Opium

Papaver somniferum.

Natural order, Papaveraceae.

Common names. Opium, Mohnsaft.

Preparation, Tincture of the gummy exudation from the unripe capsules.

Authorities. (Nos. 1 to 99 from Hahnemann, R. A. M. L., 1, 278, with critical annotations in brackets, by Dr. Hughes.) 1, Hahnemann ; 2, Gubitz ; 3, Gutmann ; 4, Schoenike; 5, Staph; 6, Act. Nat. Gur., IV, Obs. 145 (ob-servation by Hasenest) ; 7, Eph. (not Act.) Nat. Gur., Gent. I, Obs. 54 (from a large dose of “ Theriaca,” given to a child of six weeks. observation by Hoyer) ; 8, JEpli, Hufel. Journ., XXV, 3 (from mixture of opium and rhubarb, given to a baby for colic); 9, Albert (not accessible) ; 10, Alpine, Med. ^egypt., IV, Cop. 1 (general statement as to Egyptian opium-eaters); 11, Alston (Essays and Observations, Edinb., V, 93, observations); 12, Baglivus, Prax. Med., Lib. I, p. 65, from too many and too large doses (statement); 13, Bard, Diss. de vir. Op., Edinb., 1765 (p. 15, experiment on self with 1^-grain doses); 14, Baker, in Act. Nat. Cur., II (Obs. 93, observation) ; 15, Bautzmann, Misc. Nat. Cur. Dec., II, Ann. 8 (Obs. 44, observation); 16, Bellonius, Libr. 3, Obs. Cop., 15 (p. 431, from opium-eating); 17, Berger, de vi opii rare facient (general statement from authors); 18, Bergius, Mat. Med. (p. 458, general statement from authors); 18a, Boerhaave, select. (general statement); 19, Bohn, de officio med., p. 362 (symptoms not found); 20, Boletus, Sepulcret. Anatomy, lib. I, sect. 1, p. 214 (symptoms not found); 21, Borellus, Cen. 4, Obs. 57 (observation); 22, Buchner, diss. de Opio. Hal., 1748, § 45 (not accessible); 23, Butter, Unterr. Ueber. d. Tcedtlichk. d. Wunden (p. 204, observation) ; 24, Charas, Pharm. Reg. Chym., C. 51 (symptoms not found) ; 25, Chardin, Voyage en Perse, Amst., 1771, Tom. IV, p. 203, 204 (statements as to opium-eaters); 26, Charvet (Act. de I’Opium, Paris, 1826, experiments with various doses); 27, Clerk (In. Essays and Obs., Edinb., Ill, 121, poisoning of a man by 20 grains) ; 28, Claude, Eph. Nat. Cur., Dec. II, Ann. 5, Obs. 178 (experiment with an extract prepared with sulphuric acid) ; 29, Cocq, in Stalpaart v. d. Will, Observ., Cent. II, Obs. 41 (symptom not found) ; 30, Crump, Nature and Properties of Opium, 1793,t effects of 1 grain of opium, taken in a teaspoonful of warm water, pulse 70, normal; 30 a, from same, a healthy man took same dose, pw/se 44, normal; 30 b, Crump, took 2h grains of Opium, pulse 70 ; 31, Delacroix, Journ. de Med., XXXIX, 1773, p. 313, from 2 grains, in a clyster, taken by a woman ; 32, Eph. Nat. Cur., Dec. II, Ann. 10, Obs. 80 (should be Misc. Nat. Cur., statement); 33, Ettmiiller, Diss. de vir. Opii Diaphor., Lips., 1694, Cop. I, § 5 (general statement) ; 34, Friend, Opera, Tom. I, Emmenol, p. 139 (general statement); 35, Garcias ab Hort, Hist. Aroioat., I, Cop. 4 (observation); 36, de Garter, Med. Dogm., Cop. I (not accessible) ; 37, Geoffroya, Mat. Med., II (general statement); 38, Grimm, Act. Nat. Cur., Ill, Obs. 19 (experiments on self, with grain i-nj); 39, Guiana (not accessible); 40, Haller, Prselect. in Boerh. Inst., IV, p. 519 (general statement); 40 a, Haller, de Part. Corp. Viritab. et Sensib., Sect. 2 (not found); 41, Hamburger, Diss. de Opio, Jen., 1749, § 16 (a general statement, cited from Geoffroya); 42, Hardens, Hufel. Journ., IX, 2 (observation on a patient) ; 43, Hecquet, Reflexions sur Usage de I’Opium, Paris, 1726, p. 184 (not accessible); 44, omitted; 45, de Hellwich, Bresl. Samml., 1702 (not accessible); 46, Hist, de I’Acad. des Sc., 1735 (not accessible); 47, Hoffmann, Diss. de op. Open, Hal., 1700 (general statement); 47 a, ibid., Diss. de Corr. Opii, Hal., 1702 (not accessible) ; 47 b, ibid., Med. Rat. Syst., II (p. 273, general statement); 48, Hufel. Journ., VIII, 4, p. 134 (not found); 49, Hunter, uber d. vener. Krankh., p. 640 (observations on patients); 50, Joerdens, Hufel. Journ., XVII, 1 (observation on self when taking laudanum to procure sleep) ; 51, Jones, the Mysteries of Opium Revealed (observations); 52, Juncker and Bohmer, Diss. Sisters Casum. Matron Largissimo usu Opii Tract., Hal., 1744 (not accessible) ; 53,

■)• From the original, as quoted in Sharp's Essays on Med., p. 15.—T. F. A. Kampfer, Ainoen. exot. Fasc., Ill, Obs. 15 (observation on self in health); 54. Kilian, Med. Annal., 1800 (not accessible) ; 55, Knebel, Ilufel. Journ., XXVI, 2 (p. 148, observation on a child with hooping-cough); 56, Lassus, Mem. de Ilnst. National des Sc. et Arts, Tom. II (from gr. 26, taken by a woman of sixty); 57, Leroux, Journ. de Med. (from nearly a drachm, in a woman of fifty-one); 58, Levesque-Blasource, Journ. de Med., 1808 (vol. 16, pt. 1, p. 21-24, from large doses in a man) ; 59, Lindestolpe, de Yenen., p. 591 (general statement); 60, Journ. Encyclop., I, pt. 2, p. 72, also Recueil period, p. 74 (observations and statements); 61, Martin, Vetensk. Acad. Handling, 1773, P. II, Nr. 7 (observation); 62, Mattei, Hufel. Journ., XI, 2 (observations on patients) ; 63, Manchart, Eph. Nat. Cur., Cent. I, Obs. 15 (from a grain of crude 0. taken by self); 64, Mead, de Venen., in Op. D., II, p. 190, edit. Getting, (general statements); 65. Mono, Essays Phys. and Lit, vol. Ill (Art. 13, experiments on frogs); 66, Muller, Hufel. Journ., XVHI (p. 55, from a mixture of tinct. Thebaica and Hoffmann’s anodyne, given for a nervous affection) ; 67, Murray, App. Med., II, p. 282 (general statement) ; 68, Muzell, Wahrn., II, p. 131 (from a mixture of Opium and Spr. Cornu cervix) ; 69, d’Outrepout (from a large dose taken by a woman eight months pregnant) ; 70, Owens, Notes Hayana3 Vorr., p. 14 (from laudanum taken for spasms of legs); 71, Pitcairne, Uiss. de Circul. in Animal., etc., also Element. Med. (observations); 72, Plater, Obs., Lib. I, p. 127 (not found) ; 73, Pyl, Aufsdtze, Saiuml., I, p. 95 (from a large dose of the extract, in a man of fifty or sixty) ; 74, Rademacher, Hufel. Journ., IV, 3, p. 587 (from tinct. Thebaica given in dysentery); 75, Reineggs, in Blumenbach’s Med. Bibl., I (an account of the effects of Opium-eating); 76, Renodieus, Mat. Med., Lib., I, sect. 13, Cop. 2 (statement); 77, Riedlin, lin. Med. Ann., IV, Decemb. Ob., 16 (observation); 78, de Rue, App. ad Nova Acta Nat., Cur., V, p. 63 (general statement); 79, Saar, Reise n. d. Orient (statement as to use of O. by Chinese) ; 80, Sacs v. Lewenheim, Misc. Nat. Cur., Ann. 2, Obs. 69 (general statement) ; 81, Sauvages, Nosol. method, I, p. 847 (a drachm and a half of laudanum drunk by a boy of fifteen) ; 82, Schelhamraer, Misc. Nat. Cur., Dec. H, Ann. V, Obs. 12 (from pills of styrax and Opium) ; 83, Schweickert, Hufel. Journ., VIH, 3 (not found); 84, Stalpaart, v. de. Will, Cent. H, Obs. 42 (from half a drachm of solid Opium); 85, Stentzelius, de Venen., I, § 46 (not accessible); 86, Sliitz, Hufel. Journ. (X, 4, 35-7, from Opium given in a convulsive attack); 87, V an Sweeten, Comment., I, p. 878 (general statements); 88, Thomasseu a Thuessink, Diss. de Op., use in syphilitic, L. B., 1785 (not accessible) ; 89, Thompson, Diss. de Opio, p. 121 (observations and statements); 90, Tralles, de usu et abuse Opii (observations and statements) ; 91, Vermendois (not accessible) ; 92, Vicat, Plant. Venen. de la Suisse, p. 226 (from overdose of laudanum mixed with amber and nitre. N.B. All the symptoms referred to Vicat belong to this case, which is in the work mentioned); 93, Waldschmid, Monita Med. Circa Opium, Hamburg, 1679 (not accessible) ; 94, Ward, Nenes Journ. d. Ausliiud. Med.-Chir. Lit., IV, 1 (from external applications); 95, Wedel, Opiologia, p. 165 (not accessible); 96, Wepfer, de Apoplexia, p. 24 (not accessible) ; 97, Whytt (Essays, Phys. and Lit., II, 308, experiments on frogs), omitted, T. E. A.; 98, Willis, Pharm. Rat., p. 305 (observations and statements); 99, Young, treatise on Opium (observations and statements), (100 to 109, Jorg’s provings from Materialien, 1825, all provings with (Opium combined with Magnesia, omitted) ; 100, Guntz, took 1 drop of tincture, afterwards 2, 4, 6, and 9 drops, and subsequently repeated doses of 2 to 18 drops; 100 a, same, took doses of Mol grain of crude Opium ; 101, Kneschke, provings with tincture, doses of 1 to 9 drops; 102, Lippert, provings with tincture, 1 to 36 drops; 103, Otto, tincture, 2 to 4 drops ; 104, Pienitz, tincture, 1 to 6-drop doses ; 105, Siebenhaar, tincture, 1 to 12-drop doses; 106, Jorg, took tincture, 1 to 3-drop doses; 107, Edwd. Jdrg, tincture, 1 to 2-drop doses; 108, Theo. Jorg, tincture, | to 2-drop doses; 109, Mrs. Ch., tincture, ^ to 2-drop doses ; (Nos. 110 to 120 Austrian provings, Zeit. des. Ver. Horn. jErzt. Aust., 1862) ; 110, Dr. Alb, effects of tincture, 5 drops, one dose ; 110 a, same, subsequent proving, 25 drops of tincture ; 111, Dr. Breslauer, provings with 30th and 12th dils., doses in the morning; 112, Duditsch, proving with 30th and 12th dil.; 113, Either, provings with 1st dil., 4 to 24-drop doses ; 113 a, same, tincture, 5 to 20-drop doses ; 114, Dr. Freud, tincture, 6-drop doses; 115, Jenitschek, 1st dil., 3 to 15-drop doses; 115 a, same, tincture, 30-drop doses; 116, Wm. Jenitschek, aged nine and a half years, 1st dil., 3 to 20 drop doses ; 116 a, same, tincture, 2 to 20-drop doses ; 117, Dr. Schauer, tincture, 20 drops; 118, Stern, tincture, 5 to 20-drop doses; 119, Szontagh, tincture, 5 to 40 drop doses; 119a, same, 1st trit., 12 to 12-grain doses; 120, Tedesco, 6th dil., three times a day; 120a, same, 1st dil., 5 to 25-drop doses; 120 5, same, tincture, daily doses of 5 to 30 drops; 121, Smith, i\Ied. Museum, 1763, a man in the habit of taking 3 drachms of O. daily, took 1^ drachms morning and noon, also statement of general effects in same man; 122, Kennedy, Edinb. Med. and Surg. J., 1794, effect of 155 grains, in a man ; 123, Pfundel, from Schlegel IMaterialien, 1800 (Frank’s Mag., 3, 600, a man took 12 to 15 grains in beer) ; 124, Lassus, Med. and Phys. Journ., 1801, p. 491, effects of 36 grains of O. in a woman of fifty-six, death after eleven hours; 125, Schlegel, Materialien, 1801 (Frank’s Mag., 3, 600), a physician took 4 an ounce in beer; 126, same, another man took l-g- drachms in beer ; 127, McKechnie, Edinb. Med. and Surg. Journ., 1811, p. 305, effects of an ounce of laudanum, in a woman aged twenty-eight; 128, Vincent, Thesis, 1816 (Wibmer), effects of a large dose ; 129, Ward, Med. and Phys. Journ., 1802, p. 130, effects of inunction (in right leg and foot) of 2 drachms of tincture of Opium with olive oil; 129 a, same, repeated two days later in left leg; 130, Weber, Med. and Phys. J., 1803, p. 435, effects of single doses large enough to })produce effects ; 131, same, effects of 2 grains, in a young lady ; 132, same, effects of 4-grain doses, in eight healthy men ; 133, same, effects of 3-grain doses, in three men; 134, same, effects of 4 grains, given the next morning to two of the preceding cases; 135, Shepherd, Med. and Phys. Journ., 1808, 1, p. 497, effects of 2^ drachms of O.; 136, Kinnis, Edinb. Med. and Surg. J., 1818, effects of 14 ounce of laudanum, in a man ; 137, Percival, Dahl. Hosp. Rep., 1818, 226, effects of 2 ounces of camphorated tincture of O., in a delicate old lady, antidoted by green tea; 138, Lond. Med. Repos., 1818, vol. 9, p. 525, effects of 3 ounces of tincture; 139, Polinieri, Bibl. Med., 1820 (Wibmer), effects of 2 grains, in a glass of wine; 140, Desruelles, Journ. Univers., 1820 (Frank’s Mag., 4, 660), effects of 2 drachms; 141, Leigh, Med.-Chn'. Rev., vol. 2, 1821, p. 888, effects of 30 and afterwards 90 drops of laudanum; 142, Richardson, Edin. Med. and Surg. J., 1821, p. 226, effects of 3 drachms, in a woman seven weeks after confinement; 143, Poison, Edin. M. and S. J., 1822, p. 49, effect of about 2 ounces of laudanum, in a girl aged eighteen; 144, same, effects of 1-2 ounces laudanum, in a girl aged seventeen ; 145, Ross, Edin. M. and S. J., 1823, p. 247, effects of 2 ounces of laudanum in two doses, in a man ; 146, Post. Med. Intell., 1824, 1, 203, effects of about an ounce of tincture of Op., in a man ; 147, saam, vol. 2, p. 135, effects of an ounce in coffee, in a woman ; 148, same, vol. 3, p. 132, 1825, effects of four teaspoonfuls of laudanum, in a child of three years; 149, Gotten, Rust’s Mag., 1825 (Frank’s Mag., 1, 597), effects of fresh juice of a poppyhead, in a child four weeks old ; 150, Olivier, Archiv. gen. de Med., 1825 (Frank’s mag., 3, 299), effects of H ounce of laudanum, in a man ; 151, Suchet, from Albert, Elements de Therap. (Wibmer), effects of a teaspoonful of laudanum, in a child seventeen months old ; 152, Kopp (Wibmer), effects of two poppyheads in milk, in a child aged six months; 153, Williams, Lancet, 1828, 2, 764, effects of a large dose, in a woman aged forty; 154, Lancet, 1828, 2, 254, effects of 2 ounces of laudanum, in a man ; 155, Bally, Mem. Roy. Acad, of Med., 1828 (Frank’s Mag., 4), effects of 20 grains, in a man ; 156, Bardsley, Edin. M. and S. J., 1828, vol. 30, p. 306, effect of a large dose, in a man ; 157, Edin. M. and S. J., 1828, vol. 29, p. 450, from J. de Chim. Med., effects of application of a poultice containing about an ounce of laudanum to an erysipelas; 158, Wibmer, experiments on self, took grain first day, 1 grain second day, 2 grains third day ; 159, Purkinje (Wibmer), took 5 grains; 160, Madden, Travels in Turkey (from Bost. M. and S. J., 1829, 2, 503), experiments on self; 161, Root, Loud. Med. Gaz., 1830, vol. 5, p. 703, effects of a 1 arge quantity, in an intemperate man ; 162, Mart, Lancet, 1831, 1, 710, effects of habitual use of Opium, ^ drachm daily for fifteen years, in a woman ; 163, same, habitual use in another woman ; 164, same, habitual use in a man, aged sixty, who had used it thirty-five years ; 165, same, habitual use in a man of forty, had taken H ounce of laudanum daily for ten years ; 166, same, habitual use, in a woman aged fifty-five, Avho took 20 grains daily for fifteen years; she died of tuberculosis pulm.; 167, Werner, Rust’s Mag., 1832 (Frank’s Mag., 1, 597), effects of the juice of a poppyhead, in a girl aged seven; 168, Lancet, 1832, 1, 639, effects of 12 drops of laudanum with marshmallow, introduced into rectum after cauterization ; 169, Strohl, Hufel. J., 1833 (Wibmer), effects of poppyheads, in a boy; 170, Oppenheim, Hamb., 1833 (Wibmer), effects of sleeping near a field of poppies in blossom; 171, same, took 7 grains of O. as an experiment; 172, Lancet, 5, 218, effects of an ounce of laudanum, in a woman of twenty-two ; 173, Lancet, 6, 124, effects of 2 ounces of tincture, in a woman ; 174, omitted ; 175, Lancet, 10, p. 732, effects of six drachms of laudanum, in a young woman ; 176, Lancet, 1833, 1, 268, effects of about an ounce of laudanum, in a man ; 177, Thompson, Bost. M. and S. J., 1835, p. 133, habitual use of laudanum, in a woman ; 178, Montault, Journ. LTiivers., 1836, effects of about 5 drachms of laudanum, in a woman (Frank’s Mag., 4, 660) ; 179, Young, Lond. Med. Gaz., 1834, vol. 14, p. 655, effects of about an ounce of laudanum, in a pregnant woman ; 180, Christison, Lancet, 1836,1, 631, effects of about 2 or 3 drops of laudanum, in an infant three days old ; death in twenty-four hours ; 181, Lancet, 1836, 1, 271, effects of about 2 ounces of laudanum, in a man ; death after nine hours; 182, Bost. M. and S. J., 1834, p. 284, effects of about an ounce of Opium, in a man; 183, Kiles, Lancet, 1837, 1, 304, 4 drops of laudanum, in a child nine months old ; death in nine hours ; 184, Bullock, Loud. Med. Gaz., 1837, p. 264, 1 ounce of laudanum, in a girl aged twenty-one ; 185, same, same dose in another girl; 186, Sigmund, Bost. M. and S. J., 1837, p. 101, effects of habitual use among the Turks; 187, .«ame, effects of 4 grains,* in divided doses; 188, Smith, Am. J. M. Sc., 1837, p. 450 (Med.-Chir. Trans., vol. 20), effects in a woman ; 189, Koch, Rust’s Mag., 1837, 15 drops of laudanum Sydenham, in a child aged four weeks ; 190, same, effects of a poppyhead in milk, in a child with hiccough ; 191, Lancet, 1838, 1, 389, 20 drops of laudanum daily for six days; no effects till after last dose, in a woman accustomed to take it for uterine pain ; 192, Bost. M. and S. J., 1838, p. 128, general effects of opium-eating; 193, Am. J. Med. Sc., 1838 (J. de Chim. Med.), effects of application of a cerate containing 15 drops of laudanum to au excoriation in a fold of skin ; 194, Husband, Bost. M. and S. J., 1838, p. 31, effects of a drachm of tincture, in a child six months old ; 195, Streeker, A. H. Z., 12, 134, proving, dose of 1 grain ; 196, Semple, Lancet, 1840, 2,186, effects of \h ounce, in a girl aged nineteen ; 197, Harrison, Lancet, 1840, effects of about six dessertspoonfuls, in a woman aged thirty two; 198, Boisragon, Loud. Med. Gaz., 1840, vol. 25, p. 878, effects of a teaspoonful of laudanum, in a child under two years ; 199, Yauderkeere, 2 drachms of laudanum, in a child aged thirteen months ; 200, Williams, Lancet, 1840, 2, 661, effects of 1^ ounce of tincture, in a woman; 201, Erichsen, Loud. Med. Gaz., 1840, vol. 28, p, 390, effects of 1 ounce, in a girl aged twentytwo ; 202, Shipman, Am. J. Med. Sc., 1840, vol. 26, p. 508, effects of a wineglassful of laudanum, in a woman eighty years old, recovery; 203, Hygeia, 13, 393, effects of injection of 20 drops of tincture, for spasms of uterus; 204, Puke, Med. Zeit. Ver. Preus., 1841, effects of a popf head, in a child aged four; 205, Choune, Lancet, 1841,2, p. 705, effects ox more than an ounce, in a man who had been drinking; 206, Hill, Lancet, 1841, 1, 820, effects of smoking O., in a Chinaman; 207, Densely, Lancet, 1841, 1, 88, effects of ^ ounce, repeated after a quarter of an hour; 208, Cowper, Lond. and Ed. Month. J., 1841, 1, 71, a person took 24 ounces of liq. op. sedative. (death after an hour and twenty minutes); 209, Buck, Bost. M. and S. J., 24, p. 126, a woman, aged twenty-two, took 1 ounce; 210, omitted ; 211, Morris, Am. J. Med. Sc., 1842, p. 148, effects of some laudanum with castor oil, in a child four mouths old ; 212, G. H. Smith, Lancet, 1842, p. 707, opium-smoking among Chinese; 213, Walth, A. H. Z., 22, 160, experiments, first took ^ a grain after each meal, then 1 grain, and afterwards 2 and 4 grains; 214, Everest, Lancet, 1842, p. 758, effects of 12 minims of tincture of Op., in a child two days old, death after fourteen hours; 215, McCune Smith, Lond. Med. Gaz., 1843, 1, 878, effects of habitual use of laudanum, in a woman aged twenty-four; 216, same, habitual use, in a man; 217, same, habitual use; 218, same, habitual use ; 219, Russell, Lond. Med. Gaz., 1843, 1, 924, 12 drops of laudanum, in a child two months old ; 220, Pharm. J., 1843, vol. 3, p. 261, effects of laudanum, in two children; 221, Taylor, Guy’s Hosp. Rep., 1844, 2, 32, effects of Ij grain of opium, divided into five doses, in a girl aged five and a half, death thirty-seven hours after first dose; 222, Gaz. des Hop., 1845 (Echo de la Frontier), effects of unripe poppyheads, in three children; 223, Sharkey, Ranking’s Abst., 1846, effect of two pills, each containing 14 grain of ext. Op., in a man ; 224, James, Lancet, 1847, 1, 639, effects of an ounce of laudanum, in a woman; 225, Barry, Ranking’s Abst., 1847, 25 minims of laudanum, in a child aged nine months ; 226, Lancet, 1848, 2, ^696, 2 ounces of laudanum, in a^'woman; 227, Iliff, Lancet, 1849, 2 874, an indefinite amount of laudanum, in a boy aged seventeen ; 228, same, an indefinite amount, in a woman ; 229, Wooden, Bost. M. and S. J., 1849, p. 133 (from Southern Med. and S. J.), effects of 1 drop of laudanum, in a child five days old ; 230, Seven, Bost. M. and S. J., 1849, p. 120, effects of repeated use of laudanum when children (now aged twentythree, twenty, and eighteen); 231, “Confessions of an English Opiumeater,” Prov. M. and S. J., 1848 ; 232, Little, Month. J. of Med. Sc., 1850, p. 524, general effects of Opium-smoking; 233, Wright, Am. J. Med. Sc., 1851, p. 540, effects of about 10 grains on self; 234, Becker, from Bernard! and Loeffler, 1851 (Frank’s Mag., 4), experiments, effects of increasing doses, in a healthy man; 235, same, a man aged forty-seven took 3 grams twice first day, -4 grams twice second day, 5 grams three times third day, same twice fourth day, 5 grams thrice and 6 grams once fifth day, 5 grams thrice sixth day, 6 grams thrice seventh day, 6 grams four times eighth day, 8 grams four times ninth day, 8 grams four times and 9 grams once tenth da}'; 235a, same, subsequent proving, took 6 grams; 236, Herpath, Lancet, 1852, 1, 303, a teaspoonful of laudanum, in an infant nine days old ; 237, Deguise, Month. J. of INIed. Sc., 1852,14, p. 88, effects of 200 minims of laudanum in a clyster; 238, Woodson, Am. J. Med. Sc., 1852, p. 573, effects of “Bateman’s drops” (Opium and Camphd. tinct. op.), in a child five days old ; 239, Kirk, Lancet, 1853, 1, 80, effects of a few drops of laudanum, in a child ; 240, Smith, Lancet, 1854,1, 419, effect of ^'oth grain Op., in a child five days old ; 241, Anderson, Month. J. Med. Sc., 1854, p. 377, 2 drachms laudanum, three drachms more after one hour and a half, in a woman ; 242, Bullock, Am. J. Med. Sc., 1854, p. 575, about 2 ounces of laudanum, in an intemperate man ; 243, Hodges, Bost. M. and S. J., 1856, p. 23, 1 ounce of laudanum, in a girl of fifteen years; 244, Blanc, Rev. de Ther. Med.-Chir., 1857 (S. J.,. 97-37), effects of three injections of Sydenham’s laudanum ; 245, Gibbs, Lancet, 1857. 2, 80, effect of 14 ounce of laudanum, in a man aged seventy-two; 246, Corbet, Lancet, 1857, 2, 220, 30 minims of tincture, in a child one day old; 247, Changing, Bost. M. and S. J., 1857, vol. 56, p. 449, from three to six teaspoonfuls of laudanum, in a man ; 248, Bost. M. and S. J., vol. 56, p. 526, 1857, effects of drinking some laudanum, in a child aged six; 249, Wood, Bost. M. and S. J., 1857, vol. 57, p. 78, effects of a few drops of “paregoric ” (probably laudanum), in a child aged nine months; 250, Chamberlain, Bost. M. and S. J., 1857, vol. 57, p. 357, about 14 grain of Op., in a child six days old ; 251, Pharm. Journ., 1857, vol. 16, p. 195, effects of laudanum, in a woman aged twenty-four; 252, O’Rorke, Gaz. des Hop., 1858, a spoonful of Sydenham’s laudanum, in a child seven months old; 253, Schiitzenberger, Gaz. des Strasburg, 1858, 40 grams of laudanum, in a woman ; 254, Murray, Edinb. Med. J., 1858, 72 drops of 1., in a child, one year old ; 255, same, 1 drachm of solution of muriate of Morph., in a. child se%'eoteen months old ; 256, IMushet, Med. Times and Gaz., 1858,. p.. 292, Opium, in a child of three months; 257, Gallagher, Am. J. Med. Sc., 1858, p. 559, 2 ounces of tincture, in a woman; 258, Jackson, Am. J. Med. Sc., 1859, p. 75, a tablespoonful of laudanum, in a youth of nineteen ; 259, Lister, Br. Med. J., 1859, p. 692, 2 drachms of laudanum, in a woman of thirty; 260, Am. J. Med. Sc., 1859, p. 281, repeated effects of Op. in slight uterine inflammation; 261, Crook, Br. Med. J., 1860, p. 341,40' minims of 1., in a child twenty-two days old ; 262, Person, Med. Times and Gaz., 1860, 2, p. 72, an indefinite amount of 1., in an infant eight weeks old ; 263 and 264, Campbell, Bost. M. and S. J., 1860, p. 101, effects of 14 ounce of 1., in a man ; 265, Andrews, Pharm. J., 1860,,p. 387, fatal effect of a black draught containing liq. Op.; 286, Pharm. J., 1860, p. 287, effects of a piece of Op. as large as a pin’s head, in a child five weeks old; 267, Duchek, When Med. Woch.-Bl., 1861 (S. J., 113, 1.65), a man took a large amount of tinct. Op.; 288, Beaupoil, J. de Chim. Med., 1861. (8. J., 110, 294), three-fourths of a poppyhead, in a child ; 269, Maschka, Prag. Vjs., 1861, effects of 1 ounce of tincture ; 270, Duncan, Lancet, 1861, 1, 637, effects of ounce of 1., in a woman ; 271, Pharra. J., 1861, p. 46, effect of a large dose, in a woman; 272, Murray, Braithwaite’s Ret. of Med., 1862, 2, 266 (Austral. Med. J.), effects of 1|^ ounce of 1., in a man aged fifty; 273, Duncan, Am. J. Med. Sc., 1862, p. 272, 2 ounces of I. , in a woman ; 274, Lee, Ranking’s Ahst., 1862, effects of Op., in a child two years old; 275, Bellis, Lancet, 1863, p. 126, ^ ounce, in a girl four and a half years old; 276, Pharm. J., 1863, p. 186, a teaspoonful of 1., in a child six years old ; 277, same, p. 136, fatal dose of Op., in a man ; 278, Taylor, Guy’s Hosp. Rep., 1865, effects of H ounce of laudanum, iu a girl aged eleven and a half; 279, omitted ; 280, O’Sullivan, Dublin Quart. J. of Med. Sc., I860, p. 221, effects of 1 scruple, in a child twelve weeks old; 281, Walley, Lancet, 1866, p. 35, habitual use of 1., for fourteen years; 282, Radcliffe, Lancet, 1868, p. 312, 3 drachms of 1., in a woman aged thirty nine; 283, same, two tablespoonfuls of 1., in a woman of sixty ; 284, Finlay, Lancet, 1868, p. 664, effect of an indefinite amount of 1. (probably used as an enema for pain in abdomen); 285, Ogle, St. Geo. Hosp. Rep., 1868, p. 222, about 2 ounces of 1., in a man; 286, same, an indefinite amount, in a man; 287, same, in another man; 288, Young, Phil. M. and S. Rep., 1869, vol. 20, p. 157, about 2 ounces of tinct. Op., after a drunken spree; 289, Farnsworth, Phil. M. and S. Rep., 1869, p. 87, about 30 grains, in a man ; 290, Hemecourt, West. Horn. Ohs., 1869, p. 89, about I ounce of 1., in a girl; 291, Dobbie, Br. Med. J., 1870, p. 33, 2 ounces of 1., in an insane woman ; 292, Olivier, Gaz. des Hop., 1871, effects of 30 grams of the tincture, on account of erections after circumcision ; 293, Spooner, Trans. Horn. Med. Sac. St. of N. Y., 1871, 2 ounces of 1. with 6 grains of Morphia, in milk; 294, Burdock, Med. Rec., 6, 343, effect of ounce of 1., in a woman of thirty; 295, Johnson, Med. Times and Gaz., 1872, 2, 268, 4 drachms of ext. of Op., in a woman; 296, same, 3 drachms of extract, in a man ; 297, same, I5 drachm of Op., in a man ; 298, same, 3 drachms of extract, in a woman aged twenty-four ; 299, same, 2 drachms of extract, in a man ; 300, same, 2 drachms of extract, in a woman of twenty-nine; 301, same, 1 drachm of extract, in a man ; 302, same, 4 drachms of extract, in a woman ; 303, same, 2 drachms of extract, in a man ; 304, same, 1^ drachm of extract, in a woman of thirty-seven ; 305, same, 3 drachms of extract, in a man ; 306, same, Med. Times and Gaz., 1873, 10 drachms of extract, in a girl aged sixteen (death in nine hours) ; 307, same, 3 drachms of extract, in a man, death in seven hours and a half; 308, same, an unknown quantity, in a woman ; 309, same, 2 drachms of extract, in a woman of thirty-six; 310, same, 4 ounce of extract, in a woman of twenty-seven ; 311, Walker, Am. J. Med. Sc., 1872, p. 283, tincture of Op. (equal to 6 or 8 grains of pulv. Op.), in a girl of fifteen ; 312, Chatarion, Gaz. des Hop., 1873, effects of 20 grains of Sydenham s laudanum 313, Pharm. J., 1873, p. 138, effects of a large dose of laudanum, iu one habituated to Opium; 314, Price, Hahn. Month., 1873, p. 474, effects of discontinuing the use of the “black drop,” that had been used for pain iu an ulcer; 315, Stockman, 3 ounces of laudanum, in a man, vomited and recovered, but next day took 2| ounces, Phil. M. and S. J., 31, 164; 316, Hartley, Lancet, 1873, p. 684, \ ounce of laudanum ; 317, Paris, Phil. M. and S. Rep., 1873, p. 343. effects of habitual use of Op., as suppository; 318, Phell, Phil. Med. Times and Gaz., 1873, p. 134, effects of fluid ounce of 1., iu a young woman; 319, Hart, Am. Horn. Obs., 1873, p. 31, about an ounce of laudanum, in a child ; 320, Sharp, Essays on Med., 1874, p, 724, experiments with 1st dil. and with tincture; 321, Heaton, Med. Times and Gaz., 1875, p. 413, large dose of laudanum, in a man; 322, Clark, Med. Times and Gaz., 1875, p. 185, a large dose of 1., in a man ; 323, Pharm. J., 3d ser., vol. 5, p. 179, a large dose of laudanum ; 324, Sharp, Essay on Med., No. 32, experiments, a man took 1 drop of 1st cent. dil. of tinct. of Op., night and morning, for ten days; 325, same, subsequent proving, 5 drops, night and morning; 326, same, subsequent proving, pulse 72, took one dose of 10 drops of tincture; 327, same, subsequently, pulse 54, took 6 drops of tincture; 328, same. Dr. Sharp, took 1 drop of tincture; 329, same, a man, well, pulse 68, took 5 drops of tincture; 330, Cameron, Am. J. Horn. Mat. Med., 1876, p. 251, proving by inhaling Op., 60th dil.; 331, C. Wesselhoeft, N. A. J. of Horn., 1876, p. 17, habitual use of Op., in a man aged fifty; 332, Fitzsimmons, Toledo Med. and Surg. Journ., May, 1877, p. 134, effects of about 2 drachms of laudanum, in a child two years old ; 333, Sake, Edin. M. and S. J., 1840, p. 151, effects of 2 drachms of laudanum, in a man; 334, Toogood, Prov. Med. and S. Journ., 1841, p. 129, effects of 10 drachms of laudanum, in a woman (recovery) ; 335, Ran, Lancet, 1845, p. 476, effects of ^ drachm of laudanum, in a man ; 336, omitted ; 337, Layman, Am. J. of Med. Sc., 1854, p. 383, effects of an ounce of laudanum, in a woman, death in three-quarters of an hour ; 338, Jackson, Am. J. of Med. Sc., 1854, p. 385, effects of 2 drachms of Op., in a woman ; 339, Cleveland, Med. Times and Gaz., 1855, p. 82, a man took 2 ounces of liquor Op.; 349, Sloane, Med. Times and Gaz., 1855, p. 445, effects of ^ ounce of laudanum, in a man; 341, Slater, Lancet, 1862, p. 326, laudanum, in a woman ; 342, Ludlow, Brit. Med. Journ., 1866, p. 15, an overdose of laudanum, in a man ; 343, Bowstead, Lancet, 1873, p. 468, effects of 8 ounces of tinct. Op., in a woman; 344, Taylor, Med. Jurisp., 1, p. 349, an ounce and a half of laudanum, in a woman ; 345, Daniel Wilson, Inaugural Dissertation on the Morbid Effects of Op., Phil., 1803, 2 drachms of Opium, in a man ; 346, ibid., an ounce of laudanum, in a woman ; 347, ibid., same, in a man ; 348, ibid., effects of habitual use of 50 to 90 grains of Opium, in a man; 349, ibid., another case; 350, ibid., Baron de Toth, observations among the Turks.

Mind p. 181

JEniotioiiat, Delirium.

Delirium

Sometimes delirium

Delirium and rage

Raging delirium, with distortion of the mouth

* Violent delirium, with red face, glistening eyes, and great physical activity

Furious delirium (fourth day),'"k

He rolls about the floor in delirium, burning with anger, threatens, does not recognize his friends, with swollen head and face, reddish-blue swollen lips, with protruding, inflamed eyes

* While delirious he talked about all sorts of things with open eyes, and afterwards remembered them only as in a dream

Talked of his business, cast up columns of figures, and started up at any noise (after three hours) ; much better (after six hours)

[10-] *Her laudanum was left off for three days, and, in addition to the other symptoms, she appeared to see the most frightful animals and other objects

Delirium lasted twenty-four hours

His joyfulness and mental bliss increased until he became irrational and delirious

Evidently delirious, but, by persevering in our endeavors, he became capable of giving very pertinent answers, though he uttered them with much labor and difficulty (after half an hour)

Made delirious attempts to resist any treatment, but soon relapsed into unconsciousness,®^h

Delirium with the spasms

mid many disconnected things, and 'pointed with his fingers to masked people who seemed to approach him. At one time he broke into loud laughter; at another he started up in affright on account of fancied swordsmen, who threatened to stab him ; became angry if any one argued with him or thought him delirious; however, he blamed himself while in delirium for his folly

* * * §She whs tormented xohile awake with an apparent vision of ghosts, spectres, and chimeras, that constantly collected about her bed and distressed her very much, while she talked deliriously

The moment of ecstasy usually commences in about three-quarters of an hour; he then becomes an altered being; the expression of countenance is horribly wild ; he exhibits his delight in a thousand different ways

he gesticulates, he talks. Some of them compose excellent verses, and address the bystanders in excellent language; at last they return to their homes, each possessing some imaginary bliss which “the dull reality of life could never give. Those who encounter them divert themselves at their expense, and make them chatter nonsense; they are, however, too happy to pay attention to anything but their own reveries. Even the loud laugh and the shootings which accompany them home produce no effect; they are wrapped in an elysium, from which they are only to be awakened by the miserable reaction which must, sooner or later, recall them to existence

An agreeable reverie, at the end of three-quarters of an hour, or an hour at most, never fails to animate these automatons, causing them to throw themselves into a thousand different postures, but always extravagant and always merry. This is the moment when the scene becomes most interesting; all the actors are happy, and each retires home in a total state of irrationality, but likewise in the entire and full enjoyment of happiness not to be procured by reason. Disregarding the ridicule of those they meet, who divert themselves by making them talk absurdly, each imagines and looks and feels himself possessed of whatever he wishes. The reality of enjoyment often gives less satisfaction

Hot, anxious, and intoxicated ; she talked of all sorts of things ; took her words back at one time ; started up in fright; at another angrily seized the hands of those about her,®®.§

Litoxieation,^'^’’*; (ninth day)

Opium-eaters are always indolent and intoxicated

Intoxication and vertigo after sleep

A kind of intoxication that prevents his keeping upon his legs

Feeling of intoxication on waking from a nap (eighth day)

Intoxicated appearance (after two hours)

Appearance of most profound intoxication (after half an hour)

When taken in larger doses than those which cause liveliness it causes intoxication

A half intoxicated and excited condition, so that I came near being run over by a carriage, and at another time of running into a horse, though I had seen it coming from some distance (second day)

Dizzy intoxication ; he reels to and fro

Great excitation

Reeling to and fro, with dull, stupid expression of countenance (after two hours')

Considerable state of excitement (after two hours and a half

It appeared to his attendants that an excited state of mind remained for some days afterwards

* Con fusion of inindf

Mind iu a state of great confusion ; at one moment she was sensible of her crime, called for assistance; at another she resisted the means used to save her (after one hour)

Conscious of being possessed of two persons of another self besides his real self, the Opium man does things which the real self considers wrong, and it is not always sure which will conquer the other

Frightful imagery

The patient was susceptible of the excitant rather than the soporific quality of the drug, and his emotional nature quickly responded to it in manifestations of passional excitement, which threatened alternately self-destruction and injury to others

f'lO.] I made my way home as fast as possible, dreading at every step that I should commit some extravagance

He acts absurdly

* r/ie patient has visions

In walking I was hardly sensible that my feet touched the ground ; it seemed as if I slid along the ground impelled by stone invisible agent, and that my blood was composed of some ethereal fluid which rendered my body lighter than air. The most extraordinary visions of delight filled my brain all night

He seems to be flying or floating in the air, and to whirl with everything about him

Sensation as if he had been taken to heaven ; vivid, lovely fantasies float before his vision like a waking dream, which the slumber drives away

Lovely fantasies, far superior to any known happiness iu one who had previously been tortured by pains

Much confused for a time with involuntary turns of laughter

He describes his sensations “as the faint, exquisite music of a dream but he had only pleasurable feelings when his eyes were open ; if they were closed they vanished. It appeared to him as if external objects only were acted on by the imagination, and magnified into images of pleasure. In walking he was hardly sensible of his feet touching the ground ; it seemed as if he slid along the street impelled by some invisible agent, and that his blood was composed of some ethereal fluid which rendered his body lighter than air

I had no longer the same pleasure when I closed ray e3'es which I had when the were open ; it appeared to me as if it was only external objects which were acted on by the imagination and magnified into images of pleasure; in short, it was “the faint, exquisite music of a dream in a waking moment

Not sleepy, but so quiet that he seemed in heaven,®®.t

Constant quiet contentment of mind, as if in heaven

Without pain, he passed the whole night in the most extreme contentment of mind,®’.]

Not seldom there is an unusual condition of self-satisfaction and an unusual quiet of mind

The most agreeable sensation that allows her to think, with mental rest and forgetfulness of all trouble

He was inoffensive and ev^en amiable in his deportment, and employed liiraself constantly in the daytime in drawing what he called maps of the different apartments in heaven, which, he said, he visited every night

The mental activity of Opium is more like a dream without sleep

Mental quiet

Under the influence of emotions, strong sensations, and any particularly strong attention and exertion of the mind, the effects appear later than usual, are less in degree, and of shorter duration. If it so happened that the cause which disturbed ray mind was removed, then all the effects would almost instantly make their appearance and take their usual course

Calm, pale, deathly (after two hours)

Uttered three or four distinct but feeble wails or cries, the first sounds since admission into hospital (third day)

A faint cry or whine would escape the child when extreme measures were employed to arouse it

Opium-eaters are inconstant; they often promise what they soon refuse to abide by (every one avoids them and wishes to have nothing to do with them)

3IoO(ls. While smoking they are loquacious at first, and the conversation highly animated ; but as the opium takes effect the conversation droops, and they frequently burst out into loud laughter from the most trifling causes, or without any apparent cause at all, unless it be from the train of thought passing through their excited imaginations. The next phase presents a vacancy of countenance, with pallor and shrinking of the features, so that they resemble people convalescing from fever. A dead silence precedes a deep sleep, which continues from half an hour to three or four hours. In this state the pulse becomes much slower, softer, and smaller than before the debauch. Such is the general process almost invariably observed among the Chinese. But with the Malays it is often very different; instead of the placidity that ushers in the profound sleep, the Malays frequently become outrageously violent and quarrelsome, and lives are occasionally lost in these frightful orgies

Audacious ferocity

Cruelty, ferocity, like a wild beast,®®.t

Page

At first he was in an excited mood for an hour and a quarter, during which the mouth was frequently distorted, as in risus sardonicus

Criminals (in India) lose their fear of death and go courageously to their execution,®®.]

Great strength, courage, contentment with himself

Sensation of courage with activity, as if he could forcibly accomplish whatever was required without dread or fear, with a peculiar sensation of lustiness (though lasting only a few minutes), (after a quarter of an hour), followed by dulness of the head, etc.,®.

Courage, fearlessness, great-heartedness

Undaunted in danger

Opium causes in those fearing surgical operations courage and endurance

The Malays are confident that opium-smoking inspires them with preternatural courage and bodily strength; it is, therefore, resorted to whenever any desperate act is in contemplation

Loss of courage

Feeling of fear (second day)

* Fear (after eight, and twelve hours)

* Fear of impending death

Fearful and frightened

* A sensation of apprehension (after half an hour, third day)

A woman suffering from sad thoughts was wonderfully relieved by it; her grief disappeared for some time,®.§

* He started at the least noise, and a fly upon any part of his body was a burden to /whi

One and a half grains of solid Opium, taken every half hour, or one grain every hour, or one and a half grains taken every hour and a half, or every two hours, has insensibly brought on a happy hiunor, increased vigor, activity, and unusual watchfulness, which I perceived after having taken about two, three, or four grains, and which continued if from time to time, I repeated the same procedure for several days and nights, without the least inclination to sleep, without tiredness, or any impaired function, except dryness in the mouth and fauces, and thirst, occasionally gripings and costiveness

Cheerfulness, courage, contentment, increased vigor

She felt very lively and cheerful, and was capable of doing any quantity of work. She had severe family afflictions, but was not at all distressed by them while under the influence of Opium, though she felt them severely at other times

Lively, inclined to work, fearless, courageous

If I was in high spirits and very active, if I walked or took such exercise as made me warm and perspire, the effects made their appearance considerably sooner, were less in degree, and much less in duration

She was unable to get in any other way complete rest and happiness of mind

It makes the opium-eaters (who are usually sad and stupid) cheerful; they carouse, sing amorous songs, laugh much, and make all sorts of gestures ; this pleasant excitement of mind and emotion lasts an hour, after which they becomeangry and rave, and finally become again sad and weeping, till at last they fall asleep and soon return to their ordinary condition

Increase of vigor, confidence, and cheerfulness (if the dose was within 2 grains)

Elevation of spirits and watchfulness remained sometimes a few hours, at other times the whole remaining part of the day (after 2 or 3 grains)

Remained cheerful for two hours, and then was overcome by a violent drowsiness, when he took 90 drops more and was immediately roused from drowsiness

Joyous mood (after half an hour)

I found myself, or at least imagined myself, more alert and sprightly than before (after half an hour)

In persons accustomed to it, it produces a high degree of animation, which the Theriaca (opium-eaters) represent as the acme of happiness

It causes for a time forgetfulness of the troubles of the soul, and produces ecstasy and refreshing quiet of mind

The effects upon her spirits were most exhilarating ; she felt lively and cheerful, and could accomplish almost any amount of household work

Uncommonly merry and much inclined to noise

So exhilarated as to grow careless of occupation and rather inclined to indulge in an excess of gayety (after a short time)

Produced an enlivening effect which enabled him to prosecute his study

Very good humor (second day)

At first ecstasy followed by sadness and despondency

Contentment

Taciturnity

He became taciturn (after the smallest dose)

Excessive anxiety

Unusual sensation of anxiety (after two hours)

* Anxiety

Anxiety,”.t

[HO.] Transient attacks of anxiety, with short, oppressed respiration and trembling of the arms and hands

Melancholy

Despondency (fifth day)

On waking, depression

Depression of spirits, in the afternoon (after three drops)

Depression of spirits (eighth day); (after three-quarters of an hour)

Pale and dispirited, next morning

Sadness

Sad mood (first and second days)

* Sullen mood

Hopeless, morose mood, fretfulness (after eight, and twelve hours)

Very morose, angry at everything without reason (fourth day)

Lamentations and howling during the first hours

Screaming

Violent screaming, immediately

Moaning (after two

•f Omit Tralles.

Hughes. hours)

Slight groaning (after three hours)

AVeeping mood,"'. Cries incessantly

Much weeping during the first night She is so vexed about a pain that she weeps

Fretful and cross when roused (after four hours)

* ■ Fretfulness (second day),"^". Very fretful (fifth day),>

Querulous state

(third day)

Mistrustful

Appeared jealous and afraid of the people around (second day),*". Evidence of irregular nervous action, slight irritability of temper whenever disturbed

Indifference to pain and pleasure

Great indifference (after two drops)

The unfortunate drown their cares and troubles in an indescribably pleasurable feeling of indifference to all around,‘‘*^ Calm indifference to earthly things; she cared for nothing on account of the ecstasy of fantasy

Alternating state of sullen grief and of cheerfulness

intellectual, More inclination for work and greater facility in it than usual

Mental activity

My faculties seemed enlarged

AVhen under its operation his intellect was more brilliant, his language more eloquent, and his talent for writing more easy than in the former and healthy periods of his life. His affections were at the same time kind and benevolent, and he felt no disposition to quarrel, as persons often do who take ardent spirits in excess

When under the influence of opium, he seems to others to be in his normal condition ; but a little intercourse with him shows his mind to be not only clear and active, but filled with gigantic schemes and theories, the realization of which seems to him quite natural and easy; his faculties are remarkably keen, and his power of expression wonderfully terse and convincing. As soon as the effect begins to subside (as it does after sleeping), he is depressed and melancholy, which soon reaches an extreme state of suicidal depression, in which the world seems terribly dull, and he feels driven to desperation, as if haunted by evil spirits. This condition is brought on by occasional attempts to resist his destructive habit; but he cannot endure abstinence long. As soon as he takes his accustomed dose of Morphia, he is at once changed from a cringing desperate creature into a spirited and energetic individual

Occupied with sublime contemplation the whole night, without sleep

It makes the senses active and disposes to earnest and arduous labor

It dissipates all inclination to sleep, increases the imagination and memory in the most wonderful manner, so that he passes the whole night in profound meditation; at daybreak he slumbers a few hours; he is unable to recollect all that he has thought about during the night,’®.f

The powers of my mind still remained so perfect as to enable me to examine the state of my pulse, which was strong and full

Profuse flow of ideas, with joyfulness

A certain hastiness at work; his thoughts also are more rapid than usual

Disinclination for work (eighth day)

Disinclination for his ordinary work (after two drops)

Obscuration and weakness of mind ; illusion, as if the eyes were four times larger than usual,®®.]

* Dulness of mind; short anxious respiration with great heaving of the chest; the exjes give out, and are full of xvater

Slight confusion of thought (within an hour)/

Loss of ideas, with inability to think

Every attempt at persistent thought was ineffectual (first day)

Inability and disinclination for work in the afternoon (after three drops)

General deterioration of all the mental faculties

The power of the will is overcome by the merest trifle

It diminishes the power of the will over the muscles fin strong people), causes heaviness of the head and great weakness

Voluntary powers suspended

Mental weakness

The mental powers disappear

All the mental powers, all the sensibilities are dull

Dimness of the head; he has mental grasp for anything, and cannot comprehend the sense of what he is reading

Dulness, indifference to external objects

* D III ness and imbecility

Dulness of mind

Dulness of sense (after eight, and twelve hours) ®

Dulness of sense, insensibility ; he is scarcely conscious of his existence, although he answers quite appropriately

Insensibility to shame and to the more refined sensibilities

Nearly rational, though when left to herself her mind seems to wander (second day)

Capable of being aroused, and answered questions, but quickly relapsed into deep solemnity (after twenty-six hours and a half)

jMeniOvy. Great forgetfulness (second day)

Forgetfulness

He replied slowly to questions, as if he forgot his words

His ideas not easily collected (after eleven hours)

Chronic loss of memory

Loss of memory; (after ten minutes)

Loss of memory for several weeks

Loss of memory,®®.]

The memory and mental powers generally became greatly impaired, attended by a miserable depression of spirits

Memory continued weak

Frequent weakness of memory,"®.§

He does not recognize his nearest relatives nor familiar objects

Comprehension wavering

Insensibility. ^Complete insensibility, so that it was impossible, either by pulling the hair or pinching the skin, to excite any wincing or signs of uneasiness, nor was any effect produced by the sudden affusion of cold water

* Insensible state,®®® ®‘® ®” ®”, etc.

Insensibility, accompanied with a complete apoplectic respiration (after three hours)

Complete immobility and insensibility

Complete insensibility

* Completeinsensibility, with her eyes open, etc. (after two hours)

* Greatinsensibility toexternalimpressionsi

Insensibility, soon ; (after five hours), 202 221 265 . (after two hours)

Perfectly insensible (after two hours)

Totally insensible, and to an ordinary observer, lifeless (after six hours)

Totally insensible (after fifteen minutes)

p^j.. fectly insensible and could not be roused

Appeared completely insensible to everything around her, and would not answer questions (after five hours and a half)

Apparently dead (after four hours and threequarters)

Insensible and motionless (after four hours)

Insensible of what was passing around her (after six hours)

Almost total absence of sensibility to external impressions

Insensible and comatose (after one hour and three-quarters)/®

Insensible, and in strong convulsions; convulsions followed each other in quick succession, with comatose intervals (after one hour)

Insensible, and could not be aroused by shaking (after twelve hours)

Could not by any means be aroused/'®®®®; (after six hours); (after four or five hours)

Could not be aroused by loud calling or shaking, or by the dashing of cold water on her face

AVas aroused with great difficulty

Answered no questions, even when put in the loudest voice (after four hours)

Insensible, though capable of being aroused (after half an hour)

Slightly diminished sensibility (after 2 or 3 grains)

Scarcely sensible (after a quarter of an hour)

Almost perfect insensibility (after twenty or thirty minutes)

Almost insensible for some hours

Almost insensible to external impressions, and when aroused by violent shaking and loud speaking, immediately sank back into a comatose sleep (after one hour and a half)®®®.

Partial insensibility ; he could be roused by shouting into his ear, but could not be made to answer any question ; when not continuously aroused, he fell off immediately into a heavy stertorous sleep ; between two assistants he was from time to time dragged along the corridors, making little effort to support himself, and when allowed to sit down, he was continuously aroused by being flapped on the face with a wet towel, which would cause him to open his eyes momentarily, but he became more completely narcotized, so that towards morning he seemed to be in imminent danger

Entire loss of intellectual faculties, of motion and perception

The child lay unconscious and insensible

Sudden loss of consciousness, with blue face and contraction of the upper extremities

She is unconscious of what is transpiring about her, and gives no sign of consciousness; the joints are supple, and all the muscles relaxed

Complete asphyxia ; not the slightest evidence of sensibility could be elicited by the application of various tests to different portions of the cutaneous surface or to Schneiderian membrane (after two hours) ; yet scarce a trace of the effects of the poison was observable (after twenty-four hours)

Not the slightest indication of consciousness was elicited by passing the finger across the naked eye, by violent shaking, or by the application of ice-water, in the form of affusion, to the head (after eight hours)

Lying on the floor in a state of unconsciousness, after sometime; total insensibility (after four hours and a half)

The patient seemed momentarily threatened with apoplexy, having all the symptoms except stupor (after a quarter of an hour); this was followed by complete insensibility and death (after three quarters of an hour)

Nearly complete narcotism

Narcotism complete (after four hours)

She was quite unconscious, and had lost the power of swallowing. After remaining in this comatose state for upwards of nine hours, she revived, the face became natural, the pulse steady, the power of swallowing returned, she was able to recognize her daughter, and, in a thick voice, to give an account of the mistake she had made. This state lasted about five minutes, the torpor then returned ; she again sank into profound coma, and died in fourteen hours after the poison had been taken

Most profound coma (after three hours)

Profound coma (after eighteen hours); (after four hours),®’®, and many others.

Profound coma for three hours (after eight hours)

Perfect coma ; the insensibility being so complete that ice-water dashed violently in her face produced not the least evidence of sensibility, nor contraction of any of the voluntary muscles (after one hour and a half)

Completely comatose, and on placing my finger on the conjunctiva there was no sensibility whatever evinced

Completely comatose, unrousable, insensible to sharp pinching, not convulsed, but arms rigid, fingers clenched, nails not livid (after two hours)

Deep coma, with the head drawn backwards, and in partial opisthotonos

Comatose condition, and snoring heavily (after twenty-three hours)

Comatose,”*; (after two hours); (after six hours),”®,etc.

She lay comatose on her back, the head resting as if inert

Coma and insensibility, with the ordinary warmth, pulse, and respiration

Able to speak and walk about without difficulty, although very drowsy (after two hours) ; quite comatose, unable to move (after three hours and a half )

Partially comatose (after two hours and a quarter) ; profound coma (after two hours and a half)

Partially comatose, but capable of being roused (after three hours); complete coma (after fourteen hours)

Partially comatose, but capable of being roused up (after three hours) ; profound coma (after four hours)

Lethargic condition (after three hours)

Lethargy

Lethargy increased so much that it required the utmost exertions to keep her awake (after six hours)

Violent stupefaction and intoxication,®®.f

Deep stupefaction (after one hour and a half)

Stupefaction (after eight minutes)

Stupefaction like an intoxication (sixth day)

Stupefaction and some delirium

Stupefaction, indifference

Stupefaction of sense and loss of reasoning power

Slowness of comprehension, stupidity, senselessness

Stupefaction of mind as if a board were before the head, with vertigo, obliging him to lie down, followed by trembling of the body, lasting some time,®".|

Dull stupefaction, with weak eyes and extreme loss of power

Stupefaction and insensibility, although he answered correctly

Sensation of stupefaction (third day)

Stupor, soon; (after five or six hours),'*

Stupor,'®.§

Lay in a deadly stupor, from which all efforts of her friends were insufficient to awaken her (after two hours)

Profound stupor; (after seven hours); (after six hours and a half )

Stupor so great that it could not be roused by any efforts that I could make (after three hours)

Stupor resembling that of narcotic poisoning, rather than true state of coma

Stupefied

Continued in a stupid state for the remainder of the day, after the relief of other symptoms by vomiting

Every few minutes she fell into a stupor and sleep, from which she could only be roused by being repeatedly moved or shaken ; she would give no answer to questions put to her, which appeared to proceed much more from the torpor and insensible state in which she was than from obstinacy or any other cause (second day)

He made no answer to any question, though put to him with a loud voice, close to his ear. On discontinuing the agitation for a moment, he immediately relapsed into a state of stupor and insensibility; the only expedient that effectually roused him was pulling him by the hair of the head. This was so completely successful on one occasion that he rose from his seat in a paroxysm of anger, and attempted to throw off his jacket and vest, but immediately fell back in a state of insensibility (after three hours and a half)

Very “stupid state, and scarcely able to answer any question put to her (after two hours) ; perfectly insensible (after four hours)

Great difficulty in rousing it, and when roused, immediately relapsing into deep stupor

Slight stupor, from which he was easily aroused

Opium-eaters are sleepy and almost stupid.'®.

Head p. 190

Confusion and Vertigo. Confusion of the head, with a sensation of dry heat in the eyes and inclination to close the eyes, without sleepiness, together with a sensation as though he had watched the previous night

* Head confused, as after intoxicating drinks

Confusion of the head, after sleep

Vertigo e? 90 99. (gj^th day; (eleventh day); (second, third, fourth, fifth, seventh, ninth, and tenth days),'*'*^etc.

Violent vertigo obliges him to lie down

Violent vertigo (after 4 drops)

Vertigo; some intoxication

* Vert(/o and dulness of the head, transient (after 4 drops)

Vertigo; was scarcely able to keep upright; even while sitting it seemed difficult to hold up the head (after 16 drops)

Vertigo, on looking to the right or left (looking straight ahead, on bending the head forward, did not cause vertigo), (after half an hour)

Vertigo, with swaying back and forth of the body

Vertigo, as if everything were turning about with him in a circle

Vertigo, caused by stooping (after twenty hours)

* Vertigo, and stupefaction of the head

Slight vertigo (after two hours and three-quarters); relieved after vomiting (after three hours and a half)

Vertigo, with numbness of limbs (after five minutes)

Dizziness, with vanishing of thoughts (after 4 drops)

Dizziness, with confusion of the head

Dizzy, anxious, irrational

Dizzy, as if intoxicated, after waking from sleep (first day)

Giddiness, sometimes headache

Feels giddy on attempting to get up (after forty-five hours)

Felt giddy and sick (soon)

Very giddy and confused (after one hour), (one case)

Slight giddiness (within an hour)

Very giddy all day

Reeling from the effects of the drug; they sink into a disturbed sleep, from which they awake towards noon

Reeling

General Head. He was unable to hold the head upright; it swayed back and forth

Slight lateral motion of the head

Head drooping (after two hours and a half)

When raised to a sitting posture the head would fall backwards or sideways

Perceptible and audible pulsation in the bloodvessels of the head (eleventh day)

Pulsations in the arteries of the head

Heat and sensible pulsation of the arteries in the head (after 2 or 3 grains)

(The bloodvessels of the brain are distended by blood),”*.f

Rush of blood to the brairi,*°

Rush of blood to the head, that was actually painful, especially affecting the forehead (after 2 drops)

Acute cerebral congestion

Congestion of brain increased (after twelve hours)

Congestion to the head

Humming in the head, as from bees, with a stopped sensation in both ears, apparently accompanied by diminished hearing (after about two hours, first day)

Roaring in the head (a few minutes after 1 drop)

He heard the blood rush to the brain, with a dull but loud noise on every beat of the heart

He hears the beating in the cerebral arteries

Swimming sensation in the head when she rises up in bed (fifth day)

Sensation in the head like that following sleep after excessive debauch

Sensation of warmth in the head

His head, though feeling free, on waking, in the morning, became quite as confused, about 8 A.M., as it had been the preceding afternoon, though it wore away towards noon (after 18 drops)

General weakness and confusion of the head (third day)

Obscuration of the head, immediately,®’.!

Heaviness of the head; (after 6 drops),’”*; (after eight minutes); (twenty minutes after 1 grain)

Head so heavy and stupid that he was obliged to rest it; it seemed to him that he could feel the rush of blood to the head (after 18 drops)

* Heaviness of the head, making thought and, in consequence, writing difficult (twenty minutes after 2 grains)

Lassitude, heaviness of the head, and dryness in the throat, after the Opium sleep,'”.f

Head very heavy for several days; the occiput feels like lead, so that the head constantly falls backward, and he cannot hold it upright

The head is heavy, and as if intoxicated, lasting twelve hours

Heaviness of the head; on raising it, a sensation as if a heavy substance were in it and moved to and fro

Heaviness of the head, especially in the sinciput (first day)

Heaviness of the head, with a feeling as if the head had been hanging down for a long time (one hour after 5 drops)

Heaviness and dulness of the head, lasting a quarter of an hour (one hour after 6 drops)

Dulness and confusion of the head, soon becoming a pressive sensation, extending forward over the orbit and backward to the nape of the neck

Dulness of the head, as if smoke rose into the brain,®®.]

Dulness of the head, especially in the frontal region

Dulness of the head; (after 1 drop),'”""; (after ten, and twenty minutes); (after one hour, fifth day); (fifth and tenth days); (first and ninth days)

Dulness of the head, becoming a real pressive pain, especially in the forehead, extending towards the eyes and down to the nose (after 1 drop)

Head dull and confused (second morning after 2 drops)

Dulness and j^pressive pain in the head (after 1 drop)

Dulness of the head and pressure in the forehead (after 2 drops)

Dulness of the head, with more rapid pulse than usual (after 7 drops)

General dulness of the head, followed by confusion, that gradually became vertigo, and made thought and speech exceedingly difficult (a quarter of an hour after 3 drops)

Dulness of the head, with pressure in the eyes (ten minutes after 2 grain)

Feeling of dulness and congestion in the head, increasing from minute to minute, with glowing heat of the face and perspiration on the head (ten minutes after 1 grain)

Dulness of the head, with inability to perform mental labor (nine hours after 1 grain)

Dulness of the head, with increased circulation of the blood, and with a full, hard pulse (after 12 drops)

* Dimness of the head, with vertigo (fourth day)

Slight dulness of the head,'”'; (after 3 drops); (a quarter of an hour after drop); (after half an hour)

Headache,^'^; (after two hours), (two cases); (second day),'’"'”'" ; (third day); (after one hour); (fifth day); (second day)

Headache, at times dull, at times very severe (first day)

Headache, after a nap (fourth day)

Dull headache (first, second, eighth, and ninth days},®®’®®

Dull headache (after ninety minutes); much increased and attended with drowsiness and nausea (after two hours); soon relieved after vomiting (after three hours and a half)

Woke with headache and dull stupefaction

Violent headache, with difficult breathing

Violent headache; (second day); (one hour after 4 grains); (second day)

Headache, with vertigo (after 1 drop)

Headache, extending from the vertex to the right orbit, a pressive pain always extending from within outward, in the afternoon and evening (after 2 drops)

Headache, on waking in the morning, that became worse after rising, but disappeared during the forenoon (after 4 drops)

Severe headache, soon; remarked that his head was splitting with pain (after three hours)

If the dose was deferred she had always severe headache/

Headache in the supraorbital region (fourth day),■

Headache almost immediately/*®.

Head ached next morning/®®.

Headache relieved by leaning against the cold wall/'’®.

Slight headache (second day)

Slight headache, on waking, in the morning (after 4 drops)

Slight pressive headache (after 3 drops)

Pressive headache (two minutes after drop)

Constant pressive headache/*®.

Pressive headache in the head and nose, as if seated in the scalp, which feels as though it had been bruised (after 3 drops)

Violent pressive headache (fourth day)

Dull pressure in the head, gradually becoming a vertigo, making thought difficult (after 24 drops)

Pressure and dulness in the head, extending over the whole head, but most violent in the vertex (a quarter of an hour after 2 drops)

Pressive, at times throbbing, headache, extending from behind forward, along the median line, during the afternoon

Pressure in the head (after half an hour); in half an hour this pressure was increased to giddiness and slight confusion (one case)

Pressing sensation in the head (sixth day)

^sensation of tension in the head

The whole head seemed in a vice; relieved by motion (after half an hour)

Feeling of fulness in the head (eleventh day)

Pressive pain in the head

Pressive pain over the whole head, with disinclination to work and great indifference (after 4 drops)

Violent pain in head, accompanied with giddiness

Excessive j)ain in the head (second day)

Pain iu the head, as if everything were torn to pieces, and a sensation as if everything in the body were turned about, with general discomfort, that made him indignant

A slight pain over the whole head, a sensation as of a rush of blood, lasting about ten minutes (soon after 4 drops)

Transient stitches, from within outward, in the head (after 18 drops)

Transient stitches in the head

Iforehead. Warmth in the forehead, with pain in it

Head, especially the frontal region, very dull (second day)

Dulness in the right side of the forehead, that was somewhat hot

Dulness in the forepart of the head, sometimes interrupted by sticking pain above the eyebrows, that after an hour extended over the whole head ; this confused condition of the head became better towards noon, and in the afternoon only some dulness of the head remained, with at times sticking pain in the head; this sensation was accompanied by warmth and flushes of heat in the face (after 12 drops)

Violent headache, especially in the right half of the forehead (after 2 drops)

Sticking headache in the frontal region, alternating with drawing pains within the ears; at last the head became so heavy that he was obliged to lie down, in order to avoid sinking down (soon after 1 grain)

Pressive stupefying headache iu the right side of the forehead (after twenty minutes)

Headache, like a pressure from within outward in the forehead

One-sided headache in the forehead, as if it would press outward, relieved by external pressure

A kind of pressure in the forehead, that seems to extend to the eyes and nose

Pressure iu the right frontal eminence (after a few minutes)

Slight pressure above the right eye and in the frontal eminence (after half an hour)

’'A sensitive pressure above the right frontal eminence, with a sensation of heat, while reading; when this disappeared it gave place to a painful pinching sensation in the right temple, as if something pressed upon the part and then again relaxed

Pain, pressing from within outward, in the right frontal eminence, preventing writing; after twenty minutes this was felt in the occiput; removed by rubbing with the hand and pressure

Pressure and slight digging iu the upper part of the forehead, with heaviness of the lids, that seem inclined to close, especially the left eye

Pressing-out pain in the left side of the forehead, recurring by paroxysms, extending over the whole right side, from the head to the tips of the toes

Pressive pain in both frontal eminences, extending down to the nose, and especially affecting both nasal bones; after an hour this pain disappeared, but gave place to pressure in the forehead, and especially above the eyes, with general dulness of the head (after 2 drops)

Pressure in the forehead and over the eyes; it seemed as though the eyes would be pressed together, a feeling like that one experiences when the eyes are irresistibly closed by sleepiness (after 10 drops)

Pressure in the forehead, lasting all day (after 2 drops)

Pressure in the forehead (after 6 drops)

Slight pressure in the right frontal region,Pressive pain in the left frontal eminence (after 2 drops)

Pressive pain in the forehead

Pressive pains in the forehead and occiput, with dulness in the head, a sensation of dizziness

Slight pressive pain in the region of the glabella, lasting only a few minutes (soon after 1 drop)

Pressive pain in the frontal region, afterwards extending to the root of the nose and even to the tip of the nose, and changing to a kind of pinching (after 3 drops)

Pressive pain in the forehead, soon

Pains across the forehead (second day)

Pain in the forehead, that was warm to touch (fifth day)

Pain, like needle stitches, in the forehead

Sticking-throbbing pains in the forehead

Violent sticking in the left frontal region, long continued, and extending deep into the brain (after two hours),"l

Tearing and beating in the forehead; sour eructations; sour vomiting; she was obliged to lie down when she perspired

Intolerable boring pain in the forehead, at times disappearing, and again extending from the forehead to the vertex (eighth and ninth days)

Stupefied sensation above the eyes

Certain sensations in the forehead, a kind of pressure and straining, the latter of which seemed to reach down to the eyes and nose, if the dose had been within 2 grains of solid purified Opium; if I had taken 2 or 3 grains these sensations would insensibly increase to a slight confusion of thought and giddiness, a heat and sensible pulsation of the arteries in the head; after 4 to 6 grains the pressure increased quite quickly, and passed on to pain

Temple. Single twitchings in the temporal muscles

Head painful, especially in the temples, where there was a sensation as if they were pressed together (fourth night)

Transient pressure in the right temple and in the right external canthus (after half an hour)

Pressingasunder pain in the temples, and especially in the forehead (after one hour and a half)

* Pressing pain in the temples (sixth day)

Vertex. Dulness in the sinciput (after 6 drops)

A very distressing persistent pain, sometimes between a sticking and a boring, in the coronal and sagittal sutures; in the latter, however, only in the middle of the vertex

Slight pressive headache in the left side of the vertex and of the forehead, in the evening (after 2 drops)

Parietals. Slight pressive pain on the right side of the vertex, under the forehead, lasting only about twenty minutes (after 3 drops)

Sticking headache, extending from the forehead to the orbit, especially involving the right half of the head, with inclination to sleep (after 1 drop)

Dulness in the left side of the head, extending to the right temple

Extremely painful headache in the occiput

Dull headache in the occiput, in the evening (seventh day)

Occiput. A pressive-tensive pain in the occiput, at the point of the insertion of the trapezius muscle, extending across the whole breadth of the nape of the neck to the upper margin of the acromion process and the inner margins of both scapulae, as far as the tips, in general corresponding to the course of the muscular fibres; the pain was most noticed in the region of the fourth dorsal vertebra, whence it extended to the last dorsal vertebra; always aggravated by motion, during rest (on waking from the midday nap it had disappeared), (second day),*'“. Slight drawing-tearing pain in the occiput, from the scalp to the ears, in a place of the size of a quarter of a dollar, in the region of the fontanelle, gradually increasing in severity, lasting about eight minutes and suddenly disappearing, though it returned after about twenty minutes, and extended thence down the whole spine, lasting about six minutes, in the afternoon (first day),”®*. Pains in the occiput (after 4 drops)

i:xteiyial Head. Tension in the skin of the forehead; relieved by stroking with the hand

A tremulous drawing in different parts of the scalp, in the forehead, and vertex (after 10 drops)

Hair very gray

Eyes p. 194

Eyes very red ; pupils dilated, with staring look (after fortyeight hours)

Eyes rotated upward under brows (after four hours)

Eyes turned upward under the upper eyelids

Eyes prominent and motionless (second day)

Eyes open, turned upward

Eyes wide open

Eyes open, and altogether distorted,®.f

Eyes distorted

Eyes fixed (after two hours)

Eyes fixed ; pupils contracted, and altogether unaffected by light (after one hour and three-quarters)

Eyes dark and glassy

Glassy, deep-sunken eyes

Eyes glistening

Eyes glistening,sparkling

Eyes sparkled

Staring look,®*®.- He stares at the bystanders with watery eyes; does not know what he is looking at,'and cannot recognize individuals

Eyes staring, with excessive lustre

Eyes wild and staring (after one hour)

Eyes became full and sparkling

Eyes look heavy (after twenty minutes)

Eyes glassy and lack lustre

Heavy, uneasy eyes (after 4 to 6 grains)

Eyes heavy and languid (second day)

Dull, unimpressive eye

Eyes dim (after two hours)

Eye lost its expression

Eyes sunk

Eyes sunk, and often glassy (after six hours)

Eyes sealed up, or dropping rheum

Eyes only half closed; pupils dilated, insensible

Eyes half open, drawn forcibly upward and outward; pupils contracted, did not dilate when light was removed

Eyes partly closed; at times open, with the eyeballs turned upward,'**.^Eyes closed, and the eyeballs turned upward and slightly outward (both of them); the pupils very much contracted ; no reflex action of eyelids

While in school he was frequently obliged to forcibly open and close the eyes, with dryness in the eyes, as from dust and frequent pressure on both eyes. On going home it was noticed that he opened and closed the eyes more frequently than natural, and was asked the reason; on examining the eyes there was found great redness of the conjunctiva of the lids and of the eyeballs

Dimness and moisture of the eyes (fifth day)

Eyes alternately moist and dim (fourth day)

Eyes dry and weak, with burning, and a sensation as if dust were in them; this lasted during the evening and after going to bed, and only passed off during the night (after 2 drops)

The eyes seem moist in the open air (sixth day)

Stiffness of the eyes (tenth day)

Heaviness of the eyes (tenth day)

On awaking, eyes dull and heavy

Sensation of dryness in the right eye

Dryness of the eyes, that seem stiff”, sometimes with much water in them (third day)

Burning in the eyes, with a sensation as if sand or dust were in them (after 2 drops)

Sensation of burning in the eyes and lachryraation

Pressure in the eyes, causing a sensation as if he had lost the power to hold the lids open (ten minutes after grain)

Slight pressure upon the right eye, as from continued reading

Slight obscuration of the eyes (sixth day),**l

Sensation as though the eyes were too large for their orbits

A sensation in the eyes as if they were swelled, and the sockets not large enough to contain them (after 2 or 3 grains)

Lid, Swelling of the lower lids

Eyelids swollen,dark-colored, half-closed

The lids hang down as if paralyzed

Eyelids drooping (second day)

Eyelids tremulous and half open ; pupils contracted

Lids trembling, only half covering the eyeballs

Eyelids closed; (after one hour)

Eyelids closed, and the child appeared in a state of slumber, and, if roused, exhibited a tendency to relapse into sleep (after eight hours)

Lids closed; pupils contracted to a point; insensible to light; eyes supraverted and divergent (after two hours)

Eyes closed ; eyelids swollen ; pupils normal in size, but insensible

Eyelids closed ; pupils upturned, strongly contracted, and little, if at all, influenced by light (after one hour)

The eyelids were closed; the patient’s efforts to raise them producing only short, tremulous contractions, and, when held open by the fingers, the eyeballs were seen to be turned upwards and a little inwards, from which position she could move them only to a slight degree and for a short time (second day)

Eyelids spasmodically closed; pupils contracted to the size of a pin’s point (after three hours)

Lids tightly closed ; eyes turned upward

The eyebrow droops; the lower eyelid becomes dark; the eye itself seems to sink and grow dim

Eyelids, lips, and wings of the nose livid

Heaviness of the upper lids, as if they were swollen

Transient sticking in the left external canthus (after 1 drop)

Cramplike sensation in the right external canthus

Laclivymal Apinirat^lS. Increased lachrymation (second day)

Conjure- 'tiva, Redness of the conjunctiva (second day)

Redness of the conjunctiva of the ball and lids, with some swelling of the caruncula laciymalis

Tunica conjunctiva replete with bloodvessels (after two hours)

Eyes glassy and conjunctiva straw-colored

Ocular conjunctiva and surface of cornea barely sensitive to touch (after six hours)

Conjunctiva and cornea quite insensible to touch (after three hours)

■ ball. Eyeballs and eyelids immovable

Eyeballs turned upward; pupils contracted

Eyeballs partially turned upward (after half an hour)

Eyeballs turned up beneath the lids and fixed ; pupils contracted and immovable

The eyeballs appeared through their coverings rather prominent; the pupils were fixed and contracted to the size of a pin’s head (after two hours and a half)

The eyeballs were forced from within outward (ten minutes after 1 grain)

Pressive sensation in the eyeball, relieved by rubbing and motion

Pupils greatly dilated; (after six hours and a half)

Dilatation of the pupils (after five or six hours)

Pupils easy to dilate

Pupils dilated (first hours)

Pupils of both eyes considerably dilated (after six hours)

Dilated pupils and obscured vision (after a quarter of an hour)

Pupils dilated and insensible to light,'***; (after one hour and a quarter); (after thirty minutes); (after four hours)

Pupils somewhat dilated (half an hour after 1 grain)

Pupils neither expanded nor dilated, but nearly natural as to size, yet did not respond to the influence of light

A slight dilatation of the pupils

* Pupils contracted,*; (after 4 to 6 grains); (after fonr hours),*®**®* *®®, etc.

Pupils contracted; eyes fixed and totally insensible (after three hours and a half)

Pupils inactive and contracted ; no reflex action could be roused in the eyes or eyelids on admission into hospital; at the time of death the pupils became very dilated/^\ Pupils extremely contracted, and did not dilate either in the dark nor when I rubbed his eyes with my finger (one case)

Pupils extremely contracted,; (after four hours) Pupils firmly contracted to the smallest point; surface of cornea and conjunctiva quite insensible to touch (after seven hours)

Pupils became contracted to a point that could scarcely be seen; at times the patient could scarcely distinguish objects

Pupils contracted to a point (after four hours); (after two hours),'*®®etc.

Great myosis, the pupils not larger than a pin’s head (after twenty-six hours and a half); (after eight hours),®*'’ Pupils contracted to the size of a pin’s head, and immovable to the impressions of light; eyes everted, fixed, and strongly congested ; eyelids closed (after one hour and a half)

Pupils turned upwards and outwards ; contracted to the size of a pin’s head

Pupils contracted to about half a line

Pupils contracted and insensible to light (after one hour); (after two hours); (after seven hours)

’•'Pupils contracted, fixed (second day)

Pupils excessively contracted,®®*®**®®*®®®, etc.

Pupils contracted ; divergent squint

Eyelids half closed; pupils quite contracted (after two hours and a half)

Irides immovable; pupils about 3*2 inch in diameter, and cornea insensible (after one hour and a half)

Pupils very small, but immovable

Pupils small; conjunctiva and cornea slightly sensitive to touch (after two hours and a half)

Pupils slightly contracted (after two hours) ; firmly contracted (after three hours and a half)

Pupils slightly contracted (after three hours) ; firmly contracted (after fourteen hours)

Slight contraction of the pupils; afterwards firm contraction

Pupils contracted, but not completely (after eight hours and a half)

Pupils slightly contracted (after eleven, and twenty hours)

Oscillation of the pupils

Pupils insensible to light; (after two hours)

Vision. ( Was able to read and write in the evening without his glasses, which usually he could not do) (sixth day)

Dimness of sight at times, which soon leaves her, and returns again after a short time (after three days)

Dimness of vision ; he seems to see through a veil

Dimness of vision while reading in the forenoon (first day)

Dimness of vision, as from a veil before the eyes, lasting a quarter of an hour (after two hours and a half)

Dimness of vision (after 4 to 6 grains); (one case); (second day)

Vision obscured, as byafog

Obscuration of vision; (ouehourafterlbdrops); (one hour after 2 grains)

Obscuration of vision, so that while writing the letters seem to swim together

Vision indistinct

Unable to see (second day)

Everything I looked at seemed increased in volume

All objects seem smaller than usual (after daily doses of 5 drops)

Says she cannot see distinctly, and sometimes there are two candles where there should be one (second day)

Said there was a mist before her eyes and she could not see (after a quarter of an hour)

Haziness of the eyes

Flickering before the eyes

It became dark before the eyes, Avith disappearance of thought, heat of the head, etc. (after 4 drops)

While completely conscious he complained that vision became dark, that he was blind (after four hours),®®.f

It seems black before the eyes, with vertigo

He thought that flashes of fire came out of his eyes,®’.]

Ears p. 197

Pressure toward the external meatus auditorium

Jerking within the ears, first in the left, then in the right

Throbbing in both ears

Hearing. Hearing more acute than usual (after half an hour)

It was very remarkable that, when the torpor and comatose heaviness were at such a height, he appeared to have almost no command of any of his muscles, nor the smallest perception of what was passing around him; his hearing was nevertheless remarkably acute, and he repeatedly requested that we would not speak louder than usual, saying that it disturbed him exceedingly to hear the loud talking

Plearing somewhat indistinct, as in slight intoxication

Difficulty of hearing in the left ear, lasting four minutes (after three hours)

Hearing so deficient that she could hardly detect the voice of any one who spoke; yet her own voice sounded most disagreeably loud to her

Difficulty of hearing

The hearing remained weaker for sometime after the proving

* Violent roaring in the ears (sixth day)

Great roaring in the ears, in the evening while sitting still

Roaring in the ears

Some roaring in the ears

Dull roaring in the ears after eating (after four hours)

Ringing in the ears; (eleventh day)

Disagreeable humming in the ears, when talking or whistling

Humming in the ears (very soon)

Nose p. 197

One symptom never failed to accompany any attempt to renounce Opium, viz., violent sternutation. This now became exceedingly troublesome, sometimes lasting for two hours at a time, and recurring at least two or three times a day

(Violent coryza, with some cough),’".t

Bloody liquid exudes from the nose and mouth during the convulsions

Copious secretion of mucus from the nose

Frothy mucus ejected from the nares (after four hours)

A large quantity of frothy-looking fluid tinged with arterial blood escaped from the nose (after seven hours and three-quarters)

Stoppage of the nose like stopped catarrh, in a warm room, after walking in the open air

Great dryness in the nose, the whole afternoon and evening (after 2 drops)

Sense of smell so impaired that she could perceive no pungency in snuff

Face p. 197

Face swollen, skin hot and dry, tongue white, hoarseness, respiration very much impeded, spitting of blood,®®.|

Swelling of the face

Face greatly swollen, and had an unmeaning ghastly expression

Face swollen, violet-colored, like the rest of the body

Spasmodic motions of the facial muscles (after seven days)

Spasm of the facial muscles,®®.§

Muscles of the face affected with spasm, and those of the limbs with convulsions

Convulsive trembling of the facial muscles, lips, and tongue

Face altered, eyes haggard, cheeks furrowed, pale

Features distorted, taciturn, with open eyes

Features distorted

Face purple and the features distorted (after fifteen minutes)

* Face bloated, red, and rather livid

Countenance bloated (after one hour and three-quarters)

Face bloated and dark

Face much congested

Distended veins in the face

Face full, and the skin of it having a smooth glassy appearance (second day)

Gave a new air of life and brightness to his face

Wild and fierce-looking (after a quarter of an hour)/^®.

Look horrid (second day)/^®-

Fixed look/®

All the muscles of the face seem relaxed, which gives the face a stupid expression ; the lower lip is inclined to hang down relaxed, the nostrils are widely opened, and the upper lid can be raised only with difficulty

He looks as though he had not slept enough, or had been revelling all night, with sunken, blinking eyes

Countenance presented that peculiar vacancy or want of definite expression which is characteristic of the influence of Opium

Countenance vacant

Countenance looks sickly (after half an hour)

On awaking, languid and stupid expression to countenance

The whole expression is that of premature old age

Somewhat haggard face (after two hours)

Countenance calm and pale (after seven hours)

* Facepale,*; (after fifty minutes); (after four hours),’®*’®*, and many others.

* Color of the face pale, earthy; eyes weak, full of water; slumbering with half open eyes, pays attention to nothing, gives indefinite answers; passed stool involuntarily ; sinks down in a heap, with short anxious respiratio?i,®®.f

Countenance pale, with an expression of deep and placid repose (after eight hours)

Face sunken, pale

Paleness of the face and forehead; eyes glassy, fixed,®'.J

Pallor

Face and lips pal e

Face very pale

Features shrunk and deathly pale

Face pale and cadaverous (after two hours)

Countenance pale and ghastly

Face white

Countenance pallid, and bathed in cold perspiration

Face pallid,'*®’®® ®®’, etc.

Countenance pale and haggard

The pallor of death was upon the lips

Pallid and ghastly expression of countenance (after four hours)

Ghastly countenance, though placid (after one hour)

Countenance ghastly

Face cadaverous and of a livid color, cheeks and nose cold, eyes sunken, surrounded by dark circles, pupils contracted, lids partly open, eyeballs turned upward

Cadaverous countenance

Cadaverous appearance (after three hours and a half)

His cadaverous countenance was literally the aspect of death (after eight hours)

Face livid and swollen (after twenty or thirty minutes)

* Face livid; (after eighteen hours); (after half an hour)

Face pale and livid; (after six hours)

Lips and face of a livid hue

Complexion of a dark livid hue

The color of the face changing to the livid (after four hours)

Countenance livid (after two hours); (after seven or eight hours)

Lips and face of a dark-lead color

* Face flushed (after one hour); (after 2 or 3 grains); (after one hour and a half)

Face and neck flushed

Countenance flushed, or rather had a blotched appearance (after four hours)

Face began to flush

Face red (second day)

Great redness of the face, with burning heat of the body, lasting eight hours; followed by convulsive throwing about of the right arm and foot, loud cries, difficult respiration, coldness of the face and hands, that are covered with drops of perspiration (soon after a dose)

Unusual redness of the face, with swollen lips

Face dark red,"®.§

Face completely red

Face entirely red, with wild and protruding red eyes

Face at first was glowing ; he felt a strong pulsation in the arteries of the head (one case)

Frequent alternations of redness and paleness of the face

Paleness of the face and nausea, with a sensation of sleepiness and diminution of all secretions and excretions, frequently even of the perspiration

Face red and eyes red and inflamed

Face red, turgid

Face not only red, but seeming: to be inflamed

The face became red and the head hot (after 4 drops)

Face and eyes red

Face red, puffy, with injected bloodvessels in the head

Face red, puffy, swollen,®^f

Withered, yellow countenance,*®'^ “h

The color of the face became yellowish during and after the proving

Complexion yellowish

Sallow complexion

Face bluish, earthy

Face leaden-colored With blue lines

Face purple, and the features distorted (after a quarter of an hour)

Countenance purplish

Face of a dark-purple hue, as were also his hands and feet (after fifteen hours)

Face of a dark-purplish hue (after eight hours)

Countenance dark and ghastly (after six hours\*®

Face cherry-brown

Countenance of a dark or dusky hue

Dark suffusion of the countenance

Dark suffusion of the countenance

Face of a dusky hue (after one hour and a half)

Black in the face (next morning)

The face seemed swollen,®*®®.]

Lips, Lower lip, towards the right corner of the mouth, swollen and bard, with excoriation of the mucous membrane (possibly caused by biting the lips)

Cracked lips

Lips distorted

Lips pallid (after two hours)

Lips, eyelids, and nails livid

Lips and nails livid (after three hours); (after two hours and a half)

* Lips (after one hour and a half); (after two hours); (after one hour and a half); (after three hours and a half); (after thirty-five minutes)

Lividity o lips and eyelids; (after three hours)

Lips somewhat livid; (after three hours)

Lips, and especially the lower one, slightly blue and swelled

Lips purple (after six hours)

The lower lip is painful when touched by the upper teeth or finger

Jaws and Chhi. Sudden trembling of the lower jaw, lasting five minutes (third day)

Tetanic spasm of the lower jaw,®*.§

Lower jaw protruded, tremulous

The lower jaw hangs down

* Lower jaw fallen (after seven hours); (after one hour and a half)

Spasmodic dropping of lower jaw (after thirty-five minutes)

Jaw somewhat fallen (after seventeen hours)

Lower jaw dropped, mouth open (after six hours and a half)

Jaws became firmly fixed, requiring force to get in the stomach-pump

Jaws firmly shut "(after twenty or thirty minutes)

Jaws rigid

Violent trismus (after a quarter of an hour)

Jaws tightly closed, as in trismus, when free from the spasmodic action

Lower jaw dropped and fixed

Kept her jaws locked (second day)

Pressure in the articulation of the jaws and bones of the cheeks

Pain in the upper jaw (after eight hours)

Violent pains in the lower jaw, rapid and momentary (after seven days),®*.l|

Acute stitches in the jaws, especially in the region of the condyles (first day)

Confused feeling in the left side of the chin, transient

Mouth p. 199

Teeth. Looseness of the teeth

Toothache

Fine gnawing pain in the nerves of the teeth (after eight hours)

G^ani, Gums eaten away, so that the teeth stood bare to the roots

Souffle, Rapid tremulous motion of the tongue

Tongue in constant motion

Tongue thrust forcibly backward and upward against the palate

Tongue and lips purple (after one hour)

When asked to put out her tongue she did so tremblingly, which was coated with a brown fur

Tongue immovable

Paralysis of the tongue

Tongue thick, with difficult speech

* Tongue black

Coated tongue (eleventh day),**"

Tongue thickly coated (second day)

Tongue coated, with a sticky, pasty taste (eighth and ninth days)

* Tongue white

Tongue coated yellow (second day)

Tongue thinly coated with brown fur (second day)

Tongue dry (third day); (second day)

Dryness of the tongue, palate, and fauces, without inclination to drink,®. Sensation of dryness in the anterior portion of the tongue, without thirst, in the morning

Tongue dry, red on its edges, and covered on the centre with a coat of thick white substance (second day)

Tongue, as far as the fauces, completely dry,"®*.f

The tongue and mouth, which were widely extended, were perfectly dry, and produced to the touch a sensation similar to reaction of a rasp (after eight hours)

Tongue dry and brown (second day)

Tongue dry and furred (after two days)

Tongue cold (after three hours)

Difficulty of moving the tongue, after waking,®®.J

It causes intolerable biting burning, like pepper, on the tongue,'®®.§

General ITLouth. Foaming at the mouth, for a few moments, at long intervals (after eight hours)

Frothing from the mouth; (after one hour)

Breath smelt strongly of Opium

Mouth open and eyelids closed (after eleven hours)

Mouth open

Distortion of the mouth,®".||

Mouth occasionally puckered, not drawn (after two hours)

The mouth could be opened only by force, and a spoonful of liquid could be swallowed only with difficulty

Mouth and lips pale and tumid (after three hours and a half)

Causes ulceration of the palate and tongue

Causes ulceration in the mouth and tongue,®®.ff

When chewed, it causes burning in the mouth and on the tongue, and inflammation of the larynx

Mouth and oesophagus dry (after 3 drops)

Dryness of the whole mouth, with little thirst

Dryness of the mouth, so that he could scarcely utter a word

Dryness of the whole mouth and tongue (first day)

Dryness of the tongue and palate (first day)

Dryness of the mouth (second, third, fourth, fifth, sixth, seventh, ninth, and tenth days)

Dryness of mouth and fauces (after 2 grains); (three cases); (after one hour); (second day)

Mouth and fauces dry, and covered with a tough viscous saliva (one case)

Tongue and mouth (which were widely extended) were perfectly dry, and produced to the touch a sensation similar to that arising from the action of a Iasp (after eight hours)

Saliva, Salivation,'®.];|

Increased secretion of saliva (after 3 drops); (eleventh day)

Saliva constantly flowed from the mouth

Profuse flow of saliva

Accumulation of water in the mouth, with frequent spitting (tenth day)

Frothy sputa

Discharge of yellow tenacious mouldy-smelling mucus from the mouth and nose, without cough or inclination to sneeze (fourth day)

It thickens the saliva, nasal mucus, and the mucus of the trachea, aud makes the tongue dry

Salivation, as from Mercury

The secretions of the salivary glands, the nasal mucus, and of the laryngeal glands suppressed

Taste, Very much impaired taste (five or six years after discontinuance)

Taste so much lost that she could not distinguish pepper or mustard

Deprived of the sense of taste (second day)

Bitter burning taste (first day)

Taste bitter; (second day); (fourth day)

Bitter taste in the mouth, the next morning

Pasty taste in the mouth (second day)

Taste sour

Taste sweetish

Saline taste in the saliva, and a bad taste in the mouth

Taste fiat, insipid, almost entirely wanting

Speech. He is unable to talk with open mouth.’®.

Spoke slowly, but correctly; it seemed difficult to articulate

Speech became weak; he spoke only a little; could speak aloud only with difficulty

Difficulty in speaking (after five minutes)

Was unable to talk; (second day)

He answered in a stammering manner, with interrupted articulation

Stammering after the Opium sleep

Stammering; (after 4 to 6 grains)

Throat p. 201

Rattled in throat, and immediately after breathed deeply (after five hours)

Rales in the throat

Pain in the throat on swallowing (fifth day)

Choking in the throat, followed by eructations (third day)

An anxious sensation of constriction in the throat

Sensation as if a tight baud were about the throat, associated with a stupid feeling in the head (after 18 drops)

Distressing sensation of constriction or strangulation in the throat; the patient thought that she would die, with inability to swallow

Remarkable dryness or burning in the throat, which urges them to repeat the Opium-smoking

Parched throat

Dryness of the throat posteriorly

Dryness in the throat and on the tongue

Throat dry (after two days)

Pharynx and Fauces. Sense of constriction about the pharynx (second day)

Fauces red (second day)

Scraping and constriction in the fauces, immediately

Sensation of dryness in the fauces and larynx

Scraping raw sensation in the fauces

Dryness of the fauces (second day)

CEsojihagus. Cramp in the oesophagus always on swallowing

A kind of cramp in the oesophagus, that made swallowing, even water, difficult

Cramp in the oesophagus during and after swallowing

Swalloielng. Inability to swallow,® ®*® ®®® ®®® ®*®, etc.

Inability to swallow, with dryness of the throat

Swallowing extremely difficult

Deglutition could not be excited until ten hours after the poison was taken

Dysphagia, becoming true aphagia, as from paralysis of the muscles

Swallowing difficult

Swallowing difficult, on account of cramp in the oesophagus

Swallowing became almost impossible (after a quarter of an hour)

External Throat. The vessels of the throat are distended and pulsate violently,®®.t

Carotids beat irregularly, about 50 in the minute (after eighteen hours)

Carotid arteries beating violently (after one hour and a half)

Stomach p. 201

Appetite. Appetite increased

Decided increase of appetite

A considerable increase of appetite

Appetite for supper better than usual

Ravenous hunger; distension and distress in the stomach after eating,®®.]

He never felt so hungry in his life; he ate his breakfast greedily, and was soon relieved of every disagreeable sensation

Frequent paroxysms of ravenous hunger, at times with a flat taste in the mouth (after three, and several hours)

Ravenous hunger

Ravenous hunger, with dread of food

Excessive hunger, with great weakness

Sensation of hunger, which, on taking food, changed to a sensation of emptiness and pressure in the stomach (third day)

Feeling of emptiness in the stomach and an unusual sensation of hunger about 11 A.M. (after six hours); although I ate as much or more dinner than usual, at 1 P.M., this sensation of emptiness continued until after 3 oclock, during which time there were frequent eructations of air (first day); sensation of emptiness in the stomach and decided hunger by 10 A.M., in order to assuage which I took two eggs, some bread, and a glass of beer, which, however, did not suffice; at noon I ate a hearty meal, as yesterday, but the sensation of hunger and emptiness was not relieved; it only disappeared after two hours of itself (second day)

Capricious appetite

Appetite either destroyed or depraved, sweetmeats and sugar being the articles that are most relished

Appetite bad (after four days)

Want of appetite for food and drink

Appetite diminished (after 4 drops); (fourth day)

Appetite diminished, though food had a natural taste (second day)

Appetite extinguished, and in place of it craving for one thing only, and that is, for another draught of the poison, which soothes but for the moment

* Loss of appetite *® ®® *® *®® *®® *** ®®

Loss of appetite, lasting for several days

No appetite at noon (ninth day)

It immediately destroys the appetite,®®.f

He eats scarcely anything

Appetite bad, usually desires only bread (after twenty minutes)

Complete loss of appetite; food was so disgusting to me that I was obliged to let it alone

He wishes to eat, but has scarcely taken a bite when he has no desire for the rest

Aversion to all nourishment for a long time

Extreme aversion to food, with extreme weakness

Extreme aversion to meat, with unclean tongue

Aversion to tobacco

Aversion to tobacco smoke

Thirst, *Great thirst (after three hours); (after half an hour); (fourth day),®®®, etc.

Unquenchable thirst

Excessive thirst, especially for thin beer

Distressing thirst

Thirst (after two hours), (two cases); (second day)

Thirst continuing all night (after one hour and a half), (one case)

Thirst during the chill

Eructations. Eructations (after five hours); (after 4 drops); (first, fifth, and tenth days)

Repeated eructations (second day)

Frequent very bitter uprisings (after twenty minutes)

Frequent eructations (after ten minutes)

Eructations (soon after 20 drops)

Eructations, with a bitter taste (after ten minutes)

Empty eructations and yawning

Eructations tasting like chamomile tea (after ten minutes)

Hiccough. Persistent hiccough, with transient interruptions

Much hiccough (fourth day)

Hiccough very distressing (second day)

Hiccough (after 4 to 6 grains); (third day)

Hiccough once (after half an hour)

Heartburn. Sensation of heartburn

JS^nausea and Vomiting. Nausea; (first day); (after sixteen hours)

Slight nausea (after 3 drops); (after 2 or 3 grains)

Very sick indeed

If she went a few hours past the usual time for taking it she was seized with the most intense fainty nausea, vomiting, and utter prostration; 35 or 40 drops of the narcotic would bring her up all right in a few minutes

Nausea, with accumulation of saliva in the mouth, relieved by eating a piece of white sugar (five minutes after 1 grain)

Nausea, and profuse secretion of saliva, lasting about five minutes (after 5 drops),*®®

Nausea, with increased secretion of saliva (after 4 drops)

Nausea and profuse salivation (after 18 drops)

Everything nauseates him

Qualmishness

Qualmishness, after waking

Peculiar qualmishness (after 2 drops)

Qualmishness, relieved by eructations

Qualmishness, as after long fasting (after 1 drop)

Qualmishness, with frequent eructations and inclination to vomit (after 4 drops)

General discomfort, emptiness, and faintness in the stomach (tenth day)

Nausea in the epigastric region (after a quarter of an hour)

Nausea, while walking on the street, so that he could scarcely keep from vomiting, associated with extreme exhaustion and weariness, that lasted the whole day (after 7 drops)

Nausea, eructations, retching, which afforded some relief (one hour after 2 grains')

Nausea without vomiting (tenth day); (after half an hour)

Slight nausea and inclination to vomit, followed by some eructations (half an hour after 1 grain)

Nausea, and inclination to vomit, after a dose (first day)

Nausea, with the headache, somewhat relieved by vinegar (after two hours); considerably augmented, and at length I threw up the contents of my stomach (after three hours and a half)

On awaking from a doze, in which he snored loudly, nausea and vomiting

Frequent nausea and vomiting

Nausea and vomiting

Nausea and vomiting, followed by bitter taste (tenth day)

Nausea and vomiting, after cold affusions

Utter prostration with the nausea and vomiting

Sickness at the stomach, with almost incessant vomiting; the fluid ejected of a brownish color, and emitting a sour smell (second day)

Vomiting just before a convulsive fit

She vomits, with pain in the stomach and convulsiv'e motions

Vomited violently (one case); (second day)

■ Persistent vomiting

Repeated vomiting

Vomiting after eating

* Vomiting,(after a few minutes); (after one hour); (after half an hour)

Vomiting eight times (five hours after 4 grains)

Vomiting and convulsions

Spontaneous vomiting; the ejected matter gave off the odor of laudanum

Frequent vomiting of grayish mucus and unripe poppyseeds

Green vomiting

Vomited a dark fluid, with a strong smell of laudanum (after two hours and a half)

Violent sickness and purging

Vomited several times (one hour after swallowing the acid, continuing to sleep during the operation)

No further effect than vomiting, which did not occur till after the lapse of several hours

Sickness and vomiting (after 4 to 6 grains)

Coffee ejected in fifteen minutes after taking it, with much mucus (after nine hours)

At length food and drink are vomited almost constantly when the system is not under the primary action of a dose

Efforts to vomit, and vomiting of blood

Inclination to vomit, on moving about

Ineffectual efforts to vomit; (second day)

Violent ineffectual retching

Stomach in General, Painful distension of the pit of the stomach

Stomach distended, meteoric

Stomach distended and painful to touch,®®.f

Acute throbbing, with visible rising and sinking, rhythmical with the pulse, of the full stomach, while lying down, after dinner; it made lying on the back intolerable; was obliged to rise and walk about, after which it gradually disappeared (thirteenth day)

Fulness of the stomach

Rumbling in the stomach and abdomen (seventh day)

Complains of tenderness and pressure in the epigastric region, and says she feels a pain there on inspiration (third day)

Great tenderness on pressure at the epigastrium (after five days)/

Stomach hot, and painful on the slightest pressure

The stomach would not tolerate more than a quart a week

The stomach is insensible to emetics

Considerable indigestion, after an early dinner, at 1.30 (after six hours)

Digestion becomes much impaired

Slow digestion

Makes digestion slow and diminishes the appetite

Disturbs digestion; causes in the stomach a sensation of heaviness and compression, and an indescribable distress in the pit of the stomach

Causes weakness of the stomach

Accumulation of flatus in the stomach and intestines .

Sensation of emptiness in the stomach, not relieved by a glass of water ; this distressing sensation was relieved for about twenty minutes after breakfast, but it was renewed and continued with only slight interruptions during the whole day, though I ate frequently (fifth day)

Uncomfortable feeling in the stomach, somewhat like that after a purge, extending into the ileum, but not causing actual colic (after drop)

Sensation of streaming warmth, commencing in the epigastric region and extending over the whole body (third day)

Coldness in the stomach (fifth day)

Feeling of constriction in the stomach, with constipation

Sensation of constriction in the stomach (first day)

[Contractive pain in the stomach, which was intolerable, and changed to deathly anxiety],®®.f

Griping in the epigastric region (second and ninth days)

Sudden pressure in the stomach and compression of the diaphragm

Great anxiety and pressure in the pit of the stomach

Violent pressure in the epigastric region, immediately after eating, relieved by walking about

Violent pressure in the stomach, immediately

Extremely distressing pressure above the stomach, after dinner, as though he had eaten too much or too hard food ; these symptoms relieved by moving about in the open air

Distressing pressure and cutting in the epigastric region and. lower down in the abdomen, with dulness of the head, especially in the frontal and temporal region (after 8 drops); during this the pulse was rather slower and weaker than usual

Pressure in the region of the stomach (one hour after 6 drops)

A pressive sensation in the stomach, as if caused by slow digestion

Pressure in the stomach, as if a stone were lying in it (after two hours)

Pressure in the stomach; (two minutes after drop, and a quarter of an hour after 1 drop); (ninth day)

Pressive pain in the stomach (tenth day)

* Violent cutting in the epigastric and umbilical regions (a few minutes after 2 drops)

* Pamful sensation in the epigastiduyn (second day)

Incessant gnawing pain in the stomach when its effect is off

* Ectreniely violent pain in the stomach,^^; (seventh day)

* Pain in the stomach (second day)

Pain and sensation of tightness across epigastrium (second day)

* Pain in stoyyiach, increased by pressure (third day)

■ Pain in the stomach when she attempts to turn in bed or take any food, which “seems to lodge, and when it goes off the pain is increased for nearly half an hour (after five days)

Abdomen p. 204

Hypochondviti, Pain in the hypochondria, especially in the right

Pressive pain in the left hypochondrium

Painful sensations in the region of the spleen and the back; also affecting the thorax (after 1 drop)

ITiiibillciis and Sides. Colic in the region of the umbilicus, followed after a few hours by a diarrhoea-like stool (after 8 drops)

Acute cutting pain in the region of the umbilicus, soon followed by desire for stool, with an evacuation that was not hard (after 3 drops)

Dull pressive pain in the umbilical region (seventh day)

Pain in the umbilical region caused by slight pressure (fifth day)

Sensation as of a weight in the abdomen, in the umbilical region, with anxiety; sensation of flushes of internal heat, and stupefaction of the head (after one hour)

Stitches in the left side of the abdomen, even when not breathing (after three hours)

Stitch in the left flank (fifth day)

General Abdomen, The abdomen became distended, especially in the umbilical region

* Abdomen offended; (after 2 drops); (after forty-eight hours)

Abdomen distended, tympanitic (fifth day)

Abdomen tense, distended

Abdomen very hard and tense

Abdomen hard

* Abdomen hard swollen and sensitive touch

* Rumbling in the abdomen (fifth day)

Rumbling and moving about in the intestines (second day)

* Rumbling in the abdomen and griping in the intestines (first day)

Rumbling in the abdomen, with emission of flatus

Rumbling, gurgling, and griping in the bowels, without emission of flatus

Rumbling and moving about in the abdomen (after ten minutes)

Rumbling and gurgling in the transverse colon, followed by urgent desire for stool, which could be restrained only with extreme difficulty; this was followed by a copious watery evacuation, accompanied by much flatus, that passed suddenly and with much noise, and was followed by burning in the rectum, which lasted several minutes, at midnight (fourth day)

Grumbling motions within the bowels (within an hour)

Grumbling and contraction of the bowels (after one hour), (one case)

* Grumbling and slight pain in the abdomen (one case)

Flatulence in the abdomen, increasing from noon till evening, without the evacuation of either gas or fieces, though late in the evening there was an evacuation that was scanty and not hard, and accomplished with great effort (after 3 drops)

Flatulence (after twenty-five minutes)

Emission of flatus difficult (tenth day)

Emission of much very offensive flatus at night (after 3 drops)

Emission of much flatus after eating

Emission of flatus (seventh day)

Emission of very offensive flatus

Frequent emission of flatus (after twenty-four hours); (fifth day)

Causes constant accumulation of flatus

’’'Colic (after 1 drop)

Transient, very violent colic (fifth day)

Colic, lasting half an hour, with desire for stool, relieved by a soft evacuation, followed by weariness, with yawning (after 4 drops)

Some colic, followed by a diarrhoea-like stool in the morning (after 6 drops the previous night)

Drawing colic

Colic as from taking cold

Colic consisting of simple pain, as if bruised (after two hours)

Colic, as after a purge (after half an hour)

Colic before and after a stool

Slight colic (second day)

Slight, persistent colic (first day)

Violent griping in the abdomen (ninth day)

* Griping in the upper abdomen

’"Griping in the abdomen, with constipation

Griping in the abdomen the whole afternoon

Griping in the abdomen (third day)

Sometimes gripings and a strong contraction of the intestines (after 2 or 3 grains)

Gripings, lasting the remainder of the day (alter two hours), (in two cases)

Griping and pinching in the abdomen, followed by the emission of an enormous quantity of odorless flatus through the night, and also eructations of gas (first day)

A tumblerful of warm milk, drank directly after it came from the cow, took the gripings away instantaneously

’"Cutting in the abdomen (after 2 drops)

Throbbing in the abdomen/.

Abdomen heavy(second morning after 2dro^s)/®

Disagreeable feeling of fulness and tension in the abdomen, without any emission of flatus (first day)

Feeling of tension and fulness in the whole abdomen, especially in the upper portion (fifth day)

Tension and a feeling of fulness in the abdomen, as though the clothes were too tight, continuing for some three weeks after the proving

* Tension in the abdomen

* Abdomen tense and painful .

Sensation of distension of the abdomen, and especially of the stomach

Tensive and pressive pain in the abdomen (after twenty-four hours)

Pressure and heaviness in the abdomen, as from a stone

Pressure and pressive distension of the abdomen, even to bursting; better on moving about; on sitting the pressure returns (after two hours)

Pressure in the abdomen (third day)

Dull pressive pain in the abdomen (sixth day)

Pressive pain in the abdomen

* Pressive pain in the abdomen, as if the intestines would be cut to pieces

* Pain in the abdomen (after one hour)

The intestines seemed paralyzed,'®./

* /i5 renders the intestinal canal so exceedingly sluggish that the most active purgatives lose their porter

* Tension in the hypogastric region, that is extremely painful to touch (after twentyfour hours)

Hechim mul Amis. Pressive pain in the rectum as from hemorrhoidal congestion, aggravated by touching the anus

Sensation as if the passage through the rectum were closed on making exertion at stool

Sensation as though the anus were suddenly and spasmodically constricted; not relieved by making an effort, as in urging to stool; external touch caused the most acute burning pain; this sensation lasted about ten minutes, disappeared gradually, but was renewed upon every touch (first day)

Excessive pressing distending pain in the rectum (after four, and six hours)

* Anus spasmodically closed during the colics, with very difficidt emission of flatus (ninth day)

Spasmodic closure of the anus (eighth and previous days)

Persistent tickling in the anus, ending with itching (second day)

Increased ineffectual efforts to evacuate the bowels (after 1 drop)

Dulness or difficulty of evacuation,®®./

Two or three evacuations of the bowels, with unusual desire following the first dose (1 drop); after 2 drops the bowel seemed indolent and as if it could not evacuate its contents; in the evening there was an evacuation, not hard

Stool p. 206

Diavrliaid Persistent diarrhoea; the discharges are not frequent, foicr or five times in twenty four hours, whitish, pasty, and causing excessive burning in the anus, that frequently lasts a quarter of an hour after the movement (after twelve to twenty-four hours)

Diarrhoea comes on, relieved only by fresh indulgence, and dysentery sometimes supervenes

Bilious diarrhoea, attended with severe pain extending from the right hypochondrium to the umbilicus (third day)

Diarrhoea for tw'o days (after sixteen days)

Watery diarrhoea,'®.§

Opium causes diarrhoea at times (secondary action)

Evacuations passed involuntarily

* Involuntary evacuation of stool and urine ®

Slight diarrhoea (third day)

Occasional diarrhoea

Bowelsslightly relaxed

The bowels, which are usually costive, became freer, continuing so for many days

Diarrhoea-like stool, preceded by colic (after eighteen hours)

Diarrhoea-like stool in the afternoon (after G drops taken in the morning)

Diarrhoea-like evacuation of the bowels, preceded by colic (after 12 drops)

The first part of the stool hard and difficult, the last part diarrhoea-like (after about a week) ; two days after he was awakened about 5 a.m. by necessity to go to stool, followed by a copious, pasty, dark-colored, almost odorless evacuation, without pain,"®

Stool in the morning, followed by a second after eating, and again after an hour (third day) ; in the evening (fifth day) ; followed by constipation

Thin stool

Stool thin, frothy, profuse, followed by great relief (second morning)

Three thin stools, with some dragging and burning in the anus, in the evening (fourth day'”*-

Very thin stool in the evening (third day)

A thin liquid stool (after 20 drops of the tincture, after taking the drug for nearly two Aveeks) ; on the next day there Averse four diarrhoea-like stools, which seemed to end the proving

Two liquid stools, one at 9 and another at 12 P.M., always associated Avith some griping colic (subsequent to the proving)

Thin liquid stool about midnight (after about two Aveeks) ; this Avas followed by frequent thin stools, sometimes three daily, Without pain and of a Whitish color

Thin frothy stool, with itching burning in the anus and violent tenesmus

Pasty evacuation of the bowels (immediately, or Within a quarter of an hour),k

Stool tenacious, gluey, yellowish-broAvn and of a mouldy odor, at 8 a.m., followed about 2.30 p.m. by a second pasty evacuation of a similar color and odor, preceded by griping about the navel (fifth day)

Faeces softer than usual (after 3 drops)

Pasty evacuation (second day after 4 drops)

Evacuation of a blackish substance Avith the stool (after twenty-four hours)

Stool increased

Stool excessive-ely offensive

* Constipation,"® 120b 132162. (second day),®*® ^®®, etc.

Almost constant constipation

* Constant retention of stool and constipation f

* Almost unconquerable chronic constipation

* Constipation for six or eight weeks, with loss of appetite ; evacuation consisting of small, hard pieces, accomplished only by means of clysters

* Constipation, not more than one motion occurring in a week

* Constipation for several months

Complete constipation for hvo days (after eleven days)

Constipation for ten days, ending with death

Constipation for some days afterwards

Complete constipation (second day after 18 drops)

* Constipation during the afternoon; only about 10 p.m. was it possible to expel the hard evacuation (after 2 drops)

No stool (first and second days)

Has hardly one evacuation of the bowels in a Aveek

No evacuation of the bowels, contrary to habit (first day)

Evacuation of the bowels and micturition interrupted

Stool infrequent

Stool retained (after forty-eight hours)

* No stool in the morning (though he usually had two in the morning) ; in the evening there occurred an unsatisfactory, rather hard stool (second day)

* Evacuation of the bowels retarded

Stool more difficult than usual

Stool indolent through the proving

The evacuations becamemore indolentandscanty (from the firstfew doses)

Stool (usually regular) generally occurring in the morning, but was delayed till 6 p.m., Avhen it Avas evacuated with great exertion, not hard, rather tenacious, dark-brown, and having an offensive mouldy smell (second day)

Retention of stool (first and second days); sudden desire for a stool that was, however, soft (third day) ; pasty, unsatisfactory stool (fourth day)

The stool, that was usually regular, was omitted (first, second, third, and fourth days); only accomplished Avith much pressure (sixth day)

The evacuation of the bowels seemed rather harder than usual

Stool hard, preceded by griping in the abdomen and flatulence

Stool hard, gray (second day)

* Stool very hard (fourth day)

Stool hard and crumbly(ninth day)

Stool hard, evacuated only with difficulty, for six days

Stool consisting of small hard nodules, with labor-like pains, as in child birth

* Stool hard, dark-brown (third day)

Stool hard, scanty, evacuated with effort

* Stool unsatisfactory and hard^’^'’. *Stool very offensive (after twenty hours),h

Urinary Organs p. 208

Kidneys and Bladder. Among affections of the kidneys Bright’s disease is not uncommon

A kind of tenesmus in the bladder; when beginning to urinate he was always obliged to wait a long time on account of twitching of the sphincter vesicm; this symptom always occurred on urinating

* The bladder became distended, but not having power to expel its contents, a catheter was introduced and gave great relief (second day); great pain and difficulty in expelling urine, and also pain in the bladder when it becomes distended (third day) ; passes a small quantity of urine at a time, with difficulty and pain (fifth day); micturition still painful, and accompanied by a sensation of bearing down (tenth day); pain and difficulty in voiding urine are increased, and from straining in the attempt has forced her womb down, which gives much additional pain (fourteenth day) ; had received a kick in hypogastric region some time ago, and had difficulty in passing urine at different times since,'®l

* It weakens the expulsive power of the bladder

JJvetllva, Some spasm on urinating in the morning; on the two following days there was acute constriction of the urethra as far as the bladder; after urinating the pain gradually disappeared ; on the third day blood was passed with the urine; this continued three days, then gradually disappeared; the spasmodic constriction of the urethra continued, after which it gradually disappeared,”‘.f

* The patient complained of pain as from need to urinate without being able to accomplish it

Sensation on evacuating urine as if the passage through the urethra were closed

31ietiirition. Frequent involuntary micturition

Emission of urine violent (after second day)

Desire to urinate, with difficult discharge (ninth day)

Micturition much more frequent than usual, always scanty, and evacuated easily

Micturition difficult; (one case)

Difficult micturition on waking from a nap (tenth day)

Difficult evacuation of urine with a full bladder, on account of cramp in the sphincter vesicle; even after much urine began to pass the full stream was at times interrupted; this continued all day,^^^^-.

Dysuria, as if the urinary passages were closed (tenth day)

Dysuria, with frequent involuntary interruptions in the stream of urine (after 4 to 6 grains)

Strangury soon made its appearance with the usual symptoms, viz., a frequent and urgent desire to micturate, but without being able to gratify it; burning and cutting pains at the neck of the bladder ; cutting pains also along ureters and urethra, and accompanied with some tenesmus. This condition compelled me to introduce the catheter for four successive days, when, in consequence of the system being under mercurial influence, I desisted from further treatment. But a return of the disease being threatened, I resumed the former treatment, which was again followed by the strangury. I suspended each remedy in succession, but the strangury continued until the Opium was at last suspended. After this the strangury ceased in twenty-four hours, but again recurred on again exhibiting the Opium

It was not till several hours elapsed that he was able to empty his bladder, although he had made several attempts; urine very high-colored (after fifteen hours),“b

* Could evacuate urine only after long exertion

Involuntary interruption of the stream of urine

Frequent interruption of the stream of urine, which commences to flow after waiting a long time, on account of a cramp in the sphincter vesicccf

Retention of urine, with very dry mouth and increased thirst

Retention of urine

Retention of urine, so that he was always obliged to use the catheter; the urine passed during twenty-four hours amounted to 190 c, c., containing 81.317 grams of urea; 6.570 grams of phosphates; 8.979 grams of chlorides (third day)

He did not succeed in making water until after twelve hours, and not before he had made several efforts in vain, and he then perceived a burning in the urethra, and frequent interruptions in the stream of urine

Evacuations of urine suppressed

Opium at times suppresses the urine; at times increases it

* Opium7n restrains the evacuation of nrinef

No urine had been passed (second day)

No passage of urine or faeces

There had been no urine since the attack ; the place of the bladder was occupied by a round, hard tumor, which was supposed to depend upon urine; about half a pint of urine was now passed (after seventeen hours)

Had not passed any urine since he took the poison (after three hours)

The patient passed no urine throughout the day, and at night only after long exertion

Has not passed an}" water since yesterday afternoon (fifth day) ; much pain in making water, which is scanty (seventh day)

TJrhie. Great secretion of urine

Increased secretion of urine (fourth day)

Secretion of urine increased during the night (from fourth to fifth day)

It stimulates the secretion of urine

Copious emission of urine in the afternoon (first day)

Evacuation of a large quantity of urine after midnight (first night); also on waking (second morning)

Urine greatly increased in quantity, out of all proportion to the amount of liquid taken ; this continued for several days

Urine very copious, pale-yellow, in the evening (first day); very copious at noon, 4.30 p.m., and about midnight (second day)

Urine of normal color, but of remarkable odor, that I could compare to nothing, in the evening (second day)

Urine brown, covered with an iridescent film (after 4 drops)

A turbid, mucous urine is discharged with unusual frequency, the result sometimes of vesical, sometimes of renal disease

Urine turbid and dark-colored (after six days)

Urine very turbid and dark red, frothy, depositing a yellowish-red, slimy sediment (eleventh day)

Urine scanty, turbid, lemon-yellow

Urine very dark, depositing a sediment

Urine dark-colored

Urine dark and tongue dry

The urine has a brickdust sediment

He passed very little urine, and that of a dark-red color, accompanied by cutting pains

Urine lemon-yellow, with much sediment

Intolerable odor to the urine (after two days)

* Urine very scanty, very red, with clouds

Bloody urine

The urine, after taking Opium, contained more water than usual; the earthy phosphates, especially the phosphates of lime, were diminished; the phosphates of magnesia were somewhat diminished, but not so much so as the phosphates of lime; soon after ceasing to take Opium the secretion of urine increased; and even on the next day, after taking the solid constituents, the urea and inorganic salts were decidedly increased

Urine.

Amount, ....

AVater, ....

Solid constituents

Urea, ....

Uric acid,....

Inorganic salts

Phosphates

Phosphate of lime

Phospluite of magnesia

A^volatile salts and extractive

Urine.

Amount, ....

AVater, ....

Solid constituents.

Urea, ....

Uric acid,....

Inorganic salts

Phosphates

Phosphate of lime

Phosphate of magnesia

Volatile salts and extractive.

Normal.

While taking Opium.

First five days.

Second five days.

Sexual Organs p. 210

In both sexes the procreative power is greatly lessened, and in those women who, nevertheless, do bear children the secretion of milk is defective. The influence of the habit on the generative functions is, indeed, so decided that, were it not for fresh arrivals from China and other parts of the East, the population of Singapore would very soon be seriously diminished

The sexual organs, at first preternaturally excitable, gradually lose their tone,“l

All opium-smokers become impotent at a much earlier period of life than others

3Iale. Cutting pain in genitals when passing water (after seven days)

Male impotency

Impotency,'^**'“I

Grade impotentise (after 4 to 6 grains)

Excessive erections,^k

Violent erections (after two hours and a half j

Frequent erections in sleep, at night

Erections during sleep, and after ■waking, impotency

Erection during sleep, and after waking, complete impotency,®k

It excites sexual desire, with erections, emissions, and lascivious dreams,®h

Amorous ecstasy; erections for twenty-four hours; lascivious dreams; nightly emissions

Excitement of sexual desire; erections; nightly emissions

Nightly emissions (first night),h

Amorous fancies ; emissions at night

Excitement of sexual desire

Immoderate lasciviousness

It is considered to enervate and weaken sexual desire

In some, excitement; in others, diminution of sexual desire

No inclination for coition during the whole proving

Sexual desire indolent

It cools the desire for coition

Female. A mucous discharge begins to flow from the organs of generation

The uterus is so soft that the movements of the child can be felt externally,®®.t

Excessive labor-like pains in the uterus, that oblige her to bend the abdomen together, with an anxious, almost ineffectual desire for stool (after a quarter of an hour)

The movements of the foetus in utero were violently painful; sometimes omitting for several hours, then returning more violent than ever

Menstruation increased (after two hours)

Menstruation appeared out of the regular order (second day),^®l

While she continued using the Opium daily her catamenia did not appear; but, on forsaking the drug for a month or two, she becomes “regular without any emmenagogue

Catamenia did not ai)pear during these five years, but afterwards the onychia was cured by an operation, and every month since the menses have punctually appeared without the aid of any medicine

Catamenia did not appear after taking the Opium, notwithstanding she had been perfectly regular until tben

Her catamenia, which had been regular, have never since appeared (after five years)

(Opium did not disturb the regularity of the menses, though it bad been used daily for thirty years, in doses as large as a drachm and over, for extremely painful and spasmodic attacks)

Respiratory Organs p. 211

Spasms of the respiratory muscles at times

LargllX. Tickling in the larynx, with violent dry racking cough, lasting ten minutes; both the dryness and cough relieved by a glass of ivater; they, however, returned after a quarter of an hour, with so great violence that tears came to the eyes; again relieved by drinking water, after which he fell asleep for over two hours, and was again awakened by paroxysms of cough, which, however, were less violent and accompanied by some expectoration of mucus, at 3 a.m. (after five hours and a half). Tickling in the larynx, causing dry cough, which lasted more than six minutes, with lachrymation, relieved by drinking water (this cough was the same as that which woke him from sleep at 3.45 a.m), (after 3.15 p.m., second day). '^'Tickling in the larynx and dry cough, soon after 2 a.m., that ceased after five or six mimdes, without drinking water (second night). Dry cough, with tickling and scraping in the larynx woke me at 3 a.m.; this time it lasted scarcely five minutes (fourth night)

bronchi. Bronchial irritation and expectoration (after eight hours')

Yoice. Voice harsh and hollow

Voice deep and harsh

Voice gruff,'®l

Voice quivering

Extreme hoarseness

Hoarseness

Hoarseness, with a very dry mouth and white tongue

Hoarseness, as if caused by mucus in the trachea

Cough and ilxiKictovation, Paroxysms of violent dry cough, followed by yawning and a sudden loud cry (after thirty-six hours)

cough, with tickling and scraping in the larynx, woke him from sleep very early in the morning (second day)

Cough hollow, very dry, immediately after a dose, soon disappearing

Cough on swallowing

Cough caused by swallowing a liquid

Cough aggravated after eating

During the whole period of years through which I had taken Opium, I had never once caught cold, not even the slightest cough, but now a violent cold attacked me, and a cough soon after

* Cough, with scanty tenacious expectoration, with much rattling in the chest (fifth day)

Expectoration of large quantities of mucus and pus

Constant expectoration of mucus

Expectorates frothy mucus

Expectoration of thick bloody mucus

Expectoration of blood

It restrains the expectoration of blood and evacuation of stool

Rapid respiration; (first day)

Respiration. Sensation of choking (after fifteen minutes)

Respiration 34 in a minute, slightly stertorous, with inspiration of a stridulous character (after two hours)

Respiration raj)id, difficult

Respiration rapid, oppressed, anxious

Rapid and anxious respiration (after five or six hours)

Breathing became more frequent

Breathed hurriedly (after half an hour)

Frequent involuntary deep breathing

Breathing oppressed

Great obstruction to the breathing

Embarrassed respiration, which soon amounted to an agony, without the least symptom of narcotism ; much the same sensation was produced by each inspiration experienced by the inhalation of pure nitrogen gas, the air seeming to leave the lungs without having performed its functions, there being at the same time a sense of dryness in the fauces and larynx ^2.% _[-i3oo.] Breathing very considerably embarrassed, the inspirations and expirations being separated by an unusually long interval, and accompanied by slight rattling

Deep, hurried respiration

Respiration moderately disturbed, rather frequent and anxious

Oppressed respiration ; (after seven hours)

Respiration difficult and rattling

Great difficulty in breathing

Breathing difficult, and was performed with intervals of half a minute at least between each respiration (after four hours)

Breathing difficult (after half an hour); stertorous, six in a minute (after six hours and a quarter)

Straitened, difficult breathing,"®.t~Difficult respiration,**.!

Breathing short

* Iiespiration laborious and drawn at long intervals

Breathing laborious, at times stertorous, at others accompanied with a distinct stridor (after eight hours)

Respiration difficidt, oppressed, especially at night

Respiration difficult, impeded

Respiration became difficult, as if the pectoral muscles were tense (fifth day)

On awaking, breathing heavy and oppressed

* Breathing laborioxis (after six hours),*"; (after one hour)

Respiration difficult; (after one hour)

Respiration anxious

Impeded respiration, dyspnoea

Respiration interrupted

He suddenly became blue in the face and tried to cough, but had no breath (suffocative catarrh), followed by deep sleep, with cold sweat over the whole body (after thirty hours)

Attacks of suffocation during sleep (nightmare)

Attacks of suffocation

Complete apoplectic respiration (after three hours); the apoplectic respiration nearly suspended (after eight hours)

Excessive dyspnoea (after four hours)

Dyspnoea (fourth day)

Dyspnoea, as if threatened by stitch in the side, and tension in the scapuljB

Asthma,®®.§

Breathing gradually becoming heavy and oppressed; stertorous (after six hours and a quarter); respiration 6 (after nine hours) ; 8, no stertor (after nine hours and a half) ; 8, attended with a soft sighing moan (after eleven hours) ; 11 (after twelve hours and a quarter) ; 12 (after twenty-nine hours)

Breathing regular, but deeper and slower than usual

Respiration very deep and sonorous (after three hours and a half)

Respiration loud, difficult, rattling.

Respiration loud, difficult

Respiration loud, heavy,®®.!!

Breathing somewhat loud and slow (after eleven hours)

Respirations long and sighing

Unusual sound of respiration,'".-

Loud breathing, soon

* Deepand frequent sighing

Snoring loudly

Snoring respiration; (after one hour and a half)

Snoring on expiration during sleep

Respiration rattling (after six hours)

Deep heavy respiration

* Deep stertorous breathing,^^) (after seven hours)

Respiration moaning, deep, stertorous

* Stertorous respiration,****®®*®®, etc.

Respirations stertorous (after five hours); hurried (after seven hours and a half)

Stertorous breathing; respiration from 6 to 8 (after two hours and twenty minutes)

Respiration stertorous, 10 per minute (after five hours)

Respirations 11, stertorous (after five hours and twenty minutes)

Respiration 12, stertorous (after three hours and a half)

Respiration 14, stertorous (after seven hours)/®®.

Respiration 20, stertorous (after three hours); slow (after four hours)

Rapid stertorous breathing (after eight hours)

Stertorous breathing; occasionally there was such an impediment in the respiration that the face became livid, and the child apparently dead,^'h

Breathing stertorous, and accompanied by hiccough (after fifteen minutes)/®®.

Breathing stertorous and embarrassed (after twenty hours)

Respiration stertorous, with a mucous rattle from the throat (after six hours and three-quarters)

Respiration stertorous, noisy,*'’/

* Respiration slow and stertorous,^*; (after two hours and a half); (after six hours and a half),®®*, etc.

Respiration slow and stertorous, very slow

* Deep, sloiv, stertorous, puffing respiration*

Breathing slow and stertorous (after thirty minutes) ; very laborious, each inspiration giving a long struggling sound ; it would draw four inspirations, at the rate of 16 per minute, and then cease to inhale about thirty seconds, when the four inspirations would again be drawn; on the fourth inspiration a general spasm of the the muscles would seize it (after three hours) ; after remedies it breathed continuously, but with great difficulty, at the rate of thirty inspirations to the minute, for twenty minutes (after six hours) ; after this it would draw only three respirations at the rate of 12 to the minute, when spasms would occur, and the suspensions of breathing become longer. At the tenth hour it drew but two inspirations together abouttwelve seconds apart, and then suspended for nearly a minute; it continued to labor for breath in this way until the end of the eleventh hour, when it died

Respiration slow, irregular, and stertorous (after three thousand half )

Respiration slow,laborious, stertorous, and very irregular ; sometimes more than a minute would intervene between the respirations, when inspiration would suddenly occur, accompanied with a loud and disagreeable snore (after one hour and a half)

Breathing irreyidar, slow, and stertorous, respirations eight in the minute (after seven hours)

Breathing labored and stertorous (afterfour thousand a half)

Breathing very irregular, with stertor (after four hours)

Respiration stertorous and difficult

Respiration 12, slightly stertorous (after five hours)

Respiration slightly stertorous (after three hours)

Occasional stertorous breathing

Respiration sobbing, interrupted

* Respiration moaning, slow (after four hours)

Loud breathing and convulsion; his hands clenched, and his teeth firmly set; breathing stertorous after the convulsion passed off (after six hours)

Respiration deep, difficult, interrupted during the convulsions

Frequent deep inspirations, with convulsive motions of the jaw

He breathed convulsively for ten times in a minute, then did not breathe for a minute (after seven or eight hours)

Gets his breath with great exertion and anxiety, with open mouth

Respiration short and rattling, from time to time stopping entirely for half a minute,’®.f

Respiration rattling, slow, and irregular

In some, difficulty of breathing is a prominent symptom, increasing gradually to an urgent sense of suffocation, and depending generally on oedema of the lungs or effusion into the pleural sac

Breathing slow and labored from the amount of mucous secretion accumulated in the bronchi, which caused a noise equal and in all respects similar to that of the “death rattle

Complete apoplectic respiration (after three hours)

Respiration irregular (after four hours); (third day)

Respiration quiet, at times associated with a kind of grunt

At times some single deep respirations, at other times arrest of breathing

f Schnarchendes is lochelnden in the original.

Hughes. for some minutes

Respiration irregular, threatening suffocation

Respiration oppressed, not only difficult, but also irregular,®*. Respiration at one time stertorous and loud, at another heavy and very weak

Breathing very irregular (after eleven hours)

Breathing very irregular, with a tendency to become weaker at every moment, occasionally ceasing altogether, until again awakened by artificial means,®**. Respiration ceases ; for five minutes he seems dead ; then short sudden gasps, as if he would hiccough

Respiration very variable, and often only 5 per minute

Respiration variable, occasionally full and deep, then ceasing for a time

Respiration became less laborious, followed by copious perspiration

Respiration is arrested for a minute at a time, then recommences with a deep sigh,®’.]

Respiration three or four times in a minute, with sighing

Respiration three or four times per minute ; jerking, and somewhat stertorous

Respiration not quite four to the minute, obstructed by accumulation of mucus (after fifteen hours) ; later a bloody mucus bubbled out of the nostrils, on turning him upon the right side

Respiration slow (after one hour) ; hut fo^ir to the minute, the intervals between the inspirations irregular, and each time we had to resort to shaking and slapping the patient to provoke the automatic action of the respiratory muscles, and to raising him suddenly to the sitting posture, for the same object (after five hours)

Breathing slow and heavy, but not stertorous

Respirations four or five per minute (after eight hours)

Respirations not quite seven per minute

Respiration eight per minute

Respiration slow,'; (after one hour); (after half an hour)

Respiration very slow

Respiration constantly shorter and shorter

Respiration slow, difficult, stertorous

Respiration slow, with from time to time a deep inspiration

Respiration constantly less and less frequent till death

* Respiration sloiv, sighing

Respiration slow and sonorous (after five hours and a half)

Respiration slow and embarrassed

Respiration slow, interrupted, attended with occasional moaning

Respiration slow, now and then moaning (after forty-eight hours)

Breathing slow, laborious, and accompanied with a loud mucous rhonchus (after eighteen hours)

Breathing slow and laborious; (after two hours)

Respiration slow, being about 20, deep drawn

Breathing less frequent than natural, but without any stertor (after four hours)

Extraordinarily slow respiration, with thready pulse, 110, remained after the poisoning

Respiration slow, but otherwise natural (after one hour)

Respiration slow, almost imperceptible (after two hours)

Breathing slow, almost imperceptible, and suspended at intervals

Respiration rare (after one hour and a half)

Breathing very shallow, both chest and abdomen being almost immovable (after twelve hours)

Respiration shallow,'*'; (after a quarter of an hour)

Respiration very imperfectly carried on, being scarcely perceptible, and occasionally slightly stertorous (after six hours)

Respiration interrupted (after half an hour)

Respiration exceedingly weak

By a casual observer, respiration would not have been discovered (after seventeen hours)

Respiration scarcely perceptible

Breathing not perceptible

Respiration impercep|)table, at times with some noise

Respiration perfectly inaudible, and some attention necessary to perceive the motion of the ribs (after two hours and a half)

Respiratory function suspended (after two hours)

f llevisei by Hughes.

Chest p. 215

Lungs somewhat oppressed Oppression of the chest (first, third, fifth and seventh days),““Indescribable oppression in the chest,^^l

Oppression of the chest, making respiration difficult, and lasting a quarter of an hour (after 12 drops)

Anxiety, with contraction and tightness of the chest

Heaviness in the chest, with frequent need of taking a deep breath, with at times gasping for air ; the clothes were too tight; the beat of the heart could not be felt (after two hours),"A

Pressure in the thorax frequently occurring, causing hacking cough, which always relieved it for a short time (after 3 drops)

Pain in the chest (fourth day),^”b

Violent pain in the chest (tenth day)

Very violent pain in the chest, lasting through the afternoon, and making respiration_ difficult (sixth day)

Pain in the chest, and a cough, which has continued ever since, five or six years (after the discontinuance of the drug)

Tensive pain beneath the short ribs, along the attachment of the diaphragm, while breathing

Constriction of the chest, as if it were stiff; difficult respiration

Recurring stitches starting from within the thorax and extending outward, especially towards the right scapula (after 3 drops)

He feels heat in the chest (perceptible to himself)

Front and Sides, Constrictive (pinching) pain in the sternum and back, felt on motion

Drawing-tearing pain in the side of the chest

Excessive pressive pain in the right side of the chest, even when not breathing, with stitches in the same side during inspiration (after one hour)

Heart and Pulse p. 215

Heart. Violent beating of the heart ^®

Pulsations of heart accelerated (after fifteen minutes)

Circulation increased in rapidity, with a sensation of heat

The imperfect and irregular action of the heart became now more alarming than ever, and was more so when in a reclining than in a sitting posture (after five hours)

Heart’s sound exceedingly weak

Heart’s action healthy, but feeble, varying with the respiration

Heart’s action could not be felt

Heart’s action suspended

Anxiety about the heart and restlessness (after two hours),®®.f

Sensation of faintness and failing about the heart, seizing him as often as he was dropping asleep,®®.]

Burning, as from glowing coals, in the heart, so that she thought that she would die

Painful stitch in the region of the heart (fourth day)

False, Pulse between 70 and 80, never above 84 ; in strength it was as remarkable for its healthy character as for its number (after seventeen hours)

Pulse regular (after three hours) ; -102, weak (after fourteen hours)

In every instance the pulse has been quickened, and sometimes rendered sensibly fuller, in two or three minutes, e. g., from 66 to 68, and from 70 to 76; after a longer or shorter interval, e, g., in from five minutes to an hour, determined by the dose, the beats return to what they were at the beginning, and sometimes afterwards descend a little below this; the manifest effect, in all these experiments, is increase of frequency, and often of fulness also

Pulse accelerated, full, and hard

Acceleration of the pulse by 10 beats (soon after 25 drops)

Accelerated pulse

Pulse accelerated, somewhat excited, during the forenoon (after 1 drop)

Pulse increased by 10 beats, large, and hard; three hours after the dose it lost its fulness and hardness, and during the afternoon (after seven or eight hours) was not more rapid than before (after 2 drops)

Pulse frequent, full

Pulse contracted, hard, increased about 10 beats; this condition of the pulse disappeared after three hours, and in the afternoon the circulation was quite normal (after 3 drops)

Pulse increased by_8 to 10 beats, rather full and hard (two hours after 2 drops

[148().J Pulse 60 (before taking); 68 (after forty-eight minutes); 72 (after one hour),"^^f

Pulse very rapid and weak (after eight hours)

Pulse very small and rapid (after eleven hours)

Pul«e rapid and feeble; could scarcely be felt; intermittent (after three hours)

Pulse more rapid, but weaker than usual (after 6 drops)

Pulse more rapid than usual, rather full and hard (after 16 drops)

Pulse rapid and unusually weak, with rapid anxious oppressed respiration (after several hours)

Pulse rapid,''*®k

Rapid pulse, with headache

Pulse hard, rapid, violent, with difficult impeded respiration

Pulse violent, rapid, hard, with dark-red face

Pulse hard, large, frequent

Pulse hard and rapid (after two hours); (second day)

Pulse rapid, small and hard

Small quick pulse (after two hours and a half)

Pulse quick; (after six hours),'®k

Pulse hard, regular

Pulse hard, contracted, not much more frequent than natural (after forty-eight hours)

Pulse sharp (after four hours)

Pulse quick and full (second and third days)

Pulse strong

Pulse large, soft, accelerated by 14 beats

Pulse large, slow, with heavy deep respiration

Pulse large, slow, with slow heavy stertorous respiration

Pulse moderately full and slow

Pulse full, of nearly normal frequency (after one hour)

Pulse full

Pulse full and hard (after seven or eight hours)

Pulse full, slow, and laboring

Pulse 60 and full (after eleven hours)

Pulse 70, full and strong (after one hour and a half)

Pulse 70 to 80, full and soft (after half an hour)

Pulse 90, full and strong

Pulse 95, full and soft (after one hour)

Pulse full, amounting to 110 per minute

Pulse 120, full and strong

* Pulse full, regular, and slow; later, respiration became more and more stertorous.?,"®.

* Pulse small, weak, and frequent

Pulse slow and strong (after a quarter of an hour)

Pulse slow, undulating, soft

* Pulse slow and soft

Pulse slow, very soft

Slow pulse ®'®.

Pulse slow, probably not exceeding 45 (after twenty or thirty minutes)

Pulse slow, small and faltering, but not irregular

Pulse slow and feeble (after seven hours) ; afterwards not to be felt at the wrist

Pulse slow and small (after four hours); (after fifteen minutes)

Pulse slow and feeble (after four hours and a half)

Slow, obscure pulse

* Pulse slow, with slow stertorous respiration; exceedingly red distended face, and extremely profuse perspiration, with convulsions,®*.]

[1530. j Pulse slow, full, regular, with deep stertorous respiration

Pulse slow and feeble (after two hours)

Pulse slow and laboring

Intermittent pulse (after seven hours)

Pulse irregular, intermittent (after two hours)

Pulse rapid, irregular

Pulse full, slow, and very irregular (after seven hours)

Pulse at first full, slow, afterwards weaker

Pulse 94, full, strong, but irregular (second day)

Pulse sometimes full and nearly normal, at others scarcely perceptible, neither slow nor labored

Pulse, which after an hour and a half was 105, fell after six hours to 90,'*®.

Pulse 60 and intermittent

Pulse 70 (before the experiment) ; 73 or 74 (twenty minutes after 1 grain); 77 (twenty minutes after 2 grains)

Pulse 80,^'*; (after five hours and twenty minutes)

Pulse 90, feeble and irregular (after five hours and a half)

Pulse 90 (second day)

Pulse 100 (after three hours)

Pulse 108,*'®.

Pulse 130,*®

* Pulse 80 (after five hours) ; 120, weak and irregular (after six hours)

Pulse 50, soft and full (after two hours and twenty minutes) ; 90, small and soft (after three hours) ; later, almost gone

Pulse 96 (after two hours and a half) ; 100, small and feeble (after six hours and a quarter); 104 (after nine hours); 136 (after ten hours); 140 to 150 (after twelve hours and a quarter) ; 150 (after thirty hours)

Pulse 82, full and incompressible (second day) ; 78, a little full and more compressible (third day) ; 78 (fourth day)

Pulse about 100, irregular, but full (after three hours and a half)

Pulse, when it could be reckoned, 126 (after one hour) ; 55 (after six hours)

Pulse diminished by about 14 beats the first four hours; after ten hours accelerated about 30 beats,'*.f

In five minutes, pulse beat 74; ten, 74; fifivsu, 74; twenty, 76; twentyfive, 78; thirty, 80; thirty-five, 72; forty, 70; forty-five, 64; fifty, 64; fifty-five, 66; sixty, 70; seventy-five, 70; ninety, 70,*®®.

In two minutes, pulse beat 70; five, 74; ten, 76; fifteen, 76; twenty, 74; twenty-five, 74; thirty, 74; thirty-five, 72; forty, 72; forty-five, 70; fifty, 70; fifty-five, 70; sixty, 70; I could scarcely perceive any variation in the strength or fulness of the pulse

In five minutes, pulse beat 68; ten, 68; fifteen, 70; twentyfive, 7(3; thirty-five, 74; sixty, 76; ninety-five, 76; one hundred and twenty, 76; one hundred and fifty, 72 ; one hundred and seventy, 68 ; two hundred, 68; three hundred, 68; three hundred and sixty, 68,*'®.

In five minutes, pulse heat 54; fifteen, 54; twenty, 57; twenty-five, 58; thirty-five, 54; forty, 52 ; forty-five, 52 ; sixty-five, 54 ; dinner, after which it rose to 64

Pulse 95 (before the experiment) ; 86, soft and easily compressed (after fifteen minutes) ; 83, weak and soft (after thirty, and forty-five minutes); 90, weak and small (after one hour)

Pulse 108, firm and regular (before the experiment); 88, soft (after ten minutes); 84 (after twenty, and thirty minutes) ; 84, weaker (after forty minutes); 72, feeble and small (after fifty minutes); 76, weak and not quite regular (after sixty minutes); 90, regular and rather stronger (after seventy minutes); 96 (after one hundred and twenty minutes); 108 (after one hundred and eighty minutes)

In five minutes, pulse beat 70; ten, 66; fifteen, 68; twenty, 70; twenty-five, 67; thirty, 68; thirty-five, 70; forty, 70; fifty, 67; sixty, 68; seventy, 62 ;4 eighty, 60; ninety, 58; one hundred, 54; one hundred and ten, 53 ; one hundred and twenty, 56; one hundred and thirty, 56; one hundred and forty, 58; one hundred and fifty-five, 59; one hundred and seventy, 57; had supper 9.15, 64,**®.

12 oclock, pulse 64, one drop of tincture of Opium in a little water; 12.3 oclock, pu]se 70; 12.10 oclock, pulse 68 ; 12.20 oclock, pulse 68, at which it continued ; increased the action of the heart at first by 6 beats in a minute, and afterwards by 4 beats for a considerable time; the action of one dose, with one effect only

In five minutes, pulse beat 44 ; ten, 44; fifteen, 44; twenty, 44; twentyfive, 50; thirty, 52; thirty-five, 54; forty, 48; forty-five, 48; fifty, 46; fifty-five, 46 ; sixty, 46 ; seventy, 46 ; eighty, 44; ninety, 42; one hundred, 42; one hundred and ten, 40; one hundred and twenty, 40; one hundred and thirty-five, 44; after twenty-five minutes had elapsed there was a manifest increase as well in the strength and fulness as in the frequency ot the pulse; in an hour this began to diminish, and continued decreasing till near the end of the experiment

Its pulse, during the last two inspirations, was about 50 to the minute; during the spasm and suspension of breathing it would run up to about 100, become very weak, and finally cease at the wrists about six seconds before the breathing was resumed (after three hours); from 90 to 100 (after six hours); would cease at the wrists before the breathing was resumed (after ten hours)

Her pulse, which was large, equal, and not very frequent, sank, and began to intermit a quarter of an hour before her death,”.f

In some, irregularity and feebleness of the pulse, with pain in the cardiac region, indicate the supervention of organic disease, or severe functional disturbance, of the heart

Pulse thready; (second day)

Laboring pulse

Pulse fluttering and scarcely perceptible

Pulse intermittent, irregular, small, 100 (third day)

Pulse weak and irregular (after three hours) ; 120, very weak (after five hours and a half)

Pulse weak and irregular, 124 (after three hours)

Pulse weak and irregular (after five hours) ; became imperceptible, and he died (after seven hours and a half)

Pulse weak and irregular (after six hours and three-quarters) ; almost imperceptible (after seven hours and three-quarters)

Pulse slow and irregular (after half an hour)

Pulse became smaller, more frequent, and irregular

Pulse slow, irregular, and feeble (after one hour and a half)

Pulse 60, but not strong (after one hour and a half)

Pulse 75 and weak (after two hours and a half)

Pulse 90, not strong (after two hours)

Pulse could be slightly felt, about 90, and very irregular

Pulse 100, feeble (after half an hour); (after fifteen hours); (after three hours and a half); (after two hours and a half)

Pulse 110, very weak

Pulse 120, weak (after seven hours); (after seven hours and a half)

Weak, sinking, tremulous, and irregular pulse (after eight hours)

Pulse feeble, beating 40 to the minute

Pulse feeble (after two hours) ”*; (after five hours); (after twelve hours)

Pulse very weak (after three hours and a half)

Pulse weak

Pulse very feeble, difficult to count (after two hours)

* Feeble, irregular pulse (after six hours and a half)

Pulse exceedingly feeble; (after four hours)

Pulse frequent and weak

Pulse weak and frequent, and sometimes fluttering

The pulse became more and more feeble, and the patient died

Pulse reduced from 108 to 72, with chilliness and shivering, diminished activity, great weakness, though with increased hunger

Pulse small, and slightly increased in frequency (after a quarter of an hour)

Pulse weak, suppressed, slow, small

It diminishes the rapidity of the pulse and respiration

The pulse was depressed, and exhibited the phenomenon of prostrated excitability, being small and almost imperceptible (after about half an hour)

Pulse small and feeble (after two hours)

Pulse weak (after one hour and a half)

Pulse feeble, scarcely to be felt (after one hour and three-quarters)

Pulse, which could scarcely be felt, extremely small and irregular (after six hours)

Pulse feeble, threadlike, and scarcely perceptible

Pulse 96, small (second day)

Pulse 100 (after two hours and a half) ; small and quick (after six hours and a quarter)

Pulse 120, small and irregular

Pulse 120, small and weak (after twenty-six hours and a

•)■ Revised by Hughes; effects of a scruple.

Hahnemann. half)/

Pulse 126, small, and irregular in force (after one hour),”®

Pulse small and weak (one hour after 3 drops)

Pulse small (after 6 drops)

Pulse almost imperceptible in the radial artery

Pulse scarcely perceptible,'*”; (after four or five horn's)

Almost pulseless

Pulse almost imperceptible and irregular (after three hours and a half)

Pulse scarcely to be felt

Impulse of heart could not be felt (after four hours)

The pulse could not be felt, but on applying the ear to the chest the heart’s action was quite perceptible

Pulse scarcely to be felt, and tremulous (the next morning)*®®.

Absence of pulsation at the wrists; slight beating of the carotids

No pulse perceptible at wrist (after eighteen hours)

Suppressed pulse; (after thirtyfive minutes) ,'®®* ; (after five or six hours); (after two hours)

Neck and Back p. 219

Great swelling and violent pulsation in the veins of the neck

The back was stiff and straightened (a kind of tonic spasm), (between one and two hours)

Bending of the spine, frequently to such a degree as to assume a circular form

The hack was curved like an arch, from the violent trembling motion of all the limbs, that irritates all the nerves

Back painful (after one hour)

Drawingtearing pain in the back

Sensation of heat, alternating with coldness, along the spine (after half an hour)

Sensation as if there were pressure inward in the back and in the thorax up to the nape of the neck; the muscles and vessels seem contracted (after 3 drops)

Pressive pain between the tip of the right scapula and the posterior wall of the thorax (after 2 drops)

Pains in the dorsal muscles, at times extending into the thorax (after 2 drops)

Pain in lumbar region (after five days)

Upper Extremities p. 219

Trembling of the hands and feet (tenth day)

* Tremidmis motion of all the limbs

Convulsive trembling of the limbs

Trembling of the upper and lower extremities (sixth day)

Spasmodic trembling of the limbs

Limbs agitated by a nervous trembling

Clonic spasms of the extremities

Involuntary motions of the arms, fingers, and toes

General spasms of extremities (after three hours)

A good deal of tremor of the various limbs

Tremors in the limbs

Convulsive movements of the extremities (after two hours)

Nails quite purple

Limbs drawn up

The limbs lie immovable and remain wherever they are placed

Limbs immovable

Joints flexible (after six hours)

Limbs flaccid ; unable to walk (after four hours)

All the limbs quite flaccid, and would remain wherever placed

Limbs flaccid

Relaxation of the limbs, and weakness

Limbs relaxed and the body felt quite flaccid (after four hours)

Muscles of limbs relaxed (after eleven hours); (after one hour and a half)

The limbs hang down relaxed (after forty-eight hours)

Increased immobility of the limbs

Limbs powerless (after fourteen hours); (after two hours and a half); (after six hours); (after six hours and three-quarters)

Weakness of the upper and lower extremities

Weariness in the legs and forearms

Heaviness of the limbs (after one hour and a quarter); (third day)

Heaviness of the limbs, especially of the left arm

Limbs, especially the thighs, very heavy (half an hour after 2 grains)

Heaviness, like lead, in the arms and feet, making all motion difficult (half an hour after 1 grain)

Heaviness in the limbs, and some stiffness in them on rising (after a quarter of an hour)

The limbs feel asleep and heavy (second day)

Uneasiness in the sound limbs, that could not rest a moment in any place,®®. -^Numbness in the limbs and body generally

Numbness and insensibility of the limbs

Numbness and insensibility of the limbs, with coldness of the whole body (after two hours)

Numbness of the limbs (five or six years after the discontinuance)

Numbness in limbs, lasting forty-eight hours

Cramps in the limbs

If she passed over the usual time for taking a dose, she felt the most distressing sensations about the joints, not of pain, but such as she is unable to describe

Jerkings with pains in the muscles, especially of the limbs (first da}’’))

Superior Extremities p. 220

Superior extremities shook violently

Afin. Automatic motions of the arms

Attacks of trembling in the left arm (after three hours)

A convulsive motion, back and forth, in one or the other arm

Arms hung motionless by her side (after two hours)

Some twitching of the arms

The left arm is paralyzed (after forty-eight hours),®®.t

Feeling of numbness, extending from the left shoulder to the tips of the fingers, most severe on the palmar surface of the hand, thumb, and little finger, lasting six minutes, returning after twenty minutes, though less severe, and lasting only four minutes (after six hours)

Drawing and tearing, now in the right, now in the left forearm, in the evening (seventh day)

Hand. Tremors in my hands (after two hours and three-quarters)

Trembling of the hands

Hands of a purple color

Hands livid (after eighteen hours)

Ti •ancient twitching in the hands (tenth day)

Numbness and sensation of swelling m the hands and forearms (second day)

Touch so much affected that she could not execute any needle-work

Fingers, Fingers blue

Fingers and wrists occasionally jerked by spasmodic twitchings of the tendons

Sensation of numbness in the left little and ring fingers, extending from the second joints to the tips of the fingers; it felt as though the fingers had been constricted for a long time, a sensation lasting only about four minutes, and disappearing after rubbing with the other hand, in the evening (second day)

A sudden drawing-tearing pain in the second joint of the right ring finger, aggravated by motion, relieved by rest, lasting ten minutes, and gradually disappearing and extending above the wrist to the head of the radius, where it lasted for more than two hours (second day)

Crawling in the fingers, as if asleep, increasing on grasping anything

Inferior Extremities p. 220

Lower extremities very much flexed and cold (after three hours)

Trembling of the lower extremities (ninth and tenth days)

Trembling, especially of the lower limbs and about the lumbar region (first day)

Stiffness in legs (soon)

Legs stiff and with difficulty separated

Stumbling gait (first, fourth, and tenth days)

Weakness of the lower extremities

Lame gait

Heaviness and weariness of the legs; his gait became stumbling, so that though he made but a few visits be was as weary as after a long journey on foot (second day)

Sensation of weariness in the lower extremities

Weariness of the lower extremities, especially of the knee-joints (eighth day)

Violent pains in the knee and hip-joints, which became so excruciating that I could neither sit nor lie, once (after 8 to 10 grains daily for a fortnight) ; removed by 8 grains in two pills

Long-continued sensation of numbness and prickling in the left lower extremity, occurring after sitting only a short time, and not relieved by walking about (after two hours)

Crawling in the lower extremities

Thiffh. Trembling of the thighs (second day)

Creeping shivering on the anterior surface of the right thigh, extending down to the knee, lasting a few seconds; after a quarter of an hour it commenced in the nape of the neck, and extended down the back to the sacrum, lasting only a few moments, without subsequent heat, disturbance of the circulation, or thirst, at 6.30 P.M. (first day)

Drawing on the outer side of the right thigh (within ten minutes),''l

Tensive pain in the flexor muscles of both thighs, extending to the hollows of the knees, lasting only twelve minutes, in the forenoon (second day)

Rheumatic pain in the thighs (after 1 drop)

■ Sensation as if some liquid were moving up and down in the left thigh (first day)

Knee, The knees were bent,^®k

Trembling and a paralyzed feeling in the knee-joints

Stiffness and weariness in the knees (eighth day)

Weariness in the knee-joints (fifth day)

Weariness in the knees ( ninth day)

Weakness in the knees

Feeling of weakness in the left knee-joint (after two hours)

Weakness, especially in the knees, with frequent yawning and stretching (after 1 drop)

Feeling of paralysis in the knee-joints, with dull pain (first day)

Paralyzed sensation in the knee-joints (second and third days)

Transient acute pain in the hollow of the knee (third day)

A sudden lightning-like tearing along the outer side of the right knee, extending to the outer surface of the leg as far down as the malleolus, disappearing as suddenly as it came (second day)

Lett, Legs slightly drawn up (after two hours)

Legs unable to support the weight of the body (after two hours)

Weakness of the legs

Weariness and sensation of heaviness in the legs, on rising from a seat, lasting till towards 6 p.m. (second day)

Sensation of heaviness in the legs (third day)

Great weariness in the legs

Distressing spasmodic jerking in the muscles of the calves

Crawling sensation in both legs (second and eighth days)

Almost no sensation in the legs,®®.t

Foot, Swelling of the feet

The foot was so stiff and sensitive that he could not walk or step upon it

Heaviness of the feet after eating (after two hours)

Numbness of the foot

Generalities p. 221

Strong convulsions, which affected the muscles of the trunk and extremities to such a degree as to make him as stiff as a frozen corpse; these spasms would continue from ten to fifteen minutes at a time, and then partially relax for two or three minutes, recurring several times (after fourteen hours); ceased altogether, a warm perspiration breaking out over the body (after fifteen hours and a half)

Frightful convulsions (after a quarter of an hour)

Frightful convulsions, with terrible pains

Frightful convulsions and images before the eyes

General convulsions (after twm hours); (after three hours)

Convidsionsf'^X^^-

Convulsions (soon); (after five or six hours); (after three hours); (after one hour)

Immediately attacked with a convulsive fit and died

Convulsions and death (after five hours and a half)

Convulsions, with screaming, bending the head backward, at times opisthotonos

Convulsions become stronger; the patient utters plaintive groans and tears everything within her reach ; bites her hands and arms ; four persons are necessary to keep her in bed

Convulsions of the extremities and face (after nine hours); death (after nine hours and a half)

The fits were almost continual (second day)

After rousing her to give a dose of tincture of belladonna, there was an almost convulsive struggle of resistance, attended by violent excitement, and followed by sudden and complete collapse; entire cessation of respiration ; pulse barely perceptible ; face pale; lips livid ; pupils unchanged and eyes rolled upward and outward, to the extreme limits of their orbits (after four hours and a quarter) ; relieved by injection of atropia

Occasional convulsions

Convulsive twitches in the muscles, especially of the abdominal extremities

Convulsive movements

Muscles strongly convulsed (after one hour) ; the violent action of the muscles occasionally relapsed, but was alternated with slight subsultus

Alternations of spasmodic contractions of the limbs and complete relaxation ; these alternations took place every two or three minutes, at times with bending of the head and trunk backward

Some slight convulsive contractions of the muscles, especially of the hands and face (after three hours)

Attacked with hysteria

First effects similar to hysteria

Spasms

Convulsive spasms occurred at regular intervals, when the eyes stared, with twitching and contraction of the muscles of the extremities

The child continued to lie in the spasms, with violent screaming, alternating with stertorous respiration ; with distortion of the eyes, contractions of the fingers and opisthotonos

He bends his head backwards (a kind of tonic spasm in the nape of the neck), (after one hour)

Tonic spasm and epileptic convulsions

Tonic spasm

Commencement of a tonic spasm, bending her backward (opisthotonos)

Clonic spasms accompanied with screaraings and tears

Clonic spasms, especially of the lower extremities, with loss of consciousness (third day)

Spasms of the muscles of the face and extremities

Spasms like opisthotonos, always ending with trembling, followed by profound quiet, with relaxation of the limbs

Spasmodic movements, accompanied by cries

Slight spasms (after thirty-five minutes)

Slight spasmodic contraction of muscles of face and extremities

Slight spasmodic movement (after eleven hours)

Epileptic attacks, with violent delirium

Epilepsy

Condition seeming apoplectic, with stertorous, rattling respiration, open mouth, pale face, covered with icy-cold perspiration, left eye completely closed, the right partly open, pupils dilated, eyeball paralyzed, with blue nails, a very full pulse, without sensation, without motion, followed by death

Paralysis,‘®.f

Limbs and body powerless

Rigors

Rigidity of the whole body (after one hour)

Rigidity of the muscles

Whole body paralyzed and stiff,’®.]

Started up in a fit and threw his arms about, vomited, and then sank, as if exhausted (soon)

He tosses the feet up and down, as if in convulsions, with a sudden loud cry

At times the patient raised himself and violently scratched either his face or chest

Their gesticulations are so whimsical as to excite mirth and merriment in those most inclined to pity them

Jerkings and throwing the arms about

Whole system excited

A nervous tremor about her (second day) ; continues to a great degree (fifth day)

Appeared nervous and twitched frequently (soon)

Trembling of the whole body, as if he were frightened, with some jerking of the body and twitching of the limbs, affecting only the flexor muscles, with external coldness of the body

Every fibre in the body trembles

Trembling, sick, and so giddy that he could not walk without a stick; he ate no dinner, and continued in this state, sometimes in bed, sometimes walking about, until evening (one case)

Tremulous motion of the whole body (second and third days)/

Trembling (after 4 to 6 grains); (one hour after 2 grains); (fifth and tenth days)

* Trembling of the whole body (fifth day)

Trembling of the whole body from time to time

Body tottered when erect

Twitching

Twitching of the whole body

* Twitching and involuntary contractions of the muscles (after six hours and a half)

No movement beyond that of the lips and chest of an unusually powerful frame

They are easily known by a kind of rickets, which this poison never fails to produce at last

The only signs of susceptibility to outward impressions were: 1st, slight contraction of the upper eyelids when water was forcibly dashed upon them ; 2d, liquids introduced into the mouth were slowly swallowed, and, as it seemed to me, somewhat more readily when the patient was imperatively told to do so; 3d, when asked to show her tongue, while the mouth was forcibly kept open, there were some slight attempts to move it

Supported in an erect posture by two strong men, who were holding her up by the shoulders, with her head hanging lifeless upon her breast, her hair in disorder, her eyes bewildered, and her countenance pale and ghastly ; her limbs were unable to do their duty in supporting her, her body was suspended as it were in the air, with the points of the toes touching the floor; the muscles were in a complete state of relaxation (after five hours and a half)

Lying on his back

Lying with the knees drawn up, for six hours and a half

He appeared twenty years older than he really was

Bloodvessels injected

The whole body was quite stiff, extremities cold, eyes convulsively distorted and half open

The child could not support its head, or take a step without assistance

He lies as if in a sunken slumber

Total attenuation of body

The same breathing, look and pulse that I have several times seen in apoplectic attacks

The body wastes and the muscles lose their tonicity

Emaciation and debility

Their pale and melancholy figures would be sufficient to raise our pity, did not their lengthened necks, their heads turned to one side, their backbone distorted, their shoulders raised up to their ear, and a number of other extravagant attitudes, which result from their disease, exhibit a picture of the most ridiculous kind

Very much emaciated

Emaciation and weakness

Emaciation

Great relaxation of the muscular system (after two hours)

Muscles in a complete state of relaxation, and he was obliged to be supported in a chair (after three hours and a half)

Muscular system completely relaxed (after fifteen hours)

Muscles were in a state of complete relaxation; she had lost the power over them, and was so feeble as to be unable to support herself in an erect position without assistance (second day)

Every muscle in a state of relaxation (after six hours); (after six hours and a half)

Entire muscular system so relaxed that the tongue hung out of the mouth, and was pushed about by the end of the stomach-tube, in certain positions, folding back into the fauces, and apparently obstructing respiration (after one hour) ; muscular system, if possible, more relaxed than ever (after five hours)

Failure of muscular power (after thirty-five minutes)

All the muscles are relaxed; (after three hours and a half); (after half an hour)

The muscular tone is relaxed, so that a kind of paralysis follows

Muscular force sunk in lassitude and languor

Muscles of her body became soft and relaxed

Muscular system not much relaxed

Muscles flaccid (after six hours)

After several hours the child fell into collapse, with cold face and extremities; pupils at first contracted, but before death widely dilated; pulse rapid, small, weak, smaller in the right arm than in the left; visible and very violent beating of the carotids; distension of the jugular veins; respiration varying, sometimes superficial, sometimes deep and with much noise, as in agony, with distension of the anterior and upper portion of the neck; abdomen retracted, hard, and tense; running of mucus from the mouth ; the child became rigid, opened its mouth and eyes; the face at last became puffy and violet-colored ; features drawn ; followed by death, without convulsions

The people seldom attain the age of forty, if they have begun to use Opium at an early age

Becomes old early

The offspring of Opiumsmokers are weak, stunted, and decrepit

The acuteness of all her senses was restored by the usual dose, the want of which was indicated by heat and flushing of the face

Some of these unfortunate creatures have wry necks, for the muscles become rigid; the head is seen contorted to one side or the other, or one shoulder is considerably higher than the other, or the head appears almost buried beneath the shoulders

By-and-by the figure stoops, and a peculiar shuffling gait is acquired, by which alone a practiced eye may recognize an old Opium debauchee

In the morning these creatures have a most wretched appearance, evincing no symptoms of being refreshed or invigorated by sleep, however profound

He is not deprived of sight or hearing, but of the senses of taste, smell, and touch, in relation to external objects, though he feels his cheeks cold when he touches them (after one hour and a half ),®*.t

His mental and body powers are destroyed

Nothing on earth can equal the apparent quiet enjoyment of the Opium-smoker; there is a lightness of the head, tingling in every limb; the eyes seem to be enlarged, and the ears sharpened to hearing; an elasticity and inclination to mount on high are experienced ; all pains are gone, and pleasure now remains; all weariness has vanished, and freshness takes its place; the loathing of food previously experienced is changed to a relish for what is piquant, and a great desire is often felt for some particular food ; the tongue is now loosened, and tells its tale, for whatever is secret becomes open, and what was intended for one becomes known to all. Still there is no excitement, but rather a calmness, soft, soothing, and sedative. He dreams not, nor thinks of the morrow; but, with a smile in his eye, fills his pipe with the last of his allowance. Slowly inhaling it he seems to brighten up, the smile that sparkled in his eye extends to other features, and his appearance is one of complete yet placid enjoyment. Presently the pipe is slowly displaced, or drops by his side; his head, if raised, is now laid on the pillow; feature after feature gives up its smile; the eye becomes glazed; the upper eyelid drops; the chin and lower lip fall; deeper and deeper inspirations follow; all perception is gone; objects may strike the eye, but no sights are seen ; sounds may fall on the ear, but none are heard, and so he passes into sleep, disturbed and broken, from which the wretched being awakes to a full conception of his miseries

The effects produced on the health by abandoning the habit of Opium-smoking, after it has become deeply rooted, are even worse than the perseverance in it. A gloomy despondency is added to the usual symptoms of the ordinary stage of depression ; a state ensues somewhat like a low state of delirium tremens, attended with extreme prostration of strength, and often with exhausting diarrhoea and vomiting; all pre-existing diseases are aggravated, dropsy frequently ensues, and death may soon result, most generally by effusion into the great cavities, and general anasarca. When these effects have begun to show themselves under a compulsory cessation of the habit, the most marked improvement of health is produced by resuming it. The result of the examination of several hundred Opium-smokers on this point was, that, by their own confession, the extent of their indulgence was limited only by their means, and the siwutaneous abandonment of it impossible. The writer of au essay on the Opium trade says, “There is no slavery on earth to name with the bondage into which Opium casts its victims; there is scarcely one known instance of escape from its toils, when once they have fairly enveloped a man

The effects were strongest if I were unwell, or if anything had in the least deranged the functions of the economy; for instance, if I had been up all night; if I had been sick and vomited, and taken no food, 2 or 3 grains would have as much effect as otherwise 4 or 5 grains

The torments of the victim of Opium, when deprived of this stimulant, are as dreadful as his bliss is complete when he has taken it

If deprived of laudamiin for a single day, the inst unpleasant symptoms came on ; loss of sleep and appetite and an indescribable feeling of languor, with a corresponding depression of spirits, and slight involuntary motions of the limbs, all of which were readily relieved by the accustomed dose of laudanum,^®b

After discontinuing its use she was more miserable than before; all the symptoms returning with increased severity, and for the first six months she was almost entirely helpless

If the dose be not taken at the usual time, there is great prostration, vertigo, torpor, discharge of water from the eyes, and in some an involuntary discharge of semen, even when wide awake. If the privation be complete, a still more formidable train of phenomena takes place. Coldness is felt over the whole body, with aching pains in all parts. Diarrhoea occurs; the most horrid feelings of wretchedness come on ; and if the poison be withheld, death terminates the victim’s existence

At length their whole organization assimilated to such a state of mind and body, and they have grown up to the size of manhood, with the avenues of their brains practically closed by drugs, so that they still have merely infantile powers of mind and strength of body. Joseph is very gluttonous and masturbates in the most shameless manner. George has a most perfect equanimity of general foolishness and indolence in all his faculties. But William is a powerful genius on digestion, and robs the swine and dogs of all the crumbs he can skim out of their food

Most Opium-eaters dislike wine and brandy; but this is not always the case. The exhilaration is most striking in the state of the mind; all is order, harmony, vigor, and tranquillity; there is no shadow of that brutality which most decidedly belongs, more or less, to vinous intoxication. No greater misery can be felt than the Opium-eater experiences when his accustomed stimulus fails him, or the dreadful reaction sets in, which is as striking to observers as it is painful to himself; the mind is much enfeebled ; the eyes lack lustre; the sensations are all disordered ; the appetite is lost; the limbs seem incapable of supporting the body’s load ; existence is loathsome; no substitute can be found for the potent juice, for to the greater number of the lovers of Opium wine and brandy are disgusting; they nauseate instead of diffusing a genial glow The accustomed dram is the only relief to be found in this sad state, and the deluded victim flies to his debauch whenever the opportunity presents itself, although selfcondemnation and the ridicule of his friends await him, and although idiocy and deformity stare him in the face

Any meal, taken within half an hour or later, after a dose of Opium, speedily brought on all its effects, and it seemed in a considerable degree higher. If taken within an hour after dinner, the effects appeared later than usual and were less in degree; I even sometimes could hardly perceive them at all, if the dose had been a moderate one

Every appearance of a man dying of compression of the brain (after four or five hours)

He believed it to be a case of epilepsy, from appearances and from what was told him ; death (after twelve hours)

Dropsical tendency

* Apoplexy not infrequent, 64 87 %

effects were the stronger the shorter the time since a former dose had been taken, even if the effects caused by the latter seemed to have subsided

The effects would last an hour or two (after 2 grains)

The effects seemed to be stronger the earlier in the day the Opium had been taken

Cold, rest, but particularly sleep, also retard the appearances of the effects, and prolong them

(When applied directly to a nerve, it does not diminish its functions),®“.|

Strumous affections of all kinds are apt to be developed, and the constitution is prone to succumb without resistance under all violent diseases

Analyses of the blood, for some time before and after taking, showed the solid constituents of the fibrinous portion increased, the watery portion also increased; the solid constituents of the blood freed from fibrin diminished, the watery portion of the same increased; the solid constituents of the serum diminished, the watery portion slightly increased, the albumen somewhat diminished ; the extractive and salts very slightly increased; the fibrin of the blood diminished ; blood-globules diminished; blood-clot diminished ; serum largely increased

Blood drawn from the arm was black

Blood flowed from a vein that had been opened recently (until death)

Impaired voluntary motion (after 4 to 6 grains)

It diminishes the power of moving the muscles

It destroys the activity of the voluntary muscles, diminishes sensation, and causes sleep

When applied to the muscles it very soon destroys their irritability

The muscles can be moved with difficulty

Vital energy decreasing (after twelve hours)

Sensation of strength ®®.

Sensation as though he had not slept enough (after two hours and a half)

The symptoms, except the trembling, disappeared after coffee, but soon returned (first day)

The symptoms disappeared after a cup of black coffee

Did not feel so refreshed and invigorated in the morning as usual (after 8 drops)

Refreshed for a moment by cool air (tenth day)

Intolerance of the open air, and a sensation as if he would take cold

Cannot lie on the left side, and experiences pain in it, even on attempting to turn in bed (third day)

A cigar, which he attempted to smoke at 10.30 a.m., as usual, caused vertigo, great nausea, inclination to vomit, cold sweat over the whole body, and trembling of the limbs; momentarily relieved by a glass of fresh water (third day)

Great restlessness

Oppression, with restlessness, confused ideas, and sparks before the eyes; with burning disagreeable heat of the head, extending over the whole body

Restless (soon)

Physical restlessness; a kind of anxiety (first day)

Restless night

Uneasiness (third day)

Night very restless

General debility (second day)

Great sense of debility and lassitude

Body debilitated, so that I was obliged to remain on the sofa all day (second day)

Unfitted for all work; weak and debilitated

Slight heaviness (after fifty-five minutes)

Indolence and inaction ; neglect of business or work. and consequent poverty ; wife and children are disregarded ; not unfrequently theft supplies the only resources for persevering in the fatal pleasure

Indolence

Indolent, in the morning, on rising (seventh day)

Relaxed, indolent

Movements indolent

Weariness, with unsteady gait (third day),^'l

Weariness (one hour after 1 grain)

Weariness over the whole body (first day)

Inclination to lie down

Great inclination to lean against everything, to stretch out the feet, and support the head upon the hand

Great weariness and sleepiness (three hours after 1 grain)

Weariness and exhaustion (after 3 drops)

General weariness and exhaustion (after 1 drop)

Unusual weariness and perspiration (after 2 drops)

Weariness in the knees, elbows, and masseter muscles (soon after a dose)

Was not refreshed by sleep at night, but rose in the morning quite as sleepy as in the evening when he went to bed (after 2 drops)

He could scarcely move his feet; could scarcely go forward, though making every exertion

Weariness, after long Opium sleep

Overpowering weariness

A pleasant kind of weariness, as from intoxication

Felt so weak that he could move his limbs only with difficulty, at the same time there was an internal restlessness that constantly impelled him to change his position, whether sitting or lying (after 4 drops)

Very easily fatigued by his ordinary occupation

Weakness,'*; (sixth day)

Weakness of the whole body (after 2 drops)

General weakness (tenth day)

A certain weakness and indolence continued for several days after the proving

Could not walk on account of weakness of legs (after four hours)

Unusual weakness (after 3 drops)

Gait slow, tottering

He lay in a condition of the greatest weakness

Tottering; cannot walk without reeling

Loss of power; sinking of the forces

Siukingof the strength,"®®.]

Weakness; all external objects distress him; he is sleepy, stupid, confused, sad, and his thoughts leave him,®'.]

Continued weak

Sensation of great weakness and prostration, extending through all the nerves, especially the sciatic nerve

Great weakness (after eight minutes); (after half an hour); (after sixty minutes); (fourth day)

Great weakness and stupefaction (second day)

It causes perceptible diminution of strength, and impairs the tone of the tissues, and motion

Discomfort; feeling of weakness of body and mind (after eight, and twelve hours)

Weakness.””.§

Weakness, with inclination to sleep (one hour after 3 drops)

Weakness and exhaustion, with disinclination for physical and mental work (after 8 drops)

More exhausted after waking, from restless dreams through the night

Slightly exhausted, and did not speak with his usual firmness of voice (after eight hours and a half )

General exhaustion and weariness (after 2 drops)

Exhaustion of strength and inability to move

Exhaustion (after eight, and twelve hours)

Complete prostration of strength,'”'; (first day),'””; (fifth day),"”®, etc.

Prostration (fifth and eighth days)

Extreme prostration of mind and body, after awaking from the somnolenc}' and dreams (from, too large or too frequent doses)

Great prostration; sinking of all the vital forces

Prostration of the whole body

Very weak, prostrated, (second day)

Languor, and lack lustre of eye

A pleasing kind of languor, gradually increasing (after forty minutes)

Languor;, immediately

Languor and indifference succeeded the delirium (after three hours), General lassitude and exhaustion (second day after 2 drops)

A lassitude and exhaustion, and strong propensity to sleep, were the late and last effects, more or less, sooner or later, in proportion as the earlier effects had been more or less strong, and lasted a shorter or longer time. If, for instance, I had taken from 4 to 6 grains, at 10 or 11 A.M., I sometimes experienced a burning heat creeping throughout my limbs, but which was particularly strong in my palms, followed by exhaustion, at 9, 10, or 12 p.m., or thereabout; sometimes I experienced lassitude and propensity to sleep next morning, when I got up at 8 or 9; sometimes at noon, or any other time during the day or night. I cannot exactly determine how long this state of relaxation lasted, but I think I sometimes felt it on the third and fourth days, after having continued most part of the second, or at least made its appearance on that day. If I had taken 10 full grains, the second day I perceived the symptoms of giddiness, trembling, etc., in a much milder degree than on the first; on the third day I was well, active, and cheerful; on the fourth I began to be despondent, tired, and exhausted, and continued in that state to the sixth and even seventh day/®

General feeling of lassitude (five or six years after discontinuance),^’k

Syncope, for some time,'‘'h

Languid and weak feeling (after twenty hours),'^l

Faintness,^A]

With increased vigor she endeavored to rise from bed, but immediately fell into faintness, and was dizzy; on lying down again her activity returned

Sudden faintness so that I could scarcely reach a seat (fifth day)

[Faintness recurring every quarter of an hour; it closed the eyes, allowed the head to hang down, with weak respiration, without consciousness, with unchanged pulse ; followed by somewhat spasmodic shuddering of the body, and, after a few minutes, the paroxysm ended with sighing, followed by anxiety],®®.§

Sensation is blunted and at times entirely destroyed

Sensation is first diminished, afterward reflex irritability

Feeling as after a night of debauch (second day)

“Felt very strangely (after half an hour)

Inability to walk far without aching pains in the limbs (five or six years after discontinuance)

After long indulgence he becomes subject to nervous or neuralgic pains, to which Opium itself brings no relief

Very violent pains (after a quarter of an hour)

Woke in the morning with pains in the limbs and loins, bathed in perspiration

Bones affected with dull gnawing pains for some hours, in the morning

Frightful pains, that pierced through the marrow of the bone,^®.ll

Burning pain and irritation

Sudden jerking over the whole body woke him from sleep

Sensation, at one time as if flushes of fire, at another, as if ice-cold water were running through the veins

The right half of the body, as far as the toes, seems beaten, with flushes of heat and burning pain

Disagreeable sensations with the coldness (after fifty minutes); did not go off until after supper

Stomach p. 228

Surface of body pale, and covered with profuse perspiration (after four hours)

Pale (after seven hours); (after half an hour)

Surface of body pallid and contracted

Skin livid

Great lividity of the skin, particularly of the extremities

Color of the skin pale and bluish/®.

Skin of extremities and face blue (after four hours)

Blue color of the skin, especially of the genitals,®.f

The cyanosis became very intense, and more extended than before (third day),'''®h

Cyanosis of the lips, tips of the fingers and toes

Blue spots here and there over the body (after fifteen hours)

Redness of the whole body

Skin of a red and inflamed color (he being a fair man, the sou of a native of Persia), and all the veins, even to the minutest branches, were uncommonly distended, and had the appearance of being stuffed and gorged with their contents (after half an hour),*^l

Congestion of the surface, especially about the neck and chest, increased

Redness and itching of the skin

Red spots on the cheeks, that are pale

Skin dry, rough, and of a dirty color

Skin dry, parched, of a sunburnt color

Skin dry to touch and shrivelly, and of a tawny color

Skin brown

Skin resembled leather

Almost black

It irritates the skin, removes the hair, and causes itching

It removes the hair, causes itching, corrodes the skin, and draws blisters

When applied to the skin as a plaster it causes great heat and pain, draws blisters, irritates the skin, and occasions mortification

Eni^ptlons, Eruptions on the skin, with at times itching

. A large pimple, sensitive to touch, ou the side of the neck

Frequent eruptions, with biting itching in the skin after the sweat

Small red, itching tetter here and there in the skin.®®.J

Burning itching and eruption of pustules,*®.§

Elevations, like hives, that itch violently, on the extensor surface of the left thigh, lasting several days, and gradually disappearing

A burning-sticking pain about the right wrist, with pimples as large as millet-seeds, surrounded by red areola ou the back and also in the palm of the hand; on the same evening two similar pimples appeared on the right cheek, and were sensitive to pressure (after 5 drops)

Some suffer excessively from boils and carbuncles, from the latter of which few confirmed Opium-smokers recover; foul, indolent ulcers are extremely common among the poor

Sensations. Skin insensible

Pruritus (after five hours),®®.||

Intolerable itching of the skin (.second day)

Intolerable itching over the whole surface, which was warm and dry (second day)

Itching over the whole body; after scratching, appearance of thick, red pimples (hives), that itch greatly, but soon disappear

Burning and sometimes itching in the skin

Fine sticking itching here and there in the skin

Very troublesome itching

Troublesome itching over the whole body

Intolerable itchiness over the whole of his skin, so that he kept five or six persons constantly employed in scratching him (after half an hour)

Intolerable itching and burning heat of the face after the poisoning

Sensation of biting and burning in the skin, especially of the face (after one hour)

Itching of the nose (after ten minutes)

Itching in the nose, and not very rarely all over the body (after 4 to 6 grains)

Itching, especially on the upper part of the body, extending from the chest over the face, particularly on the nose

Itching on the arms and shoulders

Violent itching about the anus (third day)

Disagreeable crawling in the hands and feet, which changes to a frightful, incessant rolling

Violent itching on the legs, in the evening

Formication on the left leg (fifth day)

Sleep p. 229

Sleepiness, Yawning twice (after half an hour)

Yawning frequently repeated (after a few minutes)/”; (fifth day)

Yawning for a quarter of an hour, Avith pain in the joints of the jaws as if they would break, Slight drowsiness (after eleven hours),'^^l

* Drowsiness (after twenty minutes); (after three-quarters of an hour); (after two hours, two cases); (after a few minutes,)®'’®, etc.

Drowsiness xvith the headache (after two hours)

Very drowsy (after five hours)

Constant drowsiness (after two hours)

Very drowsy, but easily roused up and able to walk about (after five hours and twenty minutes)

Very drowsy all day

Extreme languor and drowsiness supervened, which threatened a deep and perhaps fatal sleep

* Great disposition to drowsiness (first day)

Extreme drowsiness, amounting almost to sopor

Exceedingly droivsy (after two hours)

Unusually drowsy (after half an hour); exhibited a peculiar facility for going to sleep in any possible position (after four hours)

She soon became very drovAsy; she could be aroused by shaking and loud speaking, and then knew every one around her, looking at them with a half-intoxicated expression, understanding all that was said to her (after two hours and a half) ; could not be aroused by shaking or loud speaking (after six hours and three-quarters) ; more easily aroused, but instantly falls asleep again (after application of electro-magnetism), (after eight hours and a quarter); now rose up to the sitting posture, and got off the couch to walk across the room, supported by two persons, looking about her with an alarmed and bewildered expression, but apparently not recognizing any one; she was, however, sufficiently awake to drink a cup of strong coffee, taking the cup in her hand (after nine hours and a quarter)

Somewhat sleepy, followed by a few minutes slumbering (one hour after 2 grains)

* Great desire to sleep; it was very difficult to keep awake ; but during the night sleep was restless, with much perspiration (after 3 drops)

Very sleepy (after a quarter of an hour)

Constant desire to slumber at night, with increased thirst, and almost clean and dry tongue, dark at the edges; cracked lips

’’'AS'/eepfuess; (after ten minutes)

Sleepiness; slumbering; stupefaction

During the fourth day was very sleepy, so that it troubled me at my work, on which account I did not take the daily dose till 9 p.m., when I took 20 drops of the tincture; fifteen minutes afterwards my head felt much relieved; I was especially lively;- I then went to bed, read for about twenty minutes, when I became so sleepy that I was obliged to lay aside the book; could no longer keep my eyes open; all efforts to keep off sleep were unavailing; I gradually became more and more sluggish, till at last I was unable to reach a glass of water standing near me, though I made every effort. My mental powers were also very much blunted; I gradually fell asleep; after about two hours I was awakened by loud cries for help in the street; after this I was unable to sleep; my memory lost its clearness, and I was unable to follow any connected thought

Sleepiness and extreme disinclination to work (after 2 drops)

Sleepiness, so that he was able to keep awake only with the greatest effort, and it was scarcely possible to talk connectedly (two hours after 18 drops)

Could not rouse himself in the morning

Sleepiness while writing at a table, followed by sleep for about twenty minutes, after which he woke, feeling quite well (first day),”®a.

So great sleepiness that he could not keep awake; lay down on a lounge, and immediately fell asleep, about noon (second day),”®.f

Unusual sleepiness about 8 A.M. (second day) Almost irresistible sleepiness after eating; best described by the adjective narcotic

Constantly sank down into sleep; heard nothing; could answer nothing,’™.

Irresistible sleep (immediately after taking 2 grains or more), that, however, was disturbed by dreams, and on waking he was not refreshed, but experienced nausea

Sudden falling asleep (after a few minutes'),™.

Sleepy, with actual though restless sleep (first day)

Soon fell asleep, and continued for six hours,^™.

Soon fell asleep ™

On lying down instantly fell asleep

Intoxicated with sleep while awake

Sleep, with consciousness; he heard everything, but couhl not rouse himself; woke after two hours,™.

Stupid sleep, without consciousness, with rattling in the chest,®k

Instead of healthy sleep, it easily causes a stupid slumber

Stupid slumber

The slumber was so stupid that he could not be made to answer

Constant slumbering, with half-open eyes; carphologia and picking all about

A kind of stupid sleep, with half-open eyes; the eyeballs turned upward under the lids; mouth more or less open, with stertorous inspiration

Slumber,™ ®'; (after one hour),™

Quiet, pleasant slumber, from which he was constantly awakened by frightful jerking in the liitibs

Sleep rather quiet; sweat violent,®'.-Sleep, with redness of the face

As soon as effort was intermitted sleep recurred, even when walking (after a quarter of an hour),*’. Deep sleep,”*™*; (after one hour); (after two hours)

* Sound sleep, with stupefaction and partly open e?/es

Dropped suddenly into sleep, and could be as suddenly aroused,™

Overcome by deep sleep, so as scarcely to be roused by all the efforts of her attendants,’™. Overpowering sleep, during which, however, he was sensible of pain, and when pinched, opened his eyes

The patient could be roused from sleep by shaking and by speaking to her; she then complained, and wished to die

Deep, still sleep (after two hours and a half)

Fell into a sleep from which he could not be roused,™

In a deep sleep, from wdiich every effort that her husband could devise could not arouse her. I shook her smartly, pinched, and bawled loudly into her ear, but could not perceive the slightest marks of sensation or consciousness; after vomiting, caused by sulphate of zinc and irritation of internal fauces, she was somewhat aroused, though still very drowsy, and desirous to be left alone; later, conia greatly increased

* Deep, sound sleep, with rattling respiration, as in an apoplectic person

Sound sleep, with rattling respiration, as after apoplexy (after six hours)

Great somnolence and feebleness, but the child could be aroused (after eleven hours)

If the dose is a little too large, or repeated too often, the excitement and energy are changed into somnolency and the stage of delicious dreams; on awaking from these the prostration of body and mind are extreme

The soporific power of Opium is very much diminished by very great pain or by great grief.

The sleep caused by Opium passes into unusual stupefaction

If allowed to remain unmolested for a few moments he lapsed into a deep sopor, whence he could with difficulty be roused to utter a whimpering cry, which was overcome midway by recurring sleepiness (after one hour)

Sopor (after twenty-five minutes)

During the following night sopor, alternated with delirium,’™.

Sopor, disappearing towards morning, but the patient sank during the following night,’®’.-r-Completely torpid

Considerable torpor, from which he could be aroused only with difficulty (after one hour)

State of torpor, from which he was easily aroused (after three hours) ; very drowsy ; if left for a moment he became quite insensible (after threehours and a half)

Sleepless ness. During the period of taking Opium she had very little sleep, and in the intervals she could not attempt to sleep from want of desire, so that she generally worked all night; what sleep she had was generally in the daytime, and that little was much confused and easily ended

Night sleepless, with restlessness and delirious talking

Sleeplessness, full of unwelcome fancies and imaginations, that were entirely distinct from surrounding objects, as in delirium

Inability to fall asleep for a long time in the evening (possibly to be ascribed to an extremely painful boil on the left nates), (second day)

It never affected him with sleep or drowsiness, but rather hindered his repose when he happened to take an overdose

AVould like to go to sleep, but cannot

Loss of sleep

No sound sleep after taking the drug

Did not sleep during the night

Slept but little (first night)

Did not sleep at night, and says she has not since admission (fifth day)

’''Although he is sleepy he is unable to fall asleep, with slow pulse

In a condition between waking and sleep he had dreams and images of dragons, skeletons, and frightful ghosts and masks

Sleep interrupted by frequent waking, after which he was unable to fall asleep again for a long time; one night rose as early as 3 oclock

Restless night; slumbering alternating with waking; much irrational talking; hot skin and stupefaction, during which he lies coiled up in a heap

Night sleepless, restless,®®.t

Restless sleep, from which he woke stupid

Disturbed sleep, watchfulness

Unrefreshing sleep, with general perspiration

Some had more or less disturbed sleep

Restless sleep, full of sighing and moaning

Sleep restless the forepart of the night, the latter part sound and refreshing

Sleep unrefreshing, interrupted by restless dreams (after 1 drop)

Sleep at night restless; awakened about midnight by oppression of the chest (after 18 drops)

* The night, that was usually quiet, xvith uninterrupted sleep, was noio very restless, xvith constant tossing and tumbling about; the sleep was frequently interrupted and was only partial; was conscious of every noise in the street, even the ticking of the clock and watch distressed him. The most varied dreams disturbed the whole night; was unable to rise as early as usual, and felt weaker than on the preceding evening before going to bed ; the head was heavy and dull; after a glass of water became fully awake (third night)

Night unusually restless ; he rose from bed to urinate, but suddenly became so dizzy and nauseated that he was obliged to lie down ; this lasted a quarter of an hour, after which he fell asleep (after 7 drops)

Inclination to sleep; she had scarcely closed her eyes, when she was aroused by most frightful images, when she spoke disconnectedly, and did not recognize the bystanders

Starting in sleep for several nights

During a deep sleep there was frequent sighing, and at times jerkings of the body

Startings, and a strange chaos of happy and disagreeable visions, if sleep sometimes surprised me while sitting in a chair (after 4 to 6 grains)

Sleep interrupted by startings

Sleep full of startings in fright; whenever he closed his eyes it seemed as though he had lost his reason (after three hours)

Starting up in sleep; after waking he seemed intoxicated and half delirious.®®.

Sleep full of frightful fantasies and frightful dreams

On dozing, started up and evinced great incoherency both in language and action (after one hour)

Moaning cries in sleep

Starting up in sleep

Unintelligible prattling during the intoxicated sleep

Sobbing during sleep (after two hours)

T)t ’eanin. Restless sleep, full of dreams (tenth day)

Anxious sleep, disturbed by tbe saddest dreams, so that while intoxicated with sleep he seemed to float in a constant delirium

Anxious sleep, full of dreams (after seven hours)

Sleep full of dreams

Frightful dreams,’’; (seventh day) ; of falling from heights (tenth day)

The sleep of Opium is not without dreams (from rather large doses)

Thousands of wonderful and vivid dreams, during which bespoke aloud

Exceedingly vivid, fretful dreams; he always fails to succeed ; many cause vexation and ill humor (after two hours)

Anxious dreams

Busy with numerous fancies and imageries all night during sleep

Lascivious dreams and nightly emissions

Joyous dreams

Unusual wild dreams at night; he, however, woke only once, soon after midnight (after 6 drop.s)

Wild dreams disturbed his sleep (after 18 drops)

Sleep disturbed by dreams, sometimes agreeable, sometimes frightful; sleep ending in either coma or apoplectic death, with convulsions

Dreams at times pleasant, at times sad, at other times anxious and fearful

Opium affects the brain and causes restless dreams

The sleep of Opium is always associated with dreams and visions

Dreaming (after Opium), in a man free from dreams for a long time

Fever p. 233

CJi illness. Chilliness immediately, in the evening, in bed, after which, as soon as she fell asleep, she broke into sweat, which was very profuse about the head

He complains of chilliness ®

Chilliness over the abdomen, with dryness of the mouth, without desire for drink

Chilliness in the back

Chilliness in the back, with suppressed, scarcely perceptible pulse

* Body cold (second day); (after one hour)

Cold and clammy (after seven hours)

Cold and weak (second day)

Cold and pulseless (after four hours)

Cold and lifeless (after five hours and a half)

Complains of being affected with a greater degree and a different kind of coldness to any he ever experienced before (after one hour)

Complains of being cold (after twenty minutes); continues, and is accompanied with disagreeable sensations (after fifty minutes); still complains of being cold (after one hundred and twenty minutes)

Coldness, with stupefaction

Cold and shivery (after half an hour); skin feels cold (after half an hour); complains much of being cold all over, but particularly his feet (after three-quarters of an hour)

Inclined to shiver

Temperature greatly diminished

Diminished warmth

At first (according to the thermometer) diminished warmth, afterwards increased perspiration

Surface of body cold and livid

Surface cold (after six hours and a half)

Surface of body cold and bluish (after one hour and a half)

Surface of body cold,'*'; (after two hours),’*’; (after one hour and three-quarters),’**®”, etc.

Surface cold and purplish, from imperfect aeration of blood (after five hours)

Surface of the body and hands cold and clammy (after four hours)

Surface and extremities cold (after two hours)

Skin very cold (after a quarter of an hour); (after twelve hours)

Skin universally cold, and partially suffused with a glutinous moisture (after eight hours)

Skin and extremities cold

Skin pale, cold, and clammy

Skin cold and pale; (after four hours)

Skin cold, particularly over the extremities (after one hour)

Skin cool and clammy

Skin of the body rather cold and dry

Nose cold; extremities cold and rigid

Face cold

Face cold and exsanguine (after four hours)

Face cold and livid (after two hours and a half); flushed (after six hours and a quarter)

Extremities cold,”*”’; (after five hours),®”**®,etc.

Extremities as cold as marble,™

Extremities cold and livid

Extremities cold, with tetanus (after two hours)

Coldness of the extremities externally

Icy coldness of the limbs,'™.

Hands, arras, and feet cold (after two hours aud a half)

Hands and feet cold; (after seven hours)

Coldness of the feet (five or six years after the discontinuance),'**; (tenth day )

* Temperature of the body cool; head somewhat warmer (after fortyeight hours)

Febrile paroxysms; at first chilliness, then transient heat of the face (with a white tongue and sweat before midnight)

Febrile paroxysms; sleep during the chill; during the chill there was no thirst; during the heat, thirst, and profuse general perspiration

Febrile paroxysms; at first shaking chill, afterwards heat, with sleep, during which he sweat very profusely

(Febrile paroxysms; trembling chill, with thirst, then increased heat of the whole body, inclination to uncover, with strong, full pulse, dryness of the fauces, without thirst, and with vivid ideas and vivid memory), (after one hour)

Alternation of moderate warmth with coldness

Heat, Heat

Increased heat

Distressing sensation of heat (after two hours)

Heat, with thirst

Intolerable heat, with great anxiety

Heat and perspiration over the whole body

Great heat of the body

It increases the heat of the whole body, and leaves a dryness of the mouth and thirst

Heat of the body, with great anxiety

Sensation of heat in the whole right half of the body

Inability to sleep at night for a long time, on account of heat and headache (after 2 drops)

Hot fever, with fantasies, which come on after a short sleep, and last twelve hours, after which he is very weak and attacked with nausea, accompanied with weak pulse; three hours afterwards, again fantasies, that last forty-eight hours, with full, hard pulse, after which there is sleep for eight hours

Feverish, soon; (third day)

Increased temperature of the body

Increased warmth over the whole body, with some perspiration (second day)

Constantly increasing warmth, seeming to commence at the stomach and to extend over the whole body, with moist skin (first day)

Increased warmth over the whole body, especially in the head; once, copious perspiration (after 3 drops)

General warmth of the whole body, with heat and redness of the cheeks, and full, hard pulse, about 10 beats more rapid than usual (after 2 drops)

Sudden warmth over the whole body, soon followed by general perspiration aud feeling of increased vigor (after 2 drops)

Warmth over the whole body, especially in the head, followed by sudden perspiration (after 2 drops)

Sensation of warmth extending from the head to the right forearm

Slight warmth (after twenty minutes), and soon after a degree of moisture on the skin

Entire surface of tbe body intensely hot, aud remained so to the time of his death

Surface of the trunk warm, lower extremities cold (after three hours)

Skin very hot (second day)

Hot skin (after three hours); afterwards cold

Skin hot (after one hour),***; (after eleven hours),***.~Skin over her body felt hot, feverish, and was covered with a clammy perspiration

Skin dry and hot; bloodvessels injected (first day),"A

Skin generally dry, hot, and turgid

Skin hot, rough, without moisture

Skin at times dry, hot, at other times slight perspiration

Skin warm, moist; (after two hours)

Skin warm

* Head hot; (after half an hour)

* Heat in the face, with perspiration collecting in large drops (two hours after 18 drops)

Glowing heat of the face aud perspiration on the head (ten minutes after 1 grain)

Heat and perspiration on the face (after 8 drops)

Burning heat in the face, with a sensation of heat, especially in the eyes, without thirst, six evenings in succession

Redness and heat of the cheeks, with a sensation of burning in them

Increased warmth of the face (twenty minutes after 1 grain)

Increased temperature of the cheeks and articulations of the jaws, with a sensation of burning, as also in the concha

Warmth in the face and scalp, with the headache (after 4 drops) ; repeated after other doses

Sweat. Profuse perspiration (third day) ; (after 4 grains)

Profuse perspiration, with sleepiness (sixth day)

Profuse perspiration, about midnight, an hour after falling asleep

Profuse perspiration, that lasts twelve hours,®’.t

Frequent perspiration

Causes almost constant perspiration ” ■** 7i 89 95_

Perspiration increased

Increased perspiration over the whole body (after 12 drops)

Perspiration over the whole body, in the afternoon (after 1 grain)

Perspired freely, soon

Perspired very freely, so much so that her mother frequently wiped her face with a cloth (after half an hour)

Skin soft and warm (after two hours and twenty minutes) ; moist and warm (after three hours)

Skin clammy and warm (after sixteen hours)

Skin moist (after six hours)

General perspiration,’; (after eight hours); (after 4 drops)

General perspiration over the extremely hot body, with great thirst, full, hard pulse, bright eves, and mental activity

Sweat all over, in the morning, during sleep, with inclination to uncover (after twelve, and thirty-six hours)

Skin covered with abundant sweat

Face bathed in perspiration and moderately warm, while the extremities were quite cool (after eight hours)

Slight perspiration on forehead (after one hour)

Sweat, especially on the upper parts, while the lower are hot and dry

Thick sweat first on the head, afterwards over the whole body, like drops of dew, and sleep,®'’.]

Perspires a good deal during the night, and towards morning has cold chills (fourth night)

Sweat, and eruption of red rash, with itching

When the sweat is more profuse, then there is more itching of the skin, with general eruption, while all the senses vanish, touch, vision, and smell

Perspiration on walking rapidly (seventh day)

Sweat only on physical exertion

Perspires easily at night (ninth day)

Strong perspiration the whole afternoon (one case)

Bathed in cold clammy sweat

Colliquative sweats (after five or six hours)

Cold sweats

* Cold perspiration over the ivhole body, except the feet, and especially on the head

Body was covered with cold clammy perspiration; (after seven hours)

Cold clammy sweat came out on the body ; large drops stood on his bald head

* Cold sweat on the forehead,’; (tenth day)

Limbs covered with cold sweat

Conditions p. 235

Aggravation.f Toward morning). Cold chill.

(Morning), Pale and dispirited ; on awaking, headache; dryness in anterior portion of tongue; bitter taste; colic, followed by diarrhoeic stool; 5 a.m., urging to stool, with pasty evacuation ; stool; 8 a.m., tenacious yellowishbrown stool; dry cough and scraping in larynx ; on awaking, pain in limbs and loins; gnawing pain in bones; bathed in perspiration ; on rising, indolent; could not rouse himself; during sleep, sweat all over; 8 a.m., sleepiness.

(Forenoon), 8 A.M., confused feeling in head; while reading, dimness of vision ; 10 and 11 a.m., emptiness in stomach and sensation of hunger; pulse accelerated; pain in flexor muscles of both thighs.

(Noon), No appetite.

(Afternoon), Depression of spirits; inability and disinclination for work ; tearing pain in occiput; griping in abdomen ; diarrhoealike stool; 2.30 p.m., tenacious yellowish-brown stool; constipation ; copious emission of urine; pain in chest; perspiration over the whole body ; strong perspiration.

(Afternoon and evening), Headache; dryness in nose.

(Evening), Pressive headache in left side of vertex and forehead ; headache in occiput; burning sensation in eyes; while sitting still, roaring in ears ; three thin stools, with burning in anus ; thin stool; 6 P.M., hard brown stool, with great exertion ; hard evacuation, with difficulty ; copious yellow urine; drawing and tearing in forearm ; numbness in left little finger ; itching on the legs ; unable to fall asleep ; in bed, chilliness ; burning heat in face.

(Night), Weeping; headache and heat; griping in abdomen, followed by emission of flatus; 9 to 12 P.M., liquid stools; in sleep, erections; 2, 3, and 3.45 A.M., tickling in larynx, with cough ; sleep restless ; desire to slumber; sleepless; easy and great perspiration.

(Bold midnight), Awakened by oppression of chest; liquid stool; profuse perspiration.

(Midnight), Rumbling in abdomen; desire for stool; burning in rectum ; watery evacuation.

(After midnight). Evacuation of large quantity of urine.

(Open air-). Eyes seem moist.

(On awaking). From a nap, feeling of intoxication; headache and stupefaction ; languid and stupid expression of countenance; from a dose, nausea; breathing heavy and oppressed ; from a nap, difficult micturition.

(After aivakirig). Dizziness ; difficulty in moving tongue ; qualmishness ; impotency.

( White aivake), Intoxicated with sleep.

(While breathing). Pain beneath short ribs.

(Daring chill). Thirst.

(Daring colic). Arms spasmodically closed.

(During convulsion). Bloody liquid exudes from nose.

(After dinner). Pressure above stomach; indigestion.

(After eating). Roaring in ears; vomiting; pressure in epigastric region; cough; sleepiness.

(Exertion at stool). Sensation as if passage through rectum wei’e closed.

(Physical exertion), Sweat.

(Taking food). Pain in stomach.

(During inspiration). Stitches in right side of chest.

(Looking to right or left). Vertigo.

( While lying down). After dinner, throbbing, with rising and sinking of the storaatjh.

(Motion), Pain in occiput, neck, and vertebrae; pain in sternum; pain in second joint of ring finger.

(Moving about). Inclination to vomit.

(Pressure), Tenderness in epigastric region; stomach hot and painful; pain in stomach.

(Raising /head). Sensation as if heavy substance moved to and fro in head.

( While reading). Sensitive pressure above right frontal eminence.

(Reclining posture). Irregular action of heart.

(Rising from a seotf), Weakness and heaviness in the legs.

(Heaviness and stiffness in limbs.

( While in inarm room). After walking in the open air, stoppage of the nose.

(After sitting),'i^lameness in left lower extremity.

(During sleep). Attacks of suffocation.

(After sleep). Intoxication.

(Smoking a cigar). Vertigo, nausea, inclination to vomit, trembling of the limbs, and cold sweat.

(Before and after stool). Colic.

(Stooping), Vertigo.

(Swallowing), Pain in throat; cramp in oesophagus; cough.

(After swallowing). Cramp in oesophagus.

(While talking or whistling). Humming in ears.

(Touching anus). Burning pain ; pressive pain in rectum.

(Turning in bed), Pain in stomach.

(Urinating),Pain in bladder; in the morning, some spasms; sensation as if passage through urethra were closed; cutting pain in genitals.

( While walking). In street, nausea ; rapidly, perspiration.

( While writing). Obscuration of vision ; at a table, sleepiness.

Amelioration p. 236

{ Towardmorning). Sopor.

(Toward noon), Dulness in head.

(Drink of milk). Griping in abdomen.

(Drinking water), Tickling in larynx, and dry cough.

(Eructations), Qualmishness.

(Eating ivhite sugar), Nausea and accumulation of water in mouth.

(Soft evacuation), Colic.

(Leaning against cold wall), Headache.

(Motion), Pressive feeling in head ; pressive sensation in eyeballs.

(Moving about). Pressure above stomach ; pressure in abdomen.

(External pressure). Headache in forehead ; pain in right frontal eminence.

(Rubbing), Pain in right frontal eminence; pressive sensation in eyeball; numbness in left little finger.

(Stroking with hand). Tension in skin of forehead.

( Walking avoid). Pressure in epigastric region.

Footnotes

† See valuable article on chemical analysis, medical history, etc., of these animals, by Dr. Mehu, Bull. Gen. de Therap., 93, p. 304, 1877.

† Caused by applying Opium to the temples.—Hahnemann. j From large doses.—Hahnemann.

† From Opium given for dysentery-like diarrhoea.—Hahnemann. -Render “ fechtern ” swordsmen.—Hughes. X This always happened whenever Opium was taken as a palliative for her ailments |)palpitation, vomiting, hiccough, cardialgia, colic, trembling, or convulsive movements.—Hahnemann. Revised by Hughes.

† Effects of Opium administered for indescribable pains, whick threatened to end in convulsions.—Hahnemann.

† From a moderate dose taken on account of intolerable pains from stone.— Hahxemann. X He had taken a grain the evening before on account of a distressing pain.— Haunemanx.

† When Opium, given in large doses to produce increased courage and vigor, has a palliative effect on the weak and tin)porous, it causes audacity, desperation, rage, anger. This palliative primary action gives the Turks, who are excited by Opium, an almost irresistible power at the beginning of a battle; but in a few hours this changes to the greatest cowardice and stupefaction, when they are more easily beaten than any other nation.—Hahnemann. + Symptoms 69, 70, 71, 72, 73, 84, 86, 89, 1881 represent palliative, primary action of Opium in those who are despondent and depressed.—Hahnemann. I In consequence of the law of opposites this acted as a palliative, and she was obliged, in order to obtain relief, not only to continue the use of Opium, but also to increase the dose, till at last in a week she took one and a half ounces of Opium.— Hayne-mann.

† The mental and emotional symptoms of Opium cannot be so well separated as those of other drugs, when the former are jdaced at the beginning with the head symptoms, the latter after all the other symptoms, because in Opium the two are commonly associated. When Opium is used for the palliation of pain, of s])Hsm in the opposite condition of mind and disposition as in S. 57, 81, 86, 88, 96, 145, 150, or for the prevention of natural sleep (in the latter case most certainly homoeopathically), it usually causes in their stead a mental ecstasy and emotional excitement, a very transient primary effect. This ecstasy and excitement are frequently like the internal clearness of somnambulism (clairvoyance.)—Hahnemann. J Omit “ Unseen Koerper.”—Hughes.

† Oj)ium diminishes the power of the will over the muscles only in its secondaryaction, when it paralyzes entirely, but in its primary action it excites it; if this primary action be interrupted by stupefaction and stupid sleep, there may be twitching in one or another limb during this sleep.—Hahnemann. X To S. 2.3, 171, 172, 173, 183, "l84, 185, 18(3, 189, 287. When these conditions have become constant and persistent after the long and repeated use of Opium, they are akin to a chronic disease and a kind of paralysis of the mental organs that may indeed be incurable; 183, 184, 185, 186, 189 are secondary effects.—Hahnemann. I From the frequent use of Opium.

† From the odor of Opium.—Hahnemann. J From a mixture of Hoffmann’s anodyne and Opium.—Hughes. ^ Revised by Hughes.

† Merely a hypothetical statement of the author.—Hughes. j Preceded by a feeling as if something mounted to her head.—Hughes.

† Revised by Hughes. J Momentarily occurring. As to S. 260.—Hughes.

† Original revised by Hughes.

† Just before death.—Hughes. J Original revised by Hughes.

† Apparently the result of taking cold from the damp weather, as in other respects 1 was perfectly well.—Freud. J From Opium taken for incipient cold when in a plethoric state. S. 666, 1271, 1286, 1451, 2250 all belong to this.—Hughes.

† With stupor —Hughes.

† Revised by Hughes. I Not mentioned by Vicat.—Hughes.

† Add “ fixed.”—Hughes.

† Omit Muller.—Hughes.

† Omit Pyl.—Hughes. J Revised by Hughes. II Revised by Hughes.

† This dryness of the mouth was noticed on waking from sleep, when I found myself lying on my back, quite contrary to habit, with open mouth. I had apparently lain in this position for a long time.—Alb I With dryness of the mouth of S 794.—Hughes.

† From small quantities taken into the mouth.—Hahnemann. II With delirium.—Hughes. ^ Refer to same note as for S. 790.—Hughes. fl From retaining Opium some time in the mouth. Hahnemann’s note revised by Hughes. Omit Reinegg.s, and note “in a phthisical old woman whenever she took 0. for colliquative diarrhoea.’’—Hughes.

† Original revised by Hughes. j Said by the reporter to be a common occurrence with him.—Hughes.

† Large closes.

† Revised by Hughes.

† From Opium taken immediately after dinner.—Hahnemann. Add to Hahnemann’s note: Young’s statement is that a man took this dose “ after a plentiful supper and load of liquor.” Bracket the symptom.—Hughes.

† Original revised by Hughes. J Ibid, g As soon as she took Opium for toothache.—Hahnemann.

† There was no visible alteration in the orifice of the urethra, except a very slight redness or irritation. Had never experienced such urinary symptoms before in my whole life. —Bkesslaukr.

† Coincident with a general paralyzed state.—Hughes. Original revised by Hughes.

† Original revised by Hughes, g Original revised by Hughes. J Omit anxiety.—Hughes. II Not found. —Hughes.

† Constantly renewed doses of Opium was the only palliative, even then for only a short time.—Hahnemann. J Revised by Hughes.

† It is to be noted that the pulse was first taken while sitting quietly and writing;; the subsequent observations were made while moving about in the open air.— Eidhkrr. J From Opium with spirits of hartshorn.—Hahnemann.

† From the inunction of 2 drachms of Opium (after fifty minutes).—Hahnemann. J Very weak.

† Revised by Hughes.

† Revised by Hughes, j From large doses.—Hahnemanx.

† From too many and too large doses.—Hahnemann. J Revised by Hughes.

† Last clause revised by Hughes.

† From large doses.—Hahnemann. J Revised by Hughes.

† Even to death.—Hahnemann. j After the primary action of Opium.—Hahnemann. ^ From the daily abuse of Opium.—Hahnemann.

† Revised by Hughes. J Omit Muller.—Hughes. I The symptoms of Muller’s patient, before and after the Opium, were so similar that they are very dubious.—Hughes. II In confirmed Opium-eaters.—Hughes. ^ From the external use.—Hahnemann.

† During the opisthotonos of S 1773.—Hughes. J Revised by Hughes. \ From the frequent use of Opium.—Hahnemank. II Revised by Hughes. ' ^ Revised by Hughes.

† This may possibly be ascribed less to the action of the drug than to the frequently interrupted sleep of the preceding night.

† Instead of “ schlaflose,’’ the original is “ traunilose,” which, however, may mean the same thing.—Hughes.

† In “ convalescence.”—Hughes. J Revised by Hughes.