly, some frequently recurring, in the afternoon (twenty-fifth day)

In cool wind, with false position, acromial rheumatism, right side (twenty-ninth day)

* The dorsal vertebrae are painful to pressure with the fingers or on leaning against any hard substance

During the chill the dorsal vertebrae were more sensitive to pressure than the cervical or lumbar vertebrae

Pressure upon the first dorsal vertebrae, and also, though in a less degree, upon the second, was painful ; this is not noticed in the cervical, in the other dorsal, nor in the lumbar vertebrae, in the afternoon (seventh day)

* Pain in the first and second dorsal vertebrae, on pressure (twenty-fourth day)

* Third dorsal vertebra very painful I to touch, with oppression of the chest; it was not noticed on pressing on the other vertebrae (twenty-second day)

Pricking to left of the irritable middorsal spine, in the forenoon (twenty-eighth day)

Carrying medicinecase in left hand, pricking in left side of middle dorsal vertebra (which is an habitually irritable part of the spine) ; have had similar prickling frequently during the proving, when straining this point in sitting bent up, etc., afternoon (twenty-sixth day)

Lumbar, Dull left lumbar uneasiness (forty-fourth day)

Lumbar pains, when sitting bent up, in a street-car (twenty-ninth day)

Lumbar pain recurs as provocations recur, left side, in the evening (twenty-eighth day)

After raw oysters, condimented, dull lumbar pain when walking, in the afternoon (thirty-first day)

Whilst out, during the day, repeated renewal of dull lumbar pain, left side, also subcutaneous sticking, noticed while walking, on right side; same, but running up, later, left side; when straightening myself on a seat (twenty-eighth day)

After dinner, at 4 p.m., sitting in streetcar, a little bent forward, dull pain in left lumbar region, say about lower end of kidney (twenty-fifth day)

Whilst going about, dull pain in left lumbar region; later, in the right side; then, while sitting, in the left again, afternoon (twenty-seventh day)

Dull pain, transient, in left lower lumbar region, while writing ; not very rare, in the evening (twelfth day)

During exertion, pleurosthotonic lumbar cramp, left side (twenty-ninth clay)

Sitting, dull aching in middle of left costo-pelvic (lumbar) muscular region, in the afternoon (fourteenth day)

Constant pain in the small of the back (twentieth day)

Dull pain in region of left kidney, whilst bent to the other side, in the afternoon (twenty-fifth day)

Bending over my table, dull pain in region of left kidney

Region of left kidney is quite persistently the seat of dull pain, with intolerance of positions, etc., which cause compression (twenty-seventh day)

Crampy ache in left renal region, evening (twenty-fifth day)

Sacral. Not having defecated, felt as if a firm mass pressed from within against sacrum, hips, and lower lumbar portions of back (relieved by stool) in the forenoon (nineteenth day)

Extremities in General p. 238

Trembling and coldness of the limbs (thirteenth day)

* Weakness in the limbs (twentieth day)

Great weakness and -weariness of arms and legs

* Trembling in the extremities; the power of the will over them seemed to be very much hampered™.

Frequent trembling of the limbs

His limbs would not obey his will

General numbness and trembling of the limbs, even on slight exertion, lasting two days (second day)

Tea rings and drawings in the hands and feet (twentythird day)

Neuralgic twinges in right index finger and right little toe when using them ; afternoon (twenty-sixth day)

Bruised feeling in the limbs (twenty-seventh day)

Superior Extremities p. 239

The arms and hands become considerably tumefied and covered with pimples, which also fill and suppurate

Whilst folding powders, arms felt as if too little supplied with nerve-force, like nervous debility, or shattering, with want of control of the muscles, not amounting to agitation, in the afternoon (twenty-third day)

The arms feel bruised the whole day (nineteenth day)

Shoulder. Cracking, so that it can be heard by others, in the shoulder-joints, on raising the arms (twenty-sixth day)

Pains in shoulders (thirtieth day)

Sitting with right arm in malposition, rheumatic threatening in right deltoid muscle ; later, in the course of the inusculo-spiral nerve to back of forearm and hand, riding in car, and resting the palm on the seat; also in the ulnar nerve, adjoining the pisiform bone, in the afternoon (fourteenth day)

All day, left deltoid region near acromion has been rheumatic ; the day cool, humid, and windy. Warmth relieved (twenty-second day)

At various times rheumatic feeling in one or other deltoid muscle, extending half way down outer arm, when the limb happened to be at all in malposition (sixteenth day)

Whilst writing (2.20 a.m., after sleeping), rheumatic feeling in right deltoid. (Some of the upper deltoid pains should, perhaps, be rather referred to the insertions of the spicata muscles into the tuberosities of the humerus, some of the lower, perhaps, to the brachialis anticus, at least as participating therein ; being rather transient, it is difficult fully to test this by muscular movements, and especially as they usually cease with change of position), (twentieth day)

Rheumatic feelings in tendons of both deltoids, and of left biceps, from muscular effort or strain from time to time, in the afternoon (nineteenth day)

Rheumatic pain in left shoulder at noon (twentieth day)

(Sitting back in arm-chair, and so pressing scapulae, rheumatic-neuralgic ache in posterior axillary fold, right side, in the afternoon), (twenty-fifth day)

Before going to bed, whilst making some motions with the arms, sharp cramp in anterior half of left deltoid after 1 a.m. (twenty-second day)

Arm. Recurrence of pain in outer right upper arm (apparently in the nerves), in the evening (twenty-fifth day)

Recurrence of rheumatic pains in right arm (outer origin of brachialis anticus), (forty-sixth day)

Whilst writing, slight and transient pain, referable to the ulnar nerve, in its middle third, from below the axilla to below elbow, left side, in the afternoon (twentieth day)

Sticking above right external condyle of humerus; then, while sitting, in dorsum of right forearm; then left brow; in the evening (eighteenth day)

Whilst writing, quick twinge in superficial nerves of upper arm, inner and outer aspects, in the evening (twentythird day)

Elbow. Slight pain front of elbow, when pulling a door, in the afternoon (first day)

On flexing the right forearm in a forcible effort, sprained feeling at biceps tendon, at elbow (twenty-third day)

Forearm. jSeuralgico-rheumatic sensations in dorsum of right forearm, extending as a hard ache to middle of ulna, whilst going about, in the afternoon (twenty-fifth day)

Carrying medicine-case in right hand, compression of ulnar nerve against body, pain to termini of nerve in little finger, etc.; afternoon (twenty-sixth day)

Recurrent neuralgic pain in right ulna, etc., whilst writing, in the early morning (twenty -sixth day I

On waking, the right arm being uncovered, rheumatic pain in shaft of ulna very decided (room not cold); disappeared after warm sponge-bath, in the morning (twenty-sixth day)

Riding in cold wind, rheumatic pain in extensor tendons of right forearm ; better by motion ; afternoon (twentysixth day)

Cramp in flexors of left forearm, when feeling for levator anguli scapulae, in the early morning (twenty-sixth day)

Aching, lower end of left ulna, whilst holding papers to write on, in the evening (twentyfifth day)

Neuralgic aching in dorsum of right forearm, two inches below head of radius (over belly of supinator longus), in the forenoon (twenty-first day)

Neuralgic aching in right ulna whilst writing, every morning (twenty-sixth day)

Sticking in dorsum of right forearm, when putting the hand behind me, at noon (nineteenth day)

Sticking, dorsum of right forearm, whilst holding a weight, in the afternoon (twenty-fourth day)

Sharp neuralgic twinge in forearm, in dorsal branches of radial nerve ; then suddenly and sharply in the digital nerves of adjacent sides of first and second fingers of left hand, middle phalanges, in the afternoon (twentieth day)

Dorsum of lower right forearm, pricking in the nerves (twenty-ninth day)

Wrist. After writing, rheumatic pain around right carpus (weather mild), in the afternoon (twenty-sixth day)

Writing: neuralgic twinges, or rather sticking (like sharp wires), in dorsum of right wrist, in the forenoon (twenty-first day)

The hands and arms refused their service (fifth day)

Peculiar sensation in the right hand, as if some drops of fluid passed thence to the shoulder; this sensation was not especially painful, during every stool,5.f

Hands seem puffy when closing them (twenty-fifth day)

After using hands vigorously, sticking in left hand, between bases of first and second metacarpal bones, in the forenoon (twenty-eighth day)

Palmar intermetacarpal sticking, right hand, between first and second fingers, in the evening (eighteenth day)

Fingers. Left index finger has a slight cut ; after taking morning sponge-bath the finger was somewhat inflamed and tumefied half way up (fortieth day)

When extending the fingers, the centre of nails look white, especially the first and second, in the morning (second day)

In cutting my finger nails I observe that they seem unusually tough (twentyfourth day)

Pains in right finger and thumb (thirtieth day)

Neuralgic pain (slight from same intermetacarpal space) along digital nerve, inner aspect of first phalanx, first finger, right hand, after midnight (nineteenth day)

Crampy,then rheumatic pain, whilst writing, in right third knuckle, and above, in the afternoon (twenty-third day)

Whilst holding papers in left hand and writing on them, neuralgic twinges in left index finger (twenty-second day)

Sharp neuralgic twinge in inner digital nerve of left second finger (twenty-first day)

Little finger-joint continues sore, frequently aggravated by friendly grips (thirty-ninth day)

Last articulation of right little finger is quite sore to pressure, looks tumid, and a little reddish, iu the evening (eighteenth day)

The last little finger-joint, right side, continues in a sore state; the base of the last phalanx in particular is hypertrophic and inflamed, causing a slight distortion ; shaking hands is often quite painful (twenty -fourth day)

The last joint of right little finger is tender, the base of last phalanx is tumid, and at the

•j- This symptom appeared constantly in three repetitions of the experiment. outer portion of the same the skin has a red spot of some size (twentysecond day)

Proximal palmar portion of last phalanx of right thumb felt sensitive to pressure, as in incipient felon ; the spot pressed by spring of my watch-case (sixteenth day)

Having day before yesterday accidentally broken my right thumb-nail to the quick, now, whilst riding in a street-car, find it very sore and stiff; later, with heat; aching, at times extending to metacarpal joint, worse from using it, throbbing when hanging down ; perceptible swelling ; temporary aggravation whilst running hot water on it from hydrant ; afterwards much ameliorated; later, entirely gone, in the afternoon (eighth day)

Inferior Extremities p. 241

Objective. The disease, which at first was confined to the neck, face, and arms, subsequently covered the legs ; one of them was much swollen, and covered with a scaly eruption, like a species of elephantiasis (in a woman, from packing the sulphate)

Walking, recurrence of disposition to aid by gravitation ; walking bent forward, to supplement muscular inertia as it were, especially in the calves, in the afternoon (twenty-fourth day i

Subject i re. Walking about, notice the recurrence of the wooden feeling a sort of constrained, stiff, awkward action of the lower extremities ; evening (twenty-sixth day)

Walking, the tendons seemed to catch and pain slightly (twenty-second day)

Hip. Hips, in walking, feel old and inert; rigid, in the morning (twenty-third day)

Just before going to bed, hips feel tired, as if from a long march; almost a stiff feeling; left side worst (fifteenth day)

Thigh. Loss of power in the thighs (second day)

Catching, stitchlike, in anterior superior portion of left gluteus maximus, while walking, in the afternoon ( twenty-fifth day)

During the day, in walking, thighs felt loggy ; knees ready to give way (forty-first day)

Walking, tired feeling in upper front of thighs, as if overworked, in the afternoon (fourteenth day)

Walking, slight recurrence of rigid feeling in rectus muscles of the thighs; then similar sensation posteriorly; then the joint and muscle debility before-mentioned, but this time in the knees, in the afternoon (twenty-fourth day)

Rheumatic feeling behind right trochanter, in the afternoon (twenty-fifth day)

Standing bent forward, rheumatic feeling in a small portion of left gluteus maximus, at noon (twenty-first day)

Rheumatic pain along inner border of left rectus femoris, whilst walking (twenty-first day)

Walking, rheumatic feeling in right vastus externus, lower half, in the afternoon (thirteenth day)

Rheumatic pain in exterior of left thigh and upper fibula, when sitting with limb suddenly doubled up, by leaning far forward ; afternoon (twenty-sixth day)

Walking, increasing tension in rectus muscles of thighs; got almost rigid; obliged to pause to allow it to pass off, in the evening (twentieth day)

Standing bent forward, right foot advanced, myalgia along right rectus femoris, exterior aspect, in the afternoon (twenty-sixth day)

Overfatigued ache in left rectus femoris, whilst sitting, in the evening (twenty-fifth day)

Crampy ache, lower border of right gluteus maximus, in the evening (twenty-fifth day)

After jumping from platform of caF, cutting across lower half of left rectus femoris, quite sharp, with every step; afternoon (twenty-sixth day)

Entering the house, felt crampy cutting across thigh, but this time on the right side, transverse in direction, and in lower half of rectus muscle ; on walking out, left thigh again, both on same level ; afternoon (twenty-seventh day)

Whilst sitting at stool, recurrence of the transverse cutting, in inner and lower portion of rectus femoris, right thigh, in the forenoon (twenty-eighth day)

Stitching behind left trochanter, while walking, in afternoon (twenty-fifth day)

Neuralgic twinge behind right trochanter; felt afterwards in walking; also similar crampy feeling at inner border of right scapula, in the afternoon (nineteenth day)

Walking, rheumatic twinge recurs behind right trochanter, in the evening (twenty-fourth day)

Ktiee. Began while walking to feel as if the bones at inner half of right knee-joint did not fit, impeding locomotion, increased to a drawing at inner part of popliteal space and up inner hamstring muscles ; thought I should have to stop walking ; did stop once or twice, and shook limb to relieve tension ; it caused awkwardness of gait; subsided while making a call, in afternoon (fifteenth day)

Contractive sensation down inner side of right knee ; afternoon (twenty-sixth day)

Sticking, left upper knee-joint, in evening (twenty-fifth day)

Let/. Twitching, left ulnar flexor (twenty-ninth day)

Tendons in front of right ulna twitching, quivering (twenty-ninth day)

On rising from seat, rheumatic feeling about lower head of right fibula, in the afternoon (twentieth day)

Slight pain on inner edge of right ulna, then upper dorsum of same, whilst resting it on table writing, more when ulnar nerve is on the stretch, less on relaxing it, or obviating its compression, in the early morning (twenty-sixth day)

Aching over inner lower right tibia, in the evening (twenty-fifth day)

Neuralgic aching in the lower half of left leg, in the course of the anterior tibial nerve, in the early morning (twenty-sixth day)

Twinges in middle of right anterior tibial nerve; evening (twenty-sixth day)

Neuralgic twinge in front of lower end of right fibula, in the evening (nineteenth day)

Sitting, left knee resting on right, pricking, right inner calf, in the afternoon (twenty-fourth day)

Ankle. After resting heel on floor or otherwise, with leg extended, and sleeping, severe feeling as if ankle were injured (thirty-eighth day)

Sprained feeling of flexor tendons under left inner malleolus, while standing

Passive forced flexion of left ankle (sitting), followed by slight sprained feeling in front of joint; afterwards, in walking, similar feeling in both sides of astragalus within the joint, down to attachments of internal lateral ligament; later, under inside of left instep, in the afternoon (twentieth day)

Sprained feelings now and then under and about left inner malleolus, also in tendo Achillis above ankle, walking (twenty-eighth day)

In the morning on rising, sticking sensation below right inner malleolus ; had it previous to this when walking, but laid it to a (probable) straw? in my stocking (fourth day)

Post-malleolar sticking, left side, in course of posterior tibial artery, in the forenoon (thirty-first day)

Foot. Trembling, especially of the feet, with aching of the malleoli (seventh day)

Sensation of numbness in the feet, on walking (twelfth day)/.

Putting on my boots, right foot feels a little swelled, in the evening (seventeenth day)

Cramp, outer part of hollow of right foot (twenty-ninth day)

Crampy feeling in hollow of left foot, inside (forty-fourth day)

Sitting, a crampy pain in outer muscles of right sole, in the early morning (twenty-sixth day)

Sharp, crampy pain in muscles of outer sole of right foot, when resting it on its inner side, in the evening (twenty-fourth day)

Crampy aching quite severe in inner muscles of hollow of left foot; worse while sitting; relieved while standing; continuing to sit, it becomes persistent, and increased in severity (forty-eighth day)

Dull pain, as if strained, hollow of right foot, in the afternoon (twenty-fourth day)

Sprained feeling in inner part of hollow of right foot (in street-car), in the afternoon (twenty-fourth day)

Slight pains at inner calcarea spaces ; left, sharp, when walking ; back of right heel (forty-sixth day)/9. -At the inner side of left instep, dull twinge (twenty-third day)

Some pains continue to recur; besides yesterday, without known cause, came a severe soreness, like a "stone bruise, in ball of left foot anteriorly, causing limping (similar to a former symptom in right thumb), continues to-dav (fifty-sixth day)49

[8801 10 p.m., boots hurt both insteps (fourteenth day)

Toes. Gouty (?) pain in right great toe-joint on pressing foot to floor (forty-first day)

Rising from bed and standing, sprained feeling of middle toe left side ; afterwards about ankle (thirty-first day)

While walking indoors, suddenly on pressing right foot to floor, a sharp separating or rending pain in the great toe-joint, reminding me of gout, something between neuralgia and a sprain ■ it soon after ceased, and several hours later recurred in a slight decree (twenty-third day)

When the warmth got to the feet an inactive corn on left little toe began to twinge under pressure of the slipper; passed off on changing its position, in the evening (seventeenth day)

Generalities p. 243

Objective. Very decided emaciation during the proving/.

General excitement of the arterial system, similar to that produced by strong wine

Pandiculation and frequent yawning (twentieth day)

Trembling

An internal trembling, wherewith the face became pale, with some urging to urinate, followed bv pale urine (second evening)/.

Tremors (68 grains)

Twitchings, in the evening (thirtieth day )

Convulsions

General physical power seems to be increased

General quietness, indolence, and "relaxed condition during the whole day (fifth day)

Woke in the morning feeling inert ; dull feeling in head. Hard to get up (fifteenth day)

* Weakness (tenth day)

Weakness and fatigue (after forty-five minutes)

Weakness and dulness on waking from the afternoon nap (twentieth day)/.

Weakness and trembling of the limbs, especially the knees (seventh day)

General weakness, indolence/.

* General weakness, especially of the feet, so that she was unable to walk (after half an hour)

Great weakness (eighth day)

Symptoms accompanied by great weakness

Great weakness of the body, so that he could scarcely remain up (fourth day)

Standing long in the evening produced much of an habitual weakness of the left side of the body, contracted by riding a rough horse in army life; relieved when recumbent, but requiring many turnings, in the morning, in bed, pressing up the left abdomen, etc., to get ready for my day's work ; always worse by sitting up very late at night (thirteenth day)

Sinking of strength

Great loss of power, and weakness throughout the proving

Disturbance of nervous system and of the heart's action, producing general prostration and feebleness of the cardiac movements

Exhaustion, as from hunger, a sensation of fasting in the stomach, with loss of appetite, so that the lunch in the middle of the day remained untouched (twentieth day)

Faintness

Attacks of "fainting, now and then

Often unable to stand, and several times fell suddenly when in the street (a scruple four times daily)

Fell to the earth senseless (after two hours)

Restlessness. Extreme restlessness

Night restless

Very restless at night/.

After taking the dose at bedtime, passed a very restless night

After writing a letter, recurred the nervous mobility in the forenoon (thirty-first day)

Uneasiness

Uneasy, cold sensation in the whole body, at 5 p.m. (second day)

Sensibility. Excessive general sensitiveness of the body, during the whole proving/.

Late this afternoon, in a street-car, down in a valley, felt that peculiar sensitiveness of mind and body, which sometimes precedes febrile diseases; as if a little more of the same would make me chilly. Have often experienced the same in Illinois, when laboring under malarial influences, and riding into valleys. It was like a sudden aura or magnetism, felt particularly about the neck and throat aud face, and Pulsatilla then seemed remedial. It is the same feeling to-day, and disappears in the clear upper strata of air, where the opposite conditions of light, with dry warm atmosphere prevail (thirteenth day)

Subjective. During the day felt rather old and wooden ;" motions aud speech unusually deliberate (sixteenth day )

Heaviness and disinclination to work during the whole day (eighth day)

Felt heavy and drowsy, in the forenoon (seventeenth day)

While walking muscular system felt inert, the will also ; stooped forward, that gravitation might supplement this inertia, in the forenoon (seventeenth day )

Felt weary in the morning (seventeenth day)

Felt utterly weary ; had lost some sleep the past week ; only left the house under the physician's must ;" slept and lounged about nearly all day (fortieth day)

Great weariness (fourth day)

Felt less weariness than usual on rising in the morning (second day)

The several shifting neuralgic pains in the localities most frequently mentioned, have recurred at other times in slight degree, in addition to those here recorded. Also, once or twice in the ball of the right thumb, in the evening (twentieth day)

Frequently I find sudden motions cause catching dull or spraining pains, e. g., in outer fibres of deltoid tendons, when raising arms ; in tendons in front of left ankle, when flexing the joint suddenly. Prior to proving had a sprained feeling in last articulation of right little finger, especially when shaking hands with others; it seems worse of late, especially after the doses (seventeenth day)

Internal quivering sensation through the body, at middle, followed by slight eructation, in the afternoon (twenty-fifth day)

At various times since proving began, little shocks or pricks like neuralgia or rheumatism in divers places, as left supra-orbital nerve, right ear, right elbow, right knuckle, etc. (sixteenth day)

During the afternoon and evening, spent mostly in street-car, on walking, or visits, had a rapid succession of transient, and principally slight symptoms, shifting locality, dull, sharp, crampy, etc., as crampy feeling in left hypochondrium in a small spot, probably in left rectus muscle; sticking in the right axillary folds (twenty-fifth day)

(The interest of the symptoms seems to ne largely in their frequent shifting and recurrence in all parts of the body, in localities new and old, many such being necessarily here omitted) (twentysixth day)

This morning, symptoms all seem wanting, for the first time. My impression is that my system, under the influence of the last dose, has established a tolerance of the drug, which I take to be another phrase, a synonym, for the incipiency of that vital resistance or reaction which characterizes Hahnemann's "secondary effects in the "resolution of its primary pathogenetic action, i. e., of return to health ; the phenomena being alternately and periodically, both primary and secondary, probably in all cases, the former waning, the latter increasing up to full health ; these thence ought to be easily distinguished (twenty-first day)

Skin p. 244

Objective, Skin soft, in the forenoon (nineteenth day)

skin of fingers, knuckles, etc., when pinched up, retains the fold ; color normal, in the morning (second day)

After three or four days the oedema and the rash subsided, but the skin of the face scaled off, and there was peeling of the hands and feet, as after scarlatina

Mmij>- tioriSf Dry, Hash all over the body, vivid as scarlatina, and attended with intolerable and incessant itching. The rash and irritation were persistent for several days, and then slowly and gradually subsided, followed by universal exfoliation of the cuticle

Scarlatina-like eruption, with extremely violent itching over the whole body, followed by desquamation, lasting fully three months

Sore pimple on right side of nose, at end of nasal bone, in the afternoon (third day)

Sore pimple, left of bridge of nose lasting two days (forty-seventh day)

Erythema of the face and limbs, with marked swelling of the right arm

Eruption on the lower lip, first on the left, afterwards on the right side (first and second months)

For some days have had a sore pimple, like a small boil, concealed by the beard, on right upper part of chin ; culminating yesterday, pressed it, watery discharge; it is much reduced (nineteenth day)

Large wheals with local redness over neck, chest, and arms

Eruptions, Moist. Vesicular exanthema, with much itching and inflammatory redness and swelling of the skin ; appears first on the genitals and thighs, then on the face, hands, and arms; it is a little moist, but it usually dries with a fine crust, sometimes causing cracks and ending with a desquamation of thick scales; with this the general condition is only slightly disturbed, sometimes with slight febrile symptoms and gastric disturbances ; its usual course is of one or two weeks,31.f

Colorless eruption on dorsa of hands, forming patches of flatlymphy papules, itching but slightly, most at radial side of hands

Eruptions, Pustular. With some, the pimples degenerate into pustules, which do not suppurate, but take on the appearance of an stitchlike crust, exceedingly repulsive

With some, pimples appear over the whole body, accompanied with an intolerable itching, and which eventually discharge a matter somewhat thicker than serum, though not exactly of the consistence of pus; having reached the suppurative stage, the eruption gives place to squamous scabs

Longcontinued offensive suppuration (two cases)

In some cases, the eruption declares itself upon the genital organs, and occasions acute suffering

Subjective. Intolerable pricking in the skin, followed by sweat, especially of the face (third and fourth nights)

Sudden, long, pricking stitches, as with needles, in the skin of the chest, back, and thighs, followed by moderate sweat on the chest and back, in the evening, while walking slowly in the open air (seventh day)

(The soreness of the little finger joint is concerned with persistent itching in right ear, and scratching it; also, in the first place, with carrying medicine-case by handle); the itching is old, but the soreness is new,19d 49.

Itching of anterior wall of left concha of ear; scratching it yields whitish scales, and allays itching; in the evening (twenty-fourth day)

Inside of tragus of left ear constantly itches, so also left side of chin and jaw under the beard ; scratching, temporary relief (old symptom), (twenty-first day)

Itching of right alar crease of nose, in the afternoon (twenty-fourth day)

Itching on both sides of chin, in head, etc., in the early morning (twenty-sixth day)

Itching, left side of scrotum, in the afternoon (twenty-fourth day)

Itching, dorsal, right side; friction, voluntary, by clothing, caused chilly creeping, round from back to sides and front of chest, after midnight (nineteenth day)

Sleep and Dreams p. 245

Sleepiness. Constant inclination to yawn, with decided weakness (second day)

Yawning (tenth day)

Yawning towards evening (eighth day)

Frequent yawning (third day)

Going out, and whilst in the street, repeated yawning and long expiration, with inclination to end in an audible ha! ho! (evening), (seventeenth day)

Sleepiness during the day,5 ; (tenth day)

Drowsiness, so that I could not maintain the clearness necessary to enter the charges of the day's visits; had to lie down and go to sleep, evening (weather rainy, since 2 p.m.), (twenty-seventh day)

Drowsiness in car and church, afternoon (twenty-sixth day)

While sitting, drowsiness, with pressure downward in the whole frontal region, extending its influence to the upper eyelids, at noon (twenty-third day)

Whilst sitting in conversation (hoth before and after dinner), drowsiness (twenty-second day)

Drowsiness in streetcar ; after getting out, loggy gait (twenty-ninth day)

Sitting, drowsy feeling like warmth about the eyes, and down to throat, in the afternoon (fifteenth day)

In the afternoon, while sitting conversing, drowsy, cannot keep my eyes open; the lids seem to spasmodically contract ; worse from glare on white wall (eleventh day) ; day before yesterday, in like circumstances, dozed in my chair (before dinner; to-day, after dinner)

Feeling a little drowsy while standing, forenoon (twentieth day)

In a close railroad car, very drowsy ; fell asleep (eighteenth day)

Felt drowsy and weary one hour ; hard to get awake ; felt very heavy in the afternoon (seventeenth day)

During the day, when conversing with patients, felt very drowsy, in warm rooms (third day)

Quiet sleep, without dreams (twenty-sixth day, after 8 grains)

Sleep more profound than usual, but did not refresh as usual, throughout the whole proving

Slept with benefit, and retired earlier than usual ; rose the next morning somewhat rested (forty-first day)

Sleeplessness. Uneasy sleep, with much cough (eighteenth night)

Sleep uneasy, full of dreams (seventeenth night)

Sleep very uneasy, interrupted by wonderful dreams, constant tossing about the bed (ninth night)

Restless sleep at night (first night)

As daylight approached, frequent waking, sleep almost semiconscious (seventeenth day)

Waking earlier than usual from an uneasy sleep

Sudden starting from sleep at 2 a.m. ; throat swollen, expectoration accomplished only with great difficulty; he was obliged to rise, and with great exertion to cough up some mucus, after which there was momentary slight relief ; besides, the more he coughed the worse the respiration seemed to become; sweat covered the whole body, especially the back and limbs ; respiration became rattling and gasping, so that he was obliged to get out of bed (without thirst, anxiety, or palpitation, only general heat very marked ; pulse 66, small, soft, irregular), (twenty-fifth night)

No sleep at night, except a few hours in the morning (eighteenth day)

Sleeplessness

Dreams. Sleep full of dreams (twenty-seventh day)

Sleep interrupted by dreams

Dream indistinct in the morning (seventh day)

Vivid dreams, towards morning (seventeenth night)

Frightful dreams, with restless sleep

Fever p. 246

Chilliness. Temperature diminished (after eight hours)

Temperature depressed

Bodily temperature fell 0.2°, lasting two hours (boy, after one hour and three-quarters)

Bodily temperature fell 0.2°, lasting thirty minutes (8 grains, after eighty minutes); 1.0°, lasting three hours and a quarter (20 grains, after fifty-five minutes); 0.4°, lasting forty-five minutes (20 grains, after eighty minutes), (girl)

Violent chill in the afternoon, while at work, lasting an hour; after the chill, the usual warmth of the skin returned; the temperature of the air rose, from 8 a.m. to 2 p.m., from 40° to 503 F. (second day)

Violent chill, with trembling in the limbs, so that she could scarcely walk; after going to bed she had violent beat, with frequent yawning and sneezing, which was followed by copious sweat (thirty-first day after 20 grains)

Decided shaking chill at 3 p.m.; at 6 i p.m., heat of the face, lasting until almost 9 p.m., but no sweat followed (fourth day)

Violent shaking chill, followed by fever

Chilliness in the afternoon (twentieth day)

Chilliness towards evening, with rapid pulse, dryness of the mouth, and thirst

Chilliness, with paleness of the face, pain in the forehead and temples, and ringing in the ears, at 11 a.m. (eleventh day)

Slight chilliness, with somewhat accelerated pulse

General chilliness over the whole body, especially the back, with painfulness in the middle dorsal vertebrae (twenty-fifth night)

Special chilliness during the whole afternoon (it seems to be in contradiction to the state of the weather), (sixth day)

Stoveheat is agreeable, in the forenoon (second day)

The fever shows itself at one time by an effervescence of the blood, causing great pulsation (or ''snapping") of the veins, at another by an icy coldness of the whole body, insomuch that it has been compared to the action of an intermittent fever; this fever seems to terminate by a sharp spontaneous accession (from breathing the dust of the bark)

Chilly creeps, right side of occiput; afterwards left side, in the afternoon (twenty-fourth day)

In the morning, had a renewal of an old symptom, from the blowing of cold air on front of chest, *. e., a cold feeling under left clavicle, requiring additional covering (eighteenth day)

Chilliness in scapular and mammary regions (twenty-third day)

Chilly creeps over the whole tract of trapezius muscle; later, from spines of scapulae to shoulders; and still later, on taking hat off in the house, from trapezius, over occiput, to vertex, and behind the ears, in the forenoon (nineteenth day)

Chilly creeps over various parts of the trapezius, as heretofore, with soreness recurring in right lower bicuspid, in the afternoon (twenty-fifth day)

Going to outhouse to urinate, the air growing slightly cool aud windy, felt slight chill from occiput over the whole space of trapezius muscle and to upper arms, in the afternoon (fifteenth day

When lying down, before breakfast, cold feeling in sacrum and left leg, from knee to foot (forty-fourth day)

Extremities cold (after eight hours)

Extremities, hands, feet, chin, and nose cold, from noon till evening (eighth day)

Feet and hands cold, especially left foot and tendo Achillis, in the afternoon (twenty-third day)

Fingers, toes, and soles cold (room heated), in the morning (second day)

Whilst sitting in warmish room in shirt-sleeves, writing, left arm feels slightly cool; single strong sneeze; tingling and snuffling afterwards, right side, then snuffling on left side; slight sense of stoppage (either side) alternates with the snuffling, in the evening (fifteenth day)

Left hand cold, whilst writing, in the afternoon (twenty-fifth day)

The left hand, holding the paper, colder than the right, using the pen, in the afternoon (first day),49.-

Backs of hands and fingers getting cold, in the afternoon (first day)

Knees getting cold (twelfth day)

The left knee, if uncovered (by my wrapper), gets cold, the right less affected thereby; hands are comfortable, the left a little cool ; not observed until thinking about it a little while, in the forenoon (twenty-fourth day)

Feet cold (sitting writing) in the afternoon (fourth day)

In a draft of air, feet getting cold to ankles, with sneezing; draft and cold feet continuing, sneezing not repeated, in the forenoon (twenty-first day)

Noticed my feet getting cold; first soles, then anterior half, especially of left, the former with sneezing (after fifteen minutes), (thirteenth day),49.f

Feet and inner calves cold, especially the left, in the forenoon (twenty-eighth day)

Feet, then knees and above boots, especially the left, getting cold, the room being without a fire, in the afternoon (first day)

Left foot cold to ankle, at noon (fourteenth day)

Having crossed my limbs to test the leftsidedness, the left foot is even colder than before; the right not proportionately, at least, in the forenoon (twenty-fourth day)

Sitting writing, left foot cold as before (perhaps this is so marked because the left is nearest to a draft from the bathroom on that side) (in the forenoon), (twenty-fourth day)

Left foot gets cold whilst sitting, right less so, at noon (twenty-fifth day)

Heat. Flushing, but left foot cold, afternoon (twenty-seventh day)

Temperature (second day), 98° (morning, noon, and night)

Temperature (fourth day), 98°, at 7 a.m., 12 M., and 9 p.m.,46.

Temperature (2 grains), 98° (after one hour) ; 99£° (after three hours) ; 98° (after eight hours) ; 98° (after nine hours)

Temperature (third day), 98£°, at 7 a.m., 98£° at 12 m., 98° at 9 p.m.,46.

Temperature (10 grains), 98j° (after one hour) ; 99° (after four hours) ; 993 ° (after six hours) ; 99£° (after eight hours) ; 98*° (after fifteen hours)

Temperature (second day), 98£°, at 7 a.m., 98}° at 12 M., 98° at 9 p.m.,46.

Temperature (4 grains), 98f° (after two hours); 99a 0 (after four hours and a half) ; 99 (after six hours) ; 99*° (after nine hours) ; 98° (after sixteen hours)

Temperature, 97° (after one hour); 99£° (after three hours) ; 100° (after four hours) ; 100° (after six hours) ; 99i° (after nine hours) ; 981° (after twelve hours) ; 98° (after fifteen hours)

Temperature rose slightly (after four hours), still more (after twenty-four hours), and returned to the normal (third day)

Temperature before taking, 37° C. ; 37° (after one hour and forty-five minutes) ; 38.8° (after two hours and forty-five minutes) ; 36.6° (after four hours) ; 37.2° (second morning) ; (first proving). Temperature before taking, 37.2° C. ; 36.9° (after one hour) ; 36.8° (after four hours) ; 37.5° (second morning) ; (second proving). Temperature before taking, 36.9° ; 37.1° (after one hour) ; 37.4° (second morning) (third proving)

Increased warmth of the skin, towards evening

A kind of pleasant warmth over the whole body; this gradually passed into sweat

Heat of the whole body (after four hours)

Heat over the whole body, which gradually breaks into sweat

Heat, followed by sweat, while perfectly quiet, towards evening (ninth day)

Sleep prevented by great heat of the body and excessive thirst (thirtieth day)

Intense heat over the whole skin

Dry heat throughout the whole body, during a sleepless night (third and fourth nights)

Slight attack of intermittent fever, in the cycle of an ordinary tertian

Previous to sitting down to supper, whilst moving the arms, felt a chilly creep over the left shoulder, shoulder-blade, and left side of the neck ; after sitting down, the room being rather warm, felt warm about face, shoulders, and downwards and backwards, gradually all over, with throbbing of heart and arteries, to feet and hands (seventeenth day)

Heat. Heat in the head (twenty-second day)

Heat of the head, with a strong rapid pulse, followed at last by sweat

The warmth is felt mainly in the forehead, then in the face, in the afternoon (fifteenth day)

Heat of the forehead, with pressive pains in it (eighteenth day)

Warmth felt down left side of face, in the afternoon (fifteenth day)

Heat of the face (seventh day),5; (first day)

Heat of the face, as after coffee

Heat of the face, town i ds evening (thirteenth day)

Towards evening, while busy writing, heat of the face, lasting nearly two hours (first day)

Flushes of heat in the face, with thirst, at 4 p.m. (thirty-first day)

Sensation of warmth, starting from the colon and spreading through the intestines (from injection into the anus)

The warmth extends downward, subjectively, to external chest, in the afternoon (fifteenth day)

Sitting writing, hands are warm, in the forenoon (twenty-eighth day)

Sweat. Feeling as if I would perspire, spreading from right scapula to left face and hand, forehead, and nape of neck, and down back successively ; found my underclothing slightly moist, with general slight perspiration, in the evening (seventeenth day)

Now and then, a feeling as if perspiration might follow (about neck and face), in the evening (seventeenth day)

Sweat breaks out over the whole body from time to time, even during perfect quiet (thirteenth day)

Sweat during the morning sleep so profuse that the bed was soaked with it (eighteenth night)

In a crowded place in the evening, general moderate perspiration (sixteenth day)

Perspiration of parts pressed by clothing, as dorsal, axillary, and perineal regions, in the evening (eighteenth day)

Conditions p. 249

Aggravation. (Morning), Head empty; on rising, especially on stooping or moving, pain in head ; feeling of tension about head ; at 3 oclock, headache, etc.; at 9 oclock, pain in side of forehead, etc.; on waking, frontal headache ; early, on raising eyebrows, pain up side of head, etc.; while writing, with head inclined to left, dull headache on left side; when bending forward, sensation in brow; early, pain in supraorbital region ; resonance in ear ; at 1.30 oclock, while writing, fauces, etc., feel dry, etc. ; twinge down lower jaw ; teeth feel rough; tongue flabby, etc.; clogging of pharynx; hunger; thirst; early, slight nausea ; pressure in region of liver ; soon after rising, commotion in bowels ; on rising, breaking wind, etc.; while standing, cramp in colic region; immediately after rising, colic, etc. ; after stool, mucous protrusion; at 6.45 oclock, diarrhoea-like stool, etc. ; early, urging to urinate ; early, feeling in hyolaryngeal space; on rising, soreness of larynx, etc.; tickling in left bronchus, etc.; cough, etc.; pain in chest ; sensation in breast; on rising, pain in side of chest ; when bending forward to urinate, feeling at ends of false ribs ; after breakfast, sitting at stool, elbow on knees, palpitation ; palpitation of heart; early, feeling in sterno-mastoid muscle, etc.; at 2.20 oclock, after sleeping, feeling in right deltoid; after 1 oclock, before going to bed, while making motions with arms, cramp in deltoid ; early, while writing, pain in ulna; on waking, right arm uncovered, pain in shaft of ulna; early, when feeling for levator anguli scapula;, cramp in flexors of forearm; early, while writing, aching in ulna; hips feel old, etc.; early, aching in leg"; on rising, sticking below malleolus; early, sitting, pain in muscles of sole; felt weary ; early, itching on chin, etc.; before breakfast, when lying down, cold feeling on sacrum, etc.; fingers, etc., cold ; during sleep, sweat

(Forenoon), Feeling in head ; after writing, fulness of head ; while sitting, writing, head feels full ; violent headache ; twinge in supraorbital nerve ; sticking in ear ; after breakfast, say at 10 oclock, brassy taste; urging to stool; at 9 oclock, stool mushy, etc.; cough, etc. ; while sitting partially doubled up, heart's action subjectively felt ; pulsations of heart accelerated ; while at stool, pulsations of heart increased ; at 10 oclock, after excitement, strong heart-beat ; conscious pulsation of heart ; pulse in temporal artery beat very strongly ; pulse full, etc.; pricking to left of dorsal spine; aching in forearm; twinges in dorsum of wrist ; after using hands vigorously, sticking in left hand; while sitting at stool, cutting in rectus femoris ; post-malleolar sticking ; after writing nervous mobility ;" felt heavy, etc.; muscular system felt inert; at 11 oclock, chilliness, etc.; stove-heat agreeable; in draft of air, feet getting cold, etc.; feet, etc., cold ; sitting writing, hands warm.

(Noon), While holding forearm flexed and pronated, hand on table, neuralgic grip in right brow ; sticking in ear; while waiting on doorstep, sneezing; on sitting, after motion, grumbling in colon; pain in shoulder ; when putting hand behind him, sticking in dorsum of forearm; feeling in gluteus maximus ; while sitting, drowsiness, etc.; while sitting, left foot gets cold.

(Afternoon), Feeling of impending evil ; towards evening, rush of blood to head ; headache ; after walking in sun, headache; towards evening, headache; frontal arteries began to pulsate, etc.; between 5 and 6 oclock, pain in forehead ; towards evening, pain in forehead, etc. ; some pain in forehead ; about 4 oclock, some pain in forehead; from 1 to 4 oclock, frontal headache; towards evening, headache; at 5 oclock, frontal headache ; dull headache; twitching of temporal muscles ; towards evening, headache in temple ; feeling in left head, etc. ; dull headache ; on going out, with head down, neuralgic twinge in and behind parietal protuberances ; twinges in occipital pi*protuberance ; eyes, etc., feel heavy; twinges about brow, etc.; flashing in supraorbital nerve; twitching of eyelid; glare of light disagreeable; sitting, tension in parotids, etc.; while walking out of doors, aching in ear; after going downstairs, sticking in auditory meatus ; twitching of the nose ; on going into room from cold air, sneezing ; air blowing on side of face, pain in zygoma, etc. ; twinge above root of zygoma ; pain in lower jaw; twinges in lower jaw; aching in molars; sticking in teeth; sensitiveness of bicuspid ; twitching of lingualis muscle ; throat full, etc.; scraping in throat ; itching of velum palate ; phlegm from pharynx; at 2 oclock, hunger, etc.; hunger; thirst; vomiting; full feeling in stomach; stitching in hypochondrium ; while sitting in room, pain about umbilicus ; distended abdomen ; after 2 oclock, sensation in upper abdomen ; while going about house, continuing while in street-car, pinching in colon; colic; at 2 oclock, colic, etc. ; pain in colon; while sitting, stitch in groin; sticking in sphincter ani ; at 2 oclock, urging to stool, etc.; when going about room, desire to urinate, etc.; aching in spermatic cord, etc.; at 4 oclock, hoarseness, etc.; short cough, etc.; walking in open air, raising of mucus, etc.; crampy feeling at angles of ribs ; sticking in right chest ; after going upstairs, pulsation of heart felt in chest ; slight palpitation ; at 4 oclock, neck began to swell, etc.; after sitting in draft of air, feeling in scapular muscles ; twinges in right scapula, etc. ; sensitiveness of dorsal vertebrae ; carrying medicine-case in left hand, pricking in dorsal vertebrae ; when walking, lumbar pain ; pain in lumbar region ; sitting, pain in pelvic muscles ; while sitting bent to other side, pain in region of left kidney ; when using the parts, twinges in index finger, etc.; while folding powders, arms felt as if wanting in nerve-force, etc.; sitting, with arm in malposition, rheumatic threatening in deltoid muscle, etc.; feelings in tendons of deltoids; sitting back in arm-chair, aching in axilla; while writing, pain in ulnar nerve; when pulling a door, pain in front of elbow ; while going about, sensations in dorsum of forearm ; carrying medicine-chest in right hand, pain in little finger, etc.; riding in cold wind, pain in tendons of forearm; while holding a weight, sticking in dorsum of forearm ; twinge in forearm, etc. ; after writing, pain around carpus; while writing, pain in knuckles, etc. ; walking bent forward; while walking, catch in gluteus maximus; tired feeling in thighs; walking, rigid feeling in thighs, etc. ; feeling behind

doubled up, pain in thigh ; standing bent forward, foot advanced, myalgul

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lectusfemoris; entering house, cutting across thigh; twinge behind tro-

S of ;fibeTatl° Hd0MT J?df °f knee; °D rishlg *™ seat feeling about

head of fibula; sitting, left knee resting on right, pricking in calf; pain

in foot; feeling in loot; pains in calcarea spaces; at 5 oclock, uneasy

sensation ; sensation through body, etc.; itching on nose; itching on sero-

tum ; towards evening, yawning; drowsiness; felt heavy; chill, etc.; at 3

o clock, shaking chill etc.; chilliness; towards evening, chilliness, etc.; special chilliness ; chilly creeps on side of occiput ; chilly creeps over trapezius muscle, etc.; from noon till evening, extremities, etc., cold ; feet etc.

cold ; while writing, left hand cold ; left hand colder than right - backs of hands, etc., getting cold ; sitting, writing, feet cool; feet, etc., getting cold ; flushing, etc ; towards evening, skin warm; towards evening, heat, etc. ; warmth of left side of face ; towards evening, heat of face ; while busy writing heat of face ; at 4 oclock, flushes of heat in face, etc.

(Evening), Heavy feeling m head ; at 7 oclock, headache ; frontal headache ; sticking in forehead ; temporal arteries full, etc. ; neuralgia in parietal region ; walking in open air, neuralgic twinge in right head ; sitting, neuralgic twinge in side of head ; threatening headache in occiput ; on holding up head suddenly to right, shock across occiput; falling of dandruff from beard, etc. ; itching of scalp ; when walking in wind, lachrymation ; while writing, stitch at left eyebrow ; while writing, aching in orbit, etc. ; while sitting in street-car, pain in supraorbital nerve; while writing, pain in supraorbital nerve ; twitching of left eyelids ; aching above mastoid process, etc.; sticking in ear; intolerance of noise of boys ; sitting in shirtsleeves, sneezing; moisture in nose ; head held obliquely down in writing, sensation at end of nasal bone ; while sitting, tingling in nose ; in cold air facial pains ; aching about malar bone ; reading, with bead inclined, varying pains ; sticking in molars ; taste of abnormal secretion ; appetite very great ; thirsty ; while sitting bent, rising of ingesta ; pyrosis ; eructations ; fasting, visiting a patient, sitting on low chair, preparing medicine on knee, sensation in stomach, etc. ; shortly before going to bed, pain in region of liver; commotion in colon ; emission of flatus; aching in rectus abdominis; sitting, inclination to left side, left-sided colic; walking about, colic in colon; sticking in colon ; standing in open air, cough, etc.; commotion in rectum, etc. ; sitting, pressure of flatus, etc. ; while walking, sticking to right of anus, etc.; urging to stool, etc. ; at 9 oclock, after urinating, pain in orifice of urethra ; relaxation, etc., of right testis; tickling in larynx, etc. ; tickling at bifurcation of trachea, etc. ; while dressing, cough, etc. ; while eating, long inspiration, etc. ; rising suddenly from seat, and attempting to swallow at same moment, arrest of breath ; feeling behind sternum ; immediately after chewing orange-peel, eating sugar, and drinking water, pressure in subensiform space, etc.; at 7 oclock, pain in left half of chest; on entering house, stitch from edge of liver ; tickling in left chest; phlegm in left chest; lumbar pain; while writing, lumbar pain; aching in renal region; pain in upper arm; sticking above condyle of humerus, etc.; while writing, twinge in nerve of arm; palmar sticking ; finger-joint sore; walking. about, feeling in lower extremities; just before going to bed, hips feel tired; walking, tension in muscles of thigh ; while sitting, ache in rectus femoris; ache in gluteus maximus; sticking in knee-joint ; when warmth got to feet, toe began to twitch ; aching over tibia ; twinges in tibial nerve; twinge in fibula; foot feels swelled; when resting it on one side, pain in muscles of sole; twitch i ngs ; while walking slowly in open air, stitches in skin of chest, etc. ; itching of concha of ear; drowsiness; left arm cool, etc.; feeling as if he would perspire, etc.; moderate perspiration ; perspiration of clothed parts.

(Night), When reading, bent forward, pain from supraorbital foramen to vertex ; at 11.30 oclock, twinge in brow; neuralgic twinges in brows; at 11.30 oclock, tension in right parotid; cutting in lower jaw; ravenous hunger; thirst;, on retiring to bed, in crouching attitude, eructations, etc.; on starting to go out of room, eructations, etc.; while going upstairs, before supper, gnawing in stomach, etc. ; near morning, on waking, oppression at epigastrium ; cough, etc. ; 10 oclock, boots hurt instep; restless.

(Midnight), While sitting, eructations; standing bent over table, just after eating piece of dry bread, heartburn ; when writing, ache at scapular border.

(After midnight), While writing, neuralgic sensation on side of head ; recurrence of ache in brow ; between 1 and 2 oclock, pain in right ear, etc.; teeth clinched ; while moving about, emission of flatus; at 1 oclock, while going about, recurring more sharply when sitting, pain at border of rectus abdominis ; neuralgic tickling ; towards morning, cough ; at 12.30 oclock, cough, etc. ; towards morning, cough; cough, etc. ; pain along digital nerve; dorsal itching, etc.

(Open air), Lachrymation ; when without overcoat, cough.

(Sitting bent up), Eructations, etc.; lumbar pains.

(Deep breathing), Pain in sternum.

(During chill), Sensitiveness of dorsal vertebrae.

(Cold air), Pain in infraorbital, etc., nerves; toothache; with false position, acromial rheumatism.

(After dinner), Pain at forehead ; at 4 oclock, sitting in street-car, pain in lumbar region.

(Eating), Hunger; pressure in stomach, etc.

(During exertion), Lumbar cramp.

(Friendly grips), Soreness of little finger-joints.

( While holding papers and writing on them), Twinges in finger.

(Sitting leaned to right), Sensation of left temple.

(Sadden movement), Pain in sternum.

(Moving eyes), Pain in forehead, etc.

-(Pressure), Colic.

(Rising suddenly to standing posture), Stitch in parietal region; colic.

(Sitting), Eructations, etc.; aching in muscles of foot.

(After sleep), Readily angry.

(Standing), Holding head down, stitch in parietal region ; stitch at sphincter ani ; sprained feeling of tendons under malleolus; after rising from bed, feeling in toe.

(During stool), Sensation in right hand.

(On stooping), Vertigo.

(After supper), Walking, after a little jar, tension in parotid, etc.; going from one room to another, tingling in left side of nose, etc.; hunger.

(Turning head), Pain in forehead, etc.

(Suddenly turning head to right), Sprained feeling in sterno-mastoid muscle, etc.

(After urinating), Evacuation of flatus.

( Walking), After eating, threatening of nausea ; pain along rectus femoris ; sensation of numbness of feet ; indoors, on pressing foot to floor, pain in toe-joint.

Amelioration p. 252

(Forenoon), Will positive, etc.

(Afternoon), Towards evening, headache.

(Evening), Buoyant feeling; more vim, etc.; resolute feeling, etc.

(Walk in open air), Lively mood, etc., returns; headache, etc.

(Bending body forwards), Sticking in chest.

(Applying cold hands), Feeling in head.

(Drinking cold water, also eating a bun), Goneness, etc., in stomach.

(Eructation), Nausea; feeling in stomach; pressure in stomach.

( Careful friction), Contraction of spermatic cord.

(Jar of going downstairs), Contraction of spermatic cord.

(Loosening clothes), Threatening of nausea; coldness in stomach, etc.; oppression of stomach.

(Lying on abdomen), Palpitation of heart.

(Motion), Pain in tendons of forearm.

(Pressure), Sensation in region of spleen ; pressure in region of liver.

(Sleep), Everything.

(Standing'), Aching in muscles of foot.

(Sugar), Hollowness of stomach.

(Supporting arm), Ache at scapular border.

(Trust in Almighty), Feeling of gloom.

( Walking in wind), Parched feeling in eyes.

( Warmth), Neuralgic pains ; toothache.

Rheumatism in deltoid region.

( Warm sponge-bath), Pain in shaft of ulna.

Footnotes p. 216

† Departure from strict "purity " seems in this case admissible; the details were obtained from the original by Dr. Holcombe.

† These crystals consisted of urate of ammonia and phosphates, and traces of quinine. % An analysis of these crystals showed that phosphates of ammonia and magnesia were certainly present; lime was not present, but soda was, which seemed to determine the peculiarity of these crystals, differing somewhat from the pure triple salt of phosphate of ammonia and magnesia. $ These crystals were not soluble in alcohol nor cold water, but were dissolved by boiling water, which redeposited a sediment after cooling; this sediment contained only traces of uric acid, consisting almost wholly of phosphates.

† One-quarter of a grain of these crystals was collected from a pound and a half of urine: they contained urate and "purpurate" of ammonia mixed with phosphates.

† She frequent!}' suffered from leucorrhoea.

† By "sticking," I mean a short stitch of indistinguishable course.

† It attacks only those workmen who are employed in precipitating, by means of milk of lime, and filtrating the crude Chinin from the acidulated solution.

† Hay fever, with cold feet and sneezing, may here find a remedy.