Copaiva

Authorities. 23, Dr. A. Kennedy, Month. Horn. Rev., vol. xx, p. 479, 1876, J. McK., set. twenty-two years, took the oil for gonorrhoea ; 24, F. Taylor, M.D., Guy’s Hosp. Rep., 1876, p. 1, Weickart’s experiments, took l-g- ounce of the Mistura Copaiba Since, containing about 20 grains, three hours after a full meal; 25, ibid., took 3 ounces of mixture two hours after a full meal.

The urine passed after forty-five minutes gave no precipitate nor turbidity with Nitric acid, but some passed after one hour and twenty minutes became opalescent on the addition of either Nitric or Acetic acid. The same reaction occurred with that passed two hours after, but not with the next instalment, passed nine hours after taking the drug,'A—The urine passed after twenty, forty, and sixty minutes gave no reaction, but a turbidity was produced in that passed one hour and twenty-five minutes after the dose, and the precipitate was abundant in that discharged fifty minutes later. Twelve hours after taking the medicine the urine became only faintly opalescent on the addition of Nitric acid, and it was not further tested,^\— Th ree weeks ago contracted a first gonorrhoea, for which he used injections of Sulphate of zinc. These arrested the discharge for a time, but it returned, and he began to take the oil of Copaiba. On May 19th he took two tablespoonfuls of the pure oil, besides having taken one tablespoonful two or three days j)previously. After each dose he was sick and vomited a little. On the 20th the discharge stopped; he had a rigor, and noticed his face swollen and red. Went to business without taking food. On the 21st he had great thirst, nausea, vomiting, complete anorexia, restlessness, with increase of swelling and redness of face. The arms and legs, and finally the body, became red and swollen. When seen. May 22d, I found the whole body oedematous, face dusky yellowish-red color; oedema, worst about eyelids, which could not be opened; some sticky discharge at margins of eyelids; surface of skin of face and neck raised rather like measles. This is more observable where the raised eruption terminates, next the hair and at lower parts of neck. Over the body is a clearly-reclrlish smooth eruption, studded with innumerable points of a deeper color scattered over the surface. The hands and feet somewhat resembled the face in appearance. The throat is inflamed, of a dusky redness, with oedema of uvula ; no difficulty in swallowing. He complains of feeling very ill; he is sick and restless, and had no sleep, hut tossed about all night. No pain complained of; no difficulty with the urine, which is rather dark in color, without deposit. Still intense thirst; tongue very foul, yellowish-white thick fur ; bowels not moved for two days. Morning temp. 104° ; pulse 140, small, thready. In the evening temp. 103° ; pulse 130 ; stronger. Complains of his head going round during day, and of slight sore throat; thirst less ; has taken a little food ; felt sick and retched after it, but retained what he took; the penis cedematous; no pain in micturition ; bowels moved slightly ; has taken 3j of brandy every two hours,“