Nitri Dulcis Spiritus

Spiritus aetheris nitroso. Sweet spirits of nitre.

This substance is essentially a solution of cethyl nitrate (C.H NO )

Authorities. 1, Lembke, Zeit. f. Horn. Kl., 4, p. 145, took repeateddoses of 5 to 30 drops; 2, same, Nene Zeit. f. Horn. Kl., 17, p. 36, took repeated doses of 10 to 40 drops; 3, same, subsequently repeated the proving- 4 same, subsequent proving with doses of 10 to 60 drops; 5, Brown, Pharm. J., 16, p. 455, effects of inhalation of vapor of “nitrous ether;” 6, second case; 7, third case; 8, effects in self.

Mind p. 3

Slight confusion of ideas

Some anxiety

Head p. 3

Confusion, Confusion of the head (soon after a dose),h

Head very much confused, heavy, and hot, for three hours

Vet‘tit/0. Vertigo ®.

Sensation of impending vertigo several times, soon; also, while sitting, a sensation as if the upper part of the body swayed to and fro

Sensation in the head as if vertigo would occur, repeated several times (soon); between these attacks, while sitting, a sensation as if the upper part of the body swayed to and fro

Ceueval Head. A dull annoying pain is felt in the head, more acutely along the course of the temporal arteries, which continues for five or six hours (after five or six hours)

Violent tearing in the head

Tearing in the head

Tearing pains in various parts of the head

Drawing and tearing in the head, especially in the right side

Drawing pressure in various parts of the head

Frequent pressure in the head

A slight degree of swimming in the head, scarcely perceptible even when at the worst

Pressure and heaviness in the head

Pressure and heaviness in the head, lasting a long time

Heaviness in the head, with pressure in the forehead

Heat and heaviness in the head, soon after a dose

Stitches on the head

Headache, continued for seventeen hours (after half an hour)

Forehead. Confusion in the forehead

Confusion in the forehead, on rising in the morning, with persistent pressure and heaviness, lasting several hours

Violent boring in the forehead

Violent persistent pain in the frontal bones

Boring in the forehead, at night

Boring in the left side of the forehead, at times very violent

Violent boring here and there in the frontal bones, frequently repeated

Boring in various parts of the forehead

Violent pressure and boring in the frontal bones,®. Drawing pains in the forehead

Drawing in the forehead and bones of the face)®.

Drawing and pressure in the forehead

Heaviness in the forehead ®.-^Pressive pains in the forehead, increasing in the evening, noticed while both walking and sitting

Pressure in various parts of the forehead (soon after a dose)

Violent pressure and heaviness in the forehead

Pressure in the forehead, especially violent

Pressure and heaviness in the forehead

Frequent pressure and heaviness in the forehead,. Frequent pressure and fulness in the forehead

Pressure in the forehead and sinciput, with a feeling of heaviness and fulness in the head,®.--Pressure in various parts of the forehead ®. Pressure in the forehead. Pain in the forehead, with pressure and heaviness, worse towards evening ®

Heat in the forehead and Temples. Boring in the temple« =

Boring as with a dull instrument in the left temple

Pressure in the temple ®

Pressure in the right temple

Pressure in the temples and fi^ntal bone

Pressure in the left temple

Pressure in the temples, with a sensation of heaviness in them,®. Pressure inward as with a dull instrument in the right iem^W

VerteQC. Stitches on the vertex

Pressure and heaviness in the sinciput

Drawing in the scalp with pressure in various parts of the skull,*.-Horripilation on the scalp .- Occijyut. Heat in the occiput (soon)

Pressure in the occiput

Heaviness in the occiput, with heat ®. • i ,3 Tina

Face p. 3

T>\x appearance of the eyes

Stitches in the eyes

TulS. Visible twitches in the right upper lid,’.-Frequent twtchmg in the margin of the right upper lid

Stitches and burning m the lids and their margins

Burning in the margins of the lids

Stitch in the upper lid and above the right eye

Lachrymation,®. Stitches in the eyeballs

Black spots and rings float before the eyes, always after a dose, with heat in the head and contracted pupils

Fever p. 4

(The left ear is closed, without swelling or pain, lasting more than an hour; it seemed to be the commencement of a violent coryza that developed the same day),b

Pressure behind the ears,®. Pressure in the left mastoid process

Stitches in the left ear

Face p. 4

The first observed effect is a bluish-purple color which the lips take on; this occurs even when the vapor is very dilute, and it may exist quite unconsciously and without any bad effects whatever; after being exposed for one or two hours to a rather diluted vapor, or after exposure for only a few seconds to a very partially diluted vapor

after it may be only three or four natural inspirations

the lips assume a deeper purple tint, the eyes a dull appearance, and the whole countenance has a ghastly, dirtylooking pallor about it, as if smoked all over; the hands, more especially beneath the nails, partake of the purple color; afterwards the hands are of a leaden-blue or purple color

Visible twitching in the middle of the left part of the upper lip, along the margin

Boring in various parts of the bones of the face

Boring in the bones of the face

Pressure in the bones of the face

Stitches in the muscles of the face

Frequent stitches in the muscles of the face

Pressure in the bones of the face, worse on the right side

Sensation as of a cloud over the upper portion of the face

Stitches in the masseter muscles

Drawing stitches in the cheeks

Drawing in the right upper jaw

Violent boring in the lower jaw, especially in the angles

Drawing in the upper jaw

Mouth p. 4

Teeth, Tearing in the upper teeth

Tearing in the lower teeth

Tearing in the upper canine and incisor teeth of the right side

Toil ffue. Cutting deep in the forepart of the tongue

Drawing in the lower teeth

Burning in the tongue

Sticking and burning in the tip of the tongue

Sharp stitches in the tongue

Stitches deep in the mass of the tongue

Violent stitches in the tip of the tongue

Stitches in the tip of the tongue

Fine stitches in the tip of the tongue

Stitches in the tongue

Very flat odor in the mouth

Saliva. Profuse clear saliva collects in the mouth after a dose

Much thin saliva in the mouth

Much thin saliva with a constant salty taste on the tip of the tongue (soon after a dose)

Profuse mucus constantly in the mouth, with a taste of lye

Much mucus in the mouth

Sensation like that preceding nausea, together with increased mucus in the mouth

Salty taste on the tongue and salivation

Throat p. 4

Constant dryness in the throat

Cramp extending from below upward in the oesophagus

Increased accumulation of mucus in the throat

Stomach p. 4

Violent paroxysmal cutting pain deep in the pit of the stomach, together with flushes of heat and general hot sweat

Peculiar sensation of aching in the pit of the stomach

Heaviness, fulness, and oppression in the pit of the stomach

Pressure in the stomach extending up the oesophagus

Pressure in the stomach

Pressure in the stomach, as from a dull instrument, aggravated by deep inspiration, pressure, and keeping the body erect, relieved by bending inward the abdomen, which is not at all soft; after half an hour the pain increased, became cutting, extended to the umbilical region, and was aggravated by even slight i aspiration, the pain continued tour hours; was very much increased by eating, when it became cutting; there was much accumulation of gas in thig jibdorDGD, after the evacuation of which the pain was relieved

EviictfttlO}lSm Eructations of air tasting of the drug/.

Eructations of air,. Sensation of qualmishness in the pit of the stomach rising into the mouth, with much mucus in the mouth

Vomiting at an early stage, not either severe or persistent

Nausea. Frequent nausea

Nausea, with some sensation of qualmishness in the stomach, accumulation of saliva and hunger

Many noises of gas in the abdomen

Rurahling in the abdomen

Rumbling in the abdomen and pressure in the umbilical region,l

Some pressure in the epigastric region

Sudden stitches in the left side, below the navel, extending towards the bladder

Urinary Organs p. 5

TJvethva. Violent cutting in the tip of the urethra,l

Stitches in the tip of the urethra ®

Violent stitches in the tip of the urethra

Numerous stitches in the tip of the urethra

Violent stitches in the tip of the urethra while urinating

Frequent stitches in the tip of the urethra

Mietaritlon. Frequent inclination to urinate

Much desire to urinate,l

Frequent micturition of profuse urine as clear as water

Frequent painless micturition

TJrhie. Frequent micturition of yellow urine,l

Urine very clear in color, with frequent desire, but not increased quantity

Urine passes frequently,I

Urine yellow during the whole proving, not increased in quantity,I

Urine scanty

The diuretic action was not apparent until twelve or fourteen hours after exposure to the vapor

Diuretic effects (within an hour or two)

Sexual Organs p. 5

Stitches in the glans penis

Respiratory Organs p. 5

* Breathing slow and regular; on walking a short distance it becomes very hurried; if the attempt is persevered in it becomes quick, difficult, and painful, and a most distressing seme of painful constriction is felt underneath the sternum

Tickling in the larynx, with short dry cough

Tickling in the larynx, with a dry cough, in the evening

Tickling in the larynx, causing a dry explosive cough

Much sticking and tickling in the larynx, with thin saliva

Numerous stitches in the larynx, in the evening, provoking cough, which was dry

Stitches and constriction in the larynx

Short dry cough

Short dry cough, several mornings

Chest p. 5

Cramp rising up in the oesophagus, with intermitting pains extending to the upper portion of the wall of the chest

Pressure moving about in the upper portion of the wall of the chest

Pressure above the lower portion of the wall of the chest

Sticking and pressure in the left wall of the thorax

Pressure above the lower portion of the thorax

Pressure in the upper part of the thorax

Stitches in various parts of the thorax

Front. Violent beating and pressure behind the sternum, while walking

Dull pressive sensation low down in the sternum, as if in the oesophagus

Pressure in the sternum

Sides, Sticking pain in the upper part of the left wall of the chest, without affecting breathing

Intermitting sticking pains in the upper part of the wall of the left chest, afterwards in the right, without affecting respiration

Pressure in the upper part of the left wall of the chest, disappearing and returning without affecting respiration or motion

Pressure in the left wall of the chest, coming and going several times without being affected by respiration or motion

Stitches in the right, then in the left wall of the chest, not aggravated by inspiration

Heart and Pulse p. 5

Heart, The sensation of violent beating in the heart occurs frequently in the evening on lying down in any position, lasting only a moment

If walking is persevered in the heart makes itself felt by its rapid, tremulous, tumultuous action

Some violent beating oi the heart

Violent beating of the heart, at times with a feeling of pressure

At times while walking a peculiar sensation in the heart, like violent beating; this symptom occurred very frequently during the day

The pulse during the first quarter of an hour after 25 drops was irregular, the beats generally fuller and harder

The pulse remained unchanged for half an hour, except that it was fuller and slower than usual

[18^0.] Pulse weak and quick; on walking a short distance it becomes very quick

Pulse frequent, for half an hour (after 20 drops),. Pulse rather fuller and somewhat slower than usual (half an hour after 10 drops)

Neck and Back p. 6

Violent pressure in the nape of the neck and cervical vertebrae

Stitches here and there in the thorax and back

Sensation as if hot water were creeping through the back from below upward, lasting a quarter of an,hour,k

Pressure and stitches in the region of the spine

Drawing in various parts of the back

Stitches in the final processes of the vertebrae

Numerous violent stitches in the vertebrae

Drawing in various parts of the dorsal muscles

Stitches in the spinous processes of the middle dorsal vertebrae

Violent sticking in the spinous processes of the last dorsal and upper lumbar vertebrae

Pressure in the lumbar muscles and hip-joints

Extremities in General p. 6

Pressive boring in the muscles and joints of the upper and lower extremities and in the head, even while walking

Boring in the fingers, wrists, shoulders, and knees

Sticking in the fingers and toes

My nails were colored blue, and also Mr. G.’s lips were the same

Pressure and boring in the bones of the wrists, tibiae, ankles, head, and face

Tearing in the fingers and toes

Pains in the limbs

Pressure in the muscles of the shoulders, upper arras, and thighs

Pressure on the hacks of the feet and in the wrists

Violent pressure in the muscles of the upper and lower extremities

Violent pressure about and above the ankles, about the leg, and afterwards in the forearms

Very frequent violent pressure in the malleoli, in the tarsal and metatarsal joints, wrists, shoulders, and muscles of the arms, with bruised pain

Pressure on the backs of the feet and in the wrists

Pressure in the elbows and arms, afterwards in the fingers and toes

Some pressure in the left knee and then in the right forearm

Pressive pain in the shoulders, knees, and ankles

Pressure in the ankles and forearms

Drawing in the calves and scapulae

Drawing in several joints and phalanges

Wandering pains in the limbs

Stitches and pressure in the toes, shoulders, fingers, and their joints

Drawing and pressure in the shoulders, arms, ankles, and occiput

Pressure in the left knee, and afterwards in the right forearm

Superior Extremities p. 6

painful sensation of weakness in the left shoulder and in several fingers, frequently during the day

Violent stitches in the shoulder-joints, some muscles of the arms, and in some finger-joints

Stitches in several finger-joints and in the shoulders

Shoulder, Violent pain in the right shoulder

Bruised or weary pain in the muscles of the arms and shoulders

Pressure in the shoulder-joints

Pressure in the shoulders and clavicles

Pressure in the left shoulder, extending to the upper arm

Pressive, stiff pain on the forepart t of the left shoulder, and scapular portion of the clavicle, aggravated by motion, in the evening

Stitches between the scapula£e

Stitches iu the shoulders,I

Weakness of the whole right arm ; on raisine. it It seems heavy, as if too thick or ful

Heaviness and weakness ot both arms

Heaviness in the arms

Pressure in the muscles and joints of the arms

Pressure in the muscles of the arms

Pressure in the arms and wrists,. Pressure in the arms

Violent pressure in the elbows and upper arms

Stitches on the inner side of the left upper arm,h

Stitches in the muscles of the upper arm

Mbow and Forearm. Drawing in the elbows

Pressive painin the elbows and wrists

Violent pain in the left elbow and upper arm

Pressure in the left elbowjoint and right forearm,^. Violent tearing deep in the left forearm, extending into the wrists, in the evening, in bed

Pressure in the forearms and wrists, in the evening

Pressure in the forearms and wrists

Violent pressure as with a plug in the middle of the left forearm, especially in the soft part

Pressure in the right forearm

Wrist and Hand. Boring in the wrists

Internal pressure on the back of the left wrist

Violent pressure in the wrists

Pressure in the wrists

Drawing in the left wrist

Stitches in the wrists

Stitches in the left wrist

Weakness of the right hand, with stitches in some of the joints, followed by weakness of the right shoulder-joint

An unsteady sensation in the hands on holding objects

Feeling of unsteadiness in the hands, like a trembling, on grasping or holding objects

Pressure in the bones of the hand, at times very violent

Fingers. Sudden, violent sticking burning pain in the first phalanx of the third finger, with swelling, redness, and very blue veins; motion is unaffected and without pain pressure decidedly aggravates the whole condition, but only for a minute; the redness and swelling last till he goes to bed, and even the next morning ; the next day violent pressure causes some pain, though much less than on the previous day

Tearing in the fingers

Violent tearing in the fingers

Tearing and pressure in the left fingers

Violent tearing in the right fingers

Tearing and pressure in the finger-joints

Pressure in the thumbs

Burning stitches on the backs of the joints of several fingers

Stitches in the second joint of the right little finger

Frequent stitches in the joints of the fingers

Stitches in several finger-joints

Stitches and pressure in one or another of the finger-joints

Stitches in the second joint of the right little finger

Some stitches through the left thumb and right index finger

Stitches in the left thumb

Violent sticking in the fingers and joints

Drawing pains in the fingers

Inferior Extremities p. 7

In General. Pains in various joints, especially persistent pressive pain in the left hip-joint

Long-continued pain in the whole left leg and ankle, especially on moving the ankle, painful towards the external malleolus

Pains in the lower extremities, even while walking

Boring pressive pain in the lower extremities

Boring in the left hip, tibiae, and feet

Violent pressure in the right leg and ankle, and in the malleoli

Drawing and pressure in the legs and the backs of the feet

Drawing pressive pains in the thighs and tibiae while sitting

Hip and Thigh. Pain in the left hip, associated with pain in the skin and soft parts about the joints

Awakened about 3 a.m. by violent boring persistent pain in the left tibia

Persistent and violent pains in the left hip-joint

Drawing in the hip-joints

Pain in the hip, aggravated by walking

Pain in the right hip-joint

Pressure in the left hip

Drawing in the right thigh

Knees. Violent persistent pressure in the left knee, worse while sitting, obliging walking about, which somewhat relieved/.

Pressure in the left, then in the right knee, and in the ankles

If walking is persevered in the knees shake, and, refusing any longer to remain rigid, give way

Pressure in the knees ^

Drawing and pressure in the knees

Sticking in the soft parts above the right knee, at times very violent boring while sitting and walking

Boring in the knees

Drawing and pressure in the knees and calves Violent stitches in the left knee in bed

Violent stitches in the forepart of the left knee,h

L(i(J» Drawing and heaviness in the calves and hollows of the knees,h

Violent boring in the lower portion of the leg

Boring in the knees and tibia0e

Boring in the right tibia, towards evening

Boring in the tibiae, even in the evening

Violent boring in the tibiae

Frequent boring in the tibiae, at times very violent

Boring on the right tibia

Boring in the tibiae

Boring on the left tibia

Drawing in the muscles of the calves

Tearing pains in the right tibia

Tearing on the right tibia

Tearing pains in the left tibia

Tearing in the tibiae

Violent pressure and boring in the tibiae

Drawing on the left tibia

Stitches and pressure in the calves

Stitches in the tibiae

Ailhle, Violent pain in the bones of the rightankle and metatarsus, persistent, worse while sitting

Boring in the left ankle and malleoli

Pressure in the right ankle, especially in the external malleolus

Pressure and drawing in the ankles and knees

Drawing and pressure in the ankles and tarsal bones

Pressure in the ankles, even while walking

Pressure in the ankles and malleoli

Drawing in the ankles and tibiae

Pressure in the ankles

Pressure in the ankles and knees, in the morning

Pressure in the bones of the right ankle

Foot, Boring on the back of the left foot

Boring as with a dull instrument on the back of the left foot

Boring in the malleoli

Boring on the back of the foot

Violent pressure in the feet and toes

Drawing and pressure in the bones on the backs of both feet

Drawing on the back of the left foot

Drawing on the back of the left foot

Drawing on the back of the right foot

Tearing in the feet

Pressure on the back of the left foot

Pressure on the backs of the feet

Pressure in the bones of the feet

Pressure in the bones on the back of the left foot

Stitches in all the toes of the left foot

Drawing in the heels

Violent drawing in the right heel

Toes. Tickling in the tips of the toes and soles of the feet

Tearing in the left toes,*._ Tearing in the toes

Pressure in the first joint of the right great toe

Pressure in the first joint of the left great toe

Pressure iu the joints of the toes

Pressure in the toes

Drawing in the toes

Drawing in the left toes

Drawing and sticking in the toes

Drawing in the tfrst left metacarpal joint

Violent stitches in the toe-joints

Stitches in several toes and in their tips

Violent stitches in the right great toe,®._ Stitches in the tips of the toes

Generalities p. 8

Great swelling of the veins

Weakness

Great weakness

General exhaustion

Sticking boring and tearing in the bones of the face, back, and various parts of the body, especially in the toes and tips of the toes, knees, and cranial bones; these symptoms occur very soon after a dose

Frequent drawing iu the cranial bones, as also in the ankles and toes

Tearing in various joints

Drawing and pressure in several joints,*.-All the pains extend from place to place and suddenly change about

Symptoms occur especially in the morning and in the evening in bed, and are frequently caused by damp weather

In general the symptoms were as numerous while walking as while sitting (though perhaps more numerous while sitting),By the time I had reached half a mile, I felt very weak and unable to walk, which at last compelled me to sit down for a little on a stair ; I recovered considerably by this, and was able to proceed ; I got a little brandy ; shortly after I felt quite strong in the limbs ; by the time I got home I again felt the weakness coiiliug,. Perfect rest, heat, and a warm atmosphere, with brandy and a little ammonia, gradually restore the powers of the muscular system

Perhaps a little debility (second morning)

The muscular debility comes on very rapidly, unaccompanied by the slightest effect upon the brain, and endures for hours,®. Loss of muscular power goes on until complete prostration ensues; but there is no consciousness of this debility until an eff)rt is made

Skin p. 9

During the night, while in bed, the skin is dry, but by no means hot; yet while there is no restlessness, it is a relief and pleasant to the feet to hunt out the coolest spot they can find

Crawling in the skin and in the forepart of the_ right tibia

Violent stitches in the skin of the left axilla,', \violent sticking and burning in the skin on the inner side of the right upper arm

Sleep p. 9

An exceeding drowsiness came on, quite like what one feels after long hard work ; but this perhaps was partly the effect of the brandy. On getting into bed I slept, and that soundly, for nine hours and a half

Many dreams of danger by fire

Fever p. 9

Chilliness. Internal chilliness, with cold hands

Frequent chilliness

Creeping chills under the skin, extending from the small of the back to the lower extremities

Chilliness followed by heat in the head and rest of the body

Chilliness over the body and limbs, frequently

Violent chilliness in the back and limbs

Chilliness in the back and limbs

Chilliness over the back

Chilliness in the back with profuse warm perspiration on the palms; the chilliness increased and the hands became cold and the perspiration of the palms continued

Chilliness in the back at 4 a.m., in bed

Chilliness through the spine, increasing with cold hands

Chilliness over the back several times

Chilliness on the back and in the limbs

Chilliness over the back, extending into the lower extremities, with cold hands

Internal chilliness, cold hands, lasting an hour

Chilliness over the back, with heat in the head and face, repeatedly while walking and sitting

Extremities cold

Sensation of coldness preceded by heat

Heat and Sweat. Heat in the head and face, soon after a dose

Heat in the head (soon after a dose)

Great heat in the face, and afterwards over the whole body

Heat in the head

Heat in the face, more internally than externally, afterwards in the whole body

Heat in the head and face, heat followed by pains in the knees, ankles, and wrists (soon after a dose)

Heat in the nape of the neck and occiput; general heat with swollen veins during rest, lasting a quarter of an hour

Heat rises from the cervical portion of the spine into the occiput (soon after a dose)

Heat in the head and face, with chilliness in the back, and cold hands

Violent heat in the head, afterwards in the whole body, with inclination to perspire, soon after a dose

Violent heat in the face, with persistent heat in the head and over the whole body

Heat rising into the face, rather internally, afterwards also in the forehead, with pressure

Heat in the back

In the back a sensation of heat rising from below upward and lasting about ten minutes

Heat in the back and over the whole body

General heat, with inclination to perspire (while sitting)

Perspiration on the palms, the veins of the hand large and distended, while sitting quietly, lasting about ten minutes

Perspiration on the hands, with greatly distended veins on them,h

Inclination to perspire, while sitting

Aggravation(d/oniinfir). On rising, confusion m forehead, with persistent pressure and heaviness ; dry cough ; pressure in ankle and knees.

(Towards evening), Boring in tibimj pain in forehead, wit pressure and heaviness ; pains increased

(Evening), Symptoms more frequent and aggravated,'*; in bed, tearing in forearm and wrist; stitches m larynx provoking cough

(Night), Boring in forehead.

(Z)eep inspiration). Dull pressure in stomach.

(Pressure), Burning in first phalanx of third finger, with swelling and redness.

(Lying down). Violent beating of heait.

(Sitting), Sensation of swaying of upper part of body; pain in bones of right ankle.

( While urinating). Stitches in tip of urethra. ( Walking), Difficult breathing; rapid beating of heart; variable pulseboring in muscles and joints of extremities; shaking in knees; pain in hip.

Amelioration p. 10

(Towards evening). Symptoms relieved,. (Bending abdomen forward) pressure in stomach. ( Walking), No symptoms