Arsenicum Album

Authorities. (227 to 230, from Berridge’s Collection, in appendix Brit. Journ. of Horn.) ; 227, Thos. Garnett, Med. and Phys. Journ., 1801, 542, fatal poisoning of a man by pills of Ars., butter, and flour; 228, Dr. S. Barium, Med. Repos., 1802, p. 43, a woman took a solution ; 229, Dr. Yellow, Edinb. Med. and Surg. Journ., 1809, p. 389, a boy, tet. sixteen years, took a pennyweight; 230, W. J. Crowfoot, Med. and Phys. Journ., 1815, 441, children ate it in food ; 231 to 235, John Marshall, Remarks on Arsenic, London, 1817, effects on five persons of eating dumplings containing oxide of arsenic, 233 being a woman seven months’ pregnant; (236 to 241, from Berridge); 236, J. Hume, Med. and Phys. Journ., 1821, p. 466, Mrs.-, set. twenty, took arsenic; 237, Astley Cooper, Lancet, 1823-24, 156, application to the eye for fungus; 238 to 241, Alexander U murray, Edinb. Med. and Surg. Journ., vol. xviii, p. 167, poisoning of a family ; 242 to 244, Robert Christison, INI.D., Trans. Medico.-Cliirurg. Sac., 1825, fatal cases; 1245 to 248, from Berridge); 245, Robert Christison, Edinb. Med. and Surg. Journ., 1827, p. 441 ; 246, John Elliotson, Med.- Chir. Rev., 1828, p. 265, a woman, set. about sixty years, took arsenic ; 247, Christison, Edinb. Med. and Surg. Journ., 1830, p. 67, six persons took it in champagne ; 248, Journ. Univ. et Hebd. (Med.-Chir. Rev., 1832, p. 162), several persons took it in food ; 249, T. Bost. Med. and Surg. Journ., vol. xiii, 1835, p. 334, fatal poisoning of T. D-, set. twenty-three years; (250 and 251, from Berridge) ; 250. Lancet, 1835-6 (1), 436, a girl, set. twentytw'o years, swallow^ed 1 oz. ; 251, Journ. de Pharm. (Lancet, 1837-8 (2), 625), several families drank water impregnated with Arsenic ; 252, B. E. Cutting, Bost. Med. and Surg. Journ., vol. xviii, 1838, p. 78, a man, set. twenty-two years, took about 2 ozs., in wine and water ; (253 to 292, from Berridge) ; 253, Londonderry Standard (Dublin Med. Press, 1840, p. 371), poisoning; 254, Theophilus Thompson, Lancet, 1843-4 (1), 98; 255, Dr. W. AVoodcock, ibid., 1845 (1), 640, Mrs. W., took li teaspoonful; 256, J. M. Adams, North. Journ. of Med., 1845, p. 262, J. P., set. forty-two years, took 2 drachms; 257, Historical Register (Lond.), (Did)lin JNIed. Press, 1845, vol. xiii, p. 61), a man made arsenical candles; 258, Alison, Lancet, 1845 (1), p. 413, a girl, jet. thirteen years, took a large teaspoonful before 4 p.m., and another dose before 5; 259, Linoli, abridged from Ann. Uuiv. de Med. (Med. Times, 1846), two men and three children had same symptoms from Arsenic in food ; 260, J. Hakes, E^inb. Med. and Surg. Journ., vol. Ixvi, 1846, p. 43, a family drank water containing Arsenic, several cases fatal; 261, Dr. Leathery, Lancet, 1847 (1), p. 44, a girl, jet. nineteen years, took at night 2 oz. fly-water, containing 2? ozs. white Arsenic, death in thirty-six hours; 262, Dr. L. Owen Fox, Lancet, 1848 (2), 503, fatal poisoning of a man, set. twenty-one years, by a teaspoonful; 263, Wm. Robert Cornish, ibid., 1849, p. 35, a man took 1 oz. ; 264, same, a girl took 1 oz.; 265, Dr. Michael McGee, ibid., p. 311, a girl, set. ten years, took 10 grs. or more ; (266 to 285, from Dublin Quart. Journ. Med. Sci., 1851, and Dublin Med. Press, 1850); 266, a man and woman, each took 24 grs.; 267, M. G., set. fifty-six years, took 1^ oz., fatal in twelve hours; 268, M iss D., set. eighteen years, took Arsenious acid ; 269, J. G., set. thirtythree years, took Arsen, acid in tea, and on the fourth day took 2 teaspoonfuls in coffee and milk; 270, a man, set. between twenty-five and thirty years, took Arsenic in food ; 271, five persons ate a cake in which a teaspoonful had been put; 272, a woman, set. twenty-five years, took some in water; 273, poisoning of five persons; 274, poisoning of seven persons; 275, two })persons took it in food; 276 to 278, a family poisoned by Arsenic in food ; 279, fatal poisoning of M. J. B.; 280, a boy, set. two years, took a spoonful of rat-powder (Arsenic and flour) ; 281, a girl, set. four years, took the same ; 282, M. B., set. thirty years, took nearly a spoonful in gruel and porter; 283, a man and woman took it in punch; 284, four persons took it in food; 285, five persons took it in soup; 286, Dr. G. E. Sanger, Guy’s Hosp. Rep., 1851, 183, poisoning of a man, set. nineteen years ; 287, Chambers’s Edinb. Journ. (Dublin Med. Press, vol. xxvii, 1852, p. 63), effects of leaving off Arsenic-eating ; 288, Dr. T. R. Mitchell, Med. Times and Gaz., 1853, p. 612, a man rubbed the liniment into axillse, pubes, and scrotum ; 289, Dr. T. Brown, Assoc. IVIed. Journ., 1853, p. 878, a woman, set. twenty-four years, took Arsenic to procure abortion ; 290, M. Dandin, Annal. d’Hyg., 1854, case of poisoning; 291, Tschudi’s report, Journ. de Chim. Med., 1854 (Bost. Med. and Surg. Journ., 1855, vol. li, p. 189), effects of suspension of Arsenic-eating; 291 a, same, a man took an overdose; 292, Dr. Walks, Guy’s Hosp. Rep., 1855, p. 364, a man, set. fifty years, took probably three teaspoonfuls; 293, Samuel C. Pointer, M.i)., Med. and Surg. Reporter, vol. ix, 1856, p. 210, Agnes Corbet, set. twenty-one years, swallowed a teaspoonful, death in twelve hours; (294 to 296, from Kesteven, Brit. Med. Journ., 1856); 294, Dr. Jago, effects on workmen ; 295, Mr. Pointer, poisoning; 296, Kesteven, effects of leaving off Arsenic-eating ; 297, Dr. Halley, Pharm. Journ., vol. xvii, 1857, p. 428, Arsenic in paperhangings ; (298 to 319, from Berridge); 298, Dr. Walter Watson, Lancet, 1857 (2), 281, effects on shepherds of wishing sheep with Arsenic; 299, Dr. Robert Crawford, ibid., p. 127 and 181, effects of same; 300, Dr. W. G. Meacham, K. Y. Journ. of Med., vol. iv, 1858, p. 430, poisoning of a man, set. twenty-five years; 301, Jas. Whitehead, Brit. Med. Journ., 1858, p. 804, a young man poisoned by arsenical wall paper; 302, Mr. H. G. Trend, ibid., p. 725, a woman took Arsenic twice a day, for three months, altogether two tablespoonfuls, to procure abortion ; 303, Jas. Begbie, Edinb. Med. Journ., 1858, vol. iii, p. 961, observations of Valleix and other French writers; 304, Begbie, ibid., effects in a ease of chorea; 305, Dr. Gibbs, Lancet, 1858 (1), p. 613, a lady took it many years for an eruption; 306, Dr. Wm. N. Brown, Edinb. Med. Journ., 1858, vol. iii, p. 148, a man washed sheep with a solution of white Arsenic; 307 to 312,’ Dr. Robert Person, ibid., p. 391, different cases of poisoning; 313, Schiller in Gesundheit der Bergleute, effects on cobalt miners ; 314 and 315, Dr. A. S. Taylor, Ophth. Hosp. Rep., 1859 (1), 270, effects of arsenical wallpaper; 316, Dublin Med. Press, 1859, vol. xli, p. 280, shepherds were poisoned by wishing^ sheep with an arsenical wash; 317, Charles, Med. Circular, vol. xiv, 1859, experiments on healthy men with ^ gr. of Arsenious acid ; 318, Gonffia’s experiments on himself, ibid.; 319, Manchester Guardian, Pharm. Journ., vol. xxiv, 1859, p. 482, three children were poisoned by arsenical wall-paper; 320, Dr. Lorenzo, quoted by Heisch, ibid., p. 556, Arsenic-esiters of iStyria ; 321, same, effects on a gentleman ; 322, J. B. Metcalfe, ibid., vol. xx, p. 343, poisoning of Clarence King, set. three years and a half; (323 to 329, from Berridge); 323, Dr. R. Biggs, Lancet, 1860 (1), p. 8, poisoning by paper; 324, Dr. Ballenden, ibid., p. 579, poisoning of three children by the same; 325, MS. Reports of St. Barth. Hosp., 1860 (Month. Horn. Rev., vol. xiv, p. 428, Rachel and Emma Taylor, j)partook of a pudding containing a teaspoonful of white Arsenic; 326, Dr. Thomas Orton, Lancet, 1862 (2), p. 576, poisoning by paper; 327, Mr. Simon’s Pub. Health Reports, Brit. Med. Journ., 1863 (2), p. 435, symptoms from Ars. green ; 328, Dr. D. McN. Parker, Edinb. Med. Journ., 1864, vol. X, p. 116, effects of A arsenic-eating on a man, set. thirty years; 329, Craig Malaga, ibid., p. 200, effects of Arsenic-eating; 330, R. C. Haniil, IM.D., Chicago INIed. Exam., 1865, p. 643, Mr. H., set. twenty-five years, took 6 or 7 drachms in cold water; after half an hour an emetic and hydrated oxide of iron were given, vomiting produced; 331, A. S. Taylor, Guy’s Hosp. Rep., 1865, 277 (Berridge), poisoning of three children by Arsenic in vermin powder; 332, Dr. Docherty, Glasgow, Mon. Journ. (Pharm. Journ., 2d sen, vol. vii, 1866, p. 243), Mrs. Keechan took i oz. in milk; 333, Profs.. Grote and Mosler, Berk Khu. Woch., 1866, p. 60, a boy, set. two years, ate a piece of paint; (334 to 339, from Berridge); 334, Dr. F. Duckworth, Madras Quart. Journ. of Med. Sci., vol. ix, 1867, 304, Arsenic in food; 335, Hutchinson, Lancet, 1869 (2), 508, general effects; 336, Dr. Suisse, JErtz. Intell. Blatt, 1869 (Brit. Med. Journ., 1869 (1), 424), four hundred persons poisoned by-bread; 337, Thomas Graham, Glasgow Med. Journ., 1869 (1), 56, poisoning; 338, Dr. Hicks, Lancet, 1870(2), 356, a man, set. forty-eight years, was engaged in pulling off wall-paper; 339, Berridge, Month. Horn. Rev., 1870, 430, a friend of mine suffering from skin eruption, took the 6th ; 340, Brit. Med. Journ., 1871 (2), 101, poisoning by wall-paper; 341, Martineau, L’Union Med., April, 1873, p. 558, poisoning;'(342 to 344, from Berridge); 342, Dr. Clement Walter, Brit. Med. Journ., 1873 (2), 700, a lady was poisoned by wall-paper; 343, Dr. J. Liddell, ibid., p. 772, effects of wall-paper; 344, Dr. John Morley, ibid., 88, poisoning of fifteen persons by Arsenic ; 345, Dr. Merbach, Vjs. fur Ger. Med., 1875, p. 48, poisoning ; 346, H. 8. Jones, ]\I.D., Virginia Med. Month., 1875, p. 194, Jesse Thomas, set. twenty-two years, swallowed nearly a teaspoonful 1; (347 to 372, from Tardieu, Etude med. leg. et din., sur L’Empoisonnement, Paris, 1875); 347, Arsenic in milk; 348 and 349, other cases ; 350, Devergie, Med. leg., 3d edit., t. 3, p. 525, poisoning; 351, same, a girl, set. seventeen years, took 10 grams; 352, Dr. Laches fils, Ann. dhyg. pul)l. et de red. leg.. Ire ser., t. 17, p. 340, a girl took a large quantity ; 353, Labored, Journ. de med.-chir. et pharm., 1787, p. 89, poisoning; 354, Bull, de la Sac. Anat., 1853, 179, a girl took a large quantity ; 355, Ann. dhyg., publ. et de ind. leg., 1847, 390, poisoning; 356, Dr. Bineau, Journ. des cours nied.-chir., 1835, 190, five children, from five to nine years, were poisoned ; 357, Filbert, Journ. de Van der Monde, 1756, 353, a man took a large quantity; 358, Barrier, Journ. de ind., 1873, 353, five men were poisoned by a solution ; 359, Dr. Conquered, Journ. des connais, medic, chir., 1839, p. 155, poisoning of three persons; 360, Dr. Seville, Revue med., 1838, 355, a woman took 3 grams; 361, Tardieu, poisoning; 362, Dr. Martineau, communication to Sac. med. des Hop., effects on a man; 363, Ann. dhyg. et de med. leg., 1847, 400, poisoning; 364, Dr. Laches fils, Ann. dhyg. publ. et de med. leg., Ire ser., t. 17, five persons were poisoned by soup; 365, same, case of a woman ; 366, ibid., t. 37, p. 121 ; 367, Dehesne, Journ. de Van der Monde, 1759, 330, poisoning; 368, JNIean, Bib. med., 1821, 401, application to the feet; 369, Deranges, Rec. de la Sac. de med. de Paris, t. 6, p. 22, application of arsenical pomade to the hair; 370, Bello, Med. leg., t. 4, p. 124, a woman applied a solution to the whole body ; 371, Dr. Vernois, Ann. dhyg. et de med. leg., 1846, application of a preparation to a tumor; 372, Dr. Vitrv, ibid., application of a preparation of Arsenic; 373, Dr. Netolitzky, Prag. Med. Wochn., 1876, 225 (S. J., 171, 138), a woman poisoned by a large dose; 374, Edward Renner, Ueber linen Fall von chron. Arsengiltung, Wurzburg, 1876 ; 375 and 376, E. W. Berridge, Am. Journ. of Horn., Mat. Med., New Ser., vol. v, p. 427, poisoning of two children by wall-paper; 377 to 384, F. H. Brown, M.D., Bust. Med. and Surg. Journ., vol. xciv, 529, cases of similar poisoning ; 385, PI. B. Donkin, M.D., Brit. ]\Ied. Journ., 1876 (2), 587, similar case; 386, A. P. Bowie, M.D., Hahn. Month., vol. xii, p. 490, John Adams swallowed ^ oz. dissolved in water; 387, J. H. Finely, M.D., New York Med. Journ., vol. xxvi, 1877, p. 401, poisoning of sixty men ; 388, Dr. U.^sher, Horn. World, vol. xii, p. 536, Mrs. S. poisoned by wallpaper; 389, same, other cases of poisoning; 390, M. Saint Philippe, Gaz. med. de Par. (Lond. Med. Rec., 1878, 215), one patient took 16 grs., and another 64 grs.

Delirium p. 334

Occasional delirium

Loss of reason from time to time,®^k

-Previous to death the patient became delirious and restless

Slight night delirium

Delirious and unconscious

Became very nervous, agitated, and delirious, suspecting people were about the house plotting against his life, jumps out of bed suddenly and reaches after imaginary objects, and stares wildly and suspiciously around him, and at every one who makes the slightest noise or stirs; is incoherent

Within two hours she was found sitting up in a chair, tossing her arms about, apparently perfectly unconscious of surrounding objects and events. She seemed to be suffering from hysteria. In half an hour she was able to speak

He pointed out to his sister a hollow between his breast ami belly, into which ‘‘she could have laid her arm

Much excited and crying (after one hour)

Much mental and bodily agitation

His head seemed very much affected, so that he scarcely knew what he said or did, and seemed to labor under a kind of insanity

When spoken to she turned away her head, and was silent

Symptoms of intoxication immediately

Arsenic-eating makes men lively and combative

Feeling of impulsiveness

Remarkable watchfulness

l2890.] Great dislike and indifference to those around

Extreme oppression

Great depression and want of interest in anything,®*h

“The whole head sick, the heart faint;” she awoke in the morning wretched, her life a burden, weariness the day’s portion, and each succeeding day like its predecessor, unless physic helped her with its little aid

Extreme anxiety

Great personal anxiety

Anxiety as regards some persons

Her easy-going natural temper was altered ; she was irritable in spite of herself, and the same demon had taken temporary habitation in a sister and brother-in-law

Morose and sullen till convalescent, which was in twelve or fourteen days

Intellectual excitation

Seemed at times hardly able to collect her thoughts

Memory enfeebled

Lying down, apparently insensible ; on being roused began to be sick (alter two hours)

Insensible (after nine hours)

Coma

Head p. 335

Vertigo,*®®*®®, etc.

Vertigo, with inability to keep erect

Dizziness in the head (after five minutes); great swimming in the head and vertigo (after ten minutes)

Head swollen

Head on one side, and pain on raising it, as from a rheumatic affection of the sterno-mastoid

Cerebral congestion on the third day, just before death

Sensation of heaviness in the head

Headache,*®**®®, etc.

Severe headache,'*®*®®®, etc.

Constant headache

Severe pain in head and across eyes (one case)

C )mplaiued of pain in head, breast, and belly, vomited several times, and was very thirsty

She complained of a queerness and strange feeling in her head These symptoms had come on suddenly, and lasted about ten days. Loss of memory of the performance of very recent acts, frequent giddiness, and some drowsiness, were the chief expressions of the “queerness she alluded to. She felt as if she were losing her mind

Pain over brows

Violent pain in the frontal region, with vertigo

Violent neuralgia of forehead and face

Falling out of the hair

Falling of the hair during convalescence

The hair on the head was thick only on the middle of the skull, and the skin desquamated freely

Eyes p. 335

Dark areolae round eyes

Livid circle round eyes

Dark areolae round eyes and mouth

When near death dark areolae around eyes

Dark areolae around eyes, which are somewhat staring

Eyes sunken

Eyes hollow, when quite half closed

Eyes hollow and dark round eyelids

Hollow, sunken eyes

Lustrous glistening eye

Eyes injected

Eyes red, lids swollen and excoriated; the redness and swelling of the lids lasted several days

Scalding of eyes

During the week she had soreness of the eyes

Soreness of eyes, which looked inflamed

Soreness and irritability of eyes ; during the second attack the conjunctiva of lids was deep red along the tarsal edges and at the ano-les ; the lids were slightly tumid, and had a tendency to eversion ; vision was painful

Lids. Swelling of eyelids

Lids oedematous (second day)

A line of excoriation on integument at external angle of each eye, and desquamation of cuticle of eyelids, with redness ot latter

• Slightinflammation of left upper eyelid

Convulsive movements of the eyelids, jaws, etc.,®®®.

Itching about eyelashes

LaeJn'Um,atl(tn. Lachrymation

Lachrymation, which corroded the lids and cheeks

Eyes suffused, even bloodshot

Conjunctivitis for a considerable time

Slight conjunctivitis, with intolerance of light

Mild conjunctival inflammation

Inflammation of tarsal portions of conjunctiva

Injected conjunctiva

In all the conjunctivse severe injected ; the next day, except in the children, the congestion had disappeared, and given place to a yellow tinge

Conjunctiva bluish white

Suffusion of conjunctiva

Pupil. Pupils dilated (after several days),'’^h

Pupils dilated, hut react normally to light

Vision. Dimness of sight,’^® etc.

[_2960.] Failure of vision

One girl, set. fourteen yeaivs, became blind, lost her speech, and fell down in a state of syncope

Flickering before the eyes

Some complained of flickering of the muscles and disturbance of vision, preventing them from knitting, sewing, or reading; and when they closed their eyes they saw shining particles floating backwards and forwards (second day)

Sparks before the eyes (second day)

Bluish sparks before the vision

Par p. 336

Kinging in ears

Nose p. 336

Long-continued excessive watery discharge from the left nostril, saturating handkerchiefs by the dozen, excoriating the nose, and making her wretched

Nosebleed

Profuse epistaxis

Tip of the nose violet, cold

Face p. 336

Anxious countenance,®’®®®®, etc.

Cadaverous countenance

■ Features pinched; eyes sunken

Features pinched, livid

Features contracted and face thin

Sunken countenance

Face sunken and ghastly

Complexion unnatural, and by gaslight a dark greenish hue

Pallor of the face

Face pale, pinched, covered with cold sweat

Face pale, contracted, and anxious

Face [rale, collapsed

Flushed face

Face red,®*’®®®, etc.

Easily flushed

-Much suffusion and some swelling of face

Face red and swollen

Countenance dusky

Face livid

Countenance livid and sunken (after six hours)

Face puffy and erysipelatous

Twitching of face muscles

Convulsive movements of the muscles of the face

Neuralgia ; often have I found this lady with her face closely wrapped up in flannel, as if she dreaded an attack with sharp ice-spears or burning needles; it came with throes of violence over the left eyebrow, and into the bones of the face, crept up the spine, and settled in the vertex, making her feel as if she could go mad, or rush out anywhere; noise was intolerant

Lips violet, cold

Lips parched and dry

Mouth p. 336

Teeth. Hordes on teeth

Teeth of a yellowish-earthy look, with very little lustre

Gums, Spongy gums

Aphthous ulceration of gums and tonsils

Gums swollen and sore (second day)

Gums inflamed

The gum exhibited a red line

Tenderness of gums

Burning in gums

Toil/ue. Tongue swollen

Tongue foul and swollen

Tongue large, somewhat indented, covered with a true silvery-white fur, the papillae projecting through it of rather a dark-red color

Tongue thick, fleshy, clean

Drew her tongue together as much as alum does

Tongue loaded

Tongue much furred

Tongue moist and covered with a thin white fur

Whiteness of tongue

White tongue, with red tip

Tongue coated white, with red margins, and painful

Tongue red and dry

The tongue presents red edges, with white fur

Tongue coated white, with scattered red papillae, resembling the tongue of scarlatina

Tongue and fauces very red (second day)

Tongue and whole mucous membrane of the mouth and pharynx intensely red

Bright green coating of the longue (one case)

Tongue had a dryish coffee-brown coloring, later changed to an inky color, the substance of the organ being injected

Tongue dry and brown

On the fifth day the tongue became dry and black, the ecchymosed spots on the skin became dry and black

Tongue dry

Tongue cold

Burning tongue

Sensation on the tongue as though there were blisters on it

General Mouth. Aphthous ulcerations on mouth and tongue

Stinging sensations in mouth and pharynx (after a quarter of an hour),'^''l

Burning heat in the mouth and anus

Sdiiva. Ptyalism

Unusual degree of salivation

He spat very much

Free secretion of saliva, as if salivated (second day)

Taste. Burning astringent taste in the mouth

One complained of a nauseous taste (second day)

Sooty taste in mouth

He had had a metallic taste in mouth and throat for some time

Strong metallic (coppery) taste in mouth

Speech monosyllabic, tremulous

Throat p. 337

Spasms in the throat

Dryness of the throat

Dryness of throat and tongue

Diphtheritis

Sore thn)at

More or less sore throat for three years

Constriction of throat,®®® ®’', etc.

Painful constriction of the throat

Slight sensation of constriction in throat

Sensation of strangling in the throat

Scraping in the th roa t

Rough ness of th roat (one case)

Husky feel ing in th roat

Burning in throat

Sensation of burning in throat

Severe burning pain in throat

Two observed that they had burning in the throat (after five to seven minutes)

Heat in the throat and stomach

Heat and uneasiness of throat, with hoarseness

Soon after his occupancy of the room, began to have tonsillitis, with dry tongue and mouth, and finally these symptoms continued through nearly the entire winter; he increased very markedly in weight, became dyspeptic, and had a foul breath, with a general sensation of malaise

On palate and uvula were small, roundish, white, acuminated prominences; seemingly the membrane covering the palate, bones, and velum pendulum detached at the parts by a whitish liquid

Redness of fauces with aphthous ulceration

Uneasiness in fauces

Spasmodic contraction of pharynx

Constriction of oesophagus

Burning in tract of oesophagus

Simple ardor in oesophagus extending to stomach, but seldom painful when the dose is not considerable

Dysphagia

Deglutition very painful on account of the spasmodic constriction of the throat

Stomach p. 337

Ai)petite and Thirst. The increase of appetite is remarkable, and is almost always observed when the dose is weak. A strong dose produces opposite effects, such as diminution and even complete loss of appetite, nausea, and vomiting

No appetite,®®®, etc.

Appetite there was none; eating became a forced business

Great loathing of stomach

Loathing of animal food

Thirsty,®®’®®®, etc.

Excessive thirst,®’®®®®, etc.

Tormenting thirst

Intense thirst, with constant desire for cold water, which even in the smallest quantity could not be retained

The thirst is more excessive in proportion as the quantity of Arsenic taken is greater

Pyrosis

Heartburn

JS^anser and Voniitimj. Nausea soon

Desire to vomit

Five centigrams Arsenious acid taken at supper caused nausea and headache the following morning, with slight diarrhoea, all of which disappeared in the course of the day

Nausea, followed by vomiting of green bilious matter, and ropy mucus, continuing for thirty hours

Nausea (after three hours); frequent violent efforts to vomit, though nothing was discharged (after five hours) ; incessant vomiting for two hours (after six hours)

Nausea and vomiting

In an hour she was constantly retching, and sometimes vomiting, with violent spasms of stomach and bowels; weak and quick pulse ; frequent dark bloody diarrhoea; frequent coldness of extremities. The next day she complained of soreness of stomach

Nausea and flow of viscid saliva from the mouth, with heat of fauces, stupor, small and frequent pulse (after forty minutes)

In about an hour he had nausea, feeling of distension of stomach, with great pain, as if there were a fire within him, burning in mouth, and subsequently vomiting of a greenish fluid ; to these were speedily added burning in throat and along oesophagus, urgent tenesmus, with slight discharge of mucus, excoriation of anus. During the latter part of his illness he had bloody discharges from his stomach,^™.

Terrible efforts to vomit, which were unsuccessful

Slight distress in the stomach (after five minutes); retching, with slight vomiting (after ten minutes)

Vomiting,^®®etc.

Vomiting and purging

Vomiting and diarrhoea, followed by collapse

Pain and vomiting

Vomiting (after some hours) ; vomited matter pinkish

Drink immediately rejected

Persistent vomiting

Vomited severely,®®’®'®, etc.

Severe vomiting, almost immediately

Intense vomiting and thirst

Vomiting, lasting till death

Chronic vomiting

Became very sick, and vomited frequently ; occasionally vomited blood

After a drink of milk, or a severe fit of vomiting, she fell back in bed utterly prostrate, and after lying quiet for a time began to toss about her legs and arms, to complain of much pain and sickness, which ended in vomiting and prostration as before

Sudden and violent vomiting, terminating in abortion, and afterwards death

Vomiting was attended with much anxiety and great prostration of strength, and a sensation of tightness at throat

Vomited a great deal, particularly when she drank anything

Spontaneous vomiting set in immediately, whereby much of the poison was thrown off

Vomiting for many hours, during which time she was very prostrate. Nothing would lie on her stomach ; she continued to vomit a greenish matter, streaked with blood

Vomited half-digested food

Sudden vomiting of food, mixed with bile

Found him lying on the bed with a basinful of water}', frothy fluid near him, which he had just thrown up. He had begun to vomit in ten minutes after swallowing the water, and it had continued till now (nearly two hours). Nothing would stay on his stomach ; water being thrown up immediately after swallowing. The vomiting was painless

Vomiting of glairy fluid, in the morning

Vomiting of glairy substances tinged with blood

Vomiting of mucus in the morning, with increased secretion of saliva

Vomited two or three times a yellowish fluid (after six hours)

Frequent vomiting, watery and bilious

Repeated bilious vomiting

Vomiting at first bilious, then bloody

Vomiting streaked with blood

Bloody vomiting

Frequent bloody vomiting

In one case a few drops of blood were vomited

Blood appeared in the matters vomited and evacuated by the bowels

Vomited repeatedly a reddish sort of matter

Green vomiting

Vomiting on drinking; vomiting green

Vomiting, latterly of a green insoluble bile

Vomited matters of a bright grass green

Persistent vomiting of green matter

Vomited matters were a brownish watery fluid, which became green on standing

Stonifich. Mucous membranes generally pale and ansemic

Indigestion in various forms

For three or four weeks had had dyspeptic symptoms, and frequently had pain after meals, and could use little else than oatmeal porridge or other light farinaceous food

Gastritis rapidly increasing, collapse, and death thirteen hours after the poisoning

Cardialgia

Violent gastrodynia

Stomatitis (third day)

Considerable tenderness on firm pressure on the epigastrium (after five hours)

Tenderness at epigastrium and upper part of abdomen (after second day)

Stomach and abdomen tender and painful to touch

Slight tenderness of epigastrium

Sensitiveness of the epigastrium

Epigastrium painful to pressure

General distress in the stomach, followed by nausea and vomiting

Burning pain in stomach

Severe burning pain in stomach

Sense of burning extending from pylorus to throat

Burning pain in epigastrium and over upper part of abdomen, especially when pressed

Burning pain in the stomach (after five hours); increased (after six hours)

Burning pain in the stomach (after half an hour); increased burning in the cardiac portion of the stomach (after three hours)

Burning in stomach, great tenderness of epigastrium, and cramps

Dreadful burning in the stomach, with a great deal of thirst

In ten minutes she became very sick. During the night there was much burning pain in the stomach. Pain in stomach and bowels, and slight tenderness; more tenderness at the large end of stomach than at any other part of abdomen

Smarting pain in the stomach

Sensation of coldness at pit of stomach

Heat in stomach, throat, and month

Excessive heat in the stomach, and burning like fire

Sensation of fulness at stomach

Constant feeling of the stomach being overloaded

Constant feeling of the stomach being overloaded at early morning

Spasmodic pain, writhing, twisting about, moaning, and making strange faces. On arriving at the house, found her more free f rom pain, but with a sensation of burning heat in throat and stomach

His stomach seemed to jump, and severe pain, with vomiting ensued. The matter vomited was fluid, apparently the water he had drank, and it relieved him. The pains soon returned, however, and were very acute over the whole belly

Pain in stomach

Pain in stomach when she drank

Pain on pressure over stomach

In three days he had pain in stomach. On continuing the applications it became excessive; convulsive tremor of the muscles followed, and he died. The stomach was found to be in the highest degree inflamed

Pain and heat in region of stomach and lower part of chest

Violent pain in the epigastrium and chest

Violent pain in the epigastrium, aggravated by pressure

Extremely acute pain in the stomach

Intense pain in region of stomach, not materially increased by pressure

Constriction of the epigastric region

Abdomen p. 339

Sensation of a bar around the flanks

Inclined to lie on abdomen

Abdomen distended

Abdomen much swollen and tympanitic

Abdomen distended, painful

Abdomen meteoric, painful

Tympanitic belly

Abdominal muscles tense, outline distinct; firm pressure excited a little pain in right hypochondriura

Abdomen retracted, not painful

Abdomen retracted

Mucous derangement of bowels and colic

Increased contractility of intestine and stomach ; increased peristaltic action of intestines

Abdomen tender on pressure,and somewhat distended

Abdomen painful,tender

Occasional uneasiness in abdomen, and sometimes ineffectual efforts to go to stool

Colic

Constant colic

Dull griping pain in bowels

Bowels griped and moved freely

Griping pains

Very violent pain in the abdomen, especially in the epigastric region

Abdominal pain and tenderness to touch

Pain referred to the upper abdomen, but not much increased on pressure

Pain and tenderness over entire abdomen (after three hours)

Dreadful pains in belly

Violent burning pain in the abdomen

Severe burning pain in bowels

Severe burning pain in whole bowels, but particularly in the side

Burning heat in the intestines

Smarting pain in the bowels

Cutting pains through the bowels (second day)

Rectum and Anus p. 340

Peculiar feeling of smarting and pain at the end of the rectum ; inclination to evacuate, but not at all of the nature of tenesmus

Tenesmus

Stool p. 340

l^iavrhwa. Diarrhoea,etc.

Tendency to dysenteric diarrluBa

Frequent diarrhoea

Purging; the stools were inodorous and unhealthy

Diarrhoea occurred in two women, one of whom had taken a purgative the previous morning (second day),^‘f

Diarrhoea, with great prostration of strength

Stools, which weakened him so much that he felt himself fainting. He could not get into bed again, his legs trembled, and his weakness was extreme. The weakness in both men was relieved by white wine

Painless, watery diarrhoea, greenish color

Involuntary stools, serous and corroding, as if there were burning fire at the anus

Purging (after some hours) ; stools a white curdy fluid

Alvine evacuations

Stools very numerous

Two thin stools a day

Profuse liquid stools

The stools are more frequent and less consistent, but this seldom, if ever, becomes changed into true diarrhoea, and more rarely still into dysentery

In two instances, one of them in my own household, it is credited with dysentery ; and bloody stools in three cases

Bloody purging and tenesmus

Bloody stools

Bloody evacuations from the bowels

Watery, greenish, involuntary stools (after six hours)

Frequent green stools

Stools frequently thin, with grumous particles

Stools black and solid (third day)

Const![tatioa. Stools dry, and only every few days

Frequent calls to stool, with discharge of small quantities of a brick-red fluid (one case)

With the exception of one minute portion of very hard fse(;es, nothing was evacuated till the sixth day, when she took a dose of castor oil, after which her bowels were natural

Constipation,**®*®®, etc.

Urinary Organs p. 340

Violent pains in the kidneys, bladder, and penis

Urethritis

Frequent efforts to urinate

Urinated frequently

Frequent urination, pain in bladder

Difficult micturition, but without pain. After eight months the impediment on urinating still continued

Micturition very difficult and painful (third day)

Urinated with pain, urine being red (fourth day)

Pain in urination

Urine is more abundant and more frequent. This increased secretion of urine alternates with the cutaneous transpiration, and is the more considerable the drier the skin is

Scanty urine

Urine very scanty (second day)

Suppression of urine,*®®®*®®*®, etc.

Suppression of urine; a very small quantity was drawn by the catheter, tested by Fehling’s liquid, was found to contain sugar

Urine scanty, and depositing lithate of ammonia

Urine high-colored and scanty

Bloody urine

Urine at first red

A very small quantity of urine was drawn by the catheter, giving with Fehliug’s liquid the characteristic reaction of glycosuria

Sexual Organs p. 340

Excessive swelling and intolerable pains in the penis, with violent efforts to urinate

Frequent priapism

Arseniceating causes strong sexual desire

He thought the genitals had been excited by the Arsenic

Premature delivery

I can trace to it miscarriage and flooding, uterine suffering, which gave way when the cause was removed

Respiratory Organs p. 340

Bronchitis, which yielded slowly

Voice. Thickness and roughness of voice,*®‘b

Hoarseness,*®®*’®, etc.

Voice hoarse, toneless

Voice feeble

Voice weak and low',®®®.

Voice trembling

Voice faint

Voice lost (after several days),^=*®

To/ff//# and Expeeforafiou. Cough/®

Short cough

Short, dry, hacking cough

On the day before death there werecoiigli and nico-crepitant rales (without dulness) in posterior part of lungs

Cough, worse at night, caused by tickling in throat, worse on speaking, causing pain in abdomen, with green expectoration

Cough, especially in the morning, with expectoration of slimy purulent masses, but rather scanty

Cough, with yellowish expectoration, and bronchitic rales in chest

liesxtiration. Respiration hurried

Respiration 25 per minute (after five hours); 30 (after six hours); more labored and rapid (after ten hours); ceased entirely (after twelve hours)

Breathing quick and audible

Respiration slow

Shortness of breath,"®*®"h

Respiration labored, sighing,*°h

Difficulty of breathing,"*® "®*, etc.

Difficulty of breathing, which lasted till death

The breathing becomes more facile, and is accompanied with a certain feeling of comfort,®’h

Dyspnoea

Chest p. 341

The pectoralis muscles seemed wasted, so that the chest had a peculiar sunken appearance

Some oppression of chest, with difficult breathing

Tightness and dryness of chest

Complained of symptoms of the lungs, which were found to be congested

Sensation of weight upon the chest

Violent pain in the chest and stomach

At first talking caused pain to shoot upwards on sides of thorax

Smarting pain in the chest, along the sternum

Shock in the apex of the right lung, with a somewhat higher percussion-sound than in the left; auscultation there was increased, vesicular mum)ur, and large and fine moist rales; the cough and expectoration disappeared after a few days, when no more signs were noticed in the right lung

Pain in the right side of the chest

Heart and Pulse p. 341

Very decided fruit de souffle of the heart (eighth day)

Tumultuous beating of tbe heart, but no pulse

Heart’s action quick and faltering (after five hours and a half)

Action of the heart rapid, feeble, with no pulse at the wrist

Action of the heart feeble and irregular

Palpitation

Severe palpitation

Pulse quick

Pulse very rapid and nearly imperceptible

Pulse rapid and extremely feeble (after six hours)

Pulse rapid and irregular.®*'’®*’. - Feeble, rapid pulse

Pulse 160 and very weak

Pulse above 120, rather unequal

Pulse 120 to 130, but not hard

Pulse thready, 120 to 130, and in two somewhat intermittent

Pulse 120, soft, a little jerking (second day)

Pulse 110, regular, but soft and weak

Pulse 100, lull and compressible; afterwards quick and fluttering; latter weak

Pulse 100 and weak

Quick, small pulse,"’® ®®’, etc.

Quick, wiry pulse

Pulse quick and somewhat jerky at first, but lowered in power and frequency

Pulse hard, feverish

Pulse slightly accelerated (after three hours); 126 and wanting in volume (after five hours) ; 130 and feeble (after six hours) ; ceased at wrists (after ten hours)

Pulse became more full and frequent, but sank again, and only beat with greater force and frequency when the dose was increased

Pulse full and strong

Pulse very weak

Feeble pulse ®*®.

Pulse small

Pulse became small and thready

Pulse small, irregular

Pulse very irregular

Pulse 50 and soft (after half an hour) ; small and thready (after three hours)

Nearly pulseless

Pulse imperceptible at wrist or temple, and felt over the heart to be beating faintly 150 a minute

Pulse imperceptible (after five hours and a half)

Neck and Back p. 341

Complete extension of the hand was not wholly possible and was painful

Pains in the back

Intense pain in back

Acute tearing pains in the lower portion of the spine, Pam in loins,-i i i

Upper Extremities p. 342

In two cases within my knowledge the nails altered color and peeled The nails were of a dirty yellowish-brown color with longitudinal furrows and cracks,Nails livid, violet,^®^ Swelling^ot limbs

The muscles of the upper and lower extremities were atrophic .

Arms and legs paralyzed, with violent pains in muscles and in bowels,'*‘'k

Tbe upper and lower extremities became paralyzed, first noticed after five weeks; on attempting to rise from bed her legs gave way, and she was unable to rise without assistance

Extremities rigid and painful, with spasms,*'’b

Occasional spasmodic twitchings of muscles of limbs, . Trembling of the limbs with the attack,"™.

Limbs tremble, cannot support the body

Excitement of muscles of extremities,"”.-

Con- Slant agitation of the hands and feet Threatened paralysis of both arms and right side and leg

The flexor muscles of the four last fingers of each hand and of all the toes were in a state of contraction, and the two last phalanges were flexed upon the first, and the balls of the fingers and toes rested upon the palms and soles, on account of which the patient walked with great difficulty

Almost complete loss of power in the e^extremities, more of the left side, without loss of sensibility (seventh day)

Lassitude in the extremities

Remarkable insensibility of hands and feet

Numbness and pain in arms and legs

Tingling in limbs

Legs and arms feel as if sornetbing were gnawing them,®'’®. Cramps in the limbs

Pains in limbs

Acute pains in limbs

Shifting pains in extremities, particularly in the arms, which had not their usual strength

Seven months before her death she had a violent attack of neuralgia of the shoulder, which afterwards extended to both groins, the thorax, and back ; this was relieved for a time, but continued with most agonizing severity ; the abdomen became enormously tympanitic ; muscular paraplegia slowly ensued, and she died

Superior Extremities p. 342

Arms in constant motion about head, as if picking at something above the head

Painful tumefaction of the right arm and hand

The arms and hands became sore, and mortified and sloughed

Pain in the arms, particularly the left, of which he had in some degree lost the strength (after six days). The motions of the hands are much less impaired than those of the arm and forearm ; in particular the power of bending the forearm on the arm is almost entirely lost

Tingling sensation in axillae for eight days

Subsultus tendinum

Neither extension nor flexion of the hand was complete

The interosseous spaces in the dorsa of the hands were deep furrows ; the hands looked as though they belonged to a skeleton ; the palms formed deep concavities

Finger clenched

Most remarkable was the complete immobility of the fingers, which were flexed on their two first phalangeal joints, forming an incompletely closed fist

Feeling of fuzziness in the fingers, extending up the arm, ending in complete loss of the sense of touch

Inferior Extremities p. 342

Paralysis of the inferior extremities

Complete, paralysis of the lower extremities

In one case, wdiich recovered after the lapse of a month, there were partial paralysis of lower extremities and desquamation of cuticle

In the lower limbs the muscles of the thigh were feeble and soft, and the calf formed only a flabby bundle of fibres ; the foot of the patient remained in an extended position, so that the back of the foot formed a line with the spine of the tibia, While at the same time the inner margin of the foot was turned somewhat inward and upward, and the plantar surface looked inward and backward ; the instep formed an angle with the tibia directed inward and forward, and the articulations of the ankle and foot were weak, and on flexing the leg the foot could be moved in a very loose manner; the toes were also flexed and motion very much restricted

Lower extremities cold, stiff, and without the power of motion (second day)

Hyperesthesia of the lower extremities; the slightest touch caused cries from the patient (after several days)

Curious sensation in her lower limbs (one case)

Violent pains in the lower extremities

Pain in knees

Paralysis of legs

The sharp prick of a pin had no effect on the left leg, and a hard pinch was requisite to excite motion in the right

Spasms in legs

Contraction of the extensors of the legs

Such a weakness in his legs that he with difficulty got into bed

Want of strength in her feet and legs (sixth day) ; a few days afterwards she had swelling of feet, with numbness and creeping in inferior extremities

Cramp in one leg (in four hours)

Much cramp in legs

Painful cramps of legs

Cramps in the legs (after five hours) ; increased (after six hours)

Muscular soreness of legs (after three hours)

Cramps in the calves

Violent and increasing cramps in calves

A feeling of hot water running down the calves from knee to ankle, lasting six hours; first in left leg, then in n'^/if

Prickling pains in both legs, from soles to about two inches above knees. Sensation was completely lost in left leg, and considerably impaired in the right. In both there was total loss of all power of motion. She said she had b^een unable to get about for the last fortnight, and that tor some weeks previously she had had considerable difficulty in doing so (after three months)

Swelling of feet (one case)

Sensation of fuzziness in the soles of the feet, with formication and pain ; this numbness and painful sensation gradually extended up the calves and thighs, associated with pains, which the patient described as if caused by cutting instruments

Generalities p. 343

Emaciation,®®®®®*, etc.

Extreme emaciation

Sank with typhoid symptoms

The woman sank in a typhoid state four days and twenty hours after taking the poison

When seen at the end of three months she was in bed, looking pale and haggard

Found ill at 3 P.M., but she would not at first speak or take anything. Afterwards she took what was offered. There was great pain in stomach, frequent severe vomitings; occasional hiccough. She continued about thirty-eight hours in this state; was then seized with occasional slight convulsive attacks, and died in a convulsion, upwards of forty hours after she was first seen by the neighbors

In about an hour she was brought in in a state of exhaustion ; pulse scarcely perceptible ; skin cold ; pupils fixed ; incapable of answering when spoken to; pressure in episgastric region gave excessive pain, under which she would writhe and utter some imperfect sound; tongue dry; appeared to wish for drink constantly. The washings of the stomach returned tinged with blood ; died

Found in bed yawning and retching a little, and complaining of headache, sickness, and pain in the bowels. Thirst, a sense of coldness, and a little vomiting. Four hours later she suddenly became blue in the face, made one or two inspirations, and expired without a struggle

Arsenical poisoning, which begins with conjunctivitis, sparkling eyes, and anasarca, simulating increased fat; ending with a hidebound skeleton slowly sinking to the tomb

They all appeared suffering from the same complaint, nor could they well explain how they felt. At night they were worse than in the daytime, and always very restless, the muscles of the face being marked by a kind of twitching

In one case (Flecker), if he intermits it for fourteen days, he feels stiff in the feet, with general lassitude and craving for another dose. If he takes a full dose he brings a great deal of wind off his stomach

After spending some time in her room, she would come out thoroughly exhausted ; was very logy became bloated, and was generally running down. For some time she had had an ulcer on the face, which had not yielded to medical treatment

His case was similar to that of the lady first mentioned, was marked, however, by more violent febrile manifestations and delirium, and he was for some time in danger of his life. One eye was lost by the sequelae of conjunctivitis, and the other permanently injured. He was for a long time unable to sleep

Found lying on stairs apparently in great agony, and complaining of a burning pain in the stomach, with violent retching, headache, and great thirst (first night). In the morning much better, her face flushed and swollen, and she complained of burning pain in the stomach, headache, and dizziness (second day)

Great pain and burning heat in the stomach, headache, immediate thirst, vomiting and purging, with olive-green alvine discharges, tension of the abdomen, the face swollen, cold chills, alternating with flushes of heat; light painful to eyes; bearing pains more or less constant in the loins (first day). Unable to endure a strong light; pulse 130; this rapid circulation was accompanied with constant sensations of fainting ; bearing pains, with the pain in the loins somewhat abated (second day). Pain in loins constant, with occasional bearing down of the womb, the thirst rather less urgent, the pulse 110, headache, vertigo, great intolerance to light, the tongue white and moist, the skin hot, frequent palpitations of the heart, and a constant sensation of fainting; a numbness extending from the right side down to the foot; the burning sensation of the stomach was excited and increased by the motion of the child in utero; the face was flushed and swollen, and the tongue and lips sore, which extended along the course of the oesophagus (third day). Violent headache, and to the light she had still great objection, as it immediately on accession increased the headache; at times the heart palpitated strongly, the thirst was considerable, the pulse 100, the tongue less charged and moist, the child in utero moved with vigor, and whenever this occurred the pain in the stomach was increased, with nausea (fourth day). Pulse continued at or about 100 for a fortnight afterward. She went her full time, and a very fine girl was born, after a safe but lingering labor

Urgent thirst somewhat allayed by frequently washing mouth with cold water (first day). All passed a restless night; the vomiting in each had greatly abated, the pain in the stomach still violent, which they all compared to a furnace, or hot irons; alvine discharges changing to a proper color, but intermixed with streaks of green, and highly offensive ; skin hot and dry ; the pulse quick, varying in each case from 100 to 130, great thirst, and violent headache; tongue white and moist (second day). Face swollen, with a fixed redness, more or less under the eyes and on the cheek-bones; vomited two or three times in the course of the night, by drinking too copious draught of the diluents, and each complained of the tongue and lips being sore and swollen. In the evening the febrile symptoms had a little abated, the pain in the stomach was intense, occasionally remitting, and again returning with increased violence, with nausea and vomiting, much pain in the head, considerable thirst, and bowels open (third day). Febrile symptoms subsided. They complained of a variety of singular nervous affections, tingling and burning sensations in the bands and feet (fourth day)

Burning sensation in the stomach, vomiting, inordinate thirst, headache, face swollen, tension of the abdomen ; purgative symptom moderate ; countenance flushed, particularly on the upper part of the cheeks (first day). Pulse 90, skin temperate, tongue moist and cleaner ; the vomiting had subsided, hut the stomach was in great pain ; he complained of extreme lassitude ; face flushed (second day). Pain in stomach occasionally troublesome, appetite returning, face less swollen, but flushed and red under the eyes and on the cheekbones, extending towards the ears (third day)

She was found in bed early in the evening suffering much from sickness, vomiting, and purging. Continued to get worse all night. Next morning the symptoms were much like those of cholera, except that the vomited matter was like thin coffeegrounds. She was extremely sullen and silent, would not answer any question, and would rather suffer thirst than ask for drink. Pulse feeble, tongue white, epigastrium tender. Next day symptoms much aggravated. Countenance had assumed a sunken aspect and dark leaden hue. Everything taken into the stomach was immediately rejected, and the purging was also frequent, with pain and straining. This state continued with little variation till next morning, when she died convulsed, sixty hours after the first symptoms were noticed

Some restlessness during the night, with watchfulness and slight pain in stomach. In morning she became sick and complained of great thirst; the pain in stomach had become much more intense. During the day sickness increased, and she was repeatedly purged ; countenance looked pinched and extremities cold. From this state she soon rallied, and next night (Wednesday) she became cheerful and slept comfortably, though she was distressed once or twice by the thirst, which still affected her. Thursday morning she was worse, being cold and drowsy; she was evidently dying; face pale and anxious; extremities cold and bedewed with clammy sweat; pulse hardly perceptible; and she lay in a state of incipient coma. From this time (9 oclock) she became more and more comatose, and gradually sank at 12,®®

Eyes a little suffused, with slight lividity of the inner portion of the under lids; skin moist, pulse accelerated, small and feeble; vomited several times freely, and in the meantime had a copious natural dejection ; at first formed, and afterwards liquid, without blood; while at stool vomited upon the floor about two ounces of porridge-like matter, tinged yellow with bile

Vomiting and purging; vomiting at first very violent and frequent; occasional purging, sometimes of blood ; soreness of tbe mouth, and pain of the throat, stomach, and bowels; hoarseness and oppressed breathing (up to fifth day); pulse 120, full, soft, and regular; skin hot and dry; tongue parched and excoriated; throat spotted inwardly with little white ulcers; voice hoarse and. feeble; breathing hurried and laborious; swallowing painful and difficult; the belly round, swollen, and painful, but not tender to the touch ; very exhausted, and complained of general soreness (fifth day) ; pulse 120, and throbbing ; breathing difficult; tongue red and parched; gums tender and shining, without salivation; soreness in the throat, descending along the gullet into the chest, and there was an excoriation on each side of the uvula, a white ulcer on the left tonsil, and redness and tenderness of the rest of the throat and back of the palate; she swallowed with such difficulty that a small quantity of any liquid caused violent gasping, hurried cough, and much pain; she complained further of sickness and dull pain, and tenderness in the stomach and bowels, and likewise of pain in the feet and legs. The vomiting continued to recur throughout the day. In the evening the fever had increased ; the pains in the feet and legs were more severe; and she complained of soreness and tenderness of the labia pudendi; though in neither situation could any unnatural appearance be discovered (sixth day); some delirium in the evening (seventh day); fever lessened in the morning and increased at night (seventh and eighth days); about midnight taken with labor pains, and in three hours brought forth a stillborn foetus, weighing nineteen ounces, and apparently between the fifth and sixth month. The delivery was difficult and distressing ; and although there was no flooding, she was so feeble she was not expected to live (eighth day); fever continued with morning remissions and evening exacerbations (ninth to twelfth day); pain in hands like those in feet (eleventh day) ; Want of power in the feet and hands, and so severe pain in them that she could not sleep without opium (twelfth day) ; headache, restlessness, fever, loss of appetite (twentyseventh day); her sufferings went on increasing steadily, her strength decayed, and she died on the forty-fifth day with symptoms of low fever

The Arsenic is taken pure in some warm liquid, as coffee, fasting, beginning with a bit the size of a pin’s head, and increasing to that of a pea. The complexion and general appearance are much improved, and the parties using it seldom look so old as they really are. The first dose is always followed by slight symptoms of poisoning, such as burning pain in the stomach and sickness, but not very severe. Once begun it can only be left off by very gradually diminishing the daily dose, as a sudden cessation causes sickness, burning pains in the stomach, and other symptoms of poisoning, very speedily followed by death. As a rule Arsenic-eaters are very long-lived, and are peculiarly exempt from infectious diseases, fevers, etc.; but unless they gradually give up the practice invariably die suddenly at last. In some Arsenic works near Salzburg, the only men who can stand the work for any time, are those who swallow daily doses of Arsenic, the fumes, etc., soon killing the others

About an hour after taking my first dose (I took the same quantity, 3 grains, daily for three months), there followed sight perspiration, with griping pains in the bowels, and after three or four hours a loose evacuation ; this was followed by a keen appetite, and a feeling of excitement. With the exception of the pain, the same symptoms follow every increase of the dose. I subjoin as a caution, that it is not advisable to begin Arsenic-eating before the age of twelve or after thirty years. Evil consequences only ensue from a long-continued interru{)tiou. From circumstances I am often obliged to leave it off for two or three days, and I feel only slight languor and loss of appetite, and I resume taking Arsenic in somewhat smaller doses. Once on the third day of the second week, after leaving off the dose, I was attacked with faintness, depression of spirits, mental weakness, and a total loss of the little appetite I still had; sleep also entirely deserted me. On the fourth day I had violent palpitation of the heart, accompanied by profuse perspiration. Inflammation of the lungs followed, and I was laid up for nine weeks, the same as on the first occasion of leaving off Arsenic. Had I not been bled I should most likely have died of apoplexy. As a restorative I resumed the Arsenic-eating in smaller doses,“h

First appeared irritation of the mucous membrane, causing diarrhoea and vomiting, with various other symptoms of severe gastric derangement, resulting in permanent indigestion; also incessant severe cold in the head, which, in one instance, lasted for several years without being touched by any remedy; ulcerated throats, with acute inflammation, resembling diphtheria and quinsy; severe spasmodic cough, spasmodic asthma, bronchitis, and congestion of the lungs; soreness of the mouth, lips, and tongue, which appeared as if scalded in patches; inflammation of the eyes and eyelids (the conjunctiva invariably being bright red), in one case threatening absolute loss of sight; congestion and torpidity of the liver, with the various symptoms resulting therefrom, and severe bilious and feverish attacks. There was, in short, irritation of every organ. In many cases, if not in all, the action of the heart was weakened, and in some palpitation frequently occurred. There were pains in various parts of the body, especially across the shoulders, down the spine and limbs, also in the joints, which were often stiff and swollen ; scaling of the skin and irritating eruptions, which no remedy ever relieved except Turkish baths. The effects upon the nervous system were most remarkable, producing a thoroughly shattered constitution ; great irritability, depression, and tendency to tears. These latter symptoms were especially marked in the children, and also in servants who had come to the house in ordinarily good health, and who each became affected by degrees as above described. The list also includes giddiness, headache, acute earache, and neuralgia ; bleeding at the nose ; frightful dreams; faintness; cramps, rigor and numbness of the limbs; rigid spasms and convulsions. The last symptoms developed in the worst cases were loss of memory, and threatenings of paralysis; also spasms, with twitching of the body and limbs

After about twelve hours, when on the stool, he suddenly felt great difficulty in breathing, with cramp in the chest, hands, and arms; immediately afterwards the cramp attacked both calves, and he became very cold all over and stiff, so that he became completely helpless, and had to be entirely lifted into bed. Violent vomiting very soon set in, and the cramp became more severe in the calves, though it did not again affect the chest and arms. The breathing, however, continued to be much oppressed for two hours. He was by this time in a state of great prostration ; countenance strangely anxious, and very restless; skin cold and clammy; pulse very feeble and frequent; eyes deeply sunken and surrounded with a wellmarked dark border; lips and tongue parched, with great thirst; breathing slow and much oppressed; sometimes sighing; burning pain in stomach, increased on pressure, and inclination to vomit; extremities icy cold in spite of hot applications; had had severe vomiting, with griping pain in bowels, and purging ; also cramps, first in chest and arms, and afterwards in calves. After a few minutes most violent cramps came on in both calves, causing intense suffering, and rendering the muscles hard and knotty. The cramp came on almost every fifteen minutes, lasting a few minutes each time; the slightest movement, such as turning in bed, seemed at once to excite the spasm. Violent vomiting of a greenish-yellow fluid also occurred at intervals. Brandy and all warm drinks were almost immediately rejected, but a little cold water was retained. Mustard plasters applied to the spine, chest, and calves, were scarcely felt by him

One man got a sore mouth ; another had every symptom of a cold, and felt a general stiffness of the limbs ; a woman was in the room for half an hour, and her throat became rough and remained so for some days. A paperhanger in the same neighborhood remarked that his mouth was always sore when he put on green paper, and his men often spoke of their eyes becoming inflamed and their hands ulcerated

The symptoms commenced within a half to three-quarters of an hour after eating dinner. They had faintness, nausea, and incessant vomiting, with a burning pain in the epigastrium, increased on pressure, and gradually extending over the whole abdomen, followed by headache and severe diarrhoea, with a sense of constriction and heat in the fauces and throat, great thirst, and in some painful respiration. Pulse quick and very feeble, from 100 to 180; cold, clammy skin, with very severe cramps in the legs in those who had diarrhoea. Some of the men had tumefaction of the penis. The above symptoms were found in all the men. Some were collapsed. A great many had severe cramps in their legs until 11 oclock at night, and some little pains in the abdomen for several days. Ten of the men had slight gastritis. One man had and still has paralysis of the left arm and leg, and the sensibility of the skin is impaired ; he complains of coldness in his limbs

Three or four years after occupying the room, or perhaps a little earlier, she began to have a feeling of general malaise. The first thing she recalls is a sensation of exhaustion. It was especially difficult for her to rise in the morning, although awake at a very early hour. The debility increased as the illness went on. She would feel quite well and strong for a time, and would at once experience the sense of prostration on making any attempt at movement, and at times, on any unusual mental exertion, making the duties of a housekeeper particularly onerous. She speedily increased considerably in weight, from about one hundred and twenty-five to one hundred and sixty pounds. This condition lasted for some months, and then gave place to emaciation. At certain intervals afterwards the various symptoms of the digestive, nervous, and circulatory systems, which I shall mention, appeared and increased in severity up to the time I saw her. The precise date of the access of each symptom is unknown, but each had shown itself, either continuously or at intervals, for a number of years before. I found her in bed, perfectly prostrated, hardly able to move hand or foot; with skin very dry and rough ; hands and feet cold or cool to myself and to the patient. Emaciation was marked ; a countenance naturally rosy had become sallow ; tongue inflamed, dry, cracked, with a brownish coat in centre; gums also dry and angry. The sensation of dryness was apparent to herself, with a feeling as if the mouth were lined with flannel. No sensation of dryness or pain in the throat or oesophagus. Nausea often about 10 p.m., and nearly always when she awakened, but not during the night, unless she happened to be up and about for any purpose. At times pressure in the stomach; frequent thirst in the evening, seldom during the day; capricious appetite. During her early years she had often had diarrhoea, but she had been free from it for some years. Two or three years ago it came on at intervals; of late it had been more marked, the discharges watery and painful. Her eyes had for some time shown signs of weakness and congestion. They had previously been very strong. At last she could not open the lids at night without lifting them with her fingers. At the time I saw her there was marked conjunctivitis, as if from some external irritation. No headache, but an aching tired sensation in base of brain. At times, during the past few years and never before, a tenderness in the neighborhood of the liver, which would pass away after slight diarrhoea. A carbuncle or perhaps a large boil on the back was reported as having occurred three or four years before. The sleep was more easily disturbed than when in health, and she had often wakened chilly or feverish. The feet and legs, to the knees, were frequently cramped, and had been relieved by warm applications and frictions. The symptoms detailed had always been, to a certain extent, relieved during absence from home; but in about ten days after her return the exhaustion and other evidences of disease would recur, and soon be as bad as ever

Involuntary twitching of muscles

Constant jactitation

Trembling

Nervous twitchings

Universal tremors

Tremblings and spasms of extremities

Convulsive spasms

Convulsions

General convulsions

Convulsions with loss of consciousness, followed by colic

Three spasms within an hour, the first one very severe, the second and third consecutively lighter (after six hours) ; slight spasm, confined to the muscles of the thighs and legs (alter seven hours)

Violent spasms, and what she termed cramps in the legs

One was seized with convulsions, and died in about five hours in a strong convulsive fit

Convulsive tremors, “so that the bed shook under him accompanied by sensations of cold and extreme faintness

Fits resembling epilepsy, except in the absence of frothing at mouth

The little boy had been in convulsions, and was then in a semicomatose state. The child had felt chilly, and had been sick. In the evening the symptoms seemed somewhat relieved by the remedies administered, but during the night he became worse; and his sister was also seized with convulsions, followed by dysenteric discharge from the bowels

Convulsion followed convulsion in rapid succession, and so stiff and rigid was the entire muscular system that no sort of external muscular force could have succeeded in producing the least amount of flexion of either arm, leg, or other joint of the body, without producing lesion. So clenched were the teeth as scarcely to admit of the escape of the froth and contents of the mouth and stomach

Found prone on the floor, body arched in a curve. As I took him by the hand and called him by name he instantly became so convulsed that three men could with difficulty restrain him. The paroxysm lasted thirty or forty seconds. The convulsive paroxysms were attended with wild, staring, bloodshot eyes, with imprecations and fearful ravings, and with maniacal fury. When the convulsions ceased he invariably sank into a temporary prostration. His pulse during the intervals was irregular, uneven, intermittent, and accelerated, ®«®.

In twelve hours he began to feel a stiffness of neck, with slight difficulty in swallowing; the cuticle of scrotum peeled off entirely, leaving the cwfis i;em exposed, inflamed, and bleeding ; both testes were enlarged, and could not be touched ; great thirst and headache; the most distressing symptom was an indescribable sensation as if the hair was standing on end, and being pulled up by the roots. Stomach was irritable with vomiting, and epigastrium was painful on pressure. He had been purged twice freely, and said he felt as if his bowels were on fire

He appeared to be nearly in article mortis; his face, which had been swollen, having assumed the appearance of the true facies hippocratic. On examining the contents of the utensils in which he had vomited, a fluid was perceived of a yellowish and greenish color, and in two of them stercoraceous matter; the pulse was gone, his voice faint and tremulous; and he pointed to the abdomen in great agony. On examination I discovered a very remarkable irregularity of surface, occasioned by the spasmodic contractions of the muscles of the abdomen, and even of the viscera; this unevenness extended from the epigastric region to the pubis, and to the right and left hypochondrium. He complained of extreme faintness, and dreadful sickness. He had been violently purged; the alvine secretions were all of a bright homogeneous green color, like paint. Each effi)rt of vomiting and purging was preceded and followed by these painful gripings and spasmodic contractions of the abdominal muscles. He also complained of great heat in the stomach, which he compared to a furnace, or red hot irons, which sensation commenced at the tongue, and was felt throughout the course of the oesophagus to the cardia, or upper orifice of the stomach ; insatiable thirst, violent headache, the eyes impatient of light, but the pupils sensible, and the extremities cold. The patient attempted in this dreadful state to get out of bed, to walk to the night table; he was directly seized with vertigo, dimness of sight, and palpitation of the heart; he fell down, and went off into an e|)septic fit; he was assisted on the bed, and in a few minutes recovered from the fit (first day). In the early part of the morning he had another attack of epilepsy; the symptomatic fever ran high, the pulse 120; he complained of spasmodic twitchings about the chest and abdomen, palpitation of the heart, great languor, accompanied with a constant sensation of fainting, tongue white but not dry, occasional chills, followed by an increase of heat, headache, and vertigo (second day). Skin moist and more temperate, tongue less coated, not dry, but sore and swollen, the burning heat in the stomach rather less violent, and he expressed a degree of hunger ; the pulse 98, spasmodic twitches in the arms and legs, with a cold sensation in the latter (third day). Tingling and burning sensations, beginning at the extremity of the fingers and gradually creeping to the shoulders; sometimes one foot, and at others both affected with a burning feel, commencing at the toes and gradually rising above the ankle-joint; palpitation of the heart, great depression of the spirits, with a perpetual sensation of swooning, and frequent twitchings of the muscles of the chest and abdomen, and of the upper and lower extremities (fourth day). Owing to eating a free portion of animal food he suffered a slight relapse of the fever and much pain in the stomach, also passed a restless night, with much thirst, and was again attacked with spasmodic twitchings in the chest and upper and lower extremities (fifth day). He complained of a very singular affection in the upper and lower extremities; the arms were several times in the course of the day seized with a numbness and prickly feeling, accompanied with a sense of great weight, like what is commonly called being asleep; and this sym[)tom continued daily, more or less frequently, for six weeks, but, upon raising the arms in an upright position, it immediately subsided. The same feeling almost as constantly attacked the legs, but occasionally with and sometimes without the corresponding affection of the arms; the legs were some minutes longer affected, by reason of his not being able, as he himself observed, to place them in the same position as the arms (ninth day),'^^l

Burning heat in the stomach, much nausea, with vomiting and severe gripings, with purging, extreme faintness, palpitation of the heart, headache, trembling of the right arm, and right lower extremity (first day). Four epileptic fits in the course of the night, preceded by violent palpitation of the heart, accompanied with a peculiar tremulous action of the right arm and lower extremity; a considerable degree of symptomatic fever, insatiable thirst, a white but moist tongue, the face flushed, the respiration hurried. Pulse 126, irregular and contracted, frequent gripings in the bowels, and spasmodic twitchings in the muscles of the chest and abdomen (second day). Much fever, respiration hurried and great thirst, violent and incessant palpitation of the heart; the fits had recurred twice in the night; he had bad no sound sleep; if he went into a doze, he woke suddenly and much agitated; the pulse 120; spasmodic twitches, with tremor in the right arm and lower extremity, violent headache, and the eyes painfully affected by light; constant vertigo, which was increased if he attempted to sit up in bed, or upon the slightest exertion (third day). Only one attack of the epileptic fit in the night, and had slept three or four hours towards the morning; pulse 100, breathing less hurried and more natural (fourth day). A relapse of the fit in the night, preceded by palpitation of the heart and tremulous agitation of the right arm and lower extremity ; the fit lasted nearly two hours (fifth day). On the eighth day an epileptic fit at 8 p.m., and it returned daily and periodically about the same hour every evening for a fortnight afterwards; the fit generally lasted nearly two hours, and he required, from the violence of his struggles, the assistance of several persons to hold him whilst the epilepsy continued. On recovering he looked tvild, forgot where he was, and talked incoherently, and as he gradually emerged from this state, complained of extreme languor, with great prostration of strength. Towards the latter end of the second week, the fit became shorter and less severe, and he sooner recovered when out of it; and at the expiration of a fortnight from the first effects of the poison, he enjoyed an interval of seven or eight days without a relapse ; hopes were then entertained that he would recover, “the fits becoming every day shorter, and recovery from each more rapid and complete But they again returned with the same or even greater degree of violence, and he has been afflicted with fits up to the present time; he appears to have outgrown his strength, possesses very delicate stamina, and serious apprehensions are still entertained of the result

Vomiting in the course of half an hour; soon afterwards, several dejections. Vomiting and purging, at short intervals, continued through the day. Evacuations consisting mostly of a serous fluid and bile. Quantity vomited during the day amounted to six or eight quarts by estimation. In the afternoon, on attempting to walk from one bed to another, he fell down senseless, was convulsed, had cramp in extremities, and was cold. At 7 in the evening, seventeen hours after taking the medicine, found him as follows : Extremities cold, bathed in perspiration ; skin blue and corrugated, feeling as if parboiled ; no pulse perceptible at wrist; pulsations of carotids rapid and fluttering; eyeballs retracted in orbits; countenance livid; voise husky and guttural; extreme thirst; distress at epigastrium; frequent vomiting; mind clear; whole appearance like that of a person affected with malignant cholera. Cramps and coldness of extremities increased, vision failed, voice faltered, throat became dry, tongue swollen, annoyed by hiccoughs, delirium, and at last death

Arsenical ointment was applied (to cure chronic inflammation) to the breast of a woman, aged thirty-nine, the cuticle having been removed. The first application was May 21st, and was immediately followed by severe violent burning in the breast. Violent headache, thirst, sickness, and occasional retching, numbness in arms anfl legs, sleeplessness, and loss of appetite supervened in a short time. The application was repeated daily till 25th. On this day the pain in the breast became intolerable; there was faintness and palpitation. Inflammatory action extended from the breast to the shoulder and arm. On the evening of the 2Gth she had severe pain in belly. On the 27th the points of the sore not sloughing were smeared with ointment. About 2 P.M., she was seized with a kind of fit, with lividity of the face, foaming at the mouth, and moaning. She continued unconscious for several minutes, and on regaining consciousness, said she had been in a queer place, that she felt as it were a dart go through her, that she then became insensible, and had no further recollection of what happened to her during the fit. In the afternoon she felt more comfortable. Between 9 and 10 pipi., she suddenly said There it is again was off in a fit, and died immediately

Cramp attacked his legs and stomach ; the muscles of the former were spasmodically contracted, and the abdomen was also rigid and tender. In the intervals of the paroxysm of the pain he lay with his eyes half closed; tongue covered with a creamy fur. The breathing soon became more rapid and rather difficult, and accompanied by an increasing lividity of face. The spasms continued, but never attained to anything like general convulsions

Great muscular activity and aptitude for walking,“‘k

Agitation,®^k

Restlessness etc.

Restless and anxious

Great restlessness,'^’” ^*‘, etc.

Tossing about the bed in a sort of anguish

General restlessness, worse at night

Uneasiness over the whole body, especially in arms and legs

The patient experienced an unusual immobility of the eye and extremities, wide the muscles of the head and face seemed normal

Two had partial paralysis (in one, of sensation in fingers, and in the other, of motion of the lower extremities)

In about five minutes a peculiar tingling sensation commenced in left arm, lasting about forty-five minutes. Fifth day, numbness of thighs and calves. Eleventh day, anaesthesia of fingers, and partial paralysis of flexors of forearm ; a similar condition shortly afterwards attended the lower extremities, and was accompanied in both by pain persisting for a few days. In five weeks from the commencement of the illness, skin of entire body had desquamated ; most remarkably so on hands. In six weeks the paralysis of flexors of both extremities was unabated, and accompanied with soreness on pressure. In two months and a half he was still unable to stand without support. In eight months the paralysis of sensation and motion and the soreness on pressure still continued, though less- In twenty-three months nearly well

Feebleness

Weakness

Extreme weakness

Gradually diminishing strength

Felt weary, could not sit up

Malaise

Lassitude (soon)

Great languor

Debility

General debility

Great exhaustion (second day)

Loss of muscular power, which assumed the form rather of great general debility than that of a partial or paralytic affection ; and existed in such a degree that she professed inability to walk

Extreme exhaustion, feeble whispering voice, pulse scarcely perceptible

Prostration,””®”®”, etc.

Internal irritation ; after three weeks I became completely prostrated, almost losing the use of my left side

Extreme prostration,”*®”®’, etc.

Faintness,””””’”, etc.

Affections of the tactile sensation

Complained of a disagreeable numbness and tingling

Cramps

Cramps general

Constant cramps

Much pain throughout the whole system

Skin p. 352

Oh)active. Skin dry

The skin seemed anaemic and without lustre, was hard parchment like, and could be raised up in thin folds from the underlying tissues, especially as all the fat had disappeared

General scurfiness of the face and body

After forty-eight hours there was desquamation of the rash, and all the symptoms disappeared

General desquamation of cuticle

Desquamation of the cuticle of the face

Three had desquamation of cuticle (some of hands, others of neck and nostrils)

The body became covered with red spots

Severe hepatic \_‘i herpetic, E. W. B.] eruptions

Lips covered with black spots

1_3500.] Arms more livid than natural

Cyanotic spots on the anterior portions of the thighs, not removed by pressure

Miliary eruption

Eruption like intense scarlet rash, covering nearly the whole body, except the face; it began on the anterior surface of the body, and spread rapidly, without disappearing from its primary seat. The skin was intensely red, much swollen, covered with numberless fine blisters. The eruption was associated with the most violent itching and burning, disturbing the sleep, reaching its height in five or six days, and then fading; followed by desquamation; the desquamation was very slow, in large and small scales

The whole body became covered with an eruption of small pimples, like miliary rash

General miliary eruption oyer the whole body, on the sixth day, immediately followed by amelioration of all the symptoms, and re-establishment of the urinary discharge ; this eruption lasted five days, after which the body was covered with fiue mealy scales

Severe eruptions, violent constitute(mal symptoms, and even death

Eruptions chiefly on hands, forearms, scrotum, and thighs, and the suffering proves intense should they have chapped hands at the time

Numerous petechial spots over the skin of the trunk and thighs

INIiliary eruption confined to the forehead, wrists, and feet (third day)

Pimples or vesicles round month (fifth day)

Towards the close small spots of purpura on neck

Pimples on the hands, chest, and forehead

Redness of the hand, with red points extending half way up the forearm

Arsenic causes shingles

A vesicular eruption over the greater part of right ear, and also of nose ; several vesicles have coalesced, forming large patches; they are all surrounded by an inflamed base

Vesicular inflammation of the whole face, with acute itching (third day)

Vesicles about the mouth (one case)

Small white blisters on the inner side of both thumbs, containing a clear watery liquid

Blistering of the feet

General erysipelas, with sensation of a devouring fire

Cutaneous affections of a mixed pustular and scaly character, attacking especially the scrotum, the depression between lower lip and chin, the angles of nose and face, the line along which the hat fits the forehead, in short, every crevice and fold where the Arsenic can accumulate

Various eruptions on the parts most exposed, chiefly arms and legs; sometimes the eruptions resemble eczema, but more frequently they are pustular, and large boils are not uncommon

Obstinate pustular eruptions

Eruption of pustules resembling the itching, followed by desquamation

In some of the persons pustules appeared on the forehead

Face covered with pustules

On the sixth day eruption of white pustules on the face and upper part of the body, resembling in appearance and progress those of varioloid

Eruption of pustules about angles of mouth

His hands were contracted, and he was frequently sick during the three months he was at work. At last the Arsenic entered the hand, the skin being broken ; his left hand and forearm were swollen ; also the left axillary glands; the hand was inflamed; purple patches gradually covered his arm and side. He died

Eruption of boils which refused to heal

In a case of chorea the Arsenical solution produced a copious crop of boils

The workmen are subject to irritations which produce itching, blotches, rawness, and perhaps boils. In one factory where one hundred women are employed in making artificial flowers, hardly any of them escaped skin diseases. The hands, face, neck, roots of hair, flexure of arms, axilla, and in a most distressing degree the genitals, were affected ; the pudendal eruptions being often so severe that they could not bear to sit down

Several small superficial ulcers extending along the inner surface of each lip, varying in size from mere specks, the largest being j-’oth inch in diameter. The smarting and annoyance were intolerable, and much increased in the evening [when he inhaled much of the poison], when the lips swelled and became so painful that eating or even speaking could scarcely be indulged in. He got better, but returned worse than ever; all the old ulcers had reopened, several new ones formed, lips much swollen, with profuse ptyalism

The lips became incrusted, and the skin cracked and peeled,^^h

Inflammation of the skin of the lower part of the abdomen, penis, scrotum, and upper part of thighs; in some places the inflammatory action had gone on to ulceration. The pain was severe and burning. There were signs of considerable constitutional derangement. The evening of the same day on which he washed the sheep he had smarting and pain in the affected region ; this increased, and the next morning the parts were red and inflamed. It was more than a fortnight before he was able to resume his work

Subjective. One woman said she had been tormented for the last two days and nights with irritation of skin, which she compared to being in a bagful of fleas (eighth day)

Prickling sensation over the whole skin

Itching over the whole body

Constant itching of eyebrows and forehead

Violent itching of the extremities

Sleep p. 354

Drowsiness

Drowsy, but easily roused (after six hours)

Sleepiness

Sleepy shortly before death

Somnolence (thirteenth day)

Somnolence just before death

Occasional light sleep, with muttering delirium

Sleeplessness

Fever p. 354

Chilliness. Chilliness

General chilliness

Chilliness, with cold extremities

Shivering and coldness of surface

Shivering

Shivering, recurring when he drank

General sense of coldness

Distressing sensation of cold during the whole night

Cold skin,®®®®®®, etc.

Skin cold and clammy

Skin cold and slightly livid (in five hours and a half)

Skin cool and moist

Trunk and extremities cold

Sensation of cold over whole body (after five hours) ; increased (after six hours)

Tip of the nose cold, pinched

Sensation as if cold water were poured down back

Cold extremities

Extremities cold, with most violent pain in the abdomen

Coldness of the hands and feet

Feet a little cold (after five hours)

Heat. Fever

General fever, with coldness of the feet

Very violent fever

She had three attacks of intermittent fever; the first in November, 1875, lasting three days; the second in December, 1875, lasting seven days, and the third from 14th to 16th of January, 1876. The symptoms of the attacks were as follows: Between 8.30 and 9 A.M., after getting out of bed, chilly, with chattering of teeth, nails and lips blue, sometimes sickness on waking, bad taste in mouth, desire for much cold drink, pulse feeble, wants to lie down and to be quiet, and wrapped up, breath offensive, tongue brown ; this lasts till 1 p.m., then fever comes on. During the fever there is full pulse, frontal pain, not much thirst, especially hot to touch on abdomen, with pain there, feet and hands cold objectively, not subjectively, cannot bear the least draught, breath offensive, tongue brown ; this lasts till 4 or 5 p.m. ; she then seems well for one or two hours. Then about 6 p.m. she is slightly chilly till about 8 P.M., then there is heat again, cannot sleep, bad dreams, cannot sleep after 3 a.m. She is losing flesh very fast, and getting very weak. The second attack was the most severe, and the third (which occurred after she had been removed to another room) was the slightest

In this waycan be produced in healthy persons attacks of remittent fever, though not such rigors as those of true fever, but only flushing heats, disappearing and returning, and chiefly felt in precordial region and forehead. Such accessions terminate sometimes in partial or general sweats, and at other times merely in a moist state of skin. This Arsenical fever never acquires any regular type. It is rare for the excitation to be carried to this degree, and there is more usually an increase, more or less considerable, of the heat of the body, which seems to have its source in the stomach and precordial region, whence it passes to the rest of the body, but is especially felt in forehead and eyebrows. To produce these effects a rather strong dose is required

Heat over the whole body, except the hands

Violent heat internally and externally

Temperature increased (in the rectum 38.6°)

The feeling of heat witlim did not leave him for a week

Heat of skin

Heat and dryness ofskin

Alternations of heat and chilliness

Sweat, Profuse sweating on the least exertion

Skin moist and temperature good (after five hours); moist and cool (after six hours)

Cold clammy sweat

Skin covered with cold clammy sweat

Clammy perspiration

Cold sweat

Whole body, and particularly hands and feet, covered with cold sweat

Cold sweats broke out profusely over surface of body

Fetid perspiration on the whole body

Abundant perspiration (after eight days)