Gelsemium

Gelsemium sempervirens. Ait. (Gelsemium lucid, Poir.; G. nitidum, Michx.; Bignonia sempervirens, Linn.; Lisianthus sempervirens. Mill.).

Natural order, Loganiacese. Common name, Yellow Jessamine.

Preparation, Tincture of the bark of the root.

Aidhorities. 1, Dr. Henry took tincture, 30 drops first and third days, and then gradually increased the dose daily for one week, Inaug. Dissert., Phila. Horn. Coll., 1852; 2, Dr. Joshua Stone took tincture, 6 drops first day, 50 drops fourth day, 50 drops eleventh day, Inaug. Dissert., Phila., ibid.; 3, Dr. F. Bigelow took tincture, 20 drops daily for one week, Inaug. Dissert., Phila., ibid.; 4, Dr. William E. Payne took fluid extract, 4 drops first day, 5 drops and 6 drops second day, 6 drops third day, 10 drops and 6 drops fourth day, 6 drops fifth and sixth days, 10 drops seventh and eighth days, 3 drops thirty-second day, 5 drops twice and 6 drops thirtythird day, 8 drops twice thirty-fourth day, 6 drops and 8 drops thirty-fifth day. Am. Horn. Review, 2, 80; 5, Dr. J. S. Douglass, provings on “ at least fifty people,” mostly with tincture, in doses of 1 to 5 drops, a few took 3d dil.. West. Journ. of Horn., 1, 1, and introductory letter in Hale’s Monograph; 6, Dr. J. C. Morgan took tincture (saturated pellets) several times, then 4 drops four times, 5 drops and 6 drops first day, 7 drops second day, 5 drops third day, 5 drops and 7 drops fourth day, 8 drops and 9 drops fifth day, 10 drops and 15 drops sixth day, 21 drops seventh day, Shipman’s Am. Journ. of Mat. Med., 1861, No. 4; 7, Dr. B. Fincke; Mrs. S. took one drop of I™ (centes.),'N. A. J., 15, 413; 8, Dr. Fincke himself took 3®g“ (centes.), ibid.; 8, Dr. E. M. Amos’s proving with 6th dil., 1 drop every two or three hours, then 2 drops per dose, Inaug. Dissert., Horn. Med. Coll, of Missouri, 1860; 10, Dr. E. M. Hale, symptoms from various observers, Monograph on Gelsemium, 1861; 11, Dr. F. L. Vincent’s proving, Hale’s Monograph ; 12, Dr. M. E. Lazarus’s proving, Hale’s Monograph ; 13, Dr. E. M. Hale, provings on several persons. Monograph (additional); 14, Zumbrock, proving with tincture, 3 drops first day, 8 drops fourth day, Brit. Journ. of Horn., 21,419; 15, Dr. J. J. Douglass, symptoms obtained by repeated provings on self and seven or eight others with tincture, in doses of 1 to 5 drops (Hale’s Domestic Medicine), Brit. Journ. of Horn., 21, 414;

f Gelsemium. 16, Dr. L. A. Fallagant; a surgeon chewed the root in mistake for licorice, Hahn. Monthly, 5, 20; 17, Tally, effects on a girl, aged 11 years, of eating the inner bark, with the sap, from the stem, Boston Med. and Surg. Journ., 7, 122; 18, Dr. King; a Mississippi planter took, by mistake, an infusion of the root for bilious fever (Dispensatory), Hale’s Monograph, p. 10; 19, Dr. Gangrene, a lady took tincture, 10,11, and 12 drops in three hours, for typhoid pneumonia, Hale’s Monograph, p. 11; 20, A steamboat waiter partook freely of a strong decoction of the root, Nashville Med. Journ., 1866, p. 225; 21, Dr. Pattee; a condemned prisoner attempted suicide with 1^ oz. fluid extract (Tilden’s Journ.), Brit. Journ. of Horn., 21, 407 ; 22, Dr. J. T. Main took, by mistake, 1 drachm fluid extract, Boston Med. and Surg. Journ., April 15th, 1869, p. 185; 23, Dr. R, P. Davis, effects on Mr. B. of a tablespoonful fluid extract (Med. Press and Circular), Am. Journ. of the Med. Sci., 1867, p. 271; 24, the same, effects on Mr. S. of a like dose, ibid.; 25, Dr. T. G. Worraley, effects on a healthy woman, several weeks pregnant, of 3 tablespoonfuls fluid extract, Am. Journ. Pharmacy, 1870, p. 14; 26, Dr. Pinkham, Mrs. F. took “probably much more than 40 drops” of fluid extract, Boston Med. and Surg. Journ., 1871, p. 89; 27, Dr. W. W. Clap; a man, 27 years old,reduced by remittent fever, was given 22 drops fluid extract within ten hours, Ohio Med. and Surg. Reporter, 5, 302; 28, Dr. J. T. Boutelle, effects on a man, aged 24 years, of 2 teaspoonfuls fluid extract, in fifteen minutes, for neuralgia, Boston Med. and Surg. Journ., 1874, p. 321; 29, Dr. J. A. Munk; a child, aged 2 years, took a teaspoonful of the tincture (Am. Med. Journ.), Am. Horn. Observer, 1875, p. 12; 30, Dr. Hale, effects of 10 drops of tincture, every four hours, for hysterical convulsions, Brit. Journ. of Horn., 21, 414; 31, Dr. E. M. Hale, effects experienced by a lady, five months’ pregnant, after second dose of 20 drops of J(jth dilution, and renewed by every repetition of the same, Hahn. Monthly, 6, 125 ; 32, effects (Tilden’s Journ.), Hale’s Monograph ; 33, Dr. Gangrene, Dr. B. took 30 drops tincture for toothache, Brit. Journ. of Horn., 21, 408 ; 34, Holden, experiment with fluid extract, 6 drops twice, then 10 drops at half hourly intervals, “The Sphygmograph,” p. 150.

Mind p. 386

Mnwtional. Intoxicated feeling, with painless, but slightly diarrhoeic stool

General vivacity after rising (second morning)

In one case (it is not said at what stage), great and almost uncontrollable mirthfulness

Depression of spirits, with dull, uncertain pains in the head, in the afternoon (fourth day)

Depression of spirits

Melancholy, desponding mood (first day); worse (third day),h

Gloomy and disinclined to exertion of any kind

Hypochondriac mood all day, dull, stupid (fourteenth day),l

Anxiety

Irritable, impatient

There was at first a cheerful, careless morale, afterwards depression of spirits,_ Intellectual. She seemed to know all that was going on ; described her symptoms

Symptoms lasted several hours, but all the while I retained a clear state of mental activity

Dulness of all the mental faculties,®._ For several days, rather dull and stupid, with disinclination to conversation, which was remarked by friends, who knew nothing of my taking medicine (fifth day)

Very dull and stupid, with aversion to study (fourth day)

* Dulness of mind, alleviated on profuse emission of watery wine

* Incapacity to think or fix the attention

Mind listless and incapable of reflection, as after ague, with a not severe, dull headache all day, and digging in the right ear all the afternoon (seventh day)

The sensorial modification consisted of a mistiness within the brain, not much affecting the lucidity of thought, but somewhat confusing the perceptions, so that I experienced some difficulty in attending to the physical details connected with my practice,*l

Inability to concentrate the mind

Found it to affect the power of concentration very materially ; I could not fix my mind on the contents of a newspaper, although the matter was of an exciting character ; I could not pursue one train of thought for any time, the ideas would vanish and leave a vacancy of mind which was quite annoying

Confusion of mind

Incoherency of thought

Stupid, intoxicated feeling

* Unconsciousness

He threw himself upon the floor and soon became unconscious (after half an hour)

Totally unconscious

Totally unconscious, and could not be aroused (after three hours)

Head p. 387

Vertigo. Transient vertiginous sensation, after breakfast (second day)

* Dizziness of the head, and blurred vision returned, and gradually increased, so that all objects appeared very indistinct, for three hours, then gradually abated (one hour after second dose, fifth day)

Sense of giddiness (one hour and twenty-five minutes after third dose),®h

Giddiness is pretty constant; an intoxicated feeling and tendency to stagger; often with dizziness or imperfection of vision.®

Swimming sensation in the head

My head began to have a swimming, turning sensation, as if I were going to be seasick

Light head

Lightheaded and dizzy, much increased by sudden movement of head and walking (one hour after first dose, third day).

Lightheaded, and dim vision, continuing for one hour (after first dose, third day)

* Her head felt very light

Head felt very light, xvith vertigo

General Head. Head cool to the touch, in the afternoon (eighth day)

He cannot hold the head ei*ect

Dulness of head, at 11 a.m. (fifth day)

Dulness of the head, with stupor, dry mouth, coated tongue, bitter taste, pulse full and strong, intoxication, vertigo unto falling

Heaviness of the head, in the afternoon (tenth day)

Heaviness of head, with dulness of mind

Heaviness, with sensation of fulness in the head, which increased to a severe headache, relieved on the third day of the proving by copious urination; after which a pleasant languor pervaded the system for some hours

Great heaviness of head ; sensation as if the brain was heavy

* Heaviness of head alleviated on profuse emission of watery urine

A very disagreeable sensation in the head was felt, even before the muscles came under the influence of the drug, but the mind was clear

Fulness about the head (sixth day)

The head feels full and excited or feverish

Full feeling of the whole head, with some throbbing and uneasiness of the occiput

Full and crowded feeling in head, with pain as if the brain were bruised, and accelerated pulse (90), (eighth day)

Full, crowded feeling in head, and heat in face (one hour after first dose, third day),h

Full and crowded feeling in the whole head, and a sensation of feverish heat in the face, nevertheless the temperature of the skin did not appear to be augmented, at 2.30 p.m. (fourth day)

Tightness of the brain

A sandlike pain surrounds the head, with shooting pain in both jaws and parietal bones (third day)

Dull pains in the head and limbs (third day after six drops)

Pain in the head is a very constant symptom, generally dull, stupefying, and pressive; more frequently in the forehead and temples

Headache beginning after dinner and lasting till evening

The headache is very distressing

After breakfast dull aching in the head, becoming more severe as the day advanced, in the occiput; headache increased till after dinner, when it was much relieved, but about 4 p.m. returned worse than before, and seemed to increase in severity until in the evening it became excruciating, accompanied with slight nausea; shaking the head seemed to slightly relieve it (sixth day)

Not severe, dull headache (part of S. 19)

On waking in the morning, pressure in the whole sinciput, as if too narrow, better by pressing with the hand; compelled to close the eyes (seventh and eighth days)

Pressive pain in the head, principally the temples, at times in the occiput, at others all over the head

* Sensation of weight and 'pressure in the head

* The sensitive bruised sensation of the brain continued for two days (after eighth day),b

* Head symptoms are aggravated by smoking

Headache ceased by sitting, in the evening, as at other times (ninth day)

During the day tendency to headache on moving, especially on going upstairs (second day)

The sensitiveness of the brain continued for several hours, and it appeared as if every step and sudden movement of the head would excite pain, but this did not occur (after second dose, third day)

Head symptoms are felt very soon, sometimes within five minutes

Foveliecid, Severe pain in the forehead and vertex, with dimness of vision ; roaring in the ears; a sensation of enlargement of the head, and a “wild feeling a confusion, almost amounting to delirium ; the pain in the head, which was of a pressing, heavy nature, would at times disappear, the concomitant symptoms being at the same time ameliorated, and severe, sharp, lahorlike pains coidd set in, in the uterine region, extending to the hack and hips; these pains would in turn leave, and the pain in the head would recur immediately after

Some fulness in the anterior part of the head, soon disappearing (after a few minutes)

A feeling of contraction in the scalp on the centre of the forehead (after first dose, first day)

Awakened at 2.30 A.M. by most intense aching pain in the left frontal region, extending to the right occipital region, and occasionally over the entire head; it lasted an hour (seventh morning)

Dull, slight headache all over the front and top of the head, after a sleep in the forenoon ; also after sleep in the evening

Pressing in the forehead as if too narrow, with pressing upon the eyes, as if too large (sixth night)

Severe and pressive pains in the forehead and vertex

Sense of weight over the forehead (quarter of an hour after third dose)

Stitch in the middle of the forehead passing inwards, at 12 M. (tenth day)

Stitch in the middle of the forehead, passing inwards, in the afternoon (tenth day)

Now and then a violent stitch in the middle of the forehead, entering as far as half the brain, in the afternoon (seventh day)

Violent stitches in the middle of the forehead, as far as half of the brain, on turning the eyes, on stooping, and on turning the head, in the evening (eighth day)

Pains of shooting character in the frontal sinus extending to the eyes and jaws; in the eyes the pains are pricking, extending from the middle of the eyes to the canthi (first day) ; on the right side the pains seem to roll about in the eye, much more violent (third day.

Violent stinging pain in the whole forehead, and pressing of the eyes, as if they were too large, with external coldness of the forehead (third d&Yfh

Temples. Pressive pains in right temple, with dizziness and blurred vision, such as may follow the use of intoxicating liquors, but without the exhilarating effects (half an hour after second dose) ; the dizziness and blurred vision were attended by nausea, and continued for three hours (third day)

Ferfeac. When writing, headache in the top of the head; afterwards in the left occipital region, directly on both sides and in the upper cervical region, and again on the top, and then in the left side, all whilst engaged in writing a few minutes; afterwards a settled, dull, dragging headache, mainly in the occiput, in the mastoid and upper cervical region, extending to the shoulder, relieved while sitting, by reclining the head and shoulders on a high pillow; in the afternoon (seventh day)

Drawing on the right side, on the crown towards the occiput (twenty minutes after 5 drops)

Pains over the whole top of the head, extending to the occiput, with a general dizziness and a disagreeable painful sensation in the whole of the head (first day), much more violent (third day),h

Parietals. Pains in the left side of the head, extending from the prominence of the parietal bone to the mastoid process of the temporal, periodically (third day),h

Dull pain on the right side of the head (sixth day)

Dull ache on the right side of the head, at breakfast (second morning)

(As usual, after exercise without breakfast,! headache on the right side, with occasional throbbing from exertion ; better after a sleep of a few hours, but renewed by exertion ; ceased in the evening when sitting, as at other times (ninth day); the semilateral headache returns (tenth day); continues, doubtless caused by the exciting news of the day (twelfth day))

Dull pain in the region of the occiput (fourteenth day),l

Dull, heavy pain in the region of the occiput (first night),l

On rising, dull pain in the occiput and slight tendency to throbbing, on the right side of the head ; previously at breakfast, transient slight cutting pressure on the left side (third day)

At 11 a.m. severe aching pain in the occipital region for a few minutes (fourth day)

* DuU aching in the occipital region, occasionally extending into the osfrontis (third night)

During the day dull aching in the occiput, increased by movement, especially on stooping; much worse towards evening (second day, after 6 drops)

Eyes p. 389

Objective. Dull eyes, in the forenoon (eleventh day)

Eyes transiently bloodshot (third day)

Strabismus, and constant inclination to squint (one case)

Eyes fixed, and inability to raise the eyelids (after five hours)

Eyes much inflamed and weak, with great flow of tears at intervals

Subjective. Dryness of the eyes

Heaviness of the eyes, as after night-watching

Pains deep in the left eye, extending from above downwards (first day); more violent (third day)

Burning of the eyes, as if they were too dry, in the forenoon (eleventh day)

Burning in the eyes, with weakness of sight and heaviness in the forehead (fifth day)

The eyes felt quite sore; it is as if some foreign body were irritating the conjunctiva, in the evening (third day)

The eyes quite sore at night; not much pain, but merely soreness, with sensitiveness to light and lachryIllation (third night)

liroiv an Orbit, Drawing over the eyes (four minutes after three drops)

Drawing over the right eye (eight minutes after five drops)

Pain in the orbits, sometimes excessive

Dull full feeling (attended with some aching) in the whole of the orbits

Bruised pain above and back of the orbits

Lids. *Drooping of the eyelids

* Eyelids partially closed and motionless

Eyelids half closed, with apparent inability to move them

* Eyes close in spite of him, on looking steadily at anything.

Difficulty in opening the eyes, or in keeping them open

Heaviness and congestion of the lids

* Great heaviness of the lids

Burning sensation around the inner canthus of the right eye

Eyelids are as it were puffed and swollen, and have also the appearance of being so

A stitch traversing the right eyelids vertically (fifteen minutes after first dose, first day)

Lachrymal Apparatus, Eyes suffused (after second dose, fifth day)

No spasmodic movements except the eyeballs, which kept up a continual twitching motion while the effects of the medicine lasted

Sharp stitches through the left eyeball, from within outward

Pliptlt Dilated pupils,Pupils dilated, but corresponding to the different degrees of light; afterwards widely dilated

Pupils dilated, not responding to the light, and could be touched without producing any contraction of the lids (after three hours)

Pupils expanded and insensible to light (after five hours)

Dilatation of the pupils, amaurosis, blindness, dimness of sight

Pupils moderately dilated,®®. Vision. Slight affection of sight, during the forenoon (eighth day)

Till 4 p.M. the disturbance of sight was great (seventh day)

Dimness of vision (part of Ss. 74 and 257)

* Dimness of sight and vertigo

Dimness of sight alleviated on profuse emission of watery urine

Distant objects seemed indistinct as I rode or walked, and one evening I could read but with difficulty (these symptoms are characteristic, as the sight is perfectly good, and I have never had anything the matter with my eyes)

Misty or glimmering appearance before the eyes

* Smoky appearance before the eyes, with pain above them (third day)

She complained of being partially blind, while eating a hearty dinner (after half an hour); this symptom rapidly increased, and in a short time she could scarcely see at all

Nearly blind; control over the upper eyelid was almost entirely lost,^'K

Blind

* Total blindness very soon after the dose, with violent dizziness (third day)

Became perfectly blind, eyes set, etc.,®

She could not see any one in the room, although persons stood close by the bed ; the eyes were wide open ; pupils dilated

* He said I cannot see you but his eyes were wide open, with dilated pupils (after ten minutes)

* Confusion of sight (one hour after first dose, third day)

Sight more or less confused all day (fifth day)

At 4 p.m. took a dessertspoonful of red wine; directly after, for the first time to-day, a return of the confusion of sight, lasting an hour only, but so extreme that some one must suspect inebriation (fourth day)

After the stool in the morning, a marked renewal of the confusion of sight, with heavy looking eyes; found this symptom much less when holding a finger vertically beyond the nose, also when either eye is closed (third day)

The confusion of sight much increased in the evening (sixth day)

Confusion of sight diminished, in the evening (third day)

Confused vision, especially of distant objects (following vertiginous sensations after breakfast) ; when turning the eyes the sight is tardy in following the movement, things for several seconds seem to be blurred, the eye remains unfixed in its new direction, yet no sensation of gauze or film it is accompanied with a disposition to partially close the eyes, as if to steady the eyeballs by the pressure of the orbicularis palpebrarum muscles ; the visual confusion might be compared to that produced by alcohol, and gradually wore off by night (second day)

* Objects appeared double; by degrees she grew completely blind

Things seem double on raising the head from a stooping position, or on looking sideways, but not when looking directly at them (one case)

Diplopia, which I could control by an effort of will

* Diplopia when inclining the head towards either side, but vision single when holding the head erect (in one case)

Ears p. 390

B,ush. of b[ood into the ears

* TAe pains which ascend from the back to the occiput often affect the ears

Heavy feeling in the ears (a quarter of an hour after third dose)

Digging in the right ear (part of S. 191,®.

Near noon, while sitting, a stitch in the external auditory meatus (eighth day)

Hearing. Sudden and temporary loss of hearing

Humming in the ears (after eighteen minutes)

Nose p. 391

Objective, Sneezing and dull headache, at 9.30 p.m. (sixth day)

Sneezing, followed by tingling and a sense of fulness of the nose, at 11.30 P.M. (first day)

Watery discharge from the nose (in a few cases)

Mucus accumulates in the nose and upper part of the trachea ; the mucus slips into the trachea while talking, which keeps up a hacking cough

Bloody mucus in the nose (eleventh day)

While sewing, lively action, as of a worm or a fish, in the region of the nose, at 6 p.m. (twelfth day)

Pain extending from the bridge of the nose to the eye (third day)

Tingling in the nares (eleventh day)

Face p. 391

Objective. Looked strange, staggered, and fell (after half an hour-)

Heavy besotted aj^appearance of the tacet

Countenance miserable, sunk, grayish-yellow, with dull dusky eyes (second day)

* Face flushed and hot to touch (after second dose, fifth day)

Yellow color of the face

Complexion yellow, also the eyes

Countenance of livid paleness

Face somewhat congested

The muscles of the face seem to contract, especially the orbicularis oris, somewhat impeding breathing

Subjective. Numbness of the face

Cheeks. Whenever she was roused from her sleepiness she felt burning in the zygomatic region and eyes (afternoon), (seventh day)

Burning at the left zygoma and in both eyes, more in the left one (fifth day), with red swelling of the zygoma, a little before 2 p.m. (sixth day)

Burning in the left zygoma, with swelling; and in both eyes, more in the left; later, also in the right zygoma, at 1 p.m. (seventh day)

Burning in the left zygoma, then in the right, drawing down to a gland at the anterior right side of the neck, where it swells, and pains as if an ulcer were forming, in the afternoon (eighth day),’.t

Lips. Pale lips, in the forenoon (eleventh day)

Lips dry and heated, at 11.30 p.m. (seventh day)

Chin. Lower jaw drooping; (after three hours)

Lower jaw drooping, leaving the mouth wide open

His lower jaw began wagging sideways; he had no control over it

Sensation of stiffness in the muscles of the jaw

Mouth p. 391

Teeth, Pain in the last back tooth on the right side up towards the temple (first day)

Stinging and burning in the left lower hollow back tooth (otherwise her teeth are good, of the ivory variety) through the lower jaw, as far as the left ear and left zygoma, at 6 p.m. ; relieved by Chamora. in watery solution (twelfth day)

Tongue Thickly coated tongue.

Tongue coated yellow (first day)

Light whitish coating on the tongue (seventh day)

* Yellowish white far on tongue (third day)

Yellowish-white coating of the tongue, with fetid breath

Tongue red, inflamed in the middle

Numbness of the tongue

I so lost the use of my tongue that I was unable to utter an intelligible expression, and my tongue felt like some foreign body clogging my mouth

* His tongue, to use his own expression, was so thick he could hardly speak

His tongue felt very thick; he could not articulate

Burning upon the tongue immediately, which after a few minutes went over the wdiole mouth and throat, feeling hot like an oven, and thence through the oesophagus into the stomach and abdomen, when the same burning pain passed around in all the intestines; simultaneously with the descent of the burning pain into the oesophagus, burning in the chest came on, followed soon by a stitch in the anterior left lower side of the chest, going through the chest into the left shoulder-blade, and accompanied by_weakness and a fluttering and beating of the heart, irregular as to quantity and quality; these symptoms lasted about three hours (first day),h

Peculiar sense of constriction at base of tongue (twenty minutes after third dose)

IMLoutll, Clammy, feverish feeling and taste

Astringent sensation in the mouth

Dryness of the raouth,^h

Slight dryness in the mouth and throat, with disposition to swallow frequently ; the dryness is lice that produced by eating salt bacon, but no bacon has l>een eaten to-day

Sdlivci. Several times during the day he found the saliva colored yellowish, as if by blood (seventh day)

During the fits, sanguineous brown mucus ran out of her mouth

Taste. Mawkish taste in the mouth

All the latter part of the day, bad, foul, spoiled taste and breath, with a frequent need to rinse the mouth or spit (seventh day)

Bitter taste

Slimy, disagreeable, bitter taste in the mouth

Speech somewhat affected

After the return of consciousness, intelligible speech was at first only possible when the jaws were supported. The tongue was stiff and the voice thick and guttural

Ineffectual efforts to articulate

Inability to speak or move,®h

Throat p. 392

Hawking up of bloody matter

The burning at times seemed intolerable, and swallowing was painful

Sore feeling during deglutition, about the root of the tongue and larynx, with accumulation of mucus in the upper part of the trachea, causing frequent clearing of the throat

Dryness and burning in the throat

Fauces and CEsojihagus. Painful dryness of the fauces

While sitting at studies, a rising of tasteless semi-solid matters in the oesophagus, with flatus and a sense of something lodged therein, slightly painful, at 12.30 (one hour after 9 drops, fifth night)

Violent burning in the gullet from the mouth quite down to the stomach

Spasmodic sensations and cramplike pains in the gullet

Tried to swallow but could not

* Owing to paralysis of the muscles of the throat the patient could not swallow when the physician was called

External Throat. *Pains in the neck, which confine themselves to the upper part of the sterno-cleido-mastoideus directly back of the parotid glands (first day),h

Stomach p. 392

Appetite. Great hunger (one case)

After a moderate meal, experienced a sudden satiety (ninth day)

Want of appetite, in the afternoon (seventh day),h

Alternate increase and loss of appetite

Thirst. Thirst during the sweat

Eructation and Hiccough. Eructations

Eructations of wind and bland fluid, at 11.30 p.m. (first day)

Sour eructations

Hiccough

Heartburn. At noon, slight heartburn and pain at the cardia, whilst riding (first day)

nausea and Vomiting. Nausea

Nausea and vomiting

Slight nausea

Considerable nausea (after three-quarters of an hour)

More or less nausea, with headache

Stomach, Feeling of emptiness and weakness of the stomach and bowels

A sensation as of something wanting in the epigastric region (third day)

Rumbling and dull pains in the epigastrium, relieved by expulsion of flatus

Pain in the stomach, extending from the pyloric end of it to the axilla and under the scapula, and down the right arm to the external side of the forearm, it terminates about a hand’s breath from the elbow; this passed off after taking biscuit and coffee

Pain in the stomach, nausea, and dimness of vision (after two hours) ; these symptoms were soon succeeded by ineffectual efforts to vomit, great restlessness, and free perspiration over the body

Gastralgia and colic, coincident with the intoxicated feeling, in the afternoon (fourth day)

Cardialgia, when driving, at 11 a.m. (fifth day)

Continued cardialgia, and eructations, when sitting in the evening (sixth day)

Burning in the stomach and abdomen (part of S. 211),h

Seized with violent cramplike pains in the epigastrium, causing an involuntary cry, lasting but a moment, and then subsiding, leaving a constricted sensation for one hour (three hours and half after first dose) ; followed by a sensation of heat and burning in the stomach (third day)

Gastric oppression ; had to loosen the waistband, after which colicky sensation to the left of the navel, as if a stool would shortly follow, at breakfast (second morning)

Abdomen p. 393

Hypochondria

Slight pains in the left hypochondriac region (third day)

Frequent sharp drawing pain through the left hypochondriac region

Pulsative pains in left hypochondrium, continuing for one hour, at 3.30 p.m. (fourth day)

Tlnibilical. Rumbling in the region of the umbilicus

Dull aching in the umbilical region, which lasted till I got up (seventh morning)

Sharp stitches around the umbilicus

Colicky pains below the navel, extending down to the testes, caused by flatus, and relieved by its expulsion, in the evening (fourth day)

Two little painful spots on the right side of the umbilicus, extending down into the bowels; the pain is increased by pressure

General Abdomen, Rumbling and rattling in the abdomen, with emission of flatus above and below (first day)

Evacuation of flatus both ways, frequently (first day)

Palpitation of the abdominal muscles about three minutes (tenth day)

Weak nauseated feeling in the bowels

Heaviness, and feeling of weight in the bowels

Pain in the^bowels towards morning (third night),®.-^light pain in the transverse colon, with yellow color of the skin of the face (one case)

Burning in the abdomen, the pain going round in the intestines, towards 12 oclock (second day)

Slight griping pains through the abdomen, mostly in the umbilical region, after supper

Dull pains in the abdomen

Dull pain in the bowels, which became very severe towards morning (first night)

Sharp pains in the bowels, with stools of a light creamy color and pappy consistence

Sleep disturbed by lancinating pain in the abdomen, relieved by copious discharge of flatus

Colic, in the evening (ninth day)

Slight colicky feeling as if the bowels would be moved, at 11.30 p.m. (first day)

Tenderness of the abdominal parietes

Gnawing pain in the region of the transverse colon, all the afternoon

Movement of flatus in the lower bowels, at 11.30 p.m. (first day)

Hypogastrium and Iliac Region, After experiencing chills, headache, feverish and prolonged sweating, seventeen hours after taking the drug, awakened by severe moving pains in the lower abdomen, soon followed by a very large but natural stool, without relief of the pains, and soon after a deeply bilious discharge, with instant relief of the pain; nine hours afterwards another bilious evacuation without pain (one case)

One of the right inguinal glands became swollen and tender to touch

Pain in the left iliac region (first day)

Slight pain in the left iliac region (two cases)

Rectum and Anus p. 393

The piles returned with raw, smarting pain

Exciting new's caused, apparently, urging to stool; stool papescent, of darkyellow color (sixth day)

Stool p. 393

Diarrhoea, Bowels loose, but great difficulty in discharging anything; there seems to be great strength in the sphincter muscles (first day),h

After breakfast a good stool; after supper a second stool, consistent (third day)

Bilious stools (twelfth day)

At 9.30 A.M., a soft bilious stool, preceded by threatenings of diarrhoea ; the latter renewed at noon by exciting news, and afterwards when walking (seventh and eighth days),®. Deep yellow, soft stool, after breakfast (tenth day)

A stool, at first consistent, then papescent, bilious, homogeneous, a few minutes past 10 A.M., preceded all the morning by flatulence (fourth day)

Decolored, semi-solid stool (eleventh day)

Stool of deep yellow color (papescent), after breakfast (fifth day)

After breakfast, a tea-colored stool, more consistent (ninth day)

Constipation. At 11 A.M., having put off the usual defecation, had a slow stool, leaving a sensation of more remaining to be passed, and abdominal repletion (second day)

Insufficient stool, at 10 A.M. (first day)

Attempted to pass a stool, but much wind only passed, in the evening (ninth day)

Relief of constipation (several cases)

Urinary Organs p. 394

Tlrethra. Painless redness about the orifice of the urethra (eighth day)

Agreeable sensation during micturition throughout the course of the urethra

feeling as if something remained behind when urinating; the stream stops and commences again.

3IictU7‘itiort. Frequent micturition ; wants to urinate every half hour

* Frequent emission of clear limpid urine, with seeming relief to the dulness and heaviness of the head

* Urine increased in quantity, clear and watery

-Urine much increased in quantity (first night),‘k

In nearly every instance the profuse emission of watery urine was accompanied by transient chilliness, tremulousness, and an evident alleviation of the sensations of heaviness of the head, dulness of mind, and dimness of sight (several, who made partial provings for me, noticed the same symptoms, with the alleviations)

JJrhie. Urine at times clear and limpid; at times milky and turbid

Sexual Organs p. 394

3TciJe. In connection with the general prostration, accompanied by diuresis, there was always much flaccidity, with coldness of the genital organs

Irritation of small spots on the raucous surface of the prepuce, with surrounding congestion (third night)

In the afternoon and evening some irritability of the right testis, afterwards dragging pain in the same, extending into both groins and the hypogastrium, followed by discharge of flatus aud relief of the pain (first day)

Emission of semen without erection (twelfth night)

Female, Severe, sharp labor-like pains in the uterine region, extending to the back and hips (part of S. 74)

A discharge of blood per vagina; came on about 4 P.M., after the symptoms had subsided, lasting one hour (second day) ; after (1 p.m. (third day)

Respiratory Organs p. 394

Larynx and Trachea. Paralysis of the glottis, with difficulty of swallowing

When eating, the food drops into the trachea, causing strangling

Burning in the larynx and down into the chest under the sternum

Voice Voice seems weak,K

Voice thick, as if the tongue were too large

Paroxysms of hoarseness, with dryness of the throat

and Expectoration. Cough, from tickling, and dry roughness of the fauces

Cough, hacking, with a feeling as if a drop of liquid had entered the windpipe, with frequent clearing of the throat

Inability to expectorate

Breathing slow, sighing, and at times sobbing

Breathing slow and superficial, with now and theli a deep inhalation

Slow breathing, with rapid pulse (primary),'®._ Breathing unnaturally slow/®.

Peculiar slowness of respiration, seven to the minute (fifty-five minutes after third dose),®h

Respirations somewhat diminished in number; afterwards breathing spasmodic

Respiration almost imperceptible

Irregular breathing and slow respiration (part of S. 510)

Sighing respiration

Respirations of a sighing, catching character

Respiration gasping, three or four per minute (after three hours)

Breathing stertorous, and very imperfect

Fetid breath

Offensive breath, slow breathing, and slow pulse (primary), followed by rapid breathing and quick, weak pulse (secondary)

Heavy breathing (in the morn-

(eighth day); (in the afternoon), (seventh day)

Heavy and labored respirations

Sudden sensation of suffocation, as in hysteria

He complained of choking (after half an hour), and soon rose struggling for breath, pushing his fingers into his throat, as if trying to tear it open

Chest p. 395

Great weakness in the chest on speaking (second day)

Heaviness upon the chest in the afternoon (seventh day)

Burning in the chest (part of S. 211)

Burning in the chest, with fulness, sighing, and anxiousness, going into the pit of the stomach, and radiating all over the whole abdomen like a tree, the stem of which is in the pit of the stomach, and the branches of which burn asunder towards the abdomen ; this burning is different in kind from the one observed on the first day; it is, to her feel, not in the intestines, but in the parts covering them; at 12 M. (fifth day)

Constrictive pain round the lower part of the chest

Short paroxysmal pain in the superior part of the right lung on taking a long breath ; it sticks from above downward ; this pain is one of the prominent symptoms (first day)

Stitches in the chest

A sensation of soreness in the chest when coughing

Pain behind the fifth rib to the left of the sternum, from flatus, relieved by eructation (third night)

Burning under the lower part of the sternum, with heaviness of the chest, drawing towards the place of the stitch in the left lower anterior side of the chest, which also now is repeated, and pain like ulceration, tender to touch; as soon as the burning went over to the left side, the chest felt easier; in the afternoon (eighth day)

Burning like fire at the very spot where she lately had the stitch in the left lower anterior side of the chest, as large as a dollar, and painful to the touch, like an ulcer, and from the pressure of even a loose dress, with fulness, at 8 A.m., lasting five minutes, and repeated four times (fifth day)

Cramp in the dight side of the region of the last short ribs

A dull, full aching, extending from the ensiform cartilage along under the free ends of the right short ribs to the lumbar region, as if the liver were congested; the worst pain is about a hand’s breadth from the lower end of the sternum

At 2 p.m., when lying down, pain under the floating ribs of the left side, suddenly, as if thrust with a sharp instrument; in an instant the pain disappeared, but appeared as suddenly in the left temple, causing an involuntary contraction of the brow (fourth day)

Stitch in the anterior lower left side of the chest in the afternoon (tenth day)

Stinging in the left lower anterior side of the chest through to the left shoulder-blade, and irregular beating of the heart on sitting quiet, and worse than yesterday (third day)

Stinging through the left lower side of the chest into the left shoulder-blade, also more severe than yesterday; at the same time irregular beating of the heart, with dyspnoea, worse than yesterday (second day)

3mamma Shuddering pain in the right breast

Periodical pains in the pectoral muscles (third day)

Heart and Pulse p. 395

Prceeor dhirn. Stitching sensation in the region of the heart,®

Shocks at the heart, with heavy breathing, at 12 M. (tenth day)

At every exertion, shocks at the heart, throbbing of the pulse through the whole body, tremulousness, weakness, and sweat, in the forenoon (eleventh day)

Ilecivt’s Action}%, ^Irregular beating of the heart from 12 M. till 5 p.m. (eighth day),’. Beating of the heart irregular as to quantity and quality (pai’t of S. 211, 367),’.-| Irregular heating of the heart, less violent than before (during the shaking, trembling of the body), in the afternoon (fifth Palpitation of the heart in the afternoon (eighth day)

Pulse» Pulse continued accelerated (after second dose, third day),h

Pulse rapid and feeble (after three hours),^®. Pulse very rapid, small, and weak

All the afternoon pulse very small and quick

Directly after the reaction has followed the chill, the pulse rises as far above the normal state as it has been previously below it On the 12th of November, at S p.m., six drops were taken, at 9.30 six drops more, and at 10 oclock ten drops; the results, which were as follows, are also indicated on the chart. Not being perfectly well, there existed either a recoil or dicrotic wave in the preliminary tracing, which in thirty minutes seemed rather to become more prominent, and, but for the records that follow, might be at once set down as a true dicrotous wave, as at this time there will also be seen diminution of compressibility, as shown by diminished amplitude under the same pressure; the prominence of the waves, whatever its explanation, must be ascribed to a morbid condition, viz., that produced by the influence of the poison administered ; the pulse at this interval has reached a minimum as to frequency, and in ten minutes more shows slight impairment of rhythm; the new dose of ten drops exhibits its first influence in the tracings in thirty minutes, by increased arterial tension and nervous stimulation, followed however in five minutes by diminution of both, and great decrease in frequency; from this time on to the end of an hour the tension in the arterial system slowly increased, although the frequency remained nearly the same, and after one hour and a half the appearance of some obstruction, as shown in the flattening of the conjoined apices of the first and second events, was manifest, and irregularity of impulse aud of rhythm exhibited the effects of the poison upon the heart. The simple deduction from this investigation, apart from what is ahead known of the remedy, lies in this, that while reducing the frequency of the pulse, it does so with an increase of arterial tension, and after awhile impairment of the heart’s action, indicating a toxic influence upon the nervous system,®h

Some depression of the pulse

Pulse very uniformly depressed, and rendered less frequent by 10 to 20 beats per minute, within the last five or ten minutes, if the subject remains quiet, but subject to great variations from exercise; in one case the pulse increased from 60 to 70 in the first five minutes, but in the next trial it was diminished 10 beats in five minutes

Within a few minutes, sometimes within two or three, a marked depression of the pulse, which becomes 10, 15, or 20 beats less in a minute if quiet; greatly disturbed by movement

Within a few minutes (sometimes two or three) a marked depression of the pulse is observed, with a diminution of 10, 15, or 20 beats per minute, but this only in a state of rest; when moving it is variable

Pulse slow and full, or slow and soft

Pulse slow and weak

Pulse 100, regular, but weak

Pulse, when sitting, 76 at 11 a.m. (third day)/.

Pulse 72 in the evening (sixth day)

Pulse 65 in the forenoon (eleventh day)

After writing awhile, pulse 64 to 68 at 11.30 p.m. (seventh day)

On lying down, pulse 54 to 60; when sitting up, 64 to 68, in the afternoon ; when sitting, 72, and always full aud strong, as usual, in the evening (third

(Tracings 204-209 inclusive.) day)

Pulse 53, small and weak, at 12.30 p.m. (fifth day),k

Irregular pulse in the afternoon (tenth day)

Pulse feeble, irregular, and sometimes intermittent (after five hours)

Pulse 58, weak, wiry, unequal; when the first stroke is stronger than the preceding one, the second one is scarcely perceptible, or vanishing altogether; irregular double action of the heart, as described above, with intermittent pulse, shaking of the heart, so that she feels it as far as the neck, at 12 m. (ninth day)

Pulse 60, hardish, intermittent, after about 10 beats; during the intermission of the pulse, two quicker double strokes of the heart are observed by auscultation, changing in rhythm, but not in time, at 12 M. (eighth day)

Fluttering pulse

Pulse full, 120,’®.

Pulse regular and full

Weak pulse

Pulse small aud feeble; afterwards, almost imperceptible

Pulse soon becomes very feeble in many cases; sometimes scarcely perceptible, with chilliness, cold feet, heat and pain of head, etc.,®.

Pulse frequent^thy soft, weak, so feeble as to be sometimes imperceptible

Neck and Back p. 397

Neck. Rheumatic pain in the left side of the neck, on lying down, soon passing off (one hour after 15 drops, sixth day)

Aching and soreness of the muscles of the neck and shoulders continued for four days (after eight days)

Aching on the left anterior part of the trapezius muscle (in the neck), when leaving a warm room (eighth day)

Contractive sensation in the right side of the neck, at 5 P.M. (seventh day)

Sack, Feeling of weakness in the back and limbs, with sleepiness

Pain in the back, as in the cold stage of ague (many cases)

Dovsal. After breakfast, sharp shooting pain from the right shoulder to the dorsal vertebrae (seventh day)

Soreness of the trapezius muscles on moving (eighth day)

lAimhav. Dull pain in the lower lumbar and sacral region (tenth day)

Aching in the loins (eighth day)

Sacral. Dull pain in the sacral and lower lumbar region (first night)

At supper-time, going into a warm room, aching in sacro-iliac and lumbar regions and lower part of left thigh, with languor and thirst, as when a fever is commencing; felt the pains more when eating (ninth day)

Dull aching pain in the sacral and lumbar regions, which came on about 3 A.M. (third day)

Extremities in General p. 397

Trembling in all the limbs; in the afternoon (eighth day)

Trembling in the limbs, with chill, at 1.30 P.M., followed by violent stinging in left mamma, from inside outwards, along the lactiferous ducts, especially in one spot, in the sternal half of the breast (second day),’.f

I gradually lost the control of my limbs, so that I could not direct their movements with precision

Weakness of the limbs towards 12 oclock (second day)

Heaviness in all her limbs (after four hours and a half)

A sensation as if a galvanic current were passing down the forearms and hands; the same also in the feet; while sitting (after one hour, fifth day)

Awakened by pains in the limbs, at 4 a.m. (seventh day),I

During the night pains in the extremities, worse after midnight, abating during the day (ninth night) During the night pains of the limbs as usual, especially forearms and calves; also in the elbow and knee-joints, all similar to the previous, only less severe (eleventh day) Pains in left elbow, wrist, and knee, and in both ankles (after second dose, third day),h

Slight pain in the muscles of the extremities (thirteenth night)

Awoke about 3 or 4 a.m., with severe pains in both the upper extremities, which seem to be seated deep in the muscles; also severe in the left arm and forearm, and in both the calves (fifth morning) Deepseated pains in the muscles of the extremities, relieved by movement (seventh morning)

Rheumatic pains in the extremities (sixth day)

Rheumatic pains in the bones and joints of the extremities and back (third night) Burning, running through all the limbs, with burning in the first joint of the left index finger, as if the blood would come out, in the afternoon (eighth day),hf

Dull pain in the humeral region, and also in the lower extremities, which seems to be in the bones or deep in the muscles, at 10 A'.m. (second day)

Dull aching pain (deep-seated), both in the upper and lower extremities, and joints generally (third day)

Pulsative pains in the left hand and joints of the fingers, and at the same time in the right foot, more severe in the ball of the great toe, continuing for two hours; when lying down (after five hours, fifth day),h

Superior Extremities p. 398

Arm. Spasmodic pains extending from the inner condyle of the right arm to the axilla (third day)

Dull pains in the muscles of the right arm and shoulder, and some of the time in the left arm and lower extremities (twelfth day)

Elboiv. After writing for a few minutes, crampy pain in the bend of the right elbow while walking (ninth day)

At 7.30 p.m., violent aching in the left elbow (thirteenth day)

At 3 p.m., in a draughty church, felt a drawing and aching about the left elbow, for a quarter of an hour (fourth day)

Sensation as if a galvanic current were passing through the forearms, at 6 p.m., continuing for half an hour (eighth day),h

Pain in the flexor muscles of the right forearm (first day),h

At 9 p.m., pain in the right wrist of a dull kind, with great weakness of the same (fourteenth day); the pain less severe, but still it is still quite weak (fifteenth day)

At 6 p.m., sharp pain in the right wrist (thirteenth day)

The flexor muscles of the hands and arms were paralyzed, while the extensors were nearly so

Sensation in hands and arms blunted, but not in proportion to the loss of motion

Drawing stitches in the dorsum of the right hand, running down into the middle and ring fingers

Pain in the little and fourth fingers (first day),h

Early in the morning sharp shooting pains in the joint of the last phalanx of the right thumb (twelfth day)

Inferior Extremities p. 398

Objective. Staggering like one intoxicated

Gait staggering and very infirm (one hour after first dose, third day),h

* He tried to walk, hut staggered as if drunk

He staggered, reeling from one room to another, as in intoxication (after half an hour),®®._ *Fatigue of the lower limbs, after slight exercise

During and after a walk, it seems as if the limbs could not be moved another step

Loss of voluntary motion of the lower extremities

Subjective. Pain in the lower limbs (very common)

Paroxysmal pain in the left lower extremities (first day)

Dull pain in the lower extremities,I

During the headache excessive drawing, contracting, and crampy pains in the lower extremities, extending from the thighs to the toes; the pains appear to proceed from the bones as well as the muscles

Mip, Pain in the left hip, only in the joint; it at times extends to the outside of the thigh ; it is a sharp drawing pain, much worse on movement (first day),h

Thigh. Transient crampy pain in the inner part of the thigh when walking (sixth day)

At 7 p.m., dull pain in the left thigh and under the left scapula (thirteenth day)

Aching of the left rectus femoris muscle and drawing in the right calf, at 11.30 p.m. (first day)

Drawing pain in the lower third of the left thigh (part of S. 559)

Drawing pain in the left hamstring, extending across the joint to the origin of the gastrocnemius

Sharp stitches of pain, as of drawing or cramping of single fasciculi of muscle, about the origin of the gluteus maximus, on the left side; the stitches run in the direction of the hip-joint

Continual jerking from the right sartorius muscle about the middle of the thigh

Slight jerking about the middle of the rectus muscle of the right thigh

Slight jerking in the vastus externus muscle of the right thigh near the knee

Knee. When walking, a feeling in the knee-joint as if the relation of the bones were deranged, and they did not fit, as in a partial luxation (seventh day)

Pain under the right knee when walking

Rheumatic pains in the right knee on walking, soon passing off (one hour after 15 drops, sixth day)

Sudden catch or twist on the inside of the patella, when sitting down to breakfast (eleventh day)

When the pains are felt above the knee, they are not felt below, and vice versa

Leg. A slight, sharp crampy pain in the left gastrocnemius, about the largest part of the muscle

Excessive drawing and contracting pains in the gastrocnemius muscle of the left leg, which do not go off in a sitting posture as all the other pains in the limbs; no position relieves it

At 3 p.m. sharp shooting pain in the right calf (thirteenth day)

Violent shooting pain in the leg in paroxysms, every one is more violent, midway between the knee and ankle (first day),k

Soreness of the gastrocnemii muscles, as if they had been beaten

A nile. Pain in the left ankle, with spasmodic contraction of the toes and drawing pains in them (first day)

Foot. Excessive crampy pains in the whole of the right foot

Cramp in the instep of the right foot

Generalities p. 399

Objective. He was lying on the left side

Tremulousness (accompanying profuse urination')

* Trembling and weakness in the afternoon (seventh day)

Trembling, with chill in the whole body, at noon (third day)

Shaking, trembling in the whole body, and whimpering (tingling) in the legs, as if asleep, in the afternoon (fifth day)

* Muscles relaxed (after three hours)

Complete relaxation of the whole muscular system, with entire motor paralysis

Mental and bodily inactivity during the afternoon (ninth day)

Listless and languid ®®.

At 10 a.m. I went to the Penn Hospital, where I saw a number of severe wounds; I am not usually affected much by the sight of wounds, but to-day, that or something else caused very unpleasant sensations ; I became very weak, and my friend remarked that I was very pale, accompanied with nausea and trembling of the lower extremities; these continued some ten minutes, but disappeared in the open air (sixth day)

When reclining, some languor and drowsiness (just before a heavy shower), (third day)

Languor and drowsiness on reclining for the purpose of study; slept an hour, and when aroused felt at first unwilling to move; less languor after stirring around awhile, in the afternoon (third day)

* Greatlassiiude

* General fatigue (eighth day)/.

* Easily fatigued, especially the lower limbs

* Became tired and greatly exhausted very easily

Weakness at 12.30 p.m. (fifth clay)/.

Weakness and a fluttering (part of S. 211)/.

* Weakness and trembling through the whole system/.

* Weak and dizzy (second morning)/k

Very weak, as after severe sickness, in the afternoon (eleventh day)

Great feebleness

Great prostration and muscular weakness, particularly of the elevators of the lower jaw and eyelids, and the muscles of the arra

Great prostration, with irregular breathing and slow respiration (after five hours)

Complete prostration of the system, with emaciation

Complete loss of muscular power; was unable to move the limbs or even to raise his eyelids, although he could hear and was cognizant of all transpiring around him

Paralytic symptoms made themselves manifest through the muscular system, first experienced in the knee, and then in the inferior tibial region, increasing unto falling

General restlessness, with chill after breakfast (fifth day)

Great restlessness (part of S. 257)

Subjective, General vigorous feeling at 8 a.m. (third day)

Sensation as though the blood had ceased to circulate

Feeling of lightness of the body and sense of instability of the whole system

Feeling of relaxation of the whole body, especially of the hands and feet, with indisposition to move

Inclination to lie down (after three-quarters of an hour)

Languid feeling of the whole body, especially of the hands and feet

Feeling of danger of stumbling or falling

One feels as though he had had a fit of sickness

General feeling of illness, as in fever

Running in all “nerves especially in the fingers, and a sensation of jumping, as from ant-bites, in the finger-ends; on looking at them, she found the nail blue halfway up from the root, at noon (third day)

Feels as if she had risen from a severe sick-bed in the forenoon (eleventh day)

Dull pains of a shifting character all day (thirteenth day),l

Erratic pains of a rheumatic character (seventh day),k

Fugitive or fixed pains here and there

Drawing and aching pains, which seem to come from the bones

In my own provings, I have frequently experienced a succession of acute, sudden, darting pains, evidently running along the single nerve branches in almost every part of the body and limbs, sometimes so sudden and acute as to make me start; at one time, a quick succession of these acute sudden pains coursed down the outside and front of the tibia for over half an hour, leaving a line of considerable tenderness marking its track

The effects were dissipated within a few hours

Skin p. 400

Objective. Yellowness of the skin in the forenoon (eleventh day)

Pale yellow color of the face and of the whole body in the afternoon (eighth day)

Eruptions. Gelsemium produces a peculiar and very marked eruption in most of the provers; it appears most on the face, less frequently and less conspicuously on the back between the shoulders, etc.; it is papulous, very much the color of the eruption of measles, which it considerably resembles, but the papulm are larger, more distant and distinct ; although very conspicuous, they are attended with little or no sensation, the subject being unaware of their existence until he happens to see himself; persons have frequently been asked what was the matter, if they had the measles, etc., when they were not aware of the eruption; this generally appears on the second or third day of the proving, and would seem to be more constantly produced by the 2d or 3d dilution than by the tincture; the eruption continues one or two weeks, or longer

Erythema of the face and neck

Papulous eruption on the face, very nearly resembling measles/l

A sore pimple on the left side of the neck at 8 a.m. ; the pimple is sore, and has an areola embracing the diameter of a pea quite red and inflamed (such an eruption not experienced at any other time), (sixth day). Two more pimples, one at the right corner of the os hyoides, the other at the left anterior temporal ridge, above the brow (eighth day). Another pimple, sore to touch, on the left side of the larynx; the first one less sore, like a small cutaneous induration; these are like minute furunculi; thus far no suppuration (ninth day). The first pimple sorest, the others less so (tenth day)

Eruption of vesico-pustules, painless, but having no other analogy to measles, appeared on the inside of tlughs

Subjective. Sudden stinging in the skin over the whole body, as if an eruption would break out, with greenish-yellow color of the skin, then burning, then itching, with profuse sweat, at 4 p m. (eleventh day),kt

Itching about the elbows and forearms at 11.30 p.m. (first day)

Intense but transient itching of small points in the face and at the edge of the hair, on the forehead, right side, and elsewhere on the scalp, at 11.30 P.M. (first day)

Sleep and Dreams p. 401

Slccpincsst Disposition to yawn; a sort of stupor; cannot keep the eyes open ; is obliged to lie down and sleep

Drowsiness in the forenoon

Drowsiness, with dimness of vision; a kind of drunken stupor

At first it seemed to cause drowsiness, afterwards aggravated the habitual sleeplessness

Slightly drowsy (half an hour after first dose) ; increasing (forty minutes after third dose),®k

Sleepiness, like a lethargy, came on after 2 p.m., lasting all the afternoon and evening (seventh day)

Sleepiness and long and sound sleep are very general symptoms

Inclined to sleep, with deep respiration and numbness of the whole body,^k

Early sleep after supper (seventh day)

Sound sleep until 7 a.m.; difficult, weary waking (second morning)

Sleeplessness. Sleeplessness the whole night (sixth night)

Wakeful till 1 in the morning, with desire to study; sound sleep the last half of the night and weary waking (third night)

Very little inclination to go to sleep, and when it does come on, he dreams much about business, etc.,®.

* Very restless flight (Qrst night)

* Very restless during the night, especially towards morning (forty-third night)

* Had a very restless night, with unpleasant dreams after midnight (first night)

Could not get asleep for a long time ; on falling asleep, a sort of nightmare awoke me again, so that no sleep came; at last it was like falling asleep, when a second time a kind of nightmare came on, never experienced before; it was as if the whole left side from the neck along the chest, trunk, and thigh, as far as the knee, were a kind of soft muscle, spasmodically jerking up and down, somewhat with the elasticity of a mass of jelly ; this motion extended deep into the interior of the chest, and the centre of this motion seemed to be in the region of the heart; it was, indeed, one great motion which concerned the whole left side as a mass, with the exception of the head and foot; this whole half of the body seemed to me to be going up and down, while the right side of the back, on which I lay, was quiet; I wondered in my mind at this turmoil going on in my body, but was unable to stir; when I woke up from this condition, I was well aware of what had happened, and found myself quietly lying on the same spot where I had fallen asleep, and the pulse, with everything else, was quiet; I certainly had not moved, and all, then, was my imagination ; I only felt a drawing pain in the lower uiirdot my left thigh, which was repeated the next day,®. DreOb'l^tS, Diearay sleep and early waking (ninth night),®. Dreams of working and ot many people (first, second, and third nights),’. Many dreams of hard work (seventh night)

During the night, much annoyed with unpleasant dreams (first night, after 6 drops)

Fever p. 402

Chilliness. Cold on the surface

Surface cold and congested

Chilliness, especially along the spine,Transient chilliness (accompanying profuse urination).

Little chilliness, then some heat, then cold sweat, but less than before, all without thirst, between 2 and 4 p.m. (sixth day)

Febrile chilliness, with cold extremities and heat of the head and face, with headache, an early symptom in most cases,®. Chilly sensations over the entire body

Very chilly at 9 p.m. (sixth day)

Feels veiy chilly all day, especially in the morning (second day), . Chill (part of S. 490)

Chill after breakfast (fifth day)

Chill, then cold sweat more than yesterday, but not as much as before, in th® afternoon, lasting till 5 p.m. (seventh day)

Chill, then weakness like fainting, then profuse cold sweat, after 2 p.m. (tenth day)

A tremor and a chill, which all of a sudden and urgently forced out a general cold sweat, so that the drops were seen standing on the arms quite densely (after four hours and a half)

Slight chills during the day (fourth day)

“ Every symptom of ague ; would have thought he had the ague

Feels aguish, with pain in and between the bones of the calf of the left leg; not able to go downstairs without holding to something

Chilliness and chills running up the back from the loins to the nape of the neck

Whilst reading exciting news, a transient chilliness on the upper half of the body, especially in the back and nape of the neck, at 3 p.m. (fifth day)

Extremities cold; (after five hours)

Coldness of the extremities, especially the feet, often severe

Extremities rather cold (after three hours)

Feet and hands cold

Feet feel as if in cold water; this symptom occurs at an early stage, and is generally accompanied with heat of the head and face, and headache

Meat. After one to several hours chilliness subsides, general heat supervenes, mostly about the head and face, with full pulse, from 80 to 100,®.

Directly after the chill comes a flying heat and pricking in the skin, rapidly followed by perspiration, which at times is profuse, and lasting even from twelve to twenty-four hours

Warmth over the whole body, as if sweat would break out, then chilly down the back, in the afternoon (fifth day)

Feverish, in the forenoon (eleventh day)

Some heat and dryness of the hands, at 10 a.m. (third day)

Hands, especially the palms, hot and dry, in the afternoon (third day)

Feverish heat in the face (eighth day)

While usually in sickness she has cold feet, they are now constantly warm, in the afternoon (eighth day)

Sweat. Skin moist (after three hours)

In most cases perspiration follows the febrile reaction, and continues from a few minutes to several hours

Walking or other movement easily induced perspiration (first day)

Free perspiration over the body (part of S. 257)

Perspiration sometimes profuse, and continuing from a few hours to twenty-four, with languor and prostration

Much sweat, with external coldness of the whole body, in the afternoon (eighth day)

A little cold sweat, chill, with hot running in the legs and burning of the soles of the feet like fire, without thirst, at 3 p.m. (fifth day)

During the stinging in the left breast, and after the chilly tremor, a profuse cold sweat broke out, more profuse than yesterday (second day)

A profuse cold sweat broke out suddenly (after the pain in the forehead), so that she was wet all over, still Averse than the day before, and lasting until 6 p.m. (third day)

Skin dry (after five hours)

Palms dry and heated, at 11.30 p.m. (seventh day)

Conditions p. 403

AggTSiva,Uon.

(3Jor7ung'), After breakfast, vertiginous sensation ; chilliness.

(Forenoon), Feverish.

(Afternoon), Heaviness of head; chilliness; general warmth, etc.

(Evening), Aching in head; confusion of sight; Avhen sitting, cardialgia.

(After midnight), AW symptoms; towards morning, pain in bowels; pains in extremities; towards morning, restlessness; unpleasant dreams.

(Cool aiV), Aching in trapezius muscle.

(Eating), Aching in sacro-iliac regions, etc.

(Eating and drinking). Especially warm things, the sufferings.

(Lying doxvn). Pain in left side of neck; pains in hand, etc.

(Movement), Especially in going upstairs, tendency to headache; aching in occiput; pain in hip.

(Sudden movement of head), Lightheadedness, etc.

(Nfffiap'), Sensation in forearms, etc.

(When sitting doivn). Catch on patella.

(After sleep), Headache over front and top ot head.

(Smoking), Head symptoms.

(Stooping), Stitches in middle of forehead; aching in occiput.

(Turning head), Stitches, m forehead.

(Turning eyes). Stitches in forehead.

(Walking), AW symptoms; lightheadedness, etc.; pain in thigh; pain under knee.

(Warmth of bed). All pains.

( While writing). Headache on top of head, etc.

(After writing). While walking, pain in bend of elbow.

Amelioration p. 403

(Closing one eye). Confusion of sight.

(Holding finger before nose). Confusion of sight.

(Movement), Pains in muscles of extremities ; languor.

(Pressure), Sensation in sinciput.

(Reclining head and shoulders on high cushion while sitting). Headache.

(Shaking head). Aching in head.

(Niffin^), Headache ; pains in limbs.

(Profuse urination), Dulness of mind; headache; heaviness of head ; dimness of sight.

Footnotes p. 389

† During the night sat up a long time with a patient; slept for five hours on hard chairs, and rode home before breakfast.

† This symptom attended a tardy convalescence from a fever (not treated by Gelsemium, except the first day) last year, continuing a week ; relieved by Nux vom.^ in part, and finally cured by Acon.®.

† At this very spot she had twenty-two jears ago a glandular abscess, which opened internally.

† When seventeen years of age she had a sore breast, with ulceration, pain on touch ; this was the result of a cancerous tumor from a contusion by a cow’s horn, and drawn out by an application of a black paste of a veterinary surgeon, Dr. Lang ; the breast got well, though it became smaller in size than the right; she afterwards nursed her six children and never bad any trouble in it; yet there was not so much milk in it and the children did not like it as well as the right; twice during pregnancy she had stinging in the place mentioned, after taking cold, but without further consequence; also from homoeopathic remedies she had never observed any pain there; still in feeling with the finger, she can detect a kind of cavity, which is always somewhat sensitive on pressure, probably from rough handling at the first confinement.

† This joint is stiff and anchylosed from a wound, incised, when she was three years old.

† At fourteen years old she had a similar sensation, when she had a dangerous ‘^Rdsselausschlag,” as they call it in Upper Austria, with sore throat, the body being densely covered with red granules, except the anterior part of the chest. Mossalia squamosa? Cf. Schmalz’s Diagnost. Tabellen, 2014; or Scarlatina miliaris?