Dioscorea

Authority. 8, Olin M. Drake, M.D., Pub. of Mass. Horn. Med. Sac., vol. iv, p. 575.

Had been subject to a dull, heavy pain at the inferior angle of the left scapula occasionally for the past twelve months, otherwise perfectly healthy.

October 29th, at 10 A.M., feeling perfectly well, took 1 grain of the first trit.; ten minutes after had considerable nausea, with rumbling in the cardiac portion of the stomach. 11 a.m., dull headache and nausea, both lasting till 3 P.M. At 3.30 had hard, lum[)y stool. 10 P.M., all unpleasant effects had passed away ; took 2 grains ; fifteen minutes after sharp pain in left side, midway eighth rib, which hinders me in taking a deep inspiration, pain in right foot, base of second toe, passing off' on motion, but immediately returning, lasting some six minutes; rumbling in the bowels; forty minutes after cutting pain in the right lobe of the liver, lasting some five minutes.

October 30th. Got up with bad-tasting mouth, tongue coated yellowish white ; 10 a.m. took 1 grain ; at once considerable nausea, but not so bad as yesterday; half an hour after the dull headache returned, through the temples mostly, lasting till afternoon; 10 p.m. took 2 grains; twenty minutes after pain in umbilicus; in half an hour heaviness in head returns, an aching over right eye.

October 31st. Awoke, after sleeping well, with a horrid headache, so severe it made me reel ; back feels weak and sore up and down the spine ; whitish-coating on my tongue, with a sickening taste; 11 a.m., feeling well, took 1 grain, producing the usual feeling in my head, but no nausea; head felt bad until after dinner (2.30 p.m.); at 10.30 p.m., took 2 grains; unpleasant feelings through temples, no other effect.

November 1st. In morning, coated tongue; at 10 a.m, took two grains, producing no symptoms ; 10 p.m., stool, first part lumpy, then diarrhoea ; 10.30 P.M., took 3 grains, with no effect save heaviness in head.

November 2d. Slept well, tongue coated, taste not so bad in my mouth as yesterday morning ; 11 a.m., took 3 grains; 10 p.m., soft stool, with considerable pain; 10.30 p.m., took 3 grains, followed by some rumbling in bowels.

November 3d. Slept well ; felt sick at the stomach, and cared for no breakfast; at 9 a.m., diarrhoeic stool, with considerable pain in the epigastrium, and cutting pain in rectum ; 9.30 a.m., took 4 grains; rumbling in bowels.

November 4th. No symptoms since last dose; 9 A.M., took 6 grains; in fifteen minutes pain in region of gall-bladder; in twenty minutes heaviness of head returned ; 10.45 a.m., head symptoms grow worse ; great salivation, with a peculiar prickly feeling at the end of the tongue, as though it had been burned with hot drink; eructations from stomach, with a taste like bile.

November 5th. Had a restless night; woke up at 12 oclock with a severe pain in right lobe of liver, also pain in left side (eighth rib), so severe could not sleep ; spinal cord feels bruised all the way up and down ; 3 p.m., have had pain off and on during the whole day in left side (eighth rib), in liver, and in left lumbar region ; 3.30 p.m., took 14 grains ; 10 p.m., severe headache since taking last dose; took 7 grains, producing pain in left side of head.

For a number of days after last dose, occasionally would feel the pains in the left side and in the liver,®.