Jaborandi

Authorities^. 23, Mr. John Tweed}'-, Nashville Journ. of Med. and Surg. (New’ Eug. Med. Gaz., vol. xi, 1876, p. 336), conclusions from experiments on himself; 24, John M. Eating, M.D., Philad. Med. Times, vol. vii, 1877, p. 434, Dr. Hull took one scruple of the leaves in infusion ; 25, J. B. Tyson, M.D., Am. Journ. Med. Sci., 1877 (2), p. 132, A. C. took a drachm of the powdered leaves infused in about 8 fluid ounces of water; 26, same, L. D., a woman, took the same; 27, C. M., a man, took the same.

Contraction of the pupil. Tension of the accommodative apparatus of the eye, with approximation of the nearest and farthest points of distinct vision. Amblyopic impairment of vision from diminished sensibility of the retina. The effects, however, do not last long. In his case the approximation of the near and far points of distinct vision declared itself in a quarter of an hour, and reached its maximum in about forty minutes. It then gradually subsided and entirely passed off, and the eye resumed its normal state in about an hour and a half,^'®.—Passed 960 cubic centimeters of urine in the twenty-four hours, containing 19 grains of urea (before experiment) ; 1026 cc. of urine, containing 20.7 grams of urea (in twenty-four hours after experiment),®*.—Passed 1000 cc. urine, sp. gr. 1018, in twentyfour hours, containing 19 grams of urea (before experiment); 900 cc. urine, sp. gr. 1022, containing 27 grams urea (after experiment),®®.—Passed in twenty-four hours 1620 cc. urine, sp. gr. 1018, containing 24.3 grains of urea (before experiment) ; 1800 cc. urine, sp. gr. 1012, containing 27 grams urea (after experiment),®'.—The first effect, which came on about eight minutes after drinking the infusion, and chewing and swallowing about one half of the leaves, was a profuse flow of saliva, which continued about three hours. During this time at least thirty or forty ounces must have flowed. Following closely upon this was the diaphoretic effect, which was extremely profuse, the perspiration running off in drops, and saturating everything. In about half an hour sudden and severe pain was experienced in the bladder, shooting down to the urethra, and causing exclamations of pain. This was followed by cutting pain in the lower bowel, though there was no tendency to diarrhoea. It became so severe as to necessitate an opium suppositor}’, which afforded great relief. About this time (one hour after taking the drug) cardiac irregularity was noticed, with great weakness and rapidity of action, and a nervous, restless condition, with a constant yawning. There was gradually developed a dimness of vision, and soon surrounding objects, beyond a couple of inches from the eye, became indistinct. A watch held closely could be read with ease. Th is condition lasted several hours, when nausea came on, followed by severe vomiting, ejecting the contents of the stomach, finally bile, and then passing off as a continued retching. The unpleasant effects were counteracted by the administration of whiskey, about two drachms, in water, and I fell asleep to awake next morning in a weak, languid state, with excessive dryness of mouth and continued thirst,'**.